DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG9934 and UBE4A

DIOPT Version :9

Sequence 1:	NP_001162967.1	Gene:	CG9934 / 34699	FlyBaseID:	FBgn0032467	Length:	1217	Species:	Drosophila melanogaster
Sequence 2:	NP_004779.2	Gene:	UBE4A / 9354	HGNCID:	12499	Length:	1073	Species:	Homo sapiens

Alignment Length:	994	Identity:	254/994 - (25%)
Similarity:	436/994 - (43%)	Gaps:	222/994 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly   346 KHHVLLYLIRCYQNYQTECSRKTP--LTQPALQLAFEQVMRMTVLVLTDRIYQNLNGHMDQSALL 408
            :.|:..||..|:|..:.|.: |.|  |...|:|.....|.....::||..||.:.|.|   ..|:
Human   170 ERHIFCYLYSCFQRAKEEIT-KVPENLLPFAVQCRNLTVSNTRTVLLTPEIYVDQNIH---EQLV 230

  Fly   409 DLM---------YMAK-----VSEPFLIDLIAHTHQDRE----------AFDTIFS--------Q 441
            |||         ||.|     |:| ||.::|.....|.|          .||.:..        |
Human   231 DLMLEAIQGAREYMNKIYFEDVTE-FLEEVIEALILDEEVRTFPEVMIPVFDILLGRIKDLELCQ 294

  Fly   442 VLRGLFAGMQ------RNICTSKISVQQIE---------WLSKL--VVIKVGSVRPIADLVSRQP 489
            :|  |:|.:.      |....:|:.|:.|:         :...|  |::.:..:.....:|....
Human   295 IL--LYAYLDILLYFTRQKDMAKVFVEYIQPKDPTNGQMYQKTLLGVILSISCLLKTPGVVENHG 357

  Fly   490 NFLPPICTKISGREIVKCSFLGPFLSVSLFAEENIKFAEFTTKNKLEDASSSRLRWELHSMRTNM 554
            .||.|  ::.|.:||                             |:::|:       :|......
Human   358 YFLNP--SRSSPQEI-----------------------------KVQEAN-------IHQFMAQF 384

  Fly   555 HVVFHSLCVN-ASSRPKT----LEYIASILRHNDRRVQFASDE------KLLARDGFMINLMSVL 608
            |...:.:..| ....|:|    |.::.:.|..|..|.:..:::      ::.|.|.|.:||.:.|
Human   385 HEKIYQMLKNLLQLSPETKHCILSWLGNCLHANAGRTKIWANQMPEIFFQMYASDAFFLNLGAAL 449

  Fly   609 QQLS---VKIKLDRI---EPNFHYYKNSLVNIEQDTKIRYSEEEYRNFLARDFSQPV-------- 659
            .:|.   .|.:..|:   .|.:...|          ::...|.:.:|...|...:..
Human   450 LKLCQPFCKPRSSRLLTFNPTYCALK----------ELNDEERKIKNVHMRGLDKETCLIPAVQE 504

  Fly   660 ----ENTNFQTQCWFLTLQAHHLGYLPAIQRYRQKVRAIKELQKLIDELDRTKSHWMNSRYAN-- 718
                :|.|..|:...||....:||:          .|...::.|:...|.|.:..|.:::.::
Human   505 PKFPQNYNLVTENLALTEYTLYLGF----------HRLHDQMVKINQNLHRLQVAWRDAQQSSSP 559

  Fly   719 RNNQFKERWEKQLRKLNRSKTCCEITLLDPGLLQRCTEFYSTVCEFMLYQF----EG-RPIEGPF 778
            ..:..:|::|:.:.....:||    .:.:|.:||.|.....::. .:|.|.    || :|||..|
Human   560 AADNLREQFERLMTIYLSTKT----AMTEPQMLQNCLNLQVSMA-VLLVQLAIGNEGSQPIELTF 619

  Fly   779 ISKLPVQQLLPTDAFSAL---PEWYIDDIAEFILFTMQHANMDIRQ----GIDHSIITWLLTCVC 836
              .||       |.:|:|   ||::.|::.:|::|..:.|: ||.:    .::| ::.::.....
Human   620 --PLP-------DGYSSLAYVPEFFADNLGDFLIFLRRFAD-DILETSADSLEH-VLHFITIFTG 673

  Fly   837 ASHLIKNPYVTAKLVEVMFVFSLKPANSVNAAMWNHELAQNALVSS------------------- 882
            :...:|||::.|||.||:           .|.|.:.:...|.||||
Human   674 SIERMKNPHLRAKLAEVL-----------EAVMPHLDQTPNPLVSSVFHRKRVFCNFQYAPQLAE 727

  Fly   883 -LMRFYVDVETTGQSTEFYDKFTIRYHISHLFKSMWENPIHRQAV---------ICESRVGNQFV 937
             |::.:||:|.||...:|..||..|..:..:.:.||....:|:::         ..|:.....|:
Human   728 ALIKVFVDIEFTGDPHQFEQKFNYRRPMYPILRYMWGTDTYRESIKDLADYASKNLEAMNPPLFL 792

  Fly   938 KFVNMLMNDTTFLLDECLENLKRIHQTQQLLSDKANLSKMSAEQQQSRLTQLATDERQCRSYLTL 1002
            :|:|:||||..|||||.::.|.:| :.||:..|:.....::.|.::.:...|....:..|.:..:
Human   793 RFLNLLMNDAIFLLDEAIQYLSKI-KIQQIEKDRGEWDSLTPEARREKEAGLQMFGQLARFHNIM 856

  Fly  1003 ARETVDLFHYLTSDIKEPFMRDELVDRLSSMLNFNLKQLAGPKCNDLKVKNPAKYGWEPRSLLAQ 1067
            :.||:....:|||:||..|:...|.:|:.||||:.|:.|.|||...||||:.:::.::|:.|::.
Human   857 SNETIGTLAFLTSEIKSLFVHPFLAERIISMLNYFLQHLVGPKMGALKVKDFSEFDFKPQQLVSD 921

  Fly  1068 IFDIYLHL-DCDRFAEALAADERSFDVQICNEAASRIKRLALRSAVEVERFKALTQRAHEIYVTN 1131
            |..|||:| |.:.|...:..|.||:...:..:....:|::. :....:..|..|.:|...:....
Human   922 ICTIYLNLGDEENFCATVPKDGRSYSPTLFAQTVRVLKKIN-KPGNMIMAFSNLAERIKSLADLQ 985

  Fly  1132 LQTEDECADAPDEFKDPLMDTLMSDPVVLPSGTV-MDRAIITRHLLNSCTDPFNRQPLTEDMLVA 1195
            .|.|:..|||.|||.||:|.|||.|||||||..| :||:.|.||||:..||||||.|||.|.:..
Human   986 QQEEETYADACDEFLDPIMSTLMCDPVVLPSSRVTVDRSTIARHLLSDQTDPFNRSPLTMDQIRP 1050

  Fly  1196 NIELKQRIDAW---RKEQR 1211
            |.|||::|..|   ||:|:
Human  1051 NTELKEKIQRWLAERKQQK 1069

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG9934	NP_001162967.1	Ufd2P_core	510..1124	CDD:287392	154/686 (22%)
CG9934	NP_001162967.1	U-box	1141..1211	CDD:252675	43/73 (59%)
UBE4A	NP_004779.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	33..56
		UFD2	170..1068	CDD:227444	253/991 (26%)
		Ufd2P_core	337..978	CDD:287392	162/727 (22%)
		U-box	995..1067	CDD:252675	42/71 (59%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5113
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53881
OrthoDB	1	1.010	-	-		D194967at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.830