DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Vha68-3 and VHA-A

DIOPT Version :9

Sequence 1:	NP_609595.1	Gene:	Vha68-3 / 34695	FlyBaseID:	FBgn0032464	Length:	743	Species:	Drosophila melanogaster
Sequence 2:	NP_001031299.1	Gene:	VHA-A / 844228	AraportID:	AT1G78900	Length:	623	Species:	Arabidopsis thaliana

Alignment Length:	609	Identity:	390/609 - (64%)
Similarity:	493/609 - (80%)	Gaps:	3/609 - (0%)

- Green bases have known domain annotations that are detailed below.

  Fly   132 DEEEEEATMGRIFGVSGPVVNAEEMAGAAMYELVRVGHSQLVGEIIRLEGDMATIQVYEDTSGVS 196
            :::|:|:..|.:..||||||.|:.||||||||||||||..|:|||||||||.|||||||:|:|::
plant    13 EDDEKESEYGYVRKVSGPVVVADGMAGAAMYELVRVGHDNLIGEIIRLEGDSATIQVYEETAGLT 77

  Fly   197 VGDPVYQTGKPLSVELGPGIMGSIFDGIQRPLRSISELTNSIYVPKGIDTPSLPRNIAYEFTPGK 261
            |.|||.:|.|||||||||||:|:|||||||||::|:.::..:|:|:|:..|:|.::..:||.|.|
plant    78 VNDPVLRTHKPLSVELGPGILGNIFDGIQRPLKTIARISGDVYIPRGVSVPALDKDCLWEFQPNK 142

  Fly   262 LKIDALITGGDIYGSVFENSMMHDHRLILPPRTKGRIRWLAPPGNYCVDEVIVETEFNDEITKHT 326
            ......|||||:|.:||||::| :|.:.|||...|:|.::||.|.|.:.:.::|.||......:|
plant   143 FVEGDTITGGDLYATVFENTLM-NHLVALPPDAMGKITYIAPAGQYSLKDTVIELEFQGIKKSYT 206

  Fly   327 MLQVWPVRRCRPVEDKLPSNSPLLTGQRVLDAFFPCVQGGTTAIPGAFGCGKTVISQALSKYSNS 391
            |||.||||..|||..||.:::|||||||||||.||.|.|||.|||||||||||||||||||||||
plant   207 MLQSWPVRTPRPVASKLAADTPLLTGQRVLDALFPSVLGGTCAIPGAFGCGKTVISQALSKYSNS 271

  Fly   392 DVIIYVGCGERGNEMSEVLRDFPQLEVEV-NGTMESIMKRTALVANTSNMPVAAREASIYTGITL 455
            |.::|||||||||||:|||.|||||.:.: :|..||:||||.||||||||||||||||||||||:
plant   272 DAVVYVGCGERGNEMAEVLMDFPQLTMTLPDGREESVMKRTTLVANTSNMPVAAREASIYTGITI 336

  Fly   456 SEYFRDMGYHVSMMADSTSRWAEALREISGRLAEMPADAGYPAYLGARLASFYERAGLVKCLGSP 520
            :||||||||:||||||||||||||||||||||||||||:||||||.|||||||||||.|||||.|
plant   337 AEYFRDMGYNVSMMADSTSRWAEALREISGRLAEMPADSGYPAYLAARLASFYERAGKVKCLGGP 401

  Fly   521 DREGSVSIVGAVSPPGGDFSDPVTSATLSIVQVFWGLDKKLAQRKHFPSVNWLQSYSKYMRTLDT 585
            :|.|||:||||||||||||||||||||||||||||||||||||||||||||||.|||||...|::
plant   402 ERNGSVTIVGAVSPPGGDFSDPVTSATLSIVQVFWGLDKKLAQRKHFPSVNWLISYSKYSTALES 466

  Fly   586 YYEESNPEFTHLRAKAKKVLQEEDDLAEIVQLVGKSSLNEEDKITLEVAKMLKDDFLQQNSYSQY 650
            :||:.:|:|.::|.||::|||.||||.||||||||.:|.|.||||||.||:|::|:|.||:::.|
plant   467 FYEKFDPDFINIRTKAREVLQREDDLNEIVQLVGKDALAEGDKITLETAKLLREDYLAQNAFTPY 531

  Fly   651 DAYCPFFKTIGMLKNMMTFYDAAILSVQNTADNEA-RVTWGLIRIKAANILYELSTMKFIDPKLG 714
            |.:|||:|::.|::|::.||:.|..:|:..|..:. ::|:.||:.:..::.|.|.:.||.||..|
plant   532 DKFCPFYKSVWMMRNIIHFYNLANQAVERAAGMDGQKITYTLIKHRLGDLFYRLVSQKFEDPAEG 596

  Fly   715 EATVLESMNKLHDNILSTFREIED 738
            |.|::|...||:|::.:.||.:||
plant   597 EDTLVEKFKKLYDDLNAGFRALED 620

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Vha68-3	NP_609595.1	V-ATPase_V1_A	141..729	CDD:273411	384/589 (65%)
		ATP-synt_ab_N	143..205	CDD:280947	44/61 (72%)
		V_A-ATPase_A	207..579	CDD:238554	268/372 (72%)
		ATP-synt_ab_C	597..738	CDD:278722	64/141 (45%)
VHA-A	NP_001031299.1	V-ATPase_V1_A	20..611	CDD:273411	384/591 (65%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	404	1.000	Domainoid score	I135
eggNOG	1	0.900	-	-		E1_COG1155
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	848	1.000	Inparanoid score	I68
OMA	1	1.010	-	-		QHG60789
OrthoDB	1	1.010	-	-		D241249at2759
OrthoFinder	1	1.000	-	-		FOG0001869
OrthoInspector	1	1.000	-	-		otm2949
orthoMCL	1	0.900	-	-		OOG6_100902
Panther	1	1.100	-	-	O	PTHR43607
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X1565
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	13	12.840