Protein Alignment Ube4B and Ube4B

DIOPT Version :10

• Sequence 1: NP_609597.1
• Gene: Ube4B / 34699
• FlyBaseID: FBgn0032467
• Length: 1217
• Species: Drosophila melanogaster
• Sequence 2: XP_061516382.1
• Gene: Ube4B / 1278085
• VectorBaseID: AGAMI1_010117
• Length: 1296
• Species: Anopheles gambiae
• Alignment Length: 1317
• Identity: 562/1317 - (42%)
• Similarity: 762/1317 - (57%)
• Gaps: 194/1317 - (14%)

  Fly    71 ELSAEEMRARRLRTLAARS--GIQCALAPLT----TTPRKPTNVSGESRLVREATPGEKE----- 124
            ||:.||:||||||.|.|::  .:..:.||.|    :|.:..|:.||.|......|..|.|
Mosquito     2 ELTPEEIRARRLRKLGAKTTKNVANSNAPSTEDGNSTSQATTSNSGSSSTTTTTTSVELEKVADS 66

  Fly   125 VSLPTS-APAWRELSGKPDMDVEMKSV---------------VSTPMQD------VDMTTALSLP 167
            ..:||: ||..   .||.| .|.|:|.               .:.|..|      ::.:..|.|.
Mosquito    67 QQMPTTVAPIG---PGKAD-TVPMESSNSDTVGSSSSLTGSNAADPKTDLILPDKIEASLMLGLE 127

  Fly   168 TAEATK------RSVLQSCKISAGNAELSI------ETVVGP-----------KK---------- 199
            .||.::      ||||.:..:||..|..::      .:||.|           ||
Mosquito   128 VAEQSQQQQQKARSVLVASSVSASTASAALRKKPIPSSVVAPSTTAPVNTWAVKKRSSSDHCATK 192

  Fly   200 ----------------------------SADEQNEQLLSRLLNATWNEYGSGSIICAQS---ASF 233
                                        ||.::..|::.|::........|.|....::   .:.
Mosquito   193 PDGADHHPNSTEGNTLDPKTHCEQDSRVSAQDELLQIMLRIMKINSKARYSNSRFTIEANVLENA 257

  Fly   234 LEQQPHRRFDFECIVANVLMEAVLKIYNGELIEGDGVSVKADDKEFSSAKKIKSD-----DTEVQ 293
            ||....:|:|..|  |.|::|.|..||.|:|||..|        |.|.|.::...     ..:|:
Mosquito   258 LEMLDRQRYDEFC--AEVIVEVVKGIYYGKLIESHG--------EDSDAGRLSDSWSTIPSKKVK 312

  Fly   294 EILANAVATGGATASGETAAAAAGASGPIE-----ATSSEAAGTCVAPPVLSIVATTKHHVLLYL 353
            .|:.:.|..|.:..||.:..||...:.|::     ....:|.|.|.:.|.:...|..:...|.||
Mosquito   313 PIMLDEVVIGRSGRSGSSGMAAGSTATPMDIDIEMQPEEDAPGYCSSKPSMKAFANNRVAALEYL 377

  Fly   354 IRCYQNYQTEC--------SRKTPL--TQPA-LQLAFEQVMRMTVLVLTDRIYQN---------- 397
            |.||.....|.        |:|..|  |.|: :.:..:|.::..:|||.: .:|:
Mosquito   378 IGCYLRSNEELYSYTKVKKSKKMYLAETLPSVVSVIRQQTLKYAILVLKN-TFQSFCQPDGGSVE 441

  Fly   398 --------LNGH--------------------MDQSALLDLMYMAKVSEPFLIDLIAHTHQD--R 432
                    :|..                    :::|.||.|||..|||..|:.:|:|.:.:.  .
Mosquito   442 SGGSSGGAINSSSSTGGSTSSSTSKTTAGSTALEKSPLLTLMYENKVSADFMSNLMAESRKSDGE 506

  Fly   433 EAFDTIFSQVLRGLFAGMQRNICTSKISVQQIEWLSKLVVIKVGSVRPIADLVSRQPNFLPPIC- 496
            |.|..||:.||..||..||..||...|....:..|.:|:..:|.:..||..|:.....||....
Mosquito   507 EDFRIIFNAVLDDLFIDMQNAICNENIVADPLNRLKELIETRVDNTHPICLLIVEHRIFLTAFTP 571

  Fly   497 TKISGREIVKCSFLGPFLSVSLFAEENIKFAEFTTKNKLEDASSSRLRWELHSMRTNMHVVFHS- 560
            .|...|||.|.|||.||||:|:..:||.|||.....:.:.|.:   |....|::.:|...|.||
Mosquito   572 DKYFAREISKVSFLAPFLSLSVMLDENPKFASHHFSDNVCDRT---LASSFHAILSNTRKVLHSI 633

  Fly   561 ---LCVNASSRPKTLEYIASILRHNDRRVQFASDEKLLARDGFMINLMSVLQQLSVKIKLDRIEP 622
               |..|..||.:.|.|||:||:.|.:|:|:.:|::.||:||||:|.|||||.|||||.|.||:|
Mosquito   634 FLVLLSNQYSRYEMLNYIAAILKSNAKRIQYNADDRFLAKDGFMLNFMSVLQLLSVKINLSRIDP 698

  Fly   623 NFHYYKNSLVNIEQDTKIRYSEEEYRNFL-----ARDFSQPVENTNFQTQCWFLTLQAHHLGYLP 682
            .:.::..|||.||.:||:::|.:||.::|     .:|:    |...|.|.||||||.|||||.:|
Mosquito   699 LYPHHPESLVEIEDETKLKFSSQEYADWLGTLKDVKDW----EQHKFVTHCWFLTLHAHHLGIIP 759

  Fly   683 AIQRYRQKVRAIKELQKLIDELDRTKSHWMNSRYANRNNQFKERWEKQLRKLNRSKTCCEITLLD 747
            |||||.:.:||.||||:::|||:.||:.|.|:..|.||.|.::|...|:.||:::|..|:|.::|
Mosquito   760 AIQRYNKLLRATKELQRMVDELNATKTQWENTPLARRNKQIRDRCVSQMNKLSKAKLSCDIAIID 824

  Fly   748 PGLLQRCTEFYSTVCEFMLYQFEGRPIEGPFISKLPVQQLLPTDAFSALPEWYIDDIAEFILFTM 812
            |.:|..|.:|||||||:||||.|.|||:|||.::.....|:.::.|.|||||||:|||:||||.|
Mosquito   825 PNVLSACMQFYSTVCEYMLYQIENRPIDGPFTNQQHPSTLVASENFCALPEWYIEDIADFILFCM 889

  Fly   813 QHANMDIRQGIDHSIITWLLTCVCASHLIKNPYVTAKLVEVMFVFS---LKPANSVNAAMWNHEL 874
            ||:: .:...:|:|||||:||.|||.|||||||:||||:||:||.|   ...:..:...:.||||
Mosquito   890 QHSS-SVIDYVDNSIITWILTLVCAPHLIKNPYITAKLIEVLFVTSPTIQTTSQRLYLQIINHEL 953

  Fly   875 AQNALVSSLMRFYVDVETTGQSTEFYDKFTIRYHISHLFKSMWENPIHRQAVICESRVGNQFVKF 939
            ||.||||:||:||.|:||||||||||||||||||||||||.:||:.:||||.:.||:.|.|||||
Mosquito   954 AQTALVSALMKFYTDIETTGQSTEFYDKFTIRYHISHLFKGLWESALHRQAFVNESKSGKQFVKF 1018

  Fly   940 VNMLMNDTTFLLDECLENLKRIHQTQQLLSDKANLSKMSAEQQQSRLTQLATDERQCRSYLTLAR 1004
            ||..:||||:|||||||.|||||:||.|:.|.:..:.::.|.||||..||..|||||||||||||
Mosquito  1019 VNFFLNDTTYLLDECLEYLKRIHETQVLMMDDSGWNALTQEAQQSRQRQLVQDERQCRSYLTLAR 1083

  Fly  1005 ETVDLFHYLTSDIKEPFMRDELVDRLSSMLNFNLKQLAGPKCNDLKVKNPAKYGWEPRSLLAQIF 1069
            ||||:|||:|.||||||:|.||:||||||||:|:.||.|||||||:|::|.|||||||.||.|:.
Mosquito  1084 ETVDMFHYMTIDIKEPFLRPELIDRLSSMLNYNMHQLCGPKCNDLRVRHPHKYGWEPRRLLGQLV 1148

  Fly  1070 DIYLHLDCDRFAEALAADERSFDVQICNEAASRIKRLALRSAVEVERFKALTQRAHEIYVTNLQT 1134
            ||||||.||.||.|||||||||:.|...:||:|::|:.:||..:|:.|:.|..:|.||||.|.:.
Mosquito  1149 DIYLHLSCDEFANALAADERSFEKQFFEDAANRVERIGIRSHRDVDEFRKLIHKAAEIYVKNQEN 1213

  Fly  1135 EDECADAPDEFKDPLMDTLMSDPVVLPSGTVMDRAIITRHLLNSCTDPFNRQPLTEDMLVANIEL 1199
            .||.|:|||:||||||||||:|||:|||||:|||||||||||||.||||||||||||||....||
Mosquito  1214 ADEFAEAPDDFKDPLMDTLMTDPVILPSGTIMDRAIITRHLLNSSTDPFNRQPLTEDMLKPATEL 1278

  Fly  1200 KQRIDAWRKEQRGKRNN 1216
            |:||..|.||.|.::.:
Mosquito  1279 KERIQQWIKEYRAQKKS 1295

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ube4B	NP_609597.1	Ufd2P_core	510..1124	CDD:463080	348/625 (56%)
		RING-Ubox_UBE4B	1138..1211	CDD:438320	57/72 (79%)
Ube4B	XP_061516382.1	None