Protein Alignment Ube4B and UFD2

DIOPT Version :10

• Sequence 1: NP_609597.1
• Gene: Ube4B / 34699
• FlyBaseID: FBgn0032467
• Length: 1217
• Species: Drosophila melanogaster
• Sequence 2: NP_010091.2
• Gene: UFD2 / 851337
• SGDID: S000002349
• Length: 961
• Species: Saccharomyces cerevisiae
• Alignment Length: 937
• Identity: 250/937 - (26%)
• Similarity: 446/937 - (47%)
• Gaps: 120/937 - (12%)

  Fly   352 YLIRCY-QNYQTECSRKTPLTQPALQLAFEQVMRMTV------------------LVLTDRIYQN 397
            ||..|: :|.|.:...|......:|...|:::.|:.:                  :.....|..|
Yeast    59 YLNDCFRRNQQQKRITKNKPNAESLHSTFQEIDRLVIGYGVVALQIENFCMNGAFINYITGIVSN 123

  Fly   398 LNGHMDQSALLDLMYMAKVSEPFLIDLIAHTHQDREAFDTIFSQVLRGLFAGMQRNICTSKIS-- 460
            :|.:.|   .|..:....:.|...:||:          :.:|..:|         ..|...:|
Yeast   124 VNSYTD---FLSQIIQRAILEGTALDLL----------NAVFPTLL---------EYCNKHVSHF 166

  Fly   461 --VQQIEWLSKLVVIKV-GSVRPIADLVSRQPNFLPPICTKISGREIVKCSFLGPFLSVS-LFAE 521
              .:.:.:.:.|.:.:: .:.:|||::.::...|......|  .::..:.:.|||.||:| :.|.
Yeast   167 DLNESVIYNNVLTIFELFVTFKPIAEIFTKIDGFFADYSCK--PQDFERKTILGPILSLSPIEAA 229

  Fly   522 ENIK-FAEFTTKNKLEDASSSRLRWELH-SMRTNMHVVFHSLCV--------NASSRPKTLEYIA 576
            ..|: :.:...::|.:.|.       :| |::....||...|..        :.:||...:.|.|
Yeast   230 VAIRNYGDNLLRSKQQTAM-------IHESLQAEHKVVIDRLFFIVDKLVRGSLNSRTDMISYFA 287

  Fly   577 SILRHNDRRVQFASDEKLLARDGFMINLMSVLQQLSVKI------KLDRIEPNFHYYKNSLVNIE 635
            .|...|..|.......|.|:.:|||.|:..:|.:.|...      |:|:|:.|:....:..:::.
Yeast   288 HIANKNHLRRADHPPFKELSSNGFMSNITLLLVRFSQPFLDISYKKIDKIDANYFNNPSLFIDLS 352

  Fly   636 QDTKIRYSEEEYRNFLARDFSQPVENTNFQTQCWFLTLQAHHLGYLPAIQRYRQKVRAIKELQKL 700
            .:|::....:|...|..::........||.:.|:||||...|.| |.....:.:|:.:  |::.|
Yeast   353 GETRLNSDFKEADAFYDKNRKTADSKPNFISDCFFLTLTYLHYG-LGGTLSFEEKMGS--EIKAL 414

  Fly   701 IDELDRTKSHWMNSRYANRNNQFKERWEKQLRKLNRS-KTCCEITLLDPGLLQRCT---EFYSTV 761
            .:|:::.|      :.|..::.|......||.|:.:: ||...:.....|.....:   |.:..:
Yeast   415 KEEIEKVK------KIAANHDVFARFITAQLSKMEKALKTTESLRFALQGFFAHRSLQLEVFDFI 473

  Fly   762 C---EFML------YQFEGRPIEGPFI-SKLPVQQLLPTD--------AFSALPEWYIDDIAEFI 808
            |   .|::      ::|..:.|:.|.| .::.|:.:...|        .|...||:.::....:.
Yeast   474 CGASTFLIRVVDPEHEFPFKQIKLPLIPDQIGVENVDNADFLRAHAPVPFKYYPEFVVEGPVNYS 538

  Fly   809 LFTMQHANMDI----RQGIDHSIITWLLTCVCASHLIKNPYVTAKLVEVMFVFSLKPANSVNAAM 869
            |:..::....|    |.|......|.:|.|   ..|:.||::..|||:::.|.::...::....|
Yeast   539 LYISKYQTSPIFRNPRLGSFVEFTTMVLRC---PELVSNPHLKGKLVQLLSVGAMPLTDNSPGFM 600

  Fly   870 ---WNH-ELAQNALVSSLMRFYVDVETTGQSTEFYDKFTIRYHISHLFKSM-WENPIHRQAVICE 929
               :.| ||....|:.:|:.|||.||.||.|::|||||..||.||.:.:.: ::.|.::..:|.:
Yeast   601 MDIFEHDELVNKNLLYALLDFYVIVEKTGSSSQFYDKFNSRYSISIILEELYYKIPSYKNQLIWQ 665

  Fly   930 SR-VGNQFVKFVNMLMNDTTFLLDECLENLKRIHQTQQLLSDKANLSKMSAEQQQSRL-TQLATD 992
            |: ..:.||:||..::||.||||||.|.||..:|..|..|.::|..:..:.|::...| |:||:.
Yeast   666 SQNNADFFVRFVARMLNDLTFLLDEGLSNLAEVHNIQNELDNRARGAPPTREEEDKELQTRLASA 730

  Fly   993 ERQCRSYLTLARETVDLFHYLTSDIKEPFMRDELVDRLSSMLNFNLKQLAGPKCNDLKVKNPAKY 1057
            .||.:|...||.:::.||...:.||...|:..|:|.||:||||:||:.|.||||.:||||:|..|
Yeast   731 SRQAKSSCGLADKSMKLFEIYSKDIPAAFVTPEIVYRLASMLNYNLESLVGPKCGELKVKDPQSY 795

  Fly  1058 GWEPRSLLAQIFDIYLHL-DCDRFAEALAADERSFDVQICNEAASRI-KRLALRSAVEVERFKAL 1120
            .:.|:.||..:..:|::| :...|..|:|.|||||:..:...|...: ::..|.|...:|:....
Yeast   796 SFNPKDLLKALTTVYINLSEQSEFISAVAKDERSFNRNLFVRAVDILGRKTGLASPEFIEKLLNF 860

  Fly  1121 TQRAHEIYVTNLQTEDECADAPDEFKDPLMDTLMSDPVVLPSGTV-MDRAIITRHLLNSCTDPFN 1184
            ..:|.|....:.:.:.|..|.||||.||||.|:|.|||:||:..: :||:.|..|||:..|||||
Yeast   861 ANKAEEQRKADEEEDLEYGDVPDEFLDPLMYTIMKDPVILPASKMNIDRSTIKAHLLSDSTDPFN 925

  Fly  1185 RQPLTEDMLVANIELKQRIDAWRKEQR 1211
            |.||..:.:..|.||:|:|..::|:::
Yeast   926 RMPLKLEDVTPNEELRQKILCFKKQKK 952

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ube4B	NP_609597.1	Ufd2P_core	510..1124	CDD:463080	184/665 (28%)
		RING-Ubox_UBE4B	1138..1211	CDD:438320	36/73 (49%)
UFD2	NP_010091.2	UFD2	1..961	CDD:227444	250/937 (27%)