Protein Alignment Ube4B and Ube4a

DIOPT Version :10

• Sequence 1: NP_609597.1
• Gene: Ube4B / 34699
• FlyBaseID: FBgn0032467
• Length: 1217
• Species: Drosophila melanogaster
• Sequence 2: NP_001333627.1
• Gene: Ube4a / 140630
• MGIID: 2154580
• Length: 1085
• Species: Mus musculus
• Alignment Length: 957
• Identity: 254/957 - (26%)
• Similarity: 446/957 - (46%)
• Gaps: 155/957 - (16%)

  Fly   346 KHHVLLYLIRCYQNYQTECSRKTP--LTQPALQLAFEQVMRMTVLVLTDRIYQNLNGHMDQSALL 408
            :.|:..||..|:|..:.|.: |.|  |...|:|.....|.....::||..||.:.|.|   ..|:
Mouse   189 ERHIFCYLYSCFQRAKEEIT-KVPENLLPFAVQCRNLTVSNTRTVLLTPEIYVDQNIH---EQLV 249

  Fly   409 DLM--------------YMAKVSEPFLIDLIAHTHQDREAFDTIFSQVLRGLFAGMQRNICTSKI 459
            |||              ::.:|.|..|:|....|          |.:|:..:|     :|..|:|
Mouse   250 DLMLEAIQGAHFEDVTEFLEEVIEALLLDEEVRT----------FPEVMIPVF-----DILLSRI 299

  Fly   460 SVQQIEWLSKLVVIKVGSVRPIADLVSRQPN----FLPPICTK-ISGREIVKCSFLGPFLSVSLF 519
              :.:|    |..|.:.:...|....:||.:    ||..|..| .|..::.:.:.||..|::|..
Mouse   300 --KDLE----LCQILLYAYLDILLYFTRQKDMAKVFLEYIQPKDPSNGQMYQKTLLGVILNISCL 358

  Fly   520 AE-----ENIKFAEFTTKN-----KLEDASSSRLRWELHSMRTNMHVVFHSLCVN-ASSRPKT-- 571
            .:     ||..|....:::     |:::|:       :|......|...:.:..| ....|:|
Mouse   359 LKTPGVVENHGFFLNPSRSSPQEIKVQEAN-------IHQFMAQFHEKIYQMLKNLLQLSPETKH 416

  Fly   572 --LEYIASILRHNDRRVQFASDE------KLLARDGFMINLMSVLQQLS---VKIKLDRI---EP 622
              |.::.:.|..|..|.:..:::      ::.|.|.|.:||.:.|.:|.   .|.:..|:   .|
Mouse   417 CILFWLGNCLHANAGRTKIWANQMPEIFFQMYASDAFFLNLGAALLKLCQPFCKPRSSRLLTFNP 481

  Fly   623 NFHYYKNSLVNIEQ----DTKIRYSEEEYRNFLARDFSQPV--ENTNFQTQCWFLTLQAHHLGYL 681
            .:...|:  :|.|:    ...:|..::|  ..|.....:|.  ::.|..|:...||....:||:
Mouse   482 TYCVLKD--LNDEERKIKSVHMRGLDKE--TCLIPAVQEPTFPQSYNLVTENLALTEYTLYLGF- 541

  Fly   682 PAIQRYRQKVRAIKELQKLIDELDRTKSHWMNSRYAN--RNNQFKERWEKQLRKLNRSKTCCEIT 744
                     .|...::.|:...|.|.:..|.:::.::  ..:..:|::|:.:.....:||    .
Mouse   542 ---------HRLHDQMVKINQNLHRLQVAWRDAQQSSSPAADNLREQFERLMTIYLSTKT----A 593

  Fly   745 LLDPGLLQRCTEFYSTVCEFMLYQF----EG-RPIEGPFISKLPVQQLLPTDAFSAL---PEWYI 801
            :.:|.:||.|.....::. .:|.|.    || :|||..|  .||       |.:|:|   ||::.
Mouse   594 MTEPQMLQNCLNLQVSMA-VLLVQLAIGNEGSQPIELSF--PLP-------DGYSSLAYVPEFFA 648

  Fly   802 DDIAEFILFTMQHANMDIRQ----GIDHSIITWLLTCVCASHLIKNPYVTAKLVEVMFV----FS 858
            |::.:|::|..:.|. ||.:    .::| ::.::.....:...:|||::.|||.||:..    ..
Mouse   649 DNLGDFLIFLRRFAE-DILETSADSLEH-VLHFITIFTGSIERMKNPHLRAKLAEVLEAVMPHLD 711

  Fly   859 LKPANSVNAAMWNHELAQN-----ALVSSLMRFYVDVETTGQSTEFYDKFTIRYHISHLFKSMWE 918
            ..|:..|::......:..|     .|..:|::.:||:|.||...:|..||..|..:..:.:.||.
Mouse   712 QTPSPLVSSVFHRKRVFCNFPYAPQLAEALIKVFVDIEFTGDPHQFEQKFNYRRPMYPILRYMWG 776

  Fly   919 NPIHRQAV---------ICESRVGNQFVKFVNMLMNDTTFLLDECLENLKRIHQTQQLLSDKANL 974
            ...:|:::         ..|:.....|::|:|:||||..|||||.::.|.:| :.||:..|:...
Mouse   777 TDCYRESIKDLADYASKNLEAMNPPLFLRFLNLLMNDAIFLLDEAIQYLSKI-KIQQIEKDRGEW 840

  Fly   975 SKMSAEQQQSRLTQLATDERQCRSYLTLARETVDLFHYLTSDIKEPFMRDELVDRLSSMLNFNLK 1039
            ..::.|.::.:...|....:..|.:..::.||:....:|||:||..|:...|.:|:.||||:.|:
Mouse   841 ESLTPEARREKEAGLQMFGQLARFHNIMSNETIGTLSFLTSEIKSLFVHPFLAERIISMLNYFLQ 905

  Fly  1040 QLAGPKCNDLKVKNPAKYGWEPRSLLAQIFDIYLHL-DCDRFAEALAADERSFDVQICNEAASRI 1103
            .|.|||...||||:.:::.::|:.|::.|..|||:| |.:.|...:..|.||:...:..:....:
Mouse   906 HLVGPKMGALKVKDFSEFDFKPQQLVSDICTIYLNLGDEENFCATVPKDGRSYSPTLFAQTVRVL 970

  Fly  1104 KRLALRSAVEVERFKALTQRAHEIYVTNLQTEDECADAPDEFKDPLMDTLMSDPVVLPSGTV-MD 1167
            |::. :....:..|..|.:|...:.....|.|:..|||.|||.||:|.|||||||||||..| :|
Mouse   971 KKIN-KPGNMIVAFSNLAERIKSLADLQQQEEETYADACDEFLDPIMSTLMSDPVVLPSSRVTVD 1034

  Fly  1168 RAIITRHLLNSCTDPFNRQPLTEDMLVANIELKQRIDAW---RKEQR 1211
            |:.|.||||:..||||||.|||.|.:..|.|||::|..|   ||:|:
Mouse  1035 RSTIARHLLSDQTDPFNRSPLTMDQIRPNTELKEKIQRWLAERKQQK 1081

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ube4B	NP_609597.1	Ufd2P_core	510..1124	CDD:463080	160/679 (24%)
		RING-Ubox_UBE4B	1138..1211	CDD:438320	46/76 (61%)
Ube4a	NP_001333627.1	Ufd2P_core	349..990	CDD:463080	160/679 (24%)
		RING-Ubox_UBE4A	1009..1078	CDD:438319	41/68 (60%)