DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG9932 and Zfp521

DIOPT Version :9

Sequence 1:	NP_609599.1	Gene:	CG9932 / 34701	FlyBaseID:	FBgn0262160	Length:	2171	Species:	Drosophila melanogaster
Sequence 2:	NP_663467.1	Gene:	Zfp521 / 225207	MGIID:	95459	Length:	1311	Species:	Mus musculus

Alignment Length:	1755	Identity:	320/1755 - (18%)
Similarity:	515/1755 - (29%)	Gaps:	648/1755 - (36%)

- Green bases have known domain annotations that are detailed below.

  Fly   232 EEKLQRDIQAFNQRQREEQQREQQRELELVATSAYERQMQVLR-------------------DYE 277
            |:|:: |.:|.:.::|.    |...|||..|..:.:..:||..                   |.|
Mouse    20 EDKIE-DGEAVDCKKRP----EDGEELEEDAVHSCDSCLQVFESLSDITEHKIHQCQLTDGVDVE 79

  Fly   278 RQSPAEPPTPSPTSGSATPPSNGE-----EPQ---NRLLKCSACEFTTLYRTQLRAHELAEHGKT 334
            .......|..||:|...|.||:||     |.:   .....|..|:.:....:.|:.||.:...|.
Mouse    80 DDPSCSWPASSPSSKDQTSPSHGEGCDFGEEEGGPGLPYPCQFCDKSFSRLSYLKHHEQSHSDKL 144

  Fly   335 KFFRCDKCSYVTHIKARFSKHVKYHS-MPMIKCVTCDFRTPYKWNLDRHMKNHGGAGAFKCAACD 398
            . |:|..||.:...|....:|:|.|: .....|..||.......:|..|:|.|.....:|||.|.
Mouse   145 P-FKCTYCSRLFKHKRSRDRHIKLHTGDKKYHCSECDAAFSRSDHLKIHLKTHTSNKPYKCAVCR 208

  Fly   399 ----FTADIKQSLTVHEMNHHVPPVGNAGSIWPRRQNKVGASEMCE---DF-------------- 442
                .::.:...:.|||.|......|:....|..:..:  ....||   ||
Mouse   209 RGFLSSSSLHGHMQVHERNKDGSQSGSRMEDWKMKDTQ--KCSQCEEGFDFPEDLQKHIAECHPE 271

  Fly   443 ---LSDSAELEDQYNNNNVDDELDGVDDADEAMSGGEE--------------QPLHLHHYGKRSK 490
               ..|.|.|:..|.:....:|...::.. |.:.|||:              :.|:.|
Mouse   272 CSPNEDRAALQCMYCHELFVEETSLMNHI-EQVHGGEKKNSCSICSESFLTVEELYSH------- 328

  Fly   491 YDDEEEPTDLSQKGGCSSDTSSVGTPTPRAQRTMPNLIPISKGAKDVLNLSKETNASRSSLTEIA 555
            .|..::|.      .|:...|             |:|:.:  |...|.:.:.::|.|..|.|.:.
Mouse   329 MDSHQQPE------SCNHSNS-------------PSLVTV--GYTSVSSTTPDSNLSVDSSTMVE 372

  Fly   556 SMFFNEKQISEMLDKSDVPQLSPATTVASQNSTRSQLTKKSSFMDKLKTGAQHENLVCQCGHVAK 620
            :             ...:|:.......|.|.   |.:|..||         :...:...|.:..|
Mouse   373 A-------------APPIPKSRGRKRAAQQT---SDMTGPSS---------KQAKVTYSCIYCNK 412

  Fly   621 CLSESI----IHGKSCHASAVIIDEDEAGLHEDDGDDRLEIDEDDEDHHSHSALNLSVTGSTRCQ 681
            .|..|:    ||.|:.|                       :|:.::.|              .||
Mouse   413 QLFSSLAVLQIHLKTMH-----------------------LDKPEQAH--------------ICQ 440

  Fly   682 HCRHRCKSSTDLMHHLKQCVEAIRCANEMYDSNSGESGDRRPDSQSLQQQAAVQQQRVCIWNKAT 746
            :|.....|..:|..||||..||                 :.|........|.|.|...|
Mouse   441 YCLEVLPSLYNLNEHLKQVHEA-----------------QDPGLIVSAMPAIVYQCNFC------ 482

  Fly   747 KEIIAAAAASLQQDKNNHNLVKSPTGSQAASNEENSYYGVETAPGYGEVTKKMTPEEEAANSSLK 811
            .|::.......:..:.:|..      :..|:.:.|:::......|:            ..:|||:
Mouse   483 SEVVNDLNTLQEHIRCSHGF------ANPAAKDSNAFFCPHCYMGF------------LTDSSLE 529

  Fly   812 KVYKCPHCSFWASTASRFHVHIVGHLNKKP----FECSLCSYRS--NWRWDITKHIRLKTIRDPS 870
            :..:..||..   :.|||...::| ..|:|    :.||.|:...  |....:.|||:      .:
Mouse   530 EHIRQVHCDL---SGSRFGSPVLG-TPKEPVVEVYSCSYCTNSPIFNSVLKLNKHIK------EN 584

  Fly   871 HKTAKVLMNDETGRRNYTKYNKYI-------------------TLMKVTEEDGDPKLMKSGEMTP 916
            ||...:.:|             ||                   |.:|:.:..|......|||...
Mouse   585 HKNIPLALN-------------YIHNGKKSRALSPLSPVAIEQTTLKMMQTVGGGPARASGEYIC 636

  Fly   917 NQVASLAFLKDYAKVGSVSGQDIT-LEPVLP-------NK--PNVLDDAHLADNLIRIPLLATMM 971
            ||..:     .|..:.|......| |:.|||       ||  ||  .::.|....|...:.:|..
Mouse   637 NQCGA-----KYTSLDSFQTHLKTHLDTVLPKLTCPQCNKEFPN--QESLLKHVTIHFMITSTYY 694

  Fly   972 NAAMAQQQHQQ----QQQKEHQSTMITPSVTISPVKRSNQASVMQGKPSDDLITEVHQEGNEKRT 1032
            ......:|...    |:......|.:....|:.       ..|...|.|..|...| :..|||:
Mouse   695 ICESCDKQFTSVDDLQKHLLDMHTFVFFRCTLC-------QEVFDSKVSIQLHLAV-KHSNEKK- 750

  Fly  1033 VYRCRKCNFGHQNRDAVLAHVKIHYQDASYPKSNSGNSSTSPLQVSVGGSPQFYMNKVFAAMCLS 1097
            ||||..||:..:|...:..|||.::.:      |.|                    ||...:...
Mouse   751 VYRCTSCNWDFRNETDLQLHVKHNHLE------NQG--------------------KVHKCIFCG 789

  Fly  1098 QTQSQSSPNSGSAGTSPAISAGLLQRAIQEAQHSPTPNASALSGLALALAGGKPQANTTKASAAS 1162
            :          |.||...:...:       ..||...|....|                ||..|.
Mouse   790 E----------SFGTEVELQCHI-------TTHSKKYNCRFCS----------------KAFHAV 821

  Fly  1163 IL--EHGEQKASQNEASADSLTSPNTTTTNSTTSRTTKDTTARSLQDLLTSPRSARNGNHPSNAN 1225
            ||  :|..:|....|..     :|| ..||..:.:..|:..  .||.|||:.:.:.|.:..|..:
Mouse   822 ILLEKHLREKHCVFETK-----TPN-CGTNGASEQVQKEEA--ELQTLLTNSQESHNSHDGSEED 878

  Fly  1226 SNS--------VVGNGLRLDAVYVASSTNNTTTPPPPPTNSVSKPNASPLPVTTTPTPISTATPL 1282
            .:|        :.|....::.:.
Mouse   879 VDSSEPMYGCDICGAAYTMETLL------------------------------------------ 901

  Fly  1283 AHPLGAGNHRSSSSHHNDQNHAPPSHMAGDGCHLASGLTHAHIINTNTKANPSSNSFPSSSSSSS 1347
                              |||....|....| ..|.....|.:|..|.|.|..|.:|.|.:....
Mouse   902 ------------------QNHQLRDHNIRPG-ESAIVKKKAELIKGNYKCNVCSRTFFSENGLRE 947

  Fly  1348 SSSMASTSSAAGSASASASSTTSSPPPPAASSSASAYMAAMAPQKH--VPTVAQMSHPQTRFHSH 1410
            .                                   ....:.|.||  .|...:      ||
Mouse   948 H-----------------------------------MQTHLGPVKHYMCPICGE------RF--- 968

  Fly  1411 SPGSPSLLTMADGDRREPSPYRCGHCHQVSNWKHVIQRHCRLKHSGDIRIETLERGASVSANAPP 1475
                |||||:.:              |:|::.|.:...:||:
Mouse   969 ----PSLLTLTE--------------HKVTHSKSLDTGNCRI----------------------- 992

  Fly  1476 IYRPLGAGASNESQSHIHNPSNPITSNILKSGSNTNANSNINSNSAQPLLLTTKQLEQIFHTPLS 1540
            ...||    .:|.:...|...:|...|.|...........:.|.      |..| :...||...:
Mouse   993 CKMPL----QSEEEFLEHCQMHPDLRNSLTGFRCVVCMQTVTST------LELK-IHGTFHMQKT 1046

  Fly  1541 ASAAAVVNAANTQQDIQAAAAYWAAACKAVVANSSAEELLQLQQNDQIEITRLPTTTEHSIGSSG 1605
            .:.::|......|   .....|..|:|        .:|....|...:::|..||
Mouse  1047 GNGSSVQTTGRGQ---HVQKLYKCASC--------LKEFRSKQDLVKLDINGLP----------- 1089

  Fly  1606 NNTKSKQQKCPVCPYISESKSQ-MNYHVSLHKP-------------------TQYECRLCTFVCA 1650
                  ...|..|..:|:|.|. ::......:|                   .:..|..|.....
Mouse  1090 ------YGLCAGCVNLSKSSSPGLSLPPGASRPGLGQNESLSAMEGKGKAGGLKTRCSSCNVKFE 1148

  Fly  1651 KKQHLSSHMRTVHQQQMVASGAGAAAGAAGGVGGGGAASLGLDFSVALQLAAAAKQVQQLPASTP 1715
            .:..|.:|::|||::.:..:.                         :.||  ...||..:|..:|
Mouse  1149 SESELQNHIQTVHRELVPDAN-------------------------STQL--KTPQVSPMPRISP 1186

  Fly  1716 LSIDLSQ----------------IQMDAAS---DAELNPQ--------QLPPEYQYKLISY---- 1749
            ...|..:                ||:..|:   |..||.:        ..|.:.|..||.:
Mouse  1187 SQSDEKKTYQCIKCQMVFYNEWDIQVHVANHMIDEGLNHECKLCSQTFDSPAKLQCHLIEHSFEG 1251

  Fly  1750 ------CPRCPARFAQKHNDERNAKQELEQHLLAHSDQEPEDQDPSYVCAYCEYRTSEETMLQLH 1808
                  ||.|...|.|.:        :|:||:.:...||    |..|.|..|..:...:|.||.|
Mouse  1252 MGGTFKCPVCFTVFVQAN--------KLQQHIFSAHGQE----DKIYDCTQCPQKFFFQTELQNH 1304

Fly 1809 1808
Mouse 1305 1304

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG9932	NP_609599.1	C2H2 Zn finger	339..359	CDD:275368	6/19 (32%)
		C2H2 Zn finger	366..386	CDD:275368	6/19 (32%)
		C2H2 Zn finger	394..414	CDD:275368	6/23 (26%)
		C2H2 Zn finger	816..836	CDD:275370	5/19 (26%)
		C2H2 Zn finger	844..862	CDD:275370	6/19 (32%)
Zfp521	NP_663467.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	81..108		9/26 (35%)
		COG5048	<83..236	CDD:227381	40/153 (26%)
		C2H2 Zn finger	120..140	CDD:275368	5/19 (26%)
		C2H2 Zn finger	148..168	CDD:275368	6/19 (32%)
		C2H2 Zn finger	176..196	CDD:275368	6/19 (32%)
		C2H2 Zn finger	204..224	CDD:275368	3/19 (16%)
		C2H2 Zn finger	248..265	CDD:275368	4/16 (25%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	357..398		9/56 (16%)
		C2H2 Zn finger	407..428	CDD:275368	7/20 (35%)
		C2H2 Zn finger	439..460	CDD:275368	9/20 (45%)
		C2H2 Zn finger	479..498	CDD:275368	2/24 (8%)
		C2H2 Zn finger	636..656	CDD:275368	4/24 (17%)
		C2H2 Zn finger	666..686	CDD:275368	5/21 (24%)
		C2H2 Zn finger	696..713	CDD:275368	2/16 (13%)
		C2H2 Zn finger	724..745	CDD:275368	6/28 (21%)
		C2H2 Zn finger	754..774	CDD:275368	7/19 (37%)
		C2H2 Zn finger	785..805	CDD:275368	3/36 (8%)
		C2H2 Zn finger	811..829	CDD:275368	7/33 (21%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	863..883		4/19 (21%)
		C2H2 Zn finger	888..909	CDD:275368	4/80 (5%)
		C2H2 Zn finger	932..952	CDD:275368	4/54 (7%)
		C2H2 Zn finger	961..981	CDD:275368	10/46 (22%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1105..1136		1/30 (3%)
		C2H2 Zn finger	1227..1247	CDD:275368	4/19 (21%)
		C2H2 Zn finger	1258..1279	CDD:275368	8/28 (29%)
		C2H2 Zn finger	1288..1307	CDD:275368	6/17 (35%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24403
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.100