DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG9934 and UFD2

DIOPT Version :9

Sequence 1:	NP_001162967.1	Gene:	CG9934 / 34699	FlyBaseID:	FBgn0032467	Length:	1217	Species:	Drosophila melanogaster
Sequence 2:	NP_010091.2	Gene:	UFD2 / 851337	SGDID:	S000002349	Length:	961	Species:	Saccharomyces cerevisiae

Alignment Length:	937	Identity:	250/937 - (26%)
Similarity:	446/937 - (47%)	Gaps:	120/937 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly   352 YLIRCY-QNYQTECSRKTPLTQPALQLAFEQVMRMTV------------------LVLTDRIYQN 397
            ||..|: :|.|.:...|......:|...|:::.|:.:                  :.....|..|
Yeast    59 YLNDCFRRNQQQKRITKNKPNAESLHSTFQEIDRLVIGYGVVALQIENFCMNGAFINYITGIVSN 123

  Fly   398 LNGHMDQSALLDLMYMAKVSEPFLIDLIAHTHQDREAFDTIFSQVLRGLFAGMQRNICTSKIS-- 460
            :|.:.|   .|..:....:.|...:||:          :.:|..:|         ..|...:|
Yeast   124 VNSYTD---FLSQIIQRAILEGTALDLL----------NAVFPTLL---------EYCNKHVSHF 166

  Fly   461 --VQQIEWLSKLVVIKV-GSVRPIADLVSRQPNFLPPICTKISGREIVKCSFLGPFLSVS-LFAE 521
              .:.:.:.:.|.:.:: .:.:|||::.::...|......|  .::..:.:.|||.||:| :.|.
Yeast   167 DLNESVIYNNVLTIFELFVTFKPIAEIFTKIDGFFADYSCK--PQDFERKTILGPILSLSPIEAA 229

  Fly   522 ENIK-FAEFTTKNKLEDASSSRLRWELH-SMRTNMHVVFHSLCV--------NASSRPKTLEYIA 576
            ..|: :.:...::|.:.|.       :| |::....||...|..        :.:||...:.|.|
Yeast   230 VAIRNYGDNLLRSKQQTAM-------IHESLQAEHKVVIDRLFFIVDKLVRGSLNSRTDMISYFA 287

  Fly   577 SILRHNDRRVQFASDEKLLARDGFMINLMSVLQQLSVKI------KLDRIEPNFHYYKNSLVNIE 635
            .|...|..|.......|.|:.:|||.|:..:|.:.|...      |:|:|:.|:....:..:::.
Yeast   288 HIANKNHLRRADHPPFKELSSNGFMSNITLLLVRFSQPFLDISYKKIDKIDANYFNNPSLFIDLS 352

  Fly   636 QDTKIRYSEEEYRNFLARDFSQPVENTNFQTQCWFLTLQAHHLGYLPAIQRYRQKVRAIKELQKL 700
            .:|::....:|...|..::........||.:.|:||||...|.| |.....:.:|:.:  |::.|
Yeast   353 GETRLNSDFKEADAFYDKNRKTADSKPNFISDCFFLTLTYLHYG-LGGTLSFEEKMGS--EIKAL 414

  Fly   701 IDELDRTKSHWMNSRYANRNNQFKERWEKQLRKLNRS-KTCCEITLLDPGLLQRCT---EFYSTV 761
            .:|:::.|      :.|..::.|......||.|:.:: ||...:.....|.....:   |.:..:
Yeast   415 KEEIEKVK------KIAANHDVFARFITAQLSKMEKALKTTESLRFALQGFFAHRSLQLEVFDFI 473

  Fly   762 C---EFML------YQFEGRPIEGPFI-SKLPVQQLLPTD--------AFSALPEWYIDDIAEFI 808
            |   .|::      ::|..:.|:.|.| .::.|:.:...|        .|...||:.::....:.
Yeast   474 CGASTFLIRVVDPEHEFPFKQIKLPLIPDQIGVENVDNADFLRAHAPVPFKYYPEFVVEGPVNYS 538

  Fly   809 LFTMQHANMDI----RQGIDHSIITWLLTCVCASHLIKNPYVTAKLVEVMFVFSLKPANSVNAAM 869
            |:..::....|    |.|......|.:|.|   ..|:.||::..|||:::.|.::...::....|
Yeast   539 LYISKYQTSPIFRNPRLGSFVEFTTMVLRC---PELVSNPHLKGKLVQLLSVGAMPLTDNSPGFM 600

  Fly   870 ---WNH-ELAQNALVSSLMRFYVDVETTGQSTEFYDKFTIRYHISHLFKSM-WENPIHRQAVICE 929
               :.| ||....|:.:|:.|||.||.||.|::|||||..||.||.:.:.: ::.|.::..:|.:
Yeast   601 MDIFEHDELVNKNLLYALLDFYVIVEKTGSSSQFYDKFNSRYSISIILEELYYKIPSYKNQLIWQ 665

  Fly   930 SR-VGNQFVKFVNMLMNDTTFLLDECLENLKRIHQTQQLLSDKANLSKMSAEQQQSRL-TQLATD 992
            |: ..:.||:||..::||.||||||.|.||..:|..|..|.::|..:..:.|::...| |:||:.
Yeast   666 SQNNADFFVRFVARMLNDLTFLLDEGLSNLAEVHNIQNELDNRARGAPPTREEEDKELQTRLASA 730

  Fly   993 ERQCRSYLTLARETVDLFHYLTSDIKEPFMRDELVDRLSSMLNFNLKQLAGPKCNDLKVKNPAKY 1057
            .||.:|...||.:::.||...:.||...|:..|:|.||:||||:||:.|.||||.:||||:|..|
Yeast   731 SRQAKSSCGLADKSMKLFEIYSKDIPAAFVTPEIVYRLASMLNYNLESLVGPKCGELKVKDPQSY 795

  Fly  1058 GWEPRSLLAQIFDIYLHL-DCDRFAEALAADERSFDVQICNEAASRI-KRLALRSAVEVERFKAL 1120
            .:.|:.||..:..:|::| :...|..|:|.|||||:..:...|...: ::..|.|...:|:....
Yeast   796 SFNPKDLLKALTTVYINLSEQSEFISAVAKDERSFNRNLFVRAVDILGRKTGLASPEFIEKLLNF 860

  Fly  1121 TQRAHEIYVTNLQTEDECADAPDEFKDPLMDTLMSDPVVLPSGTV-MDRAIITRHLLNSCTDPFN 1184
            ..:|.|....:.:.:.|..|.||||.||||.|:|.|||:||:..: :||:.|..|||:..|||||
Yeast   861 ANKAEEQRKADEEEDLEYGDVPDEFLDPLMYTIMKDPVILPASKMNIDRSTIKAHLLSDSTDPFN 925

  Fly  1185 RQPLTEDMLVANIELKQRIDAWRKEQR 1211
            |.||..:.:..|.||:|:|..::|:::
Yeast   926 RMPLKLEDVTPNEELRQKILCFKKQKK 952

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG9934	NP_001162967.1	Ufd2P_core	510..1124	CDD:287392	184/665 (28%)
CG9934	NP_001162967.1	U-box	1141..1211	CDD:252675	35/70 (50%)
UFD2	NP_010091.2	UFD2	1..961	CDD:227444	250/937 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C157343957
Domainoid	1	1.000	209	1.000	Domainoid score	I510
eggNOG	1	0.900	-	-		E1_COG5113
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H107623
Inparanoid	1	1.050	282	1.000	Inparanoid score	I555
Isobase	1	0.950	-	0	Normalized mean entropy	S2779
OMA	1	1.010	-	-		QHG53881
OrthoFinder	1	1.000	-	-		FOG0004816
OrthoInspector	1	1.000	-	-		oto99021
orthoMCL	1	0.900	-	-		OOG6_101833
Panther	1	1.100	-	-	LDO	PTHR13931
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1598
SonicParanoid	1	1.000	-	-		X3397
TreeFam	1	0.960	-	-
	16	15.740