Protein Alignment Ube4B and UBE4B

DIOPT Version :10

• Sequence 1: NP_609597.1
• Gene: Ube4B / 34699
• FlyBaseID: FBgn0032467
• Length: 1217
• Species: Drosophila melanogaster
• Sequence 2: NP_001397673.1
• Gene: UBE4B / 10277
• HGNCID: 12500
• Length: 1353
• Species: Homo sapiens
• Alignment Length: 1386
• Identity: 456/1386 - (32%)
• Similarity: 686/1386 - (49%)
• Gaps: 284/1386 - (20%)

  Fly    71 ELSAEEMRARRLRTLAARSGIQCALAPLTTTPRK------------------------------P 105
            ||||:|:|.|||..||.....| ...|||:..|:                              |
Human     3 ELSADEIRRRRLARLAGGQTSQ-PTTPLTSPQRENPPGPPIAASAPGPSQSLGLNVHNMTPATSP 66

  Fly   106 TNVSGESRLVREATPGEKEVSLPTSAPA------WRELSGKPDMDVEMKSVVSTPMQDVDMTTAL 164
            ...||    |...:...:.||..:|:|:      .:.||....||::..|...: |..||:.:.:
Human    67 IGASG----VAHRSQSSEGVSSLSSSPSNSLETQSQSLSRSQSMDIDGVSCEKS-MSQVDVDSGI 126

  Fly   165 -SLPTAEATKRSVLQSCKISAGNAELSIETVVGPKKSADEQNEQLLSRLLNATWNEYGSGSIICA 228
             ::...|..:|.     |.|..:.|.|    .||:.| :||..||:.::...:|.:.....|..:
Human   127 ENMEVDENDRRE-----KRSLSDKEPS----SGPEVS-EEQALQLVCKIFRVSWKDRDRDVIFLS 181

  Fly   229 QSASFLEQQPHRRF-DFECIVANVLMEAVLKIYNGELIEGDGVSVKADDKEFSSAKKIKSDDTEV 292
            ..::..:|.|...| ||:.::..:||| ||.:......|....|:.|..:..::|  .:|.|
Human   182 SLSAQFKQNPKEVFSDFKDLIGQILME-VLMMSTQTRDENPFASLTATSQPIAAA--ARSPD--- 240

  Fly   293 QEILAN------------AVATGGAT--------------------------------------- 306
            :.:|.|            :||:.||:
Human   241 RNLLLNTGSNPGTSPMFCSVASFGASSLSSLYESSPAPTPSFWSSVPVMGPSLASPSRAASQLAV 305

  Fly   307 ----------ASGETAA-----------------AAAG-------------ASGP--IEATSSEA 329
                      |||..|.                 |::|             ||.|  :.|:||..
Human   306 PSTPLSPHSAASGTAAGSQPSSPRYRPYTVTHPWASSGVSILSSSPSPPALASSPQAVPASSSRQ 370

  Fly   330 AGTCVAPPV--LSIVATTKH--------------------------------------------- 347
            ..:...||:  .|..||::.
Human   371 RPSSTGPPLPPASPSATSRRPSSLRISPSMYDNPFSFLFLALSGDSSDEEDEEEDDDDGDGDDEG 435

  Fly   348 ----------------------------------------HVLLYLIRCYQNYQTECSRKTP--L 370
                                                    .:|.|||.|:.....| .:|.|  .
Human   436 GGGGDDFSCVQFGSSLGASGGASNWDSYSDHFTIETCKETDMLNYLIECFDRVGIE-EKKAPKMC 499

  Fly   371 TQPALQLAF----EQVMRMTVLVLTDRIYQNLNGHMDQSALLDLMYMAKVSEPFLIDLIAHTHQD 431
            :|||:....    .|.:..|.|||...:.|. ......|.|:..|....:...|:.:|:..||||
Human   500 SQPAVSQLLSNIRSQCISHTALVLQGSLTQP-RSLQQPSFLVPYMLCRNLPYGFIQELVRTTHQD 563

  Fly   432 REAFDTIFSQVLRGLFAGMQRNICTSKISVQQIEWLSKLVVIKVGSVRPIADLVSRQPNFLPPIC 496
            .|.|..||..:|:||....:.....|......:..|.:|...|.|...|:.:||:....:||...
Human   564 EEVFKQIFIPILQGLALAAKECSLDSDYFKYPLMALGELCETKFGKTHPVCNLVASLRLWLPKSL 628

  Fly   497 TKISGREIVKCSFLGPFLSVSLFAEENIKFAE-------FTTKNKLEDASSSRLRWELHSMRTNM 554
            :...|||:.:.|:||.|.|.|:|||:::|..|       .|.:|  ....|..|:..|...|..:
Human   629 SPGCGRELQRLSYLGAFFSFSVFAEDDVKVVEKYFSGPAITLEN--TRVVSQSLQHYLELGRQEL 691

  Fly   555 HVVFHSLCVNASSRPKTLEYIASILRHNDRRVQFASDEKLLARDGFMINLMSVLQQLSVKIKLDR 619
            ..:.||:.:|..:|...|.|:|:::..|.::.|..:|::|::.||||:|.:.||||||.||||:.
Human   692 FKILHSILLNGETREAALSYMAAVVNANMKKAQMQTDDRLVSTDGFMLNFLWVLQQLSTKIKLET 756

  Fly   620 IEPNFHYYKNSLVNIEQD-TKIRYSEEEYRNFLAR------DFSQPVENTNFQTQCWFLTLQAHH 677
            ::|.:.::....:.:..| |::..:.|:..::|..      .||:|    .|.|:|:||||.|||
Human   757 VDPTYIFHPRCRITLPNDETRVNATMEDVNDWLTELYGDQPPFSEP----KFPTECFFLTLHAHH 817

  Fly   678 LGYLPAIQRYRQKVRAIKELQKLIDELDRTKSHWMNSRYANRNNQFKERWEKQLRKLNRSKTCCE 742
            |..||:.:||.:::|||:||.:.:::|...:|.|.:|..|.|:.:..:|.:.||:||.|.|.|.:
Human   818 LSILPSCRRYIRRLRAIRELNRTVEDLKNNESQWKDSPLATRHREMLKRCKTQLKKLVRCKACAD 882

  Fly   743 ITLLDPGLLQRCTEFYSTVCEFMLYQFEGRPIEG--PFISKLPVQQLLPTDAFSALPEWYIDDIA 805
            ..|||...|:||..||..:.:.:|     |.::.  |.|: ||:...:| ..|:||||:|::|:|
Human   883 AGLLDESFLRRCLNFYGLLIQLLL-----RILDPAYPDIT-LPLNSDVP-KVFAALPEFYVEDVA 940

  Fly   806 EFILFTMQHANMDIRQGIDHSIITWLLTCVCASHLIKNPYVTAKLVEVMFVFSLKPANSVNAAMW 870
            ||:.|.:|::...:.:.....|:.:|:..:|..:.|:|||:.||||||||:  ..||.......:
Human   941 EFLFFIVQYSPQALYEPCTQDIVMFLVVMLCNQNYIRNPYLVAKLVEVMFM--TNPAVQPRTQKF 1003

  Fly   871 -----NHELAQNALVSSLMRFYVDVETTGQSTEFYDKFTIRYHISHLFKSMWENPIHRQAVICES 930
                 ||.|:...||.|||:||.|||.||.::|||||||||||||.:|||:|:|..|....:.|.
Human  1004 FEMIENHPLSTKLLVPSLMKFYTDVEHTGATSEFYDKFTIRYHISTIFKSLWQNIAHHGTFMEEF 1068

  Fly   931 RVGNQFVKFVNMLMNDTTFLLDECLENLKRIHQTQQLLSDKANLSKMSAEQQQSRLTQLATDERQ 995
            ..|.|||:::|||:|||||||||.||:|||||:.|:.:.:|....::..:|||:|.:|||.|||.
Human  1069 NSGKQFVRYINMLINDTTFLLDESLESLKRIHEVQEEMKNKEQWDQLPRDQQQARQSQLAQDERV 1133

  Fly   996 CRSYLTLARETVDLFHYLTSDIKEPFMRDELVDRLSSMLNFNLKQLAGPKCNDLKVKNPAKYGWE 1060
            .||||.||.||||:||.||..:::||:|.||..||::||||||:||.||||.||||:||.|||:|
Human  1134 SRSYLALATETVDMFHILTKQVQKPFLRPELGPRLAAMLNFNLQQLCGPKCRDLKVENPEKYGFE 1198

  Fly  1061 PRSLLAQIFDIYLHLDCDRFAEALAADERSFDVQICNEAASRIKRLALRSAVEVERFKALTQRAH 1125
            |:.||.|:.||||.|||.|||:|:|.|:||:..::..|..|::::..::|.:.:|:||.|.::..
Human  1199 PKKLLDQLTDIYLQLDCARFAKAIADDQRSYSKELFEEVISKMRKAGIKSTIAIEKFKLLAEKVE 1263

  Fly  1126 EIYVTNLQTEDECADAPDEFKDPLMDTLMSDPVVLPSGTVMDRAIITRHLLNSCTDPFNRQPLTE 1190
            ||...|.:.|.:.:||||||:||||||||:|||.|||||:|||:||.||||||.|||||||.|||
Human  1264 EIVAKNARAEIDYSDAPDEFRDPLMDTLMTDPVRLPSGTIMDRSIILRHLLNSPTDPFNRQTLTE 1328

  Fly  1191 DMLVANIELKQRIDAWRKEQR 1211
            .||....|||::|.||.:|::
Human  1329 SMLEPVPELKEQIQAWMREKQ 1349

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ube4B	NP_609597.1	Ufd2P_core	510..1124	CDD:463080	267/634 (42%)
		RING-Ubox_UBE4B	1138..1211	CDD:438320	52/72 (72%)
UBE4B	NP_001397673.1	Ufd2P_core	642..1262	CDD:463080	267/634 (42%)
		RING-Ubox_UBE4B	1276..1349	CDD:438320	52/72 (72%)