DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG9934 and Ube4b

DIOPT Version :9

Sequence 1:	NP_001162967.1	Gene:	CG9934 / 34699	FlyBaseID:	FBgn0032467	Length:	1217	Species:	Drosophila melanogaster
Sequence 2:	XP_006239449.1	Gene:	Ube4b / 298652	RGDID:	1304738	Length:	1388	Species:	Rattus norvegicus

Alignment Length:	1415	Identity:	463/1415 - (32%)
Similarity:	691/1415 - (48%)	Gaps:	307/1415 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly    71 ELSAEEMRARRLRTLAARSGIQCALAPLTTTPRK-------PTNVSGESRL----VREATP---- 120
            ||||:|:|.|||..||.....| ...|||:..|:       ..:|.|.|:.    |...||
  Rat     3 ELSADEIRRRRLARLAGGQTSQ-PTTPLTSPQRENPPGPPIAASVPGPSQSLGLNVHNTTPATSP 66

  Fly   121 -----------GEKEVSLPTSAPA------WRELSGKPDMDVEMKSVVSTPMQDVDMTTAL-SLP 167
                       ..:.||..:|:|:      .:.||....||::..|...: |..||:.:.: ::.
  Rat    67 IGAAGVAHRSQSSEGVSSLSSSPSNSLETQSQSLSRSQSMDIDGVSCEKS-MSQVDVDSGIENME 130

  Fly   168 TAEATKRSVLQSCKISAGNAELSIETVVGPKKSADEQNEQLLSRLLNATWNEYGSGSIICAQSAS 232
            ..|..:|.     |.|..:.|.|    .||:.| :||..||:.::...:|.:.....|..:..::
  Rat   131 VDENDRRE-----KRSLSDKEPS----SGPEVS-EEQALQLVCKIFRVSWKDRDRDVIFLSSLSA 185

  Fly   233 FLEQQPHRRF-DFECIVANVLMEAVLKIYNGELIEGDGVSVKADDKEFSSAKKIKSDDTEVQEIL 296
            ..:|.|...| ||:.::..:||| ||.:......|....|:.|..:..::|  .:|.|   :.::
  Rat   186 QFKQNPKEVFSDFKDLIGQILME-VLMMSTQTRDENPFASLTATSQPIATA--ARSPD---RNLM 244

  Fly   297 ANAVATGG-----------------------------------------ATASGETAAAAAGASG 320
            .|..::.|                                         |:.|....||:..:|.
  Rat   245 LNTGSSSGTSPMFCSLGSFSASSLSSLYETSPAPSTSLWSFVPGLSPSFASPSHTAPAASPHSSA 309

  Fly   321 PIEATSS-----EAAGT------CVAP------PVL------SIVAT------------TKHH-- 348
            |..|.:|     ::|.|      .|||      |.|      |::||            |..|
  Rat   310 PQGAVASQSLSPQSAATHPLSPHSVAPQAAVPSPSLSSHSTASVIATGSQPSSPRYRPYTVTHLW 374

  Fly   349 ----------------------------------------------------------------- 348

  Rat   375 GSSPCPTPRSSILANPPGFPAHSSSPRAVPASSSRQRPRSRAPAFPPASPSAASRRPSSLRISPS 439

  Fly   349 ----------------------------------------------------------------- 348

  Rat   440 MYDSPFSSLFLALSGDSSEEEEEEDEEDDDEGGGDDDFSCVQFGSSLGASGGASTWDSYSDHFTI 504

  Fly   349 -------VLLYLIRCYQNYQTECSRKTP--LTQPALQLAF----EQVMRMTVLVLTDRIYQNLNG 400
                   :|.|||.|:.....| .:|.|  .:|||:....    .|.:..|.|||...:.|. ..
  Rat   505 ETCKETDMLNYLIECFDRVGIE-EKKAPKMCSQPAVSQLLSNIRSQCISHTALVLQGSLTQP-RS 567

  Fly   401 HMDQSALLDLMYMAKVSEPFLIDLIAHTHQDREAFDTIFSQVLRGLFAGMQRNICTSKISVQQIE 465
            ....|.|:..|....:...|:.:|:..||||.|.|..||..:|:||....:.....|......:.
  Rat   568 LQQPSFLVPYMLCRNLPYGFIQELVRTTHQDEEVFKQIFIPILQGLARAAKECSLDSDYFKYPLM 632

  Fly   466 WLSKLVVIKVGSVRPIADLVSRQPNFLPPICTKISGREIVKCSFLGPFLSVSLFAEENIKFAE-- 528
            .|.:|...|.|...|:.:||:..|.:||...:..||||:.:.|:||.|.|.|:|||::.|..|
  Rat   633 ALGELCETKFGKTHPMCNLVASLPLWLPKSLSPGSGRELQRLSYLGAFFSFSVFAEDDAKVVEKY 697

  Fly   529 -----FTTKNKLEDASSSRLRWELHSMRTNMHVVFHSLCVNASSRPKTLEYIASILRHNDRRVQF 588
                 .|.:|  ....|..|:..|...|..:..:.||:.:|..:|...|.|:|:|:..|.::.|.
  Rat   698 FSGPAITLEN--TRVVSQSLQHYLELGRQELFKILHSILLNGETREAALSYMAAIVNANMKKAQM 760

  Fly   589 ASDEKLLARDGFMINLMSVLQQLSVKIKLDRIEPNFHYYKNSLVNIEQD-TKIRYSEEEYRNFLA 652
            .:|::|::.||||:||:.||||||.||||:.::|.:.::....:.:..| |:|..:.|:...:|.
  Rat   761 QADDRLVSTDGFMLNLLWVLQQLSTKIKLETVDPTYIFHPRCRITLPNDETRINATMEDVNEWLT 825

  Fly   653 R------DFSQPVENTNFQTQCWFLTLQAHHLGYLPAIQRYRQKVRAIKELQKLIDELDRTKSHW 711
            .      .||:|    .|.|:|:||||.||||..||:.:||.:::|||:||.:.:::|...:|.|
  Rat   826 ELYGDQPPFSEP----KFPTECFFLTLHAHHLSILPSCRRYIRRLRAIRELNRTVEDLKNNESQW 886

  Fly   712 MNSRYANRNNQFKERWEKQLRKLNRSKTCCEITLLDPGLLQRCTEFYSTVCEFMLYQFEGRPIEG 776
            .:|..|.|:.:..:|.:.||:||.|.|.|.:..|||...|:||..||..:.:.||     |.::.
  Rat   887 KDSPLATRHREMLKRCKTQLKKLVRCKACADAGLLDESFLRRCLNFYGLLIQLML-----RVLDP 946

  Fly   777 --PFISKLPVQQLLPTDAFSALPEWYIDDIAEFILFTMQHANMDIRQGIDHSIITWLLTCVCASH 839
              |.|: ||:...:| ..|:||||:|::|:|||:.|.:|::...:.:.....|:.:|:..:|..:
  Rat   947 AYPDIT-LPLNSEVP-KVFAALPEFYVEDVAEFLFFIVQYSPQVLYEPCTQDIVMFLVVMLCNQN 1009

  Fly   840 LIKNPYVTAKLVEVMFVF--SLKPANSVNAAM-WNHELAQNALVSSLMRFYVDVETTGQSTEFYD 901
            .|:|||:.||||||||:.  |::|.......| .||.|:...||.|||:||.|||.||.::||||
  Rat  1010 YIRNPYLVAKLVEVMFMTNPSVQPRTQKFFEMIENHPLSTKLLVPSLMKFYTDVEHTGATSEFYD 1074

  Fly   902 KFTIRYHISHLFKSMWENPIHRQAVICESRVGNQFVKFVNMLMNDTTFLLDECLENLKRIHQTQQ 966
            |||||||||.:|||:|:|..|....:.|...|.|||:::|||:|||||||||.||:|||||:.|:
  Rat  1075 KFTIRYHISTIFKSLWQNIAHHGTFMEEFNSGKQFVRYINMLINDTTFLLDESLESLKRIHEVQE 1139

  Fly   967 LLSDKANLSKMSAEQQQSRLTQLATDERQCRSYLTLARETVDLFHYLTSDIKEPFMRDELVDRLS 1031
            .:.::....::..:|||:|.:|||.|||..||||.||.||||:||.||..:::||:|.||..||:
  Rat  1140 EMKNQEQWDQLPRDQQQARQSQLAQDERVSRSYLALATETVDMFHLLTKQVQKPFLRPELGPRLA 1204

  Fly  1032 SMLNFNLKQLAGPKCNDLKVKNPAKYGWEPRSLLAQIFDIYLHLDCDRFAEALAADERSFDVQIC 1096
            :||||||:||.||||.||||:||.|||:||:.||.|:.||||.|||.|||:|:|.|:||:..::.
  Rat  1205 AMLNFNLQQLCGPKCRDLKVENPEKYGFEPKKLLDQLTDIYLQLDCARFAKAIADDQRSYSKELF 1269

  Fly  1097 NEAASRIKRLALRSAVEVERFKALTQRAHEIYVTNLQTEDECADAPDEFKDPLMDTLMSDPVVLP 1161
            .|..|::::..::|.:.:|:||.|.::..||...|.:.|.:.:||||||:||||||||:|||.||
  Rat  1270 EEVISKMRKAGIKSTIAIEKFKLLAEKVEEIVAKNARAEIDYSDAPDEFRDPLMDTLMTDPVRLP 1334

  Fly  1162 SGTVMDRAIITRHLLNSCTDPFNRQPLTEDMLVANIELKQRIDAWRKEQR 1211
            |||:|||:||.||||||.|||||||.|||.||....|||::|.||.:|::
  Rat  1335 SGTIMDRSIILRHLLNSPTDPFNRQMLTESMLEPVPELKEQIQAWMREKQ 1384

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG9934	NP_001162967.1	Ufd2P_core	510..1124	CDD:287392	271/632 (43%)
CG9934	NP_001162967.1	U-box	1141..1211	CDD:252675	51/69 (74%)
Ube4b	XP_006239449.1	Ufd2P_core	677..1297	CDD:287392	271/632 (43%)
Ube4b	XP_006239449.1	U-box	1314..1384	CDD:252675	51/69 (74%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166341502
Domainoid	1	1.000	510	1.000	Domainoid score	I308
eggNOG	1	0.900	-	-		E1_COG5113
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H107623
Inparanoid	1	1.050	704	1.000	Inparanoid score	I635
OMA	1	1.010	-	-		QHG53881
OrthoDB	1	1.010	-	-		D194967at2759
OrthoFinder	1	1.000	-	-		FOG0004816
OrthoInspector	1	1.000	-	-		oto95644
orthoMCL	1	0.900	-	-		OOG6_101833
Panther	1	1.100	-	-	LDO	PTHR13931
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X3397
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	15	14.810