Protein Alignment Vha68-3 and ATP6V1A

DIOPT Version :10

• Sequence 1: NP_609595.1
• Gene: Vha68-3 / 34695
• FlyBaseID: FBgn0032464
• Length: 743
• Species: Drosophila melanogaster
• Sequence 2: NP_001681.2
• Gene: ATP6V1A / 523
• HGNCID: 851
• Length: 617
• Species: Homo sapiens
• Alignment Length: 608
• Identity: 449/608 - (73%)
• Similarity: 524/608 - (86%)
• Gaps: 3/608 - (0%)

  Fly   133 EEEEEATMGRIFGVSGPVVNAEEMAGAAMYELVRVGHSQLVGEIIRLEGDMATIQVYEDTSGVSV 197
            :|::|:|.|.:.|||||||.|.:|||||||||||||||:|||||||||||||||||||:||||||
Human    11 DEDKESTFGYVHGVSGPVVTACDMAGAAMYELVRVGHSELVGEIIRLEGDMATIQVYEETSGVSV 75

  Fly   198 GDPVYQTGKPLSVELGPGIMGSIFDGIQRPLRSISELTNSIYVPKGIDTPSLPRNIAYEFTPGK- 261
            ||||.:|||||||||||||||:|||||||||..||..|.|||:|:|::..:|.|:|.::|||.|
Human    76 GDPVLRTGKPLSVELGPGIMGAIFDGIQRPLSDISSQTQSIYIPRGVNVSALSRDIKWDFTPCKN 140

  Fly   262 LKIDALITGGDIYGSVFENSMMHDHRLILPPRTKGRIRWLAPPGNYCVDEVIVETEFNDEITKHT 326
            |::.:.||||||||.|.|||:: .|:::||||.:|.:.::||||||...:|::|.||.....|.|
Human   141 LRVGSHITGGDIYGIVSENSLI-KHKIMLPPRNRGTVTYIAPPGNYDTSDVVLELEFEGVKEKFT 204

  Fly   327 MLQVWPVRRCRPVEDKLPSNSPLLTGQRVLDAFFPCVQGGTTAIPGAFGCGKTVISQALSKYSNS 391
            |:||||||:.|||.:|||:|.|||||||||||.||||||||||||||||||||||||:|||||||
Human   205 MVQVWPVRQVRPVTEKLPANHPLLTGQRVLDALFPCVQGGTTAIPGAFGCGKTVISQSLSKYSNS 269

  Fly   392 DVIIYVGCGERGNEMSEVLRDFPQLEVEVNGTMESIMKRTALVANTSNMPVAAREASIYTGITLS 456
            |||||||||||||||||||||||:|.:||:|.:||||||||||||||||||||||||||||||||
Human   270 DVIIYVGCGERGNEMSEVLRDFPELTMEVDGKVESIMKRTALVANTSNMPVAAREASIYTGITLS 334

  Fly   457 EYFRDMGYHVSMMADSTSRWAEALREISGRLAEMPADAGYPAYLGARLASFYERAGLVKCLGSPD 521
            |||||||||||||||||||||||||||||||||||||:||||||||||||||||||.|||||:|:
Human   335 EYFRDMGYHVSMMADSTSRWAEALREISGRLAEMPADSGYPAYLGARLASFYERAGRVKCLGNPE 399

  Fly   522 REGSVSIVGAVSPPGGDFSDPVTSATLSIVQVFWGLDKKLAQRKHFPSVNWLQSYSKYMRTLDTY 586
            |||||||||||||||||||||||||||.||||||||||||||||||||||||.|||||||.||.|
Human   400 REGSVSIVGAVSPPGGDFSDPVTSATLGIVQVFWGLDKKLAQRKHFPSVNWLISYSKYMRALDEY 464

  Fly   587 YEESNPEFTHLRAKAKKVLQEEDDLAEIVQLVGKSSLNEEDKITLEVAKMLKDDFLQQNSYSQYD 651
            |::...||..||.|||::||||:|||||||||||:||.|.|||||||||::||||||||.|:.||
Human   465 YDKHFTEFVPLRTKAKEILQEEEDLAEIVQLVGKASLAETDKITLEVAKLIKDDFLQQNGYTPYD 529

  Fly   652 AYCPFFKTIGMLKNMMTFYDAAILSVQNTADNEARVTWGLIRIKAANILYELSTMKFIDP-KLGE 715
            .:|||:||:|||.||:.|||.|..:|:.||.::.::||.:||....:|||:||:|||.|| |.||
Human   530 RFCPFYKTVGMLSNMIAFYDMARRAVETTAQSDNKITWSIIREHMGDILYKLSSMKFKDPLKDGE 594

  Fly   716 ATVLESMNKLHDNILSTFREIED 738
            |.:.....:|.:::.:.||.:||
Human   595 AKIKSDYAQLLEDMQNAFRSLED 617

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Vha68-3	NP_609595.1	V-ATPase_V1_A	141..729	CDD:273411	442/589 (75%)
ATP6V1A	NP_001681.2	V-ATPase_V1_A	17..609	CDD:273411	443/592 (75%)