DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ACXC and CYR1

DIOPT Version :9

Sequence 1:	NP_609593.1	Gene:	ACXC / 34689	FlyBaseID:	FBgn0040508	Length:	1130	Species:	Drosophila melanogaster
Sequence 2:	NP_012529.3	Gene:	CYR1 / 853452	SGDID:	S000003542	Length:	2026	Species:	Saccharomyces cerevisiae

Alignment Length:	1229	Identity:	217/1229 - (17%)
Similarity:	399/1229 - (32%)	Gaps:	437/1229 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly   146 FYKNDWPLNTSFDVFTLCMIYMFLPIPSIKGA-ALLASSVSLIYVAFFMHSLTFNAVYTDRDSFG 209
            ||::...:. |.||.....|  |||:..|:.: .||:..:..|..:.|..::|          ..
Yeast   811 FYQHTSEIE-SLDVSNNANI--FLPLEFIESSIKLLSLRMVNIRASKFPSNIT----------KA 862

  Fly   210 YDVISTDILHNLGFNMMGIFFRIMNDTMVRASFLDRHQFIMEETWLRHALLQESILLDSILPPQI 274
            |.::|.::..|        |.|.:.:::::.|.|                        :||..|.
Yeast   863 YKLVSLELQRN--------FIRKVPNSIMKLSNL------------------------TILNLQC 895

  Fly   275 AKPVQEKIKSKITQSENSPDRFQMGPRTTESFMAIQIHPDVSILYADVVNYTHLTTTLTVGNLVK 339
            .:  .|.:.:...:.:|    .|:...::..||    |      |.:|:||        ..||::
Yeast   896 NE--LESLPAGFVELKN----LQLLDLSSNKFM----H------YPEVINY--------CTNLLQ 936

  Fly   340 VLHDL-YGRFD-----------IAASNFKVQRIKFLGDCYYCVAGLTTPDPDHAKCCVSLGISMI 392
            :  || |.:..           :|..|....::.|:||                          :
Yeast   937 I--DLSYNKIQSLPQSTKYLVKLAKMNLSHNKLNFIGD--------------------------L 973

  Fly   393 SNIQEVRAERGLDIDMRIGVHSGSLLAGIIGEAKLQFDIWGTDVEIANHLESTGEPGYVHVSGRT 457
            |.:.::|.     :::|.     :.::.|...|....:::.||..|:|..::..:...:.:....
Yeast   974 SEMTDLRT-----LNLRY-----NRISSIKTNASNLQNLFLTDNRISNFEDTLPKLRALEIQENP 1028

  Fly   458 LSMLN-----PADYTILSGTQKAQSDPVLQYIHTYLLTGQVARESFITSIGGVRSSSVLEVKSID 517
            ::.::     |.:.|.|: ..|||    |..|...|||    :.||:..:       .|...::.
Yeast  1029 ITSISFKDFYPKNMTSLT-LNKAQ----LSSIPGELLT----KLSFLEKL-------ELNQNNLT 1077

  Fly   518 RIRSSRPSQSSMTDEF------REEFRNMPVGGINLNSPCCRRTRLDTHKKTQRE---------- 566
            |:    |.:.|...:.      |.:...:|.....|.|   .|| ||.|....|:
Yeast  1078 RL----PQEISKLTKLVFLSVARNKLEYIPPELSQLKS---LRT-LDLHSNNIRDFVDGMENLEL 1134

  Fly   567 --IGIFCAAFKDSSLEWNYLHQPDF---IFKSSMLL----------AWGIGCCLIYIQIVT---N 613
              :.|...||.:||||.::.|...:   :.||.|..          .|.:..|.:.::::.   |
Yeast  1135 TSLNISSNAFGNSSLENSFYHNMSYGSKLSKSLMFFIAADNQFDDAMWPLFNCFVNLKVLNLSYN 1199

  Fly   614 NFSCTACIVVDLVTFFFLT--SLLCLAWYKNVCWWK-------------------SGRYEFRIYG 657
            |||..:.:.::.:|..:|:  .|..|:. ..|..|.                   |...:..::.
Yeast  1200 NFSDVSHMKLESITELYLSGNKLTTLSG-DTVLKWSSLKTLMLNSNQMLSLPAELSNLSQLSVFD 1263

  Fly   658 ------KYSCMAFHIFEKIQHSVSLRITVYLGILFS---YYAVISLIMLNCDRDMYELSYI-ESK 712
                  ||:...:|.....:::..|:   ||.  ||   .:.:.|.|..:.|.|:.:|:.: :.|
Yeast  1264 VGANQLKYNISNYHYDWNWRNNKELK---YLN--FSGNRRFEIKSFISHDIDADLSDLTVLPQLK 1323

  Fly   713 IYHYEMDRDTCFHPWVFTNMISLILGISYTFARIP-----FGLKIVISCCETLAY-LLIVFFQFA 771
            :..                    ::.::....::|     |.|:...|....:.| :.....|..
Yeast  1324 VLG--------------------LMDVTLNTTKVPDENVNFRLRTTASIINGMRYGVADTLGQRD 1368

  Fly   772 FIFQHSATTTPF----------------MKAELAHCL---------RVCMMLLTMYAKERQSEFN 811
            ::.....|...|                ..|:..|.:         ::.:..|..|..|......
Yeast  1369 YVSSRDVTFERFRGNDDECLLCLHDSKNQNADYGHNISRIVRDIYDKILIRQLERYGDETDDNIK 1433

  Fly   812 T-------KMNYKLNVDLQNKQKAADLTNQSIIILLNN-----------------------ILPS 846
            |       ::|.::|..|.:....||:.|.|...||:.                       ||..
Yeast  1434 TALRFSFLQLNKEINGMLNSVDNGADVANLSYADLLSGACSTVIYIRGKKLFAANLGDCMAILSK 1498

  Fly   847 HVVDLYLNSLAKHEL---------------YYENYRMVSVM-FAMLINFPMNLPSLRVLNDI--- 892
            :..|  ..:|.|..|               |..|.::..|: .:..:.|...||.:....||
Yeast  1499 NNGD--YQTLTKQHLPTKREEYERIRISGGYVNNGKLDGVVDVSRAVGFFDLLPHIHASPDISVV 1561

  Fly   893 -ITQFDRLLTAYR----EYYVVEKI----------------------KVVGCTYMAACGLDFNLA 930
             :|:.|.:|....    ||..|:.:                      ...|||..... |...|.
Yeast  1562 TLTKADEMLIVATHKLWEYMDVDTVCDIARENSTDPLRAAAELKDHAMAYGCTENITI-LCLALY 1625

  Fly   931 SNIRQTDHF---RNSSL--HVEVEHARNHRMTDENYDSDMNNDEVVFI---MTTFALDL----MR 983
            .||:|.:.|   :||.:  ....|.....|:..| ......|..:||.   .:||..:|    ||
Yeast  1626 ENIQQQNRFTLNKNSLMTRRSTFEDTTLRRLQPE-ISPPTGNLAMVFTDIKSSTFLWELFPNAMR 1689

  Fly   984 TLAACN--------RAY--------SSSF---FERSLSQGKICIGIS------------------ 1011
            |....:        |.|        ..:|   |....|....|:.:.
Yeast  1690 TAIKTHNDIMRRQLRIYGGYEVKTEGDAFMVAFPTPTSGLTWCLSVQLKLLDAQWPEEITSVQDG 1754

  Fly  1012 ------SGEIM-------AGV-VGASQPHYDI-------WGNPVNMASRMESTGLPGHIQVTEES 1055
                  :|.|:       .|: .|...|..|:       .|..||.|:|::.....|.|.:   |
Yeast  1755 CQVTDRNGNIIYQGLSVRMGIHWGCPVPELDLVTQRMDYLGPMVNKAARVQGVADGGQIAM---S 1816

  Fly  1056 AKILQEFDIKCIYRGMTFVKGRGDIPTYFVGIDENLK-FMSAKLVNRSLSRRFSVMSSL 1113
            :....||: |.:......|||:           |:|| ....:::...|.|..:::.|:
Yeast  1817 SDFYSEFN-KIMKYHERVVKGK-----------ESLKEVYGEEIIGEVLEREIAMLESI 1863

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ACXC	NP_609593.1	AC_N	<33..285	CDD:292831	26/139 (19%)
		CYCc	293..468	CDD:214485	28/191 (15%)
		Nucleotidyl_cyc_III	307..466	CDD:299850	26/175 (15%)
		CYCc	833..1060	CDD:214485	67/365 (18%)
		Nucleotidyl_cyc_III	861..1085	CDD:299850	64/339 (19%)
CYR1	NP_012529.3	Ad_cyc_g-alpha	368..418	CDD:369912
		RA_PHLPP_like	678..776	CDD:340473
		PLN00113	792..>1273	CDD:215061	107/593 (18%)
		leucine-rich repeat	796..817	CDD:275380	2/5 (40%)
		leucine-rich repeat	818..839	CDD:275380	8/23 (35%)
		leucine-rich repeat	840..864	CDD:275380	5/33 (15%)
		leucine-rich repeat	865..887	CDD:275380	4/29 (14%)
		leucine-rich repeat	888..910	CDD:275380	5/47 (11%)
		leucine-rich repeat	911..933	CDD:275380	8/39 (21%)
		leucine-rich repeat	934..956	CDD:275380	4/23 (17%)
		leucine-rich repeat	957..978	CDD:275380	6/46 (13%)
		leucine-rich repeat	979..1018	CDD:275380	8/48 (17%)
		leucine-rich repeat	1019..1041	CDD:275380	1/21 (5%)
		leucine-rich repeat	1042..1065	CDD:275380	10/31 (32%)
		leucine-rich repeat	1066..1088	CDD:275380	4/32 (13%)
		leucine-rich repeat	1089..1111	CDD:275380	3/21 (14%)
		leucine-rich repeat	1167..1187	CDD:275380	2/19 (11%)
		leucine-rich repeat	1191..1211	CDD:275380	4/19 (21%)
		leucine-rich repeat	1236..1258	CDD:275380	1/21 (5%)
		leucine-rich repeat	1259..1287	CDD:275380	3/27 (11%)
		PP2C	1374..1617	CDD:395385	40/244 (16%)
		CYCc	1613..1825	CDD:214485	44/217 (20%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900