DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Vha68-3 and Atp6v1a

DIOPT Version :9

Sequence 1:	NP_609595.1	Gene:	Vha68-3 / 34695	FlyBaseID:	FBgn0032464	Length:	743	Species:	Drosophila melanogaster
Sequence 2:	NP_001101788.1	Gene:	Atp6v1a / 685232	RGDID:	1596464	Length:	617	Species:	Rattus norvegicus

Alignment Length:	608	Identity:	448/608 - (73%)
Similarity:	524/608 - (86%)	Gaps:	3/608 - (0%)

- Green bases have known domain annotations that are detailed below.

  Fly   133 EEEEEATMGRIFGVSGPVVNAEEMAGAAMYELVRVGHSQLVGEIIRLEGDMATIQVYEDTSGVSV 197
            :|::|:|.|.:.|||||||.|.:|||||||||||||||:|||||||||||||||||||:||||||
  Rat    11 DEDKESTFGYVHGVSGPVVTACDMAGAAMYELVRVGHSELVGEIIRLEGDMATIQVYEETSGVSV 75

  Fly   198 GDPVYQTGKPLSVELGPGIMGSIFDGIQRPLRSISELTNSIYVPKGIDTPSLPRNIAYEFTPGK- 261
            ||||.:|||||||||||||||:|||||||||..||..|.|||:|:|::..:|.|:|.:||.|.|
  Rat    76 GDPVLRTGKPLSVELGPGIMGAIFDGIQRPLSDISSQTQSIYIPRGVNVSALSRDIKWEFIPSKN 140

  Fly   262 LKIDALITGGDIYGSVFENSMMHDHRLILPPRTKGRIRWLAPPGNYCVDEVIVETEFNDEITKHT 326
            |::.:.||||||||.|.|||:: .|:::||||::|.:.::||||||...:|::|.||.....|.:
  Rat   141 LRVGSHITGGDIYGIVNENSLI-KHKIMLPPRSRGSVTYIAPPGNYDASDVVLELEFEGVKEKLS 204

  Fly   327 MLQVWPVRRCRPVEDKLPSNSPLLTGQRVLDAFFPCVQGGTTAIPGAFGCGKTVISQALSKYSNS 391
            |:||||||:.|||.:|||:|.|||||||||||.||||||||||||||||||||||||:|||||||
  Rat   205 MVQVWPVRQVRPVTEKLPANHPLLTGQRVLDALFPCVQGGTTAIPGAFGCGKTVISQSLSKYSNS 269

  Fly   392 DVIIYVGCGERGNEMSEVLRDFPQLEVEVNGTMESIMKRTALVANTSNMPVAAREASIYTGITLS 456
            |||||||||||||||||||||||:|.:||:|.:||||||||||||||||||||||||||||||||
  Rat   270 DVIIYVGCGERGNEMSEVLRDFPELTMEVDGKVESIMKRTALVANTSNMPVAAREASIYTGITLS 334

  Fly   457 EYFRDMGYHVSMMADSTSRWAEALREISGRLAEMPADAGYPAYLGARLASFYERAGLVKCLGSPD 521
            |||||||||||||||||||||||||||||||||||||:||||||||||||||||||.|||||:|:
  Rat   335 EYFRDMGYHVSMMADSTSRWAEALREISGRLAEMPADSGYPAYLGARLASFYERAGRVKCLGNPE 399

  Fly   522 REGSVSIVGAVSPPGGDFSDPVTSATLSIVQVFWGLDKKLAQRKHFPSVNWLQSYSKYMRTLDTY 586
            |||||||||||||||||||||||||||.||||||||||||||||||||||||.|||||||.||.|
  Rat   400 REGSVSIVGAVSPPGGDFSDPVTSATLGIVQVFWGLDKKLAQRKHFPSVNWLISYSKYMRALDEY 464

  Fly   587 YEESNPEFTHLRAKAKKVLQEEDDLAEIVQLVGKSSLNEEDKITLEVAKMLKDDFLQQNSYSQYD 651
            |::...||..||.|||::||||:|||||||||||:||.|.|||||||||::||||||||.|:.||
  Rat   465 YDKHFTEFVPLRTKAKEILQEEEDLAEIVQLVGKASLAETDKITLEVAKLIKDDFLQQNGYTPYD 529

  Fly   652 AYCPFFKTIGMLKNMMTFYDAAILSVQNTADNEARVTWGLIRIKAANILYELSTMKFIDP-KLGE 715
            .:|||:||:|||.||::|||.|..:|:.||.::.::||.:||.....|||:||:|||.|| |.||
  Rat   530 RFCPFYKTVGMLSNMISFYDMARRAVETTAQSDNKITWSIIREHMGEILYKLSSMKFKDPVKDGE 594

  Fly   716 ATVLESMNKLHDNILSTFREIED 738
            |.:.....:|.:::.:.||.:||
  Rat   595 AKIKADYAQLLEDMQNAFRSLED 617

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Vha68-3	NP_609595.1	V-ATPase_V1_A	141..729	CDD:273411	441/589 (75%)
		ATP-synt_ab_N	143..205	CDD:280947	52/61 (85%)
		V_A-ATPase_A	207..579	CDD:238554	296/372 (80%)
		ATP-synt_ab_C	597..738	CDD:278722	81/141 (57%)
Atp6v1a	NP_001101788.1	V-ATPase_V1_A	17..609	CDD:273411	442/592 (75%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166341525
Domainoid	1	1.000	108	1.000	Domainoid score	I6369
eggNOG	1	0.900	-	-		E1_COG1155
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG60789
OrthoDB	1	1.010	-	-		D160349at33208
OrthoFinder	1	1.000	-	-		FOG0001869
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100902
Panther	1	1.100	-	-	O	PTHR43607
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X1565
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	13	12.720