DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG9934 and Ube4b

DIOPT Version :9

Sequence 1:	NP_001162967.1	Gene:	CG9934 / 34699	FlyBaseID:	FBgn0032467	Length:	1217	Species:	Drosophila melanogaster
Sequence 2:	XP_036020183.1	Gene:	Ube4b / 63958	MGIID:	1927086	Length:	1465	Species:	Mus musculus

Alignment Length:	1249	Identity:	444/1249 - (35%)
Similarity:	659/1249 - (52%)	Gaps:	161/1249 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly    46 PGQQLPEQPNPDVQPQQPAESVV---VTELSAEEMRARRLRTLAARSGIQC------ALAPLTTT 101
            |...||..|.|  |...|::|:.   |...:|...::.....:|.::.:..      .:||....
Mouse   291 PSFALPSHPAP--QAAMPSQSLSPHGVAPQAAVPSQSLSPHGVAPQAAVPSQSLSPHGVAPQVAV 353

  Fly   102 PRKPTNVSGESRLVREATPGEKEVSLPTSAPAWRELSGKPDMDVEMKSV--------VSTPMQDV 158
            |.:..:..|.:  .:.|.|.:   ||.|...|       |...|..:|:        |:.|.|
Mouse   354 PSQSLSTHGVA--PQAAVPSQ---SLSTHGVA-------PQAAVPSQSLSTHGVAPQVAVPSQ-- 404

  Fly   159 DMTTALSLPTAEATKRSVLQSCKIS-----AGNAELSIETVVGPKKSADEQNEQLLSRLLNATWN 218
                  ||.|.....::.:.|..:|     :|||       .|.:.|:.......::       :
Mouse   405 ------SLSTHGVAPQAAVPSPPLSPHSTASGNA-------AGSQPSSPRYRPYTVT-------H 449

  Fly   219 EYGSG------SIICAQS--------------ASFLEQQPHRR---FDFECIVANVLMEAVLKI- 259
            .:||.      |.|.|.|              ||...|:|..|   |......|.....:.|:|
Mouse   450 PWGSSPCPTPRSSILASSPGFPSHASSPRAVPASSSRQRPRSRVPAFPPASPSAASRRPSSLRIS 514

  Fly   260 -------YNGELIEGDGVSVKADDKEFSSAKKIKSDDTEVQEILANAVATGGA------TASGET 311
                   ::...:|..|.|...|::|         |:.|:.|        ||.      ...|.:
Mouse   515 PSMSNSPFSFLFLELSGDSSDDDEEE---------DEEELDE--------GGGDDDFSYVQFGSS 562

  Fly   312 AAAAAGASGPIEATSSEAAGTCVAPPVLSIVATTKHHVLLYLIRCYQNYQTECSRKTP--LTQPA 374
            ..|:.|||.....:......||....:|:           |||.|:.....| .:|.|  .:|||
Mouse   563 LGASGGASNWDSYSDHFTIETCKETDMLN-----------YLIECFDRVGIE-EKKAPKMCSQPA 615

  Fly   375 LQLAF----EQVMRMTVLVLTDRIYQNLNGHMDQSALLDLMYMAKVSEPFLIDLIAHTHQDREAF 435
            :....    .|.:..|.|||...:.|. ......|.|:..|....:...|:.:|:..||||.|.|
Mouse   616 VSQLLSNIRSQCISHTALVLQGSLTQP-RSLQQPSFLVPYMLCRNLPYGFIQELVRTTHQDEEVF 679

  Fly   436 DTIFSQVLRGLFAGMQRNICTSKISVQQIEWLSKLVVIKVGSVRPIADLVSRQPNFLPPICTKIS 500
            ..||..:|:||....:.....|......:..|.:|...|.|...|:.:||:..|.:||...:..|
Mouse   680 KQIFIPILQGLALAAKECSLESDYFKYPLMALGELCETKFGKTHPMCNLVASLPLWLPKSLSPGS 744

  Fly   501 GREIVKCSFLGPFLSVSLFAEENIKFAE-------FTTKNKLEDASSSRLRWELHSMRTNMHVVF 558
            |||:.:.|:||.|.|.|:|||::.|..|       .|.:|  ....|..|:..|...|..:..:.
Mouse   745 GRELQRLSYLGAFFSFSVFAEDDAKVVEKYFSGPAITLEN--TRVVSQSLQHYLELGRQELFKIL 807

  Fly   559 HSLCVNASSRPKTLEYIASILRHNDRRVQFASDEKLLARDGFMINLMSVLQQLSVKIKLDRIEPN 623
            ||:.:|..:|...|.|:|:::..|.::.|..:|::|::.||||:||:.||||||.||||:.::|.
Mouse   808 HSILLNGETREAALSYMAALVNANMKKAQMQADDRLVSTDGFMLNLLWVLQQLSTKIKLETVDPT 872

  Fly   624 FHYYKNSLVNIEQD-TKIRYSEEEYRNFLAR------DFSQPVENTNFQTQCWFLTLQAHHLGYL 681
            :.::....:.:..| |:|..:.|:....|..      .||:|    .|.|:|:||||.||||..|
Mouse   873 YIFHPRCRITLPNDETRINATMEDVNERLTELYGDQPPFSEP----KFPTECFFLTLHAHHLSIL 933

  Fly   682 PAIQRYRQKVRAIKELQKLIDELDRTKSHWMNSRYANRNNQFKERWEKQLRKLNRSKTCCEITLL 746
            |:.:||.:::|||:||.:.:::|...:|.|.:|..|.|:.:..:|.:.||:||.|.|.|.:..||
Mouse   934 PSCRRYIRRLRAIRELNRTVEDLKNNESQWKDSPLATRHREMLKRCKTQLKKLVRCKACADAGLL 998

  Fly   747 DPGLLQRCTEFYSTVCEFMLYQFEGRPIEGPFIS-KLPVQQLLPTDAFSALPEWYIDDIAEFILF 810
            |...|:||..||..:.:.||     |.::..:.. .||:...:| ..|:||||:|::|:|||:.|
Mouse   999 DESFLRRCLNFYGLLIQLML-----RILDPAYPDVTLPLNSEVP-KVFAALPEFYVEDVAEFLFF 1057

  Fly   811 TMQHANMDIRQGIDHSIITWLLTCVCASHLIKNPYVTAKLVEVMFVF--SLKPANSVNAAM-WNH 872
            .:|::...:.:.....|:.:|:..:|..:.|:|||:.||||||||:.  |::|.......| .||
Mouse  1058 IVQYSPQVLYEPCTQDIVMFLVVMLCNQNYIRNPYLVAKLVEVMFMTNPSVQPRTQKFFEMIENH 1122

  Fly   873 ELAQNALVSSLMRFYVDVETTGQSTEFYDKFTIRYHISHLFKSMWENPIHRQAVICESRVGNQFV 937
            .|:...||.|||:||.|||.||.::|||||||||||||.:|||:|:|..|....:.|...|.|||
Mouse  1123 PLSTKLLVPSLMKFYTDVEHTGATSEFYDKFTIRYHISTIFKSLWQNIAHHGTFMEEFNSGKQFV 1187

  Fly   938 KFVNMLMNDTTFLLDECLENLKRIHQTQQLLSDKANLSKMSAEQQQSRLTQLATDERQCRSYLTL 1002
            :::|||:|||||||||.||:|||||:.|:.:.:|....::..:|||:|.:|||.|||..||||.|
Mouse  1188 RYINMLINDTTFLLDESLESLKRIHEVQEEMKNKEQWDQLPRDQQQARQSQLAQDERVSRSYLAL 1252

  Fly  1003 ARETVDLFHYLTSDIKEPFMRDELVDRLSSMLNFNLKQLAGPKCNDLKVKNPAKYGWEPRSLLAQ 1067
            |.||||:||.||..:::||:|.||..||::||||||:||.||||.||||:||.|||:||:.||.|
Mouse  1253 ATETVDMFHLLTKQVQKPFLRPELGPRLAAMLNFNLQQLCGPKCRDLKVENPEKYGFEPKKLLDQ 1317

  Fly  1068 IFDIYLHLDCDRFAEALAADERSFDVQICNEAASRIKRLALRSAVEVERFKALTQRAHEIYVTNL 1132
            :.||||.|||.|||:|:|.|:||:..::..|..|::::..::|.:.:|:||.|.::..||...|.
Mouse  1318 LTDIYLQLDCARFAKAIADDQRSYSKELFEEVISKMRKAGIKSTIAIEKFKLLAEKVEEIVAKNA 1382

  Fly  1133 QTEDECADAPDEFKDPLMDTLMSDPVVLPSGTVMDRAIITRHLLNSCTDPFNRQPLTEDMLVANI 1197
            :.|.:.:||||||:||||||||:|||.|||||||||:||.||||||.|||||||.|||.||....
Mouse  1383 RAEIDYSDAPDEFRDPLMDTLMTDPVRLPSGTVMDRSIILRHLLNSPTDPFNRQMLTESMLEPVP 1447

  Fly  1198 ELKQRIDAWRKEQR 1211
            |||::|.||.:|::
Mouse  1448 ELKEQIQAWMREKQ 1461

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG9934	NP_001162967.1	Ufd2P_core	510..1124	CDD:287392	269/631 (43%)
CG9934	NP_001162967.1	U-box	1141..1211	CDD:252675	52/69 (75%)
Ube4b	XP_036020183.1	PHA03247	<296..521	CDD:223021	50/260 (19%)
		Ufd2P_core	754..1374	CDD:402160	269/631 (43%)
		RING-Ubox_UBE4B	1387..1461	CDD:319572	53/73 (73%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167837758
Domainoid	1	1.000	509	1.000	Domainoid score	I329
eggNOG	1	0.900	-	-		E1_COG5113
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H107623
Inparanoid	1	1.050	702	1.000	Inparanoid score	I665
Isobase	1	0.950	-	0	Normalized mean entropy	S2779
OMA	1	1.010	-	-		QHG53881
OrthoDB	1	1.010	-	-		D194967at2759
OrthoFinder	1	1.000	-	-		FOG0004816
OrthoInspector	1	1.000	-	-		oto92076
orthoMCL	1	0.900	-	-		OOG6_101833
Panther	1	1.100	-	-	LDO	PTHR13931
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1598
SonicParanoid	1	1.000	-	-		X3397
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	18	17.750