Protein Alignment Ube4B and Ube4b

DIOPT Version :10

• Sequence 1: NP_609597.1
• Gene: Ube4B / 34699
• FlyBaseID: FBgn0032467
• Length: 1217
• Species: Drosophila melanogaster
• Sequence 2: XP_006239449.1
• Gene: Ube4b / 298652
• RGDID: 1304738
• Length: 1388
• Species: Rattus norvegicus
• Alignment Length: 1415
• Identity: 463/1415 - (32%)
• Similarity: 691/1415 - (48%)
• Gaps: 307/1415 - (21%)

  Fly    71 ELSAEEMRARRLRTLAARSGIQCALAPLTTTPRK-------PTNVSGESRL----VREATP---- 120
            ||||:|:|.|||..||.....| ...|||:..|:       ..:|.|.|:.    |...||
  Rat     3 ELSADEIRRRRLARLAGGQTSQ-PTTPLTSPQRENPPGPPIAASVPGPSQSLGLNVHNTTPATSP 66

  Fly   121 -----------GEKEVSLPTSAPA------WRELSGKPDMDVEMKSVVSTPMQDVDMTTAL-SLP 167
                       ..:.||..:|:|:      .:.||....||::..|...: |..||:.:.: ::.
  Rat    67 IGAAGVAHRSQSSEGVSSLSSSPSNSLETQSQSLSRSQSMDIDGVSCEKS-MSQVDVDSGIENME 130

  Fly   168 TAEATKRSVLQSCKISAGNAELSIETVVGPKKSADEQNEQLLSRLLNATWNEYGSGSIICAQSAS 232
            ..|..:|.     |.|..:.|.|    .||:.| :||..||:.::...:|.:.....|..:..::
  Rat   131 VDENDRRE-----KRSLSDKEPS----SGPEVS-EEQALQLVCKIFRVSWKDRDRDVIFLSSLSA 185

  Fly   233 FLEQQPHRRF-DFECIVANVLMEAVLKIYNGELIEGDGVSVKADDKEFSSAKKIKSDDTEVQEIL 296
            ..:|.|...| ||:.::..:||| ||.:......|....|:.|..:..::|  .:|.|   :.::
  Rat   186 QFKQNPKEVFSDFKDLIGQILME-VLMMSTQTRDENPFASLTATSQPIATA--ARSPD---RNLM 244

  Fly   297 ANAVATGG-----------------------------------------ATASGETAAAAAGASG 320
            .|..::.|                                         |:.|....||:..:|.
  Rat   245 LNTGSSSGTSPMFCSLGSFSASSLSSLYETSPAPSTSLWSFVPGLSPSFASPSHTAPAASPHSSA 309

  Fly   321 PIEATSS-----EAAGT------CVAP------PVL------SIVAT------------TKHH-- 348
            |..|.:|     ::|.|      .|||      |.|      |::||            |..|
  Rat   310 PQGAVASQSLSPQSAATHPLSPHSVAPQAAVPSPSLSSHSTASVIATGSQPSSPRYRPYTVTHLW 374

  Fly   349 ----------------------------------------------------------------- 348
                                                                             
  Rat   375 GSSPCPTPRSSILANPPGFPAHSSSPRAVPASSSRQRPRSRAPAFPPASPSAASRRPSSLRISPS 439

  Fly   349 ----------------------------------------------------------------- 348
                                                                             
  Rat   440 MYDSPFSSLFLALSGDSSEEEEEEDEEDDDEGGGDDDFSCVQFGSSLGASGGASTWDSYSDHFTI 504

  Fly   349 -------VLLYLIRCYQNYQTECSRKTP--LTQPALQLAF----EQVMRMTVLVLTDRIYQNLNG 400
                   :|.|||.|:.....| .:|.|  .:|||:....    .|.:..|.|||...:.|. ..
  Rat   505 ETCKETDMLNYLIECFDRVGIE-EKKAPKMCSQPAVSQLLSNIRSQCISHTALVLQGSLTQP-RS 567

  Fly   401 HMDQSALLDLMYMAKVSEPFLIDLIAHTHQDREAFDTIFSQVLRGLFAGMQRNICTSKISVQQIE 465
            ....|.|:..|....:...|:.:|:..||||.|.|..||..:|:||....:.....|......:.
  Rat   568 LQQPSFLVPYMLCRNLPYGFIQELVRTTHQDEEVFKQIFIPILQGLARAAKECSLDSDYFKYPLM 632

  Fly   466 WLSKLVVIKVGSVRPIADLVSRQPNFLPPICTKISGREIVKCSFLGPFLSVSLFAEENIKFAE-- 528
            .|.:|...|.|...|:.:||:..|.:||...:..||||:.:.|:||.|.|.|:|||::.|..|
  Rat   633 ALGELCETKFGKTHPMCNLVASLPLWLPKSLSPGSGRELQRLSYLGAFFSFSVFAEDDAKVVEKY 697

  Fly   529 -----FTTKNKLEDASSSRLRWELHSMRTNMHVVFHSLCVNASSRPKTLEYIASILRHNDRRVQF 588
                 .|.:|  ....|..|:..|...|..:..:.||:.:|..:|...|.|:|:|:..|.::.|.
  Rat   698 FSGPAITLEN--TRVVSQSLQHYLELGRQELFKILHSILLNGETREAALSYMAAIVNANMKKAQM 760

  Fly   589 ASDEKLLARDGFMINLMSVLQQLSVKIKLDRIEPNFHYYKNSLVNIEQD-TKIRYSEEEYRNFLA 652
            .:|::|::.||||:||:.||||||.||||:.::|.:.::....:.:..| |:|..:.|:...:|.
  Rat   761 QADDRLVSTDGFMLNLLWVLQQLSTKIKLETVDPTYIFHPRCRITLPNDETRINATMEDVNEWLT 825

  Fly   653 R------DFSQPVENTNFQTQCWFLTLQAHHLGYLPAIQRYRQKVRAIKELQKLIDELDRTKSHW 711
            .      .||:|    .|.|:|:||||.||||..||:.:||.:::|||:||.:.:::|...:|.|
  Rat   826 ELYGDQPPFSEP----KFPTECFFLTLHAHHLSILPSCRRYIRRLRAIRELNRTVEDLKNNESQW 886

  Fly   712 MNSRYANRNNQFKERWEKQLRKLNRSKTCCEITLLDPGLLQRCTEFYSTVCEFMLYQFEGRPIEG 776
            .:|..|.|:.:..:|.:.||:||.|.|.|.:..|||...|:||..||..:.:.||     |.::.
  Rat   887 KDSPLATRHREMLKRCKTQLKKLVRCKACADAGLLDESFLRRCLNFYGLLIQLML-----RVLDP 946

  Fly   777 --PFISKLPVQQLLPTDAFSALPEWYIDDIAEFILFTMQHANMDIRQGIDHSIITWLLTCVCASH 839
              |.|: ||:...:| ..|:||||:|::|:|||:.|.:|::...:.:.....|:.:|:..:|..:
  Rat   947 AYPDIT-LPLNSEVP-KVFAALPEFYVEDVAEFLFFIVQYSPQVLYEPCTQDIVMFLVVMLCNQN 1009

  Fly   840 LIKNPYVTAKLVEVMFVF--SLKPANSVNAAM-WNHELAQNALVSSLMRFYVDVETTGQSTEFYD 901
            .|:|||:.||||||||:.  |::|.......| .||.|:...||.|||:||.|||.||.::||||
  Rat  1010 YIRNPYLVAKLVEVMFMTNPSVQPRTQKFFEMIENHPLSTKLLVPSLMKFYTDVEHTGATSEFYD 1074

  Fly   902 KFTIRYHISHLFKSMWENPIHRQAVICESRVGNQFVKFVNMLMNDTTFLLDECLENLKRIHQTQQ 966
            |||||||||.:|||:|:|..|....:.|...|.|||:::|||:|||||||||.||:|||||:.|:
  Rat  1075 KFTIRYHISTIFKSLWQNIAHHGTFMEEFNSGKQFVRYINMLINDTTFLLDESLESLKRIHEVQE 1139

  Fly   967 LLSDKANLSKMSAEQQQSRLTQLATDERQCRSYLTLARETVDLFHYLTSDIKEPFMRDELVDRLS 1031
            .:.::....::..:|||:|.:|||.|||..||||.||.||||:||.||..:::||:|.||..||:
  Rat  1140 EMKNQEQWDQLPRDQQQARQSQLAQDERVSRSYLALATETVDMFHLLTKQVQKPFLRPELGPRLA 1204

  Fly  1032 SMLNFNLKQLAGPKCNDLKVKNPAKYGWEPRSLLAQIFDIYLHLDCDRFAEALAADERSFDVQIC 1096
            :||||||:||.||||.||||:||.|||:||:.||.|:.||||.|||.|||:|:|.|:||:..::.
  Rat  1205 AMLNFNLQQLCGPKCRDLKVENPEKYGFEPKKLLDQLTDIYLQLDCARFAKAIADDQRSYSKELF 1269

  Fly  1097 NEAASRIKRLALRSAVEVERFKALTQRAHEIYVTNLQTEDECADAPDEFKDPLMDTLMSDPVVLP 1161
            .|..|::::..::|.:.:|:||.|.::..||...|.:.|.:.:||||||:||||||||:|||.||
  Rat  1270 EEVISKMRKAGIKSTIAIEKFKLLAEKVEEIVAKNARAEIDYSDAPDEFRDPLMDTLMTDPVRLP 1334

  Fly  1162 SGTVMDRAIITRHLLNSCTDPFNRQPLTEDMLVANIELKQRIDAWRKEQR 1211
            |||:|||:||.||||||.|||||||.|||.||....|||::|.||.:|::
  Rat  1335 SGTIMDRSIILRHLLNSPTDPFNRQMLTESMLEPVPELKEQIQAWMREKQ 1384

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ube4B	NP_609597.1	Ufd2P_core	510..1124	CDD:463080	271/632 (43%)
		RING-Ubox_UBE4B	1138..1211	CDD:438320	52/72 (72%)
Ube4b	XP_006239449.1	PHA03307	227..>442	CDD:223039	26/219 (12%)
		Ufd2P_core	677..1297	CDD:463080	271/632 (43%)
		RING-Ubox_UBE4B	1311..1384	CDD:438320	52/72 (72%)