DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment CG9934 and ube4b

DIOPT Version :9

Sequence 1:NP_001162967.1 Gene:CG9934 / 34699 FlyBaseID:FBgn0032467 Length:1217 Species:Drosophila melanogaster
Sequence 2:XP_021325394.1 Gene:ube4b / 170784 ZFINID:ZDB-GENE-020205-1 Length:1349 Species:Danio rerio


Alignment Length:1388 Identity:455/1388 - (32%)
Similarity:693/1388 - (49%) Gaps:287/1388 - (20%)


- Green bases have known domain annotations that are detailed below.


  Fly    71 ELSAEEMRARRLRTLAARSGIQCAL---APLTTTPRK--PTNVSGESRLVREATPGEKEVSL--- 127
            :||.||:|.|||..||.....|.:.   .|||:..|:  |..:.|.|....:..|.....:|   
Zfish     3 QLSPEEIRRRRLARLAGGQTSQPSTPLSTPLTSPQRETPPGPLPGPSGASSQPVPPAPSHTLALN 67

  Fly   128 -----PTSAP------AWR--------ELSGKPDMDVEMKSVVSTPMQDVDMTTA-----LSLPT 168
                 |.::|      |:|        .||..|...:|.:|...:..|.:|:.||     :|...
Zfish    68 AQNVTPATSPMGASGVAYRSQSSEGVSSLSSSPSNSLETQSQSLSRSQSMDIDTASCEKSMSQVD 132

  Fly   169 AEA-------------TKRSVLQSCKISAGNAELSIETVVGPKKSADEQNEQLLSRLLNATWNEY 220
            .::             .||::.:  |.|:.|.::|.|..:           ||:.::|..:|.|.
Zfish   133 VDSGIENMEVEDSDRREKRNLAE--KDSSSNPDVSEELAL-----------QLICKILRVSWKEQ 184

  Fly   221 GSGSIICAQSASFLEQQPHRRF-DFECIVANVLMEAVLKIYNGELIEGDGVSVKADD-KEFSSAK 283
            ....|.....|:..::.|...: ||:.::..:||||::            :|.::.| ..|:|..
Zfish   185 DRDVIFLPSLAAEFQKNPKDVYSDFKDLIGQILMEALM------------MSTRSRDCNPFASLT 237

  Fly   284 KIKSDDTEVQE-----------------------------------ILANAVATGGATASGETAA 313
            ......|..:.                                   ...|.:|...|..|..:..
Zfish   238 ATSQPITAARSPDHHLTLVPPSSQGGSPMMPCAGSFGASSLSSLYGCSPNPLALSSARLSAPSVP 302

  Fly   314 AAAGA-------------------------------------SGPIEATSSEAAGTCVAPPVLS- 340
            .|:.|                                     |.||..:|..|....:..|..| 
Zfish   303 PASPAALPVSLSPPISRPPASLPSPSAPLPISQRYRPYSLSSSIPISPSSRSAPSGMLTSPTTSE 367

  Fly   341 ----------------------------------------------------------------- 340
                                                                             
Zfish   368 TPSRPSPRQHSTQTSMPFPFPPGSPTTMARRTALATRMPSSSPFSLLFFALSDLPQDSSDEEQEE 432

  Fly   341 --------------------------------IVATTKHHVLLYLIRCYQNYQTECSRKTP--LT 371
                                            |.:..:..:|.|||..:.:...| .||.|  .:
Zfish   433 EGEEDFSGVQFGSSLGASAGGMAGDSGSDRFTIESCKETEMLNYLIERFDSVGME-ERKAPKMCS 496

  Fly   372 QPALQLAFEQVMRMTV----LVLTDRIYQNLNGHMDQSALLDLMYMAKVSEPFLIDLIAHTHQDR 432
            |||:......:....:    |||...:.|. ...:..|.|:..|....:...|:.:|:..|||:.
Zfish   497 QPAVSQLLSNIRSQCISHAALVLQGALTQP-RAPLQPSLLVPYMLCRNLPYGFIQELVRMTHQEE 560

  Fly   433 EAFDTIFSQVLRGLFAGMQRNICTSKISVQQIEWLSKLVVIKVGSVRPIADLVSRQPNFLPPICT 497
            :.|..||..:|:||...::.....|......:..|::|..||.|...|:.:|::..|.:.|...:
Zfish   561 DVFKQIFVPILQGLALAVKECSFDSDNFKFPLMALAELCEIKFGKTHPVCNLITSLPLWCPDPLS 625

  Fly   498 KISGREIVKCSFLGPFLSVSLFAEENIKFAE-------FTTKNKLEDASSSRLRWELHSMRTNMH 555
            ..:||||.:.||||.|.|:|:|||::.|..:       .|.:|  ....|..|:..|.|.|.::.
Zfish   626 PGTGREIQRLSFLGAFFSLSVFAEDDTKVGDKYFSGPAITMEN--TRVVSQSLQHYLESARGDLF 688

  Fly   556 VVFHSLCVNASSRPKTLEYIASILRHNDRRVQFASDEKLLARDGFMINLMSVLQQLSVKIKLDRI 620
            .:.|::.:|..:|...|.|:|:::..|.::.|..:|:||::.||||:|.:.||||||:||||:.:
Zfish   689 KILHNILLNGETREAALSYMAALVNRNVKKAQMQTDDKLVSTDGFMMNFLWVLQQLSMKIKLETV 753

  Fly   621 EPNFHYYKNSLVNIE-QDTKIRYSEEEYRNFLAR------DFSQPVENTNFQTQCWFLTLQAHHL 678
            :|.:.::....:|:. ::|:::.:.||.:::|..      .||:|    .|.|:|:||||.||||
Zfish   754 DPLYIFHPKCRLNVSPEETRLKATMEELKSWLTELHEDPTKFSEP----KFPTECFFLTLHAHHL 814

  Fly   679 GYLPAIQRYRQKVRAIKELQKLIDELDRTKSHWMNSRYANRNNQFKERWEKQLRKLNRSKTCCEI 743
            ..||..:||.:::|||::|.:.::||..:::.|.:|..|.|:.:..:|.:.||:||.|||.|.:.
Zfish   815 SILPCCRRYIRRLRAIRDLNRTVEELKNSENQWKDSPLAGRHREMLKRCKTQLKKLVRSKACADA 879

  Fly   744 TLLDPGLLQRCTEFYSTVCEFMLYQFEGRPIEG--PFISKLPVQQLLPTDAFSALPEWYIDDIAE 806
            .|||..||:||.:|:|.|.:.:|     |.:|.  |.:| ||:...:| .:|:||||:||:|:||
Zfish   880 GLLDENLLRRCLQFFSMVIQLIL-----RMVEPAFPHVS-LPLNPEIP-KSFAALPEFYIEDVAE 937

  Fly   807 FILFTMQHANMDIRQGIDHSIITWLLTCVCASHLIKNPYVTAKLVEVMFVFSLKPANSVNAAMW- 870
            |:||.:|:....:.:.....|:|:|:..:|:.:.|||||:.||||||:||  ..||.......: 
Zfish   938 FMLFIVQYFPQVLYEPCTEDIVTFLIVFICSQNYIKNPYLIAKLVEVLFV--TNPAVQPRTQRFF 1000

  Fly   871 ----NHELAQNALVSSLMRFYVDVETTGQSTEFYDKFTIRYHISHLFKSMWENPIHRQAVICESR 931
                ||.|:.|.||.:||:||.|||.||.::|||||||||||||.:|||:|:|..|:...:.|..
Zfish  1001 EMLENHPLSVNQLVPALMKFYTDVEHTGATSEFYDKFTIRYHISTIFKSLWQNINHQGTFLEEFN 1065

  Fly   932 VGNQFVKFVNMLMNDTTFLLDECLENLKRIHQTQQLLSDKANLSKMSAEQQQSRLTQLATDERQC 996
            .|.|||:::|||:|||||||||.||:|||||:.|:.:.:|.....:..||||||.:||..|||..
Zfish  1066 SGKQFVRYINMLINDTTFLLDESLESLKRIHEIQEEMKNKEQWDLLPREQQQSRQSQLTQDERVS 1130

  Fly   997 RSYLTLARETVDLFHYLTSDIKEPFMRDELVDRLSSMLNFNLKQLAGPKCNDLKVKNPAKYGWEP 1061
            ||||.||.||||:||.||..:::||:|.||..||::|||:||:||.||||.||||:||.|||:||
Zfish  1131 RSYLALATETVDMFHILTKQVQKPFLRPELGPRLAAMLNYNLQQLCGPKCRDLKVENPEKYGFEP 1195

  Fly  1062 RSLLAQIFDIYLHLDCDRFAEALAADERSFDVQICNEAASRIKRLALRSAVEVERFKALTQRAHE 1126
            :.||.|:.||||.|||.|||:|:|.|:||:..::..|..|::::..::|.:.:|:||.|.::..|
Zfish  1196 KKLLDQLTDIYLQLDCPRFAKAIADDQRSYSRELFEEVISKMRKAGIKSTIAIEKFKLLLEKVEE 1260

  Fly  1127 IYVTNLQTEDECADAPDEFKDPLMDTLMSDPVVLPSGTVMDRAIITRHLLNSCTDPFNRQPLTED 1191
            |...|.|:|.:.:|||||||||||||||:|||.||||.:|||:||.||||||.|||||||||||.
Zfish  1261 IVARNSQSEMDYSDAPDEFKDPLMDTLMTDPVQLPSGNIMDRSIILRHLLNSPTDPFNRQPLTES 1325

  Fly  1192 MLVANIELKQRIDAW-RKEQRGK 1213
            ||....|||:||.|| |::|.|:
Zfish  1326 MLEPVPELKERIQAWMREKQTGR 1348

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CG9934NP_001162967.1 Ufd2P_core 510..1124 CDD:287392 275/634 (43%)
U-box 1141..1211 CDD:252675 53/70 (76%)
ube4bXP_021325394.1 Atrophin-1 <239..413 CDD:331285 14/173 (8%)
Ufd2P_core 638..1258 CDD:313606 275/634 (43%)
RING-Ubox_UBE4B 1271..1345 CDD:319572 54/73 (74%)
U-box domain, a modified RING finger 1281..1318 CDD:319572 29/36 (81%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C170581502
Domainoid 1 1.000 503 1.000 Domainoid score I331
eggNOG 1 0.900 - - E1_COG5113
Hieranoid 1 1.000 - -
Homologene 1 1.000 - - H107623
Inparanoid 1 1.050 708 1.000 Inparanoid score I637
OMA 1 1.010 - - QHG53881
OrthoDB 1 1.010 - - D194967at2759
OrthoFinder 1 1.000 - - FOG0004816
OrthoInspector 1 1.000 - - oto40333
orthoMCL 1 0.900 - - OOG6_101833
Panther 1 1.100 - - LDO PTHR13931
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R1598
SonicParanoid 1 1.000 - - X3397
SwiftOrtho 1 1.000 - -
TreeFam 1 0.960 - -
ZFIN 00.000 Not matched by this tool.
1716.800

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