Protein Alignment Ube4B and Ube4A

DIOPT Version :10

• Sequence 1: NP_609597.1
• Gene: Ube4B / 34699
• FlyBaseID: FBgn0032467
• Length: 1217
• Species: Drosophila melanogaster
• Sequence 2: XP_321414.5
• Gene: Ube4A / 1281494
• VectorBaseID: AGAMI1_001783
• Length: 1039
• Species: Anopheles gambiae
• Alignment Length: 969
• Identity: 261/969 - (26%)
• Similarity: 444/969 - (45%)
• Gaps: 161/969 - (16%)

  Fly   342 VATTKHHVLLYLIRCYQNYQTECSRKTPLTQPALQLAFEQVMRMTVLVLTD--------RIY--Q 396
            :|.||  .:|||..|::       |.....:|...:|.:...:|..|:|.:        .:|  |
Mosquito    90 IAETK--AILYLYGCFE-------RNEKPVEPNDSVALDNQRKMKALILRNVCTSLKQPELYEGQ 145

  Fly   397 NLNGHMDQSALLDLMYMAK-----VSEPFLIDLIAHTHQDREAFDTIFSQVLRGLFAG-----MQ 451
            ||:     :.|||:.....     |:..|:.:.:.....|.|.....|: ::||:|..     |:
Mosquito   146 NLS-----NQLLDIFKQCSTDDYAVAGRFVSEAVNEIFTDTETESEGFA-IIRGIFGPIFVVVMK 204

  Fly   452 RNICTSKISVQQIEWL-------------SKLVVIKVGSVRPIADLVSRQPNFLPPICTKISGRE 503
            .....|.|:::.  |:             .:|.:|.:|...|            ||....|...:
Mosquito   205 ALRAASLITIEC--WVMPFLQVFPSDKNNPRLALIFLGYTTP------------PPDSDGIKYSD 255

  Fly   504 IVKCSFLGPFLSVSLFAEENIKFAEF-----TTKNKLEDASSSRLRW---ELHSMRTNMHVVFHS 560
                |.||..||:|:....:....|:     ||.....|:.||.| |   :.|..|  ||....|
Mosquito   256 ----SLLGQLLSLSIMPRNHNGPYEYYENPLTTNRSAVDSLSSNL-WNYTKRHLAR--MHAFVKS 313

  Fly   561 -LCVNASSRPKTLEYIASILRHNDRRVQFAS--------DEKLLARDGFMINLMSVLQQ-----L 611
             |.:..:.|.|.|::|...|..|..|.|..:        ..:..:.|.|.|||..||.:     |
Mosquito   314 FLLLGGTVRSKMLDWIGRCLHANVPRGQIWNTHHGMGMFGNQTTSPDAFSINLAGVLLRLCQPLL 378

  Fly   612 SVKIKLDRIEPNFHYYKNS--------LVNIEQDTKIRYSEEEYRNFLARDFSQPVENTNFQTQC 668
            ..::|:..::|.:...|.:        :::.|::|.:...|::....|..|      ..||.|:|
Mosquito   379 KPQLKVLIVDPTYCAVKEADKETKAVHMLDAEKETCLLPLEDDKEQRLEAD------RYNFVTEC 437

  Fly   669 WFLTLQAHHLGYLPAIQRYRQKVRAIKELQKLIDELDRTKSHWMNSRYANRNNQFKERWEKQLRK 733
            :|:|.:|..|||...|:::.:..|.:..||.:..|:       |:...|:..:...:....|:::
Mosquito   438 FFMTHKAIDLGYRVCIEKFFRMNRELHRLQTMYYEM-------MSQNGADVPSDLMQMVSSQMQQ 495

  Fly   734 LNRSKTCCEITLLDPGLLQRCTEFYSTVCEFMLYQFEGR---------PIEG-------PFISKL 782
            .    .|.:..||:|...:...:||. .....|.|...|         |.:|       |.  .|
Mosquito   496 F----LCLQNVLLEPETDELLLQFYE-ASAIWLTQLSAREASQIDTLEPAKGFSPQTQQPV--NL 553

  Fly   783 PVQQLLPTDAFSALPEWYIDDIAEFILFTMQHANMDIRQGID--HSIITWLLTCVCASHLIKNPY 845
            |:..:..:.....:||:.|::|..::.|:....:..:|..:|  .||.|.:|..:.:|..|:||:
Mosquito   554 PLVGVAVSRVLKCIPEYIIENIVGYLQFSRHFDSRSLRVDVDAQRSIFTMILIFMGSSERIRNPH 618

  Fly   846 VTAKL---VEVMFVFSLKPAN-SVNAAMWNHELAQNALVSSLMRFYVDVETTGQSTEFYDKFTIR 906
            :.|:|   :|.:.....:||. |::|.::.:...:..::.:|:|.:|.:|.||||.:|..||..|
Mosquito   619 LRARLAEGLESLLPKESEPAGFSLSATLFTNHPHRLEIIPNLLRVFVSIEMTGQSVQFEQKFNYR 683

  Fly   907 YHISHLFKSMWE--------NPIHRQAV-ICESRVGNQFVKFVNMLMNDTTFLLDECLENLKRIH 962
            ..:..:...:|:        ..:.|||: ..|:.....|::|:|:|:||..|||||.|.||::|.
Mosquito   684 RPMYAIMDYLWKIDEQKECFRALERQAIENIEAEDPPIFLRFINLLINDAIFLLDESLSNLQQIR 748

  Fly   963 QTQQLLSDKANLSKMSAEQQQSRLTQLATDERQCRSYLTLARETVDLFHYLTSDIKEPFMRDELV 1027
            |.|. ..|......::..::|..:..|.......|....|.|:|:::...|||:.|..|....:|
Mosquito   749 QMQG-AQDAGEWESLAQTERQQNVANLRNLGMLARFDNILGRDTINILQLLTSETKSIFCHSSMV 812

  Fly  1028 DRLSSMLNFNLKQLAGPKCNDLKVKNPAKYGWEPRSLLAQIFDIYLHL-DCDRFAEALAADERSF 1091
            ||:::|||:.|..|.|||..:.|||:..::.::|...:.:|..||::| :||.|..|::.|.||:
Mosquito   813 DRVAAMLNYFLLNLTGPKKGNFKVKDKREFEFDPARTVLEICRIYVNLCECDAFCLAVSQDGRSY 877

  Fly  1092 DVQICNEAASRIKRLALRSAV-EVERFKALTQRAHEIYVTNLQTEDECA--DAPDEFKDPLMDTL 1153
            ..|:...|...:.|:.....: |::.|....||     :...|..||.|  |.||||.||:|.:|
Mosquito   878 SPQLFEYAEQVLTRIGGGQLIGEMQEFAQKVQR-----IEKQQKIDEEALIDPPDEFLDPIMSSL 937

  Fly  1154 MSDPVVLPSGTV-MDRAIITRHLLNSCTDPFNRQPLTEDMLVANIELKQRIDAWRKEQR 1211
            |:|||:|||..: :||:.|.||||:..:|||||.|||.:.:..|.|||.:||||.:|:|
Mosquito   938 MADPVILPSSRITVDRSTIARHLLSDQSDPFNRSPLTMEQVKRNDELKAKIDAWMREKR 996

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ube4B	NP_609597.1	Ufd2P_core	510..1124	CDD:463080	175/676 (26%)
		RING-Ubox_UBE4B	1138..1211	CDD:438320	41/75 (55%)
Ube4A	XP_321414.5	Ufd2P_core	266..908	CDD:463080	169/665 (25%)
		RING-Ubox_UBE4A	927..996	CDD:438319	38/68 (56%)