Protein Alignment Ube4B and ube4a

DIOPT Version :10

• Sequence 1: NP_609597.1
• Gene: Ube4B / 34699
• FlyBaseID: FBgn0032467
• Length: 1217
• Species: Drosophila melanogaster
• Sequence 2: XP_012822472.1
• Gene: ube4a / 100101757
• XenbaseID: XB-GENE-922256
• Length: 1073
• Species: Xenopus tropicalis
• Alignment Length: 1156
• Identity: 282/1156 - (24%)
• Similarity: 482/1156 - (41%)
• Gaps: 192/1156 - (16%)

  Fly   155 MQDVDMTTALSLPTAEATKRSVLQSCKISAGNAELSIETVVGPKKSADEQNEQLLSRLLNATWNE 219
            |.|.:...:.|.....|...|:.::.:..||..|...:|....::|.||.:..:...|.:.
 Frog     1 MTDQENNNSFSANPFAALFGSLAEARQFVAGQKEQLRQTEDDAEESQDESDNSVSESLDDC---- 61

  Fly   220 YGSGSIICAQSASFLEQQPHRRFDFECIVANVLMEAVLKI----YNGELIEGDGVSVKAD----- 275
               ...:...|.||..||.    ..|.:..|.:::.:..|    .:..|..|:|:.::..
 Frog    62 ---DDSVAEISRSFRSQQE----ICEQLNINHMIQRIFLITLDNSDPSLKSGNGIPLRCVYLEEL 119

  Fly   276 DKEFSSAKKIKSDDTEVQEILANAVATGGATASGETAAAAAGASGPIEATSSEAAGTCVAPPVLS 340
            ..|......:..|:.|........:...|......|::.|...|...:|...:
 Frog   120 GSELDGQDWLDMDNVEQALFTRLLLPEPGKYLICMTSSGAPNLSAERDAGEKQ------------ 172

  Fly   341 IVATTKHHVLLYLIRCYQNYQTECSRKTP--LTQPALQLAFEQVMRMTVLVLTDRIYQNLNGHMD 403
                    ::.:|..|::..:.|.: |.|  |...|::.....|.....::||..||   :|...
 Frog   173 --------IIPFLFSCFRRAKKEVT-KVPENLLPYAVRCKALTVSNARTVLLTPEIY---HGQDI 225

  Fly   404 QSALLDLMY-------MAKVSEPFLIDLIAHTHQDRE--AFDTIFSQVLRGLFAGMQ-RNICTSK 458
            .:.|:|||.       ..:|.| ||.::|....:|.|  :|..:|..|...|...:| .::|
 Frog   226 ATQLVDLMLEELRGANFEEVKE-FLEEVIEALLKDEEVRSFSEVFHPVFDVLLERVQDLDLC--- 286

  Fly   459 ISVQQIEWLSKLVVIKVGSVRPIADLVSR--QPNFLPPICTKISGREIVKCSFLGPFLSVSLFAE 521
               |.:.:....:::.....:.||.:...  ||.      ...:|.:..| :.||..|::|....
 Frog   287 ---QMLLYTYLDLLLYCTHQKDIAKVFVEYIQPQ------DPTNGHQYQK-TLLGVILNISCLLR 341

  Fly   522 -----ENIKFAEFTTKNKLEDASSSRLRWELHSMRTNMHVVFHSLCVN-----ASSRPKTLEYIA 576
                 ||..|  |...::............:|......|...:.|..|     ..::.:.|.::.
 Frog   342 TPGVVENHGF--FINPSRSSPQEIKVQESNIHQFMAQFHEKIYQLLKNLLQLSPDTKHRILSWLG 404

  Fly   577 SILRHNDRRVQFASDE------KLLARDGFMINLMSVLQQLSVKIKLDR------IEPNFHYYKN 629
            :.|..|..|.:..:::      :..|.|.|.:||.:.|.:|.......|      ..|.:...|.
 Frog   405 NCLHANAGRTKIWANQVPEIFMQTYASDSFFLNLGAALLRLCQPFSKPRSARLLTFNPTYCALKE 469

  Fly   630 SLVNIEQDTKIRYSEEEYRNFLARDF--------SQP--VENTNFQTQCWFLTLQAHHLGYLPAI 684
              ||.|:    |.|...:...|.::.        .||  .||.|..|:...||....|||:
 Frog   470 --VNEEE----RRSRNMHMKGLDKETCLIPAAADQQPDFPENFNLVTENLVLTQYTLHLGF---- 524

  Fly   685 QRYRQKVRAIKELQKLIDELDRTKSHWMNSRYANRNNQFKERWEKQLRKLNRSKTCCEITLLDPG 749
                  .|..:::.|:...|.|.:..|.:::.:  .:...|...:|..:|.....|.:..|.:|.
 Frog   525 ------HRLHEQMVKVNQSLHRLQGAWRDAQQS--GSPTAENLREQFERLMTIYLCLKTALSEPQ 581

  Fly   750 LLQRCTEFYSTVCEFMLYQFEGRPIEGPFISKLPVQQLLPTDAFSAL---PEWYIDDIAEFILFT 811
            :||.|.....:....::....|.....|.....|    :|....|||   ||::.|::.:|.:|.
 Frog   582 MLQNCIHLQVSTALLLVQIAYGNKGTEPVALSFP----MPNVQHSALAYVPEFFADNLGDFFIFL 642

  Fly   812 MQHANMDIRQGID--HSIITWLLTCVCASHLIKNPYVTAKLVEVMFVFSLKPANSVNAAMWNHEL 874
            .:.|:..:....|  ..|:.::.....:...:|||::.|||.||:           .|.|.:.|.
 Frog   643 RRFADEVLETAADSLEQILDFITVFTGSVERMKNPHLRAKLAEVL-----------EAVMPHLEQ 696

  Fly   875 AQNALVSS--------------------LMRFYVDVETTGQSTEFYDKFTIRYHISHLFKSMWEN 919
            .||.|:||                    |::.:||:|.||...:|..||..|..:..:.|.||..
 Frog   697 VQNPLISSVFHRQRIFCSYQHAPHLAEALIKVFVDIEFTGDPHQFEQKFNYRRPMYPILKYMWGR 761

  Fly   920 PIHRQAV--ICESRVGN-------QFVKFVNMLMNDTTFLLDECLENLKRIHQTQQLLSDKANLS 975
            ..:||::  :.:....|       .|::|:|:||||..|||||.::.|.:| :..|:..|:....
 Frog   762 DNYRQSIKNLADYASKNLEAVNPPLFLRFLNLLMNDAVFLLDEAIQYLSKI-KVLQIERDRGEWD 825

  Fly   976 KMSAEQQQSRLTQLATDERQCRSYLTLARETVDLFHYLTSDIKEPFMRDELVDRLSSMLNFNLKQ 1040
            .:|.|.::.:.:.|....:..|.:..::.||:....:|||||:..|::..|.||..||||:.|:.
 Frog   826 ALSPESRREKESNLLMFGQLARFHNIMSNETIGTLAFLTSDIRSLFVQPFLADRTISMLNYFLQH 890

  Fly  1041 LAGPKCNDLKVKNPAKYGWEPRSLLAQIFDIYLHL-DCDRFAEALAADERSFDVQICNEAASRIK 1104
            |.|||...||||:.:::.::|:.|::.|..|||:| :.:.|..::..|.||:...:..:....:|
 Frog   891 LVGPKMGALKVKDFSEFDFKPQQLVSDICTIYLNLGEEEHFCASVPKDGRSYSPMLFAQTVRVLK 955

  Fly  1105 RLALRSAVEV------ERFKALTQRAHEIYVTNLQTEDECADAPDEFKDPLMDTLMSDPVVLPSG 1163
            ::.....:.|      |:.|:|..|..       |.|:..|||||:|.||:|.|:|||||:|||.
 Frog   956 KINKPGNMIVAFTNLAEQIKSLADRQQ-------QEEETFADAPDDFLDPIMSTVMSDPVILPSS 1013

  Fly  1164 TV-MDRAIITRHLLNSCTDPFNRQPLTEDMLVANIELKQRIDAW---RKEQ 1210
            .| :||:.|.||||:..||||||.|||.|.:..|:|||.||..|   ||:|
 Frog  1014 RVTVDRSTIARHLLSDQTDPFNRSPLTMDQIKPNVELKDRILQWLAQRKQQ 1064

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ube4B	NP_609597.1	Ufd2P_core	510..1124	CDD:463080	164/686 (24%)
		RING-Ubox_UBE4B	1138..1211	CDD:438320	46/77 (60%)
ube4a	XP_012822472.1	Ufd2P_core	330..974	CDD:463080	162/679 (24%)
		RING-Ubox_UBE4A	993..1062	CDD:438319	39/68 (57%)