DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Vha68-3 and Vha68-1

DIOPT Version :9

Sequence 1:	NP_609595.1	Gene:	Vha68-3 / 34695	FlyBaseID:	FBgn0032464	Length:	743	Species:	Drosophila melanogaster
Sequence 2:	NP_001260426.1	Gene:	Vha68-1 / 45668	FlyBaseID:	FBgn0265262	Length:	614	Species:	Drosophila melanogaster

Alignment Length:	607	Identity:	441/607 - (72%)
Similarity:	526/607 - (86%)	Gaps:	2/607 - (0%)

- Green bases have known domain annotations that are detailed below.

  Fly   133 EEEEEATMGRIFGVSGPVVNAEEMAGAAMYELVRVGHSQLVGEIIRLEGDMATIQVYEDTSGVSV 197
            :||.|:..||::.||||||.||.|:|:|||||||||:.:|||||||||||||||||||:||||:|
  Fly     9 DEERESEYGRVYAVSGPVVTAEAMSGSAMYELVRVGYYELVGEIIRLEGDMATIQVYEETSGVTV 73

  Fly   198 GDPVYQTGKPLSVELGPGIMGSIFDGIQRPLRSISELTNSIYVPKGIDTPSLPRNIAYEFTPGKL 262
            ||||.:||||||||||||||||||||||||||.|..:|||||:|||::|.:|.|:..:||.|..:
  Fly    74 GDPVLRTGKPLSVELGPGIMGSIFDGIQRPLRDIGVMTNSIYIPKGVNTTALSRSEMWEFNPLNV 138

  Fly   263 KIDALITGGDIYGSVFENSMMHDHRLILPPRTKGRIRWLAPPGNYCVDEVIVETEFNDEITKHTM 327
            ::.:.|||||:||.|.||::: ..|:|:.||.||.:|::||.|||.::::::||||:.|||||||
  Fly   139 RVGSHITGGDLYGVVHENTLV-KQRMIVAPRAKGTVRYIAPAGNYNLEDIVLETEFDGEITKHTM 202

  Fly   328 LQVWPVRRCRPVEDKLPSNSPLLTGQRVLDAFFPCVQGGTTAIPGAFGCGKTVISQALSKYSNSD 392
            |||||||:.|||.:|||:|.||.|||||||:.|||||||||||||||||||||||||||||||||
  Fly   203 LQVWPVRQPRPVTEKLPANHPLFTGQRVLDSLFPCVQGGTTAIPGAFGCGKTVISQALSKYSNSD 267

  Fly   393 VIIYVGCGERGNEMSEVLRDFPQLEVEVNGTMESIMKRTALVANTSNMPVAAREASIYTGITLSE 457
            ||||||||||||||||||||||:|..|::|..|||||||||||||||||||||||||||||||||
  Fly   268 VIIYVGCGERGNEMSEVLRDFPELTCEIDGVTESIMKRTALVANTSNMPVAAREASIYTGITLSE 332

  Fly   458 YFRDMGYHVSMMADSTSRWAEALREISGRLAEMPADAGYPAYLGARLASFYERAGLVKCLGSPDR 522
            |||||||:|:||||||||||||||||||||||||||:|||||||||||:||||||.|||||:|:|
  Fly   333 YFRDMGYNVAMMADSTSRWAEALREISGRLAEMPADSGYPAYLGARLATFYERAGRVKCLGNPER 397

  Fly   523 EGSVSIVGAVSPPGGDFSDPVTSATLSIVQVFWGLDKKLAQRKHFPSVNWLQSYSKYMRTLDTYY 587
            ||||||||||||||||||||||||||.||||||||||||||||||||:|||.|||||||.||.||
  Fly   398 EGSVSIVGAVSPPGGDFSDPVTSATLGIVQVFWGLDKKLAQRKHFPSINWLISYSKYMRALDEYY 462

  Fly   588 EESNPEFTHLRAKAKKVLQEEDDLAEIVQLVGKSSLNEEDKITLEVAKMLKDDFLQQNSYSQYDA 652
            :::.|||..||.|.|::||||:||:||||||||:||.|.||:||||||:||||||||||||.||.
  Fly   463 DKNYPEFVPLRTKVKEILQEEEDLSEIVQLVGKASLAETDKVTLEVAKLLKDDFLQQNSYSPYDR 527

  Fly   653 YCPFFKTIGMLKNMMTFYDAAILSVQNTADNEARVTWGLIRIKAANILYELSTMKFIDP-KLGEA 716
            .|||:||:|||:|:|.||:.|..:|::||.::.::||..||.....|:|:||:|||.|| |.||.
  Fly   528 VCPFYKTVGMLRNIMAFYETARHAVESTAQSDNKITWNTIRESMGGIMYQLSSMKFKDPVKDGEQ 592

  Fly   717 TVLESMNKLHDNILSTFREIED 738
            .:....::|::::...||.:||
  Fly   593 KIKADYDQLYEDLQQAFRNLED 614

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Vha68-3	NP_609595.1	V-ATPase_V1_A	141..729	CDD:273411	434/588 (74%)
		ATP-synt_ab_N	143..205	CDD:280947	47/61 (77%)
		V_A-ATPase_A	207..579	CDD:238554	295/371 (80%)
		ATP-synt_ab_C	597..738	CDD:278722	78/141 (55%)
Vha68-1	NP_001260426.1	V-ATPase_V1_A	15..606	CDD:273411	434/591 (73%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45449906
Domainoid	1	1.000	404	1.000	Domainoid score	I135
eggNOG	1	0.900	-	-		E1_COG1155
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	848	1.000	Inparanoid score	I68
Isobase	1	0.950	-	0	Normalized mean entropy	S546
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D160349at33208
OrthoFinder	1	1.000	-	-		FOG0001869
OrthoInspector	1	1.000	-	-		otm2949
orthoMCL	1	0.900	-	-		OOG6_100902
Panther	1	1.100	-	-	P	PTHR43607
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X1565
	12	11.750