DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG9934 and ufd-2

DIOPT Version :9

Sequence 1:	NP_001162967.1	Gene:	CG9934 / 34699	FlyBaseID:	FBgn0032467	Length:	1217	Species:	Drosophila melanogaster
Sequence 2:	NP_495691.1	Gene:	ufd-2 / 174295	WormBaseID:	WBGene00006734	Length:	984	Species:	Caenorhabditis elegans

Alignment Length:	914	Identity:	267/914 - (29%)
Similarity:	458/914 - (50%)	Gaps:	93/914 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly   349 VLLYLIRCY----QNYQTECSRKT-PLTQPALQLAFEQVMR----------MTVLVLTDRIYQNL 398
            :|:..:||:    ::..:.|.:|| ..|:.|:...|..:.|          ...||.|.|:.::
Worm   115 LLINFVRCHHELGKSGTSNCYKKTLESTRKAVFSVFVMIQRGYLESQLRSQHASLVFTKRLLED- 178

  Fly   399 NGHMDQSALLDLMYMAKVSEPF---LIDLIAHTHQ-DREAFDTIFSQVLRGLFAGMQRNIC---- 455
                            .||..|   |::.:|.|.: |.:|....|:.:...|.:|:   ||
Worm   179 ----------------TVSNVFLRTLVEYLASTDECDEDAITETFNPIFGILRSGI---ICQRFE 224

  Fly   456 --TSKISVQQIEWLSKLVVIKVGS--VRPIADLVSRQPNFLPPICTKISGREIVKCSFLGPFLSV 516
              ..:|..|.:..::.|:.|::.|  .||:::|:..:.:|||....||.|||....||||||.|.
Worm   225 DNKDEIVRQILRVMNLLLSIRLPSNGPRPLSNLLVNREDFLPTPSEKIQGREFGLMSFLGPFFSY 289

  Fly   517 SLFAEENIK------FAEFTTKNKLEDAS---SSRLRWE-LHSMRTNMHVVFHSLCVNASSRPKT 571
            .|  |.:.:      |.:.....:..|.|   ..:|.:: :..:||.:|.:...|..:..||.||
Worm   290 GL--ESSARRPNHRVFVDCEEDARKYDGSVNTEQKLYFQRMDPIRTMLHQLMLPLASDQGSRNKT 352

  Fly   572 LEYIASILRHNDRRVQFASDEKLLARDGFMINLMSVLQQLSVKIKLDRIEPNFHYYKNSLVNIEQ 636
            |.:||:|:..||.|.:...|...:..|.:|.|.:||:...|.||.|.:|..::.:..:||:||.:
Worm   353 LRWIATIISTNDIRTRSHYDPSDVLCDHYMTNFLSVMYMFSEKIDLSKIIVDYPFLPSSLINISK 417

  Fly   637 DTKIRYSEEEYRNFLARDFSQPVENTNFQTQCWFLTLQAHHLGYLPAIQRYRQKVRAIKELQKLI 701
            :|:::..|.....| |..|:...:..:|.|.|:|||:.|..|...|.:.:..:..|.:|||:..|
Worm   418 ETRLKMDESGAVAF-ASQFADRPDEYHFSTVCFFLTIAAQRLVIPPLMNQISEYSRHLKELKHKI 481

  Fly   702 DELD---RTKSHWMNSRYANRNNQFKERWEKQLRKLNRSKTCCEITLLDPGLLQRCTEFYSTVCE 763
            :.|.   .|.|.:..:....:.|...|.|    :.::|...|.:....||.|:....:|.....:
Worm   482 NALKEKLNTVSGFERAEVEKKLNYETEHW----KLMSRHLLCVKTQAQDPALMASSMDFVDKQMK 542

  Fly   764 FMLYQFEGRPIEGPFISKLPVQQLLPTDA---FSALPEWYIDDIAEFILFTMQHANMDIRQGIDH 825
            |:|......      :..|.....|||:.   |.||||::::|..:|.:|.:.: .|.:....:.
Worm   543 FILNLLCDN------LDLLGDDSQLPTEVSQMFCALPEYFLEDALDFYIFAISN-GMKLLMERNA 600

  Fly   826 SIITWLLTCVCASHLIKNPYVTAKLVEVMFVFSLKPANSVNAAMWNH----ELAQNALVSSLMRF 886
            ..|:.|.......|.||:|::.:|||.|:        :|:...:|.:    .:||..|:..:::|
Worm   601 DWISRLTVLFTQYHYIKSPFLVSKLVRVL--------SSIQPPLWFNVVRLRMAQENLLMCMIKF 657

  Fly   887 YVDVETTGQSTEFYDKFTIRYHISHLFKSMWENPIHRQAVICESR-VGNQFVKFVNMLMNDTTFL 950
            |.|.|..|   :||:||.:|.:|.::.:.|.|:..::...:..:| .|.:|::||||::||.|:.
Worm   658 YSDFEDNG---DFYEKFNVRGNIQYMLEKMEEDMFYKGKFMDMARECGAEFIRFVNMVINDATWC 719

  Fly   951 LDECLENLKRIHQTQQLLSDKANLSKMSAEQQQSRLTQLATDERQCRSYLTLARETVDLFHYLTS 1015
            :||.|..||.||..::.:::|........|.:...|......:|:.:.:|..|:..:.|...:|.
Worm   720 IDESLSGLKSIHDVEKKMANKVEWDNTDQEIRNQDLGVYEEAKRKVKGWLGTAKSNLKLLLSITV 784

  Fly  1016 DIKEPFMRDELVDRLSSMLNFNLKQLAGPKCNDLKVKNPAKYGWEPRSLLAQIFDIYLHLDCDRF 1080
            :..|||....|.:||::|||.||.||.|.|.::||||:|..||||||..::.:..|||.|:...|
Worm   785 NSPEPFRTPVLGERLAAMLNHNLSQLIGSKASELKVKDPRSYGWEPREFVSLLISIYLKLNMPAF 849

  Fly  1081 AEALAADERSFDVQICNEAASRIKRLALRSAVEVERFKALTQRAHEIYVTNLQTEDECADAPDEF 1145
            .:.:|.|||::..:..:.|...:::.::....::|.|:.|.:...:.|....:.|:|..|.|:||
Worm   850 VKYIAYDERTYSPEFFHNAIECMRKNSIVGFSQLESFEHLAEDVKKEYEAKAELEEEYDDVPEEF 914

  Fly  1146 KDPLMDTLMSDPVVLPSGTVMDRAIITRHLLNSCTDPFNRQPLTEDMLVANIELKQRIDAWRKEQ 1210
            |||:||.:|.|||.||||.|||||:|.||||::..:||||.||:.:.|..:.|||.:|..|..::
Worm   915 KDPIMDAIMVDPVKLPSGHVMDRAVIERHLLSTPNNPFNRAPLSHNELSPDSELKAKIQEWICQK 979

  Fly  1211 RGKR 1214
            |..:
Worm   980 RNSK 983

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG9934	NP_001162967.1	Ufd2P_core	510..1124	CDD:287392	179/634 (28%)
CG9934	NP_001162967.1	U-box	1141..1211	CDD:252675	38/69 (55%)
ufd-2	NP_495691.1	Ufd2P_core	283..893	CDD:313606	179/634 (28%)
		RING-Ubox_UBE4B	906..980	CDD:319572	40/73 (55%)
		U-box domain, a modified RING finger	916..953	CDD:319572	23/36 (64%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160159671
Domainoid	1	1.000	256	1.000	Domainoid score	I1096
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H107623
Inparanoid	1	1.050	369	1.000	Inparanoid score	I1239
Isobase	1	0.950	-	0	Normalized mean entropy	S2779
OMA	1	1.010	-	-		QHG53881
OrthoDB	1	1.010	-	-		D194967at2759
OrthoFinder	1	1.000	-	-		FOG0004816
OrthoInspector	1	1.000	-	-		oto18651
orthoMCL	1	0.900	-	-		OOG6_101833
Panther	1	1.100	-	-	LDO	PTHR13931
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1598
SonicParanoid	1	1.000	-	-		X3397
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	15	14.890