DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment CG9934 and UBE4B

DIOPT Version :9

Sequence 1:NP_001162967.1 Gene:CG9934 / 34699 FlyBaseID:FBgn0032467 Length:1217 Species:Drosophila melanogaster
Sequence 2:XP_005263479.1 Gene:UBE4B / 10277 HGNCID:12500 Length:1353 Species:Homo sapiens


Alignment Length:1386 Identity:456/1386 - (32%)
Similarity:686/1386 - (49%) Gaps:284/1386 - (20%)


- Green bases have known domain annotations that are detailed below.


  Fly    71 ELSAEEMRARRLRTLAARSGIQCALAPLTTTPRK------------------------------P 105
            ||||:|:|.|||..||.....| ...|||:..|:                              |
Human     3 ELSADEIRRRRLARLAGGQTSQ-PTTPLTSPQRENPPGPPIAASAPGPSQSLGLNVHNMTPATSP 66

  Fly   106 TNVSGESRLVREATPGEKEVSLPTSAPA------WRELSGKPDMDVEMKSVVSTPMQDVDMTTAL 164
            ...||    |...:...:.||..:|:|:      .:.||....||::..|...: |..||:.:.:
Human    67 IGASG----VAHRSQSSEGVSSLSSSPSNSLETQSQSLSRSQSMDIDGVSCEKS-MSQVDVDSGI 126

  Fly   165 -SLPTAEATKRSVLQSCKISAGNAELSIETVVGPKKSADEQNEQLLSRLLNATWNEYGSGSIICA 228
             ::...|..:|.     |.|..:.|.|    .||:.| :||..||:.::...:|.:.....|..:
Human   127 ENMEVDENDRRE-----KRSLSDKEPS----SGPEVS-EEQALQLVCKIFRVSWKDRDRDVIFLS 181

  Fly   229 QSASFLEQQPHRRF-DFECIVANVLMEAVLKIYNGELIEGDGVSVKADDKEFSSAKKIKSDDTEV 292
            ..::..:|.|...| ||:.::..:||| ||.:......|....|:.|..:..::|  .:|.|   
Human   182 SLSAQFKQNPKEVFSDFKDLIGQILME-VLMMSTQTRDENPFASLTATSQPIAAA--ARSPD--- 240

  Fly   293 QEILAN------------AVATGGAT--------------------------------------- 306
            :.:|.|            :||:.||:                                       
Human   241 RNLLLNTGSNPGTSPMFCSVASFGASSLSSLYESSPAPTPSFWSSVPVMGPSLASPSRAASQLAV 305

  Fly   307 ----------ASGETAA-----------------AAAG-------------ASGP--IEATSSEA 329
                      |||..|.                 |::|             ||.|  :.|:||..
Human   306 PSTPLSPHSAASGTAAGSQPSSPRYRPYTVTHPWASSGVSILSSSPSPPALASSPQAVPASSSRQ 370

  Fly   330 AGTCVAPPV--LSIVATTKH--------------------------------------------- 347
            ..:...||:  .|..||::.                                             
Human   371 RPSSTGPPLPPASPSATSRRPSSLRISPSMYDNPFSFLFLALSGDSSDEEDEEEDDDDGDGDDEG 435

  Fly   348 ----------------------------------------HVLLYLIRCYQNYQTECSRKTP--L 370
                                                    .:|.|||.|:.....| .:|.|  .
Human   436 GGGGDDFSCVQFGSSLGASGGASNWDSYSDHFTIETCKETDMLNYLIECFDRVGIE-EKKAPKMC 499

  Fly   371 TQPALQLAF----EQVMRMTVLVLTDRIYQNLNGHMDQSALLDLMYMAKVSEPFLIDLIAHTHQD 431
            :|||:....    .|.:..|.|||...:.|. ......|.|:..|....:...|:.:|:..||||
Human   500 SQPAVSQLLSNIRSQCISHTALVLQGSLTQP-RSLQQPSFLVPYMLCRNLPYGFIQELVRTTHQD 563

  Fly   432 REAFDTIFSQVLRGLFAGMQRNICTSKISVQQIEWLSKLVVIKVGSVRPIADLVSRQPNFLPPIC 496
            .|.|..||..:|:||....:.....|......:..|.:|...|.|...|:.:||:....:||...
Human   564 EEVFKQIFIPILQGLALAAKECSLDSDYFKYPLMALGELCETKFGKTHPVCNLVASLRLWLPKSL 628

  Fly   497 TKISGREIVKCSFLGPFLSVSLFAEENIKFAE-------FTTKNKLEDASSSRLRWELHSMRTNM 554
            :...|||:.:.|:||.|.|.|:|||:::|..|       .|.:|  ....|..|:..|...|..:
Human   629 SPGCGRELQRLSYLGAFFSFSVFAEDDVKVVEKYFSGPAITLEN--TRVVSQSLQHYLELGRQEL 691

  Fly   555 HVVFHSLCVNASSRPKTLEYIASILRHNDRRVQFASDEKLLARDGFMINLMSVLQQLSVKIKLDR 619
            ..:.||:.:|..:|...|.|:|:::..|.::.|..:|::|::.||||:|.:.||||||.||||:.
Human   692 FKILHSILLNGETREAALSYMAAVVNANMKKAQMQTDDRLVSTDGFMLNFLWVLQQLSTKIKLET 756

  Fly   620 IEPNFHYYKNSLVNIEQD-TKIRYSEEEYRNFLAR------DFSQPVENTNFQTQCWFLTLQAHH 677
            ::|.:.::....:.:..| |::..:.|:..::|..      .||:|    .|.|:|:||||.|||
Human   757 VDPTYIFHPRCRITLPNDETRVNATMEDVNDWLTELYGDQPPFSEP----KFPTECFFLTLHAHH 817

  Fly   678 LGYLPAIQRYRQKVRAIKELQKLIDELDRTKSHWMNSRYANRNNQFKERWEKQLRKLNRSKTCCE 742
            |..||:.:||.:::|||:||.:.:::|...:|.|.:|..|.|:.:..:|.:.||:||.|.|.|.:
Human   818 LSILPSCRRYIRRLRAIRELNRTVEDLKNNESQWKDSPLATRHREMLKRCKTQLKKLVRCKACAD 882

  Fly   743 ITLLDPGLLQRCTEFYSTVCEFMLYQFEGRPIEG--PFISKLPVQQLLPTDAFSALPEWYIDDIA 805
            ..|||...|:||..||..:.:.:|     |.::.  |.|: ||:...:| ..|:||||:|::|:|
Human   883 AGLLDESFLRRCLNFYGLLIQLLL-----RILDPAYPDIT-LPLNSDVP-KVFAALPEFYVEDVA 940

  Fly   806 EFILFTMQHANMDIRQGIDHSIITWLLTCVCASHLIKNPYVTAKLVEVMFVFSLKPANSVNAAMW 870
            ||:.|.:|::...:.:.....|:.:|:..:|..:.|:|||:.||||||||:  ..||.......:
Human   941 EFLFFIVQYSPQALYEPCTQDIVMFLVVMLCNQNYIRNPYLVAKLVEVMFM--TNPAVQPRTQKF 1003

  Fly   871 -----NHELAQNALVSSLMRFYVDVETTGQSTEFYDKFTIRYHISHLFKSMWENPIHRQAVICES 930
                 ||.|:...||.|||:||.|||.||.::|||||||||||||.:|||:|:|..|....:.|.
Human  1004 FEMIENHPLSTKLLVPSLMKFYTDVEHTGATSEFYDKFTIRYHISTIFKSLWQNIAHHGTFMEEF 1068

  Fly   931 RVGNQFVKFVNMLMNDTTFLLDECLENLKRIHQTQQLLSDKANLSKMSAEQQQSRLTQLATDERQ 995
            ..|.|||:::|||:|||||||||.||:|||||:.|:.:.:|....::..:|||:|.:|||.|||.
Human  1069 NSGKQFVRYINMLINDTTFLLDESLESLKRIHEVQEEMKNKEQWDQLPRDQQQARQSQLAQDERV 1133

  Fly   996 CRSYLTLARETVDLFHYLTSDIKEPFMRDELVDRLSSMLNFNLKQLAGPKCNDLKVKNPAKYGWE 1060
            .||||.||.||||:||.||..:::||:|.||..||::||||||:||.||||.||||:||.|||:|
Human  1134 SRSYLALATETVDMFHILTKQVQKPFLRPELGPRLAAMLNFNLQQLCGPKCRDLKVENPEKYGFE 1198

  Fly  1061 PRSLLAQIFDIYLHLDCDRFAEALAADERSFDVQICNEAASRIKRLALRSAVEVERFKALTQRAH 1125
            |:.||.|:.||||.|||.|||:|:|.|:||:..::..|..|::::..::|.:.:|:||.|.::..
Human  1199 PKKLLDQLTDIYLQLDCARFAKAIADDQRSYSKELFEEVISKMRKAGIKSTIAIEKFKLLAEKVE 1263

  Fly  1126 EIYVTNLQTEDECADAPDEFKDPLMDTLMSDPVVLPSGTVMDRAIITRHLLNSCTDPFNRQPLTE 1190
            ||...|.:.|.:.:||||||:||||||||:|||.|||||:|||:||.||||||.|||||||.|||
Human  1264 EIVAKNARAEIDYSDAPDEFRDPLMDTLMTDPVRLPSGTIMDRSIILRHLLNSPTDPFNRQTLTE 1328

  Fly  1191 DMLVANIELKQRIDAWRKEQR 1211
            .||....|||::|.||.:|::
Human  1329 SMLEPVPELKEQIQAWMREKQ 1349

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CG9934NP_001162967.1 Ufd2P_core 510..1124 CDD:287392 267/634 (42%)
U-box 1141..1211 CDD:252675 51/69 (74%)
UBE4BXP_005263479.1 Ufd2P_core 642..1262 CDD:287392 267/634 (42%)
U-box 1279..1350 CDD:252675 51/71 (72%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C165147675
Domainoid 1 1.000 509 1.000 Domainoid score I322
eggNOG 1 0.900 - - E1_COG5113
Hieranoid 1 1.000 - -
Homologene 1 1.000 - - H107623
Inparanoid 1 1.050 711 1.000 Inparanoid score I652
Isobase 1 0.950 - 0 Normalized mean entropy S2779
OMA 1 1.010 - - QHG53881
OrthoDB 1 1.010 - - D194967at2759
OrthoFinder 1 1.000 - - FOG0004816
OrthoInspector 1 1.000 - - oto88507
orthoMCL 1 0.900 - - OOG6_101833
Panther 1 1.100 - - LDO PTHR13931
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R1598
SonicParanoid 1 1.000 - - X3397
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 1 0.960 - -
User_Submission 00.000 Not matched by this tool.
1716.750

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