DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG9932 and lin-13

DIOPT Version :9

Sequence 1:	NP_609599.1	Gene:	CG9932 / 34701	FlyBaseID:	FBgn0262160	Length:	2171	Species:	Drosophila melanogaster
Sequence 2:	NP_498678.3	Gene:	lin-13 / 176083	WormBaseID:	WBGene00003002	Length:	2248	Species:	Caenorhabditis elegans

Alignment Length:	2489	Identity:	428/2489 - (17%)
Similarity:	706/2489 - (28%)	Gaps:	873/2489 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly    71 QLLQQQRQAAAVV-----AVVNSVQQ--QQQQQPQQVGMDAKEEGLPQCKIKRNYSCNHCAYFTQ 128
            :|.||..|.|.:|     .|.:..||  ..|..|.:.|:......:...|.:........|.|.|
Worm     5 ELFQQLNQTAPLVKTEEPEVPDEFQQANNNQSAPLRTGLSDLSHEIAAAKQREEEEAQRLADFMQ 69

  Fly   129 ----NPRYHLTHLRDVHGEKIVINKCKLCLYA-SRHFQKLVRHMKMVHGCTDGIPSGHGQAR--- 185
                .|........:.:.:..:.:|..|..:. |...::.|.:..:..|       ...||:
Worm    70 KDMKEPAVKRKRGSEEYKKDPLESKAPLSTFGHSSRPRRSVNYASIERG-------DEAQAQSLV 127

  Fly   186 ---GKRGMSREARKRR-------LEESVGVMG--------GQSLTVTVPDVPTLEQVKRELLLQE 232
               |.||..::.::.|       :||:.|..|        |.|....||.:||..........||
Worm   128 TDFGSRGNRKKPKRTRDELDENYMEENEGNSGRKKKPNAKGASRQFQVPGLPTYASQYSRPPKQE 192

  Fly   233 E------KLQRDIQAFNQRQ---REEQQREQQR-------------------------ELELVAT 263
            :      .|..|.:|..:|.   |.:.|...:|                         :|.:|..
Worm   193 DVFKTIVPLAEDARAEGERVIGFRLDSQPAVRRASGGFRRFCAWLSDNQIFSIMQTVDKLCIVGA 257

  Fly   264 SAYERQMQVLRDYERQSPAEPPT-----------------------PSPTSG-SATPPSNGEEP- 303
            :..:....:|:.......|.|||                       |.|.|. |.|.|.:...|
Worm   258 NNEDHDEILLKSIRHVYNAMPPTFRRDWEYAARKDVFDSRLFVQNMPMPLSEISVTDPRHPPSPI 322

  Fly   304 -QNRLLKCSACEFTTLYRTQLRA--HELAEHGKTKFFRCDKCSYVTHIKARFSKH---------- 355
             :...::.:.||...|:......  |.|..|.....|.||.|..|...:...:||
Worm   323 ARGTTVRPNCCENQPLFLNMCETIEHYLGHHDVVHLFGCDICYRVYPSRYELTKHDCKEFAEYLR 387

  Fly   356 ---------------------------------------------------------VKYHSMPM 363
                                                                     |.|...|:
Worm   388 QLTFKQQTLHLEAAYMYLCCSQCGLWLSVKPSGEGKKGWTYFATALMNHSCQPLVPVVAYFPKPL 452

  Fly   364 ----------------------IKCVTC---------DFRTPYKWNLDRHMKNHGGAGAFKCAAC 397
                                  :.|..|         :....:|   ::|..||      .|..|
Worm   453 KDEGKGIRIQFQVMSELNIGLPLSCSECNIEEFHSVVEIEEHFK---EKHEANH------TCIKC 508

  Fly   398 DFTADIKQSLTVHEMNH------------------------HVPPVGNAGSIWPR----RQNKVG 434
            ..|...:..|..|..:|                        .:|.||...|| |.    ...:|.
Worm   509 GKTFGTEFMLKHHAQSHTTQTAQFANYLQMSATYQPPPSSGRLPYVGFGSSI-PAIGGLTSGEVQ 572

  Fly   435 ASEMCEDFLSDSAELEDQY----------------NNNNVDDELDGVDDADEAMSGGEEQPLHLH 483
            |.|..|:..|:..| .|:|                .|.|:.|..:.....:...|.|||
Worm   573 ALEASENKKSEFVE-PDEYTIRKKLLRWKHAKTKKENRNITDSNEKEFSYEPGESSGEE------ 630

  Fly   484 HYGKRSKYDDEEEPTDLSQKGGCSSDTSSVGTP-TPRAQRTMPNLIPISKGAKDVLNLSK---ET 544
                    |.::...:...:...|||:.|.... |...|:...|:........:.:|.:|   ..
Worm   631 --------DFQKSLLEQDNQSSSSSDSDSDSDDFTSSKQKKKRNIKIRGDLGYEHINRNKFFERP 687

  Fly   545 NASRSSLTEIASMFFNEKQIS--EMLDKSDVPQLSPATTVASQNSTRSQLT-------------K 594
            .:.:.:...|..::.....:|  .:||..:..::...:.:...||.:|.|.             .
Worm   688 ESEKEARKRIEKVYKKHVLLSRERLLDPEEALRILEESRMVHLNSIQSTLADDIAMSCIRTISLP 752

  Fly   595 KSSFMDKLKTGAQHENLVCQCGHVAKC----LSESIIHGKSCHASAVIIDEDEAGLHEDDGDDRL 655
            .|:.:|.||.......:...|   .||    ..:.::|..||
Worm   753 ASNCIDPLKDLLLVNKIFYFC---TKCNYIFSKDPVVHCLSC----------------------- 791

  Fly   656 EIDEDD--EDHHSHSALNLSVTGSTRC--QHCR-HRCKSSTDLMHHLKQCVEAIRCANEMYDSNS 715
            |:.|||  |.:|:.|..:..|    ||  ..|: |.| |...|..||.. |.:.:...|:.   |
Worm   792 EVTEDDLIEVYHAASGPHAGV----RCIDPECKAHLC-SVISLKTHLSD-VHSKQATLELV---S 847

  Fly   716 GE----SGDRRPDSQSLQQQAAVQQQ---RVCIWNKATKEIIAAAAASL---------------Q 758
            ||    |.:|...|..|..:...|.|   |..:......|.....:..|               |
Worm   848 GELDNFSENRFDRSLMLMAKHFTQLQFDERTYLARFTDIECFMPFSGLLEAKDQPRPMPIRQQPQ 912

  Fly   759 QDKNNHNLVKSPTGSQAASNEENSYYGVETA--PGYGEVTKKMTPEEEAANSSLKKVYKCPHCSF 821
            |.|..::||:...   .|.||....|.:..|  ||     :::.|            ||.|..|.
Worm   913 QIKPAYSLVRPDI---IAPNELMRPYTLTPAIRPG-----QRIKP------------YKVPRTSR 957

  Fly   822 WASTA----------------SRFHVHIVGHLNKKPFECSLC----SYRSNWRWDITKHI----- 861
            |.|.:                :|||.|          .|..|    |.::..|..:...:
Worm   958 WYSCSWCDREYESLNQFVDHLTRFHTH----------PCPSCGKAFSSQNTRRTHVCSRLFAEIK 1012

  Fly   862 -RLKTI--RDPS----HKTAKV---LMNDETGRRNYT---------------KYN---------K 892
             |..|:  :.||    |:..::   ::|.......|.               :||         .
Worm  1013 GRGATLCGQCPSCPEIHQVERIFVHMLNRHFSTIEYVLATGELLPPARDVGIRYNHGENGGYGRS 1077

  Fly   893 YITLMKVTEEDGDPKLMKSGEMTPNQVASLAFLKDYAKVGSVSGQDITLEP----------VLPN 947
            |.:|..:.:...||   :|.:....||...|.        .:.|.::...|          |.|.
Worm  1078 YESLRAIEQSVVDP---RSPDYRLKQVKISAL--------PIHGVELNRLPARDPPMGSFTVCPP 1131

  Fly   948 KPNVLDDA------------------HLADN---LIRIPLLATMMNAAMAQQQHQQQQQ------ 985
            |...:|..                  |:.|:   ....|..|.........|:|..|:.
Worm  1132 KDKNIDPRLMCYMCELTFDSYDELTHHMDDHPEKWANCPFCAANTPTHFDLQKHLIQEHVVQISG 1196

  Fly   986 -------KEHQSTMITPSVTISPVKRSNQASVMQGKPSDDLITEVHQEGNEKRTVYR-------- 1035
                   :||...|  .|..:...||.::.::...|.:|.|...||.:.:...|:.|
Worm  1197 QACCAFCQEHHRFM--SSHILFRCKRVSRCTICGVKSNDPLANRVHIQRSHALTLRRFQCAYCIK 1259

  Fly  1036 --------------------------------------------------CRKCNFGHQNRDAVL 1050
                                                              |:.|::...::|.::
Worm  1260 VFVSVGEYYEHECASGGGRVYSCTCSPNKFFNSPIEFCDHFDSVHILRNKCQLCSYDAPSQDGMV 1324

  Fly  1051 AHVKIHYQDAS---------------YPKSNSGNS---STSPLQVSVGGSPQFYMNKVFAAMCLS 1097
            .|.|.|.:...               :||.|||..   ...|:..|.....:..||.:   ||..
Worm  1325 KHRKTHMRSGCPKEQTKKLFILMKCLFPKHNSGYMRFIEGGPVPASYQDVDRSQMNYL---MCNM 1386

  Fly  1098 QTQSQSSPNS----------GSAGTSPAISAGLLQRAIQEAQHSPTPNASALSGLA--------- 1143
            .|.|.|...|          ...|.:....:|.||:.:........|::|.:..|:
Worm  1387 GTVSPSCHKSYAQAPRTLLEALEGVASDSRSGGLQKVVNVTTRMNEPSSSDVIMLSDDEDDDCVV 1451

  Fly  1144 --LALAGGKPQANTTKASAASILEHGEQKASQNEASADSLTSPNTTTTNSTTSRTTKDTTARSLQ 1206
              .|:..|..|.::|.........:.|.:...::|.......|.....:.|
Worm  1452 FEKAVPNGVAQGSSTSTPNPESSINCEVRVETSQAGYGGAQQPGYVDEDDT-------------- 1502

  Fly  1207 DLLTSPRSARNGNHP-SNANSNSVVGNGLRLDAVYVASSTNNTTTPPPPPTNSVSKPNASPLPVT 1270
            ||    ..|:.|..| .......||......:...||...|:|.|.|    :|:|..........
Worm  1503 DL----EVAQGGKSPYGEPVVKEVVDENGDDELAVVAEVENSTGTLP----SSISAGREKKFKCQ 1559

  Fly  1271 TTPTPISTATPLA-----HPLGAGNHRSSSSH-------------------HNDQNHAPPSHMA- 1310
            .......|...|.     |...||....:.::                   .|...:  ..|||
Worm  1560 KCSLAFYTNGSLESHMRDHRQDAGAQLCTETYGIPVVTKASWLCRNCCVVFENQPKY--QKHMAI 1622

  Fly  1311 -GDGC----HLASGLTHAH-IINTNTKANPSSN----------SFPSSSSSSSSSSMASTSS--- 1356
             ||.|    | .||:...| .|..:.|::....          :|.|..:.....|:|...|
Worm  1623 HGDTCLTCIH-CSGIAFNHTAIQNHMKSHEEKKVRYSCGTCLCTFASDLALFDHLSVAHGVSLYY 1686

  Fly  1357 ---AAGSASASASSTTSSPPPPAASSSASAYMAAMAPQKHVPTVAQMSHPQTRFHSHSPGSPSLL 1418
               ..|..|.||.|..                      :|:.  ....|..:...........||
Worm  1687 FCKVCGFGSTSADSVF----------------------QHIS--IHNGHNYSLVQRFGACPAQLL 1727

  Fly  1419 TMADGDRRE------------PSPYRCGH---------------CHQVSNWKHVIQRHCRLKHSG 1456
            .....|..|            .||..|.|               ||....|.:.:..:...:.:|
Worm  1728 NYDPTDELEFRSQILNKTIQLVSPSDCSHRSMLLQCETVVSCKTCHCTQAWFNYMAFNNHSEETG 1792

  Fly  1457 DIRIETLERGASVSANAPPIYRPLG----------AGASNESQSHIHNPSNPITSNILKSGSNTN 1511
            ..:.:.::.......:. |:.|.|.          ..|.:.|.:|.|..:.|.............
Worm  1793 FPQFKNVDLANDYRRDF-PLSRHLNERNALSMSQFGNAKHGSANHSHGQAQPNKRTFRHEVPYRT 1856

  Fly  1512 A--NSNINSNSAQPLLLTTKQLEQIFHTPLSASAAAVVNAANTQQDIQAAAAYWAAACKAVVANS 1574
            |  .|::.:|.:....:||.....:..:|        .|:.|.  .::.|....|...:.|:|||
Worm  1857 AAPRSSLQTNGSSMGSVTTNGGRVVRPSP--------PNSMNV--TLRRAPPQQAPPRRIVIANS 1911

  Fly  1575 SAEELLQLQQNDQIEITRLPTTTE------------------HSIGSSGNNTKSKQQKCPVCPYI 1621
            :       ..|..:....:..||:                  ||:.||.::...:|     |.:.
Worm  1912 A-------PNNTNVLRNHVAVTTKCQFKDCDKVLHSEFDRQLHSMHSSNSSWFCRQ-----CGHS 1964

  Fly  1622 SESKSQMNYH-VSLHKPTQYE---------------C--RLCT---FVCAKKQHLSSHMRTVHQQ 1665
            .:|:..:..| :.:|....|:               |  |.||   |...|.  ...||||.|..
Worm  1965 PKSEIDLFLHYIQVHLKPAYDKHQSNSFKSNVFHLKCPIRSCTSPEFQSPKA--FEKHMRTAHAA 2027

  Fly  1666 QMVASGAGAAAGAAGGVGGGGAASLGLDFSVALQLAAAAKQVQQLPAS------TPL--SIDLSQ 1722
            ::....:...|..|               |.||.:....:....|.::      .|:  |:.:..
Worm  2028 ELPFEASCCDARFA---------------SKALCVKHDQEHASFLDSNGTDASCCPICGSLSMWS 2077

  Fly  1723 IQMDAASDAELNPQQLPPEYQYKLISYCPRCPARFAQKHNDERNAKQELEQH-LLAHSDQEPEDQ 1786
            :..|..:|. |....:.....|:  |.|.:|..:|....|.::.....|:.| :..|.:
Worm  2078 LPKDPHTDC-LQSHIIRHGLDYR--SSCRQCLKQFPADVNQDQVIAHILDTHGMSMHGN------ 2133

  Fly  1787 DPSYVCAYCEYRT-SEETMLQLHRAVHMSHYQEKCQELYRNCKEDVEYPAPKLLQLTGPETIWVV 1850
              ::.|..|...| :.|...:..|..|:.|...|.....|.          :|:..||.|    .
Worm  2134 --TFHCNLCTTGTKTVEEFAEHCRKAHVFHILVKSSHSTRG----------ELVVTTGQE----Y 2182

  Fly  1851 DNELSLQLLQQTTGGAVST---STGGFDNQNSLLKKQLESGGGQMVPLPLKVSVNKNEAEVPEED 1912
            :|.:.|:.:.:.:..::|:   |..|...|.|:|.    :|.|....|.:..::.:.|
Worm  2183 ENYVGLKSVTRASLNSISSQRASNAGETAQPSVLC----AGSGNAALLTIAAAIGEPE------- 2236

  Fly  1913 EERHSSSTPSTSASVATSD 1931
                   |.:.:|.|.|.|
Worm  2237 -------TSNNTAEVLTLD 2248

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG9932	NP_609599.1	C2H2 Zn finger	339..359	CDD:275368	7/86 (8%)
		C2H2 Zn finger	366..386	CDD:275368	4/28 (14%)
		C2H2 Zn finger	394..414	CDD:275368	5/19 (26%)
		C2H2 Zn finger	816..836	CDD:275370	8/35 (23%)
		C2H2 Zn finger	844..862	CDD:275370	4/27 (15%)
lin-13	NP_498678.3	C2H2 Zn finger	961..982	CDD:275368	1/20 (5%)
lin-13	NP_498678.3	C2H2 Zn finger	986..1003	CDD:275368	4/16 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24403
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.100