DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Vha68-3 and vma1

DIOPT Version :9

Sequence 1:	NP_609595.1	Gene:	Vha68-3 / 34695	FlyBaseID:	FBgn0032464	Length:	743	Species:	Drosophila melanogaster
Sequence 2:	NP_593425.1	Gene:	vma1 / 2541660	PomBaseID:	SPAC343.05	Length:	619	Species:	Schizosaccharomyces pombe

Alignment Length:	606	Identity:	386/606 - (63%)
Similarity:	477/606 - (78%)	Gaps:	6/606 - (0%)

- Green bases have known domain annotations that are detailed below.

  Fly   134 EEEEATMGRIFGVSGPVVNAEEMAGAAMYELVRVGHSQLVGEIIRLEGDMATIQVYEDTSGVSVG 198
            :|.|...|.||.||||||.|..|.|.:|||||||||.:||||:||:..|..||||||:|||::||
pombe    19 DEHENRYGSIFSVSGPVVVAANMLGCSMYELVRVGHEELVGEVIRIHQDKCTIQVYEETSGLTVG 83

  Fly   199 DPVYQTGKPLSVELGPGIMGSIFDGIQRPLRSISELTNSIYVPKGIDTPSLPRNIAYEFTPGK-L 262
            |||.:||||||||||||:..:|:|||||||:.|.:.:.|||:|:||:|.||.|...::|||.| |
pombe    84 DPVQRTGKPLSVELGPGLAETIYDGIQRPLKQIFDKSQSIYIPRGINTESLNREHKWDFTPNKDL 148

  Fly   263 KIDALITGGDIYGSVFENSMMHDHRLILPPRTKGRIRWLAPPGNYCVDEVIVETEFNDEITKHTM 327
            :|...::|||::|||||||:.:||:::||||.:|.:.::|..|:|.|||.::|.|||.:....:|
pombe   149 RIGDHVSGGDVFGSVFENSLFNDHKIMLPPRARGTVTYIAEAGSYHVDEKLLEVEFNGKKHSFSM 213

  Fly   328 LQVWPVRRCRPVEDKLPSNSPLLTGQRVLDAFFPCVQGGTTAIPGAFGCGKTVISQALSKYSNSD 392
            |..||||..|||.|.|.:|.|||||||||||.:|||||||||||||||||||||||:||||||||
pombe   214 LHTWPVRAARPVADNLTANQPLLTGQRVLDALYPCVQGGTTAIPGAFGCGKTVISQSLSKYSNSD 278

  Fly   393 VIIYVGCGERGNEMSEVLRDFPQLEVEVNGTMESIMKRTALVANTSNMPVAAREASIYTGITLSE 457
            :|:|||||||||||:|||.|||:|.:::||..|.|||||.|||||||||||||||||||||||:|
pombe   279 LIVYVGCGERGNEMAEVLMDFPELTIDINGKPEPIMKRTTLVANTSNMPVAAREASIYTGITLAE 343

  Fly   458 YFRDMGYHVSMMADSTSRWAEALREISGRLAEMPADAGYPAYLGARLASFYERAGLVKCLGSPDR 522
            |:||.|.:||||||||||||||||||||||||||||:||||||||:|||||||||..:|||||||
pombe   344 YYRDQGKNVSMMADSTSRWAEALREISGRLAEMPADSGYPAYLGAKLASFYERAGRARCLGSPDR 408

  Fly   523 EGSVSIVGAVSPPGGDFSDPVTSATLSIVQVFWGLDKKLAQRKHFPSVNWLQSYSKYMRTLDTYY 587
            ||:|||||||||||||||||||||||.||||||||||||||||||||:|...|||||:..|..:|
pombe   409 EGTVSIVGAVSPPGGDFSDPVTSATLGIVQVFWGLDKKLAQRKHFPSINTSLSYSKYINALQPWY 473

  Fly   588 EESNPEFTHLRAKAKKVLQEEDDLAEIVQLVGKSSLNEEDKITLEVAKMLKDDFLQQNSYSQYDA 652
            ||..|.|..||.:.|:::|:||.:.||:||||||:|:|.||:||::|.::|:||||||.||.||.
pombe   474 EERVPGFNTLRDQIKQIIQQEDSMLEIIQLVGKSALSETDKVTLDIAGIIKNDFLQQNGYSDYDR 538

  Fly   653 YCPFFKTIGMLKNMMTFYDAAILSVQNTADNEARVTWGLIRIKAANILYELSTMKFIDPKLGEAT 717
            .||.:||..|::||:.:|..|..:|:.     ..|.|..|:...::|.|||::|||.:|..||..
pombe   539 CCPLYKTYHMMRNMIAYYTKAKSAVET-----GSVPWSKIKESTSDIFYELTSMKFENPNEGEKE 598

  Fly   718 VLESMNKLHDNILSTFREIED 738
            ::|....||..|...|..:.:
pombe   599 IVEHYETLHKKIEDKFHTLTE 619

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Vha68-3	NP_609595.1	V-ATPase_V1_A	141..729	CDD:273411	382/588 (65%)
		ATP-synt_ab_N	143..205	CDD:280947	41/61 (67%)
		V_A-ATPase_A	207..579	CDD:238554	271/372 (73%)
		ATP-synt_ab_C	597..738	CDD:278722	60/140 (43%)
vma1	NP_593425.1	V-ATPase_V1_A	24..611	CDD:273411	382/591 (65%)
		ATP-synt_ab_N	28..90	CDD:280947	41/61 (67%)
		V_A-ATPase_A	92..465	CDD:238554	271/372 (73%)
		ATP-synt_ab_C	483..619	CDD:278722	60/140 (43%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	408	1.000	Domainoid score	I94
eggNOG	1	0.900	-	-		E1_COG1155
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	816	1.000	Inparanoid score	I62
OMA	1	1.010	-	-		QHG60789
OrthoFinder	1	1.000	-	-		FOG0001869
OrthoInspector	1	1.000	-	-		otm47164
orthoMCL	1	0.900	-	-		OOG6_100902
Panther	1	1.100	-	-	O	PTHR43607
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X1565
TreeFam	1	0.960	-	-
	12	11.830