Protein Alignment ACXC and Adcy2

DIOPT Version :9

• Sequence 1: NP_609593.1
• Gene: ACXC / 34689
• FlyBaseID: FBgn0040508
• Length: 1130
• Species: Drosophila melanogaster
• Sequence 2: NP_112269.2
• Gene: Adcy2 / 81636
• RGDID: 619965
• Length: 1095
• Species: Rattus norvegicus
• Alignment Length: 1190
• Identity: 328/1190 - (27%)
• Similarity: 538/1190 - (45%)
• Gaps: 214/1190 - (17%)

  Fly    30 LWEHS-----YLREKCKE-----------LNLEEEYRYYQVRLMVSNLTIFYVLFIILAMSFLTI 78
            :|:.:     |||::.:.           |....::.|.....|.....:  ::|::|.:....:
  Rat     1 MWQEAMRRRRYLRDRAEAAAAAAAGGGEGLQRSRDWLYESYYCMSQQHPL--IVFLLLIVMGACL 63

  Fly    79 ELLYVQHYNAVFF----------NFVIRVVSTILVLTVLSINFCEKFVSRHRWVMIASSVLSVY- 132
            .||      ||||          .|:|.|.:.:.:...:.|..|.:.|.:        .:|.|:
  Rat    64 ALL------AVFFALGLEVEDHVAFLITVPTALAIFFAIFILVCIESVFK--------KLLRVFS 114

  Fly   133 LVVLTDIVMISYHFY-----KNDWPLNTSFDVFTLCMIYMFLPIPSIKG--AALLASSVSLIYVA 190
            ||:...:|.:.|.|.     .:.|. ..||.:|.:.::|..||......  |::|.||...|.::
  Rat   115 LVIWICLVAMGYLFMCFGGTVSAWD-QVSFFLFIIFVVYTMLPFNMRDAIIASILTSSSHTIVLS 178

  Fly   191 FFMHSLTFNAVYTDRDSFGYDVISTDILHNLGFNMMGIFFRIMNDTMVRASFLDRHQFIMEETWL 255
            .:: |.|..|    ::...:.:::..|:...| |:.|.:.:.:.:..::.::.|....|.....|
  Rat   179 VYL-SATPGA----KEHLFWQILANVIIFICG-NLAGAYHKHLMELALQQTYRDTCNCIKSRIKL 237

  Fly   256 RHALLQESILLDSILPPQIAKPVQEKIKSKITQSENSPDRFQMGPRTTESF--MAIQIHPDVSIL 318
            .....|:..||.|:||..||.    ::|::|.|....|...||  ..|.:|  :.::.|.:||||
  Rat   238 EFEKRQQERLLLSLLPAHIAM----EMKAEIIQRLQGPKAGQM--ENTNNFHNLYVKRHTNVSIL 296

  Fly   319 YADVVNYTHLTTTLTVGNLVKVLHDLYGRFDIAASNFKVQRIKFLGDCYYCVAGLTTPDPDHAKC 383
            |||:|.:|.|.:..:.|.||.:|::|:|:||..|...:..|||.||||||||:||....|:|||.
  Rat   297 YADIVGFTRLASDCSPGELVHMLNELFGKFDQIAKENECMRIKILGDCYYCVSGLPISLPNHAKN 361

  Fly   384 CVSLGISMISNIQEVRAERGLDIDMRIGVHSGSLLAGIIGEAKLQFDIWGTDVEIANHLESTGEP 448
            ||.:|:.|...|::||...|:||:||:|||||::|.|:||..|.|:|:|..||.:|||:|:.|.|
  Rat   362 CVKMGLDMCEAIKKVRDATGVDINMRVGVHSGNVLCGVIGLQKWQYDVWSHDVTLANHMEAGGVP 426

  Fly   449 GYVHVSGRTLSMLNPADYTILSGTQKAQSDPVLQ--YIHTYLL---TGQVARESFI-----TSIG 503
            |.||:|..||..||.| |.:..|..:.: ||.|:  .:.||.:   .|:......:     |..|
  Rat   427 GRVHISSVTLEHLNGA-YKVEEGDGEIR-DPYLKQHLVKTYFVINPKGERRSPQHLFRPRHTLDG 489

  Fly   504 GVRSSSVLEVKSIDRIRSSRP-----SQSSMTDE-FREEFRNMPVGGINLNSPCCRRTRLDTHKK 562
            ....:||...:.::...:::|     .:.|||.| .:....::|:|..|..:   |..|..:.||
  Rat   490 AKMRASVRMTRYLESWGAAKPFAHLHHRDSMTTENGKISTTDVPMGQHNFQN---RTLRTKSQKK 551

  Fly   563 ------------------------TQREIGIFCAAFKDSSLEWNYLHQPDFIFKSSMLLAWGIGC 603
                                    ...:|......|.:.::|..|.......||..:..|..|..
  Rat   552 RFEEELNERMIQAIDGINAQKQWLKSEDIQRISLLFYNKNIEKEYRATALPAFKYYVTCACLIFL 616

  Fly   604 CLIYIQIVTNNFSCTACIVVDLVTFFFLTSLLCLAWYKNVCW----------------W---KSG 649
            |:..:||:       ......::.|.|..:.|.|.:...||:                |   .||
  Rat   617 CIFIVQIL-------VLPKTSILGFSFGAAFLSLIFILFVCFAGQLLQCSKKASTSLMWLLKSSG 674

  Fly   650 RYEFRIYGKYSCMAFHIFEKIQHSVSLRITVYLGILFSYYAVISLIMLNCDRDMYELSYIESKIY 714
            ....|.:.:.|...      :..::.|.:.|:.....|.....:|...|.......:...::.|.
  Rat   675 IIANRPWPRISLTI------VTTAIILTMAVFNMFFLSNSEETTLPTANTSNANVSVPDNQASIL 733

  Fly   715 HYEMDRDTCFHPWVFTNMISLILGI--SYTFARIPFGLKIVISCCETLAYLLIVFFQFAFIFQHS 777
            |   .|:..|.|:.   :.|.|||:  ...|.|:.:.||::|.....:.|..|:....|.:.. :
  Rat   734 H---ARNLFFLPYF---IYSCILGLISCSVFLRVNYELKMLIMMVALVGYNTILLHTHAHVLD-A 791

  Fly   778 ATTTPFMKAELAHCLR------VCMMLLTMYAKERQSEFNTKMNYKLNVDLQNKQKAADLTNQSI 836
            .:...|.:..:...|:      :.:..:|:....||||:..::::......:.:::..:......
  Rat   792 YSQVLFQRPGIWKDLKTMGSVSLSIFFITLLVLGRQSEYYCRLDFLWKNKFKKEREEIETMENLN 856

  Fly   837 IILLNNILPSHVVDLYL-NSLAKHELYYENYRMVSVMFAMLINF----------PMNLPSLRVLN 890
            .:||.|:||:||.:.:| .||...|||:::|..|.||||.:.:|          ...|..||:||
  Rat   857 RVLLENVLPAHVAEHFLARSLKNEELYHQSYDCVCVMFASIPDFKEFYTESDVNKEGLECLRLLN 921

  Fly   891 DIITQFDRLLTAYREYYVVEKIKVVGCTYMAACGLDFNLASNIRQTDHFRNSSLHVEVEHARNHR 955
            :||..||.||:. .::..|||||.:|.|||||.||     |.|...:|.:      |.|....|
  Rat   922 EIIADFDDLLSK-PKFSGVEKIKTIGSTYMAATGL-----SAIPSQEHAQ------EPERQYMH- 973

  Fly   956 MTDENYDSDMNNDEVVFIMTTFALDLMRTLAACNRAYSSSFFERSLSQGKICIGISSGEIMAGVV 1020
                           :..|..||..|:..|.|.|:        .|.:..|:.:||:.|.::|||:
  Rat   974 ---------------IGTMVEFAYALVGKLDAINK--------HSFNDFKLRVGINHGPVIAGVI 1015

  Fly  1021 GASQPHYDIWGNPVNMASRMESTGLPGHIQVTEESAKILQEFDIKCIYRGMTFVKGRGDIPTYFV 1085
            ||.:|.||||||.||:||||:|||:...||||||::.|||.....|..||:..|||:||:.||||
  Rat  1016 GAQKPQYDIWGNTVNVASRMDSTGVLDKIQVTEETSLILQTLGYTCTCRGIINVKGKGDLKTYFV 1080

  Fly  1086 GIDENLKFMSAKLVNRSLSR 1105
            ..:          ::||||:
  Rat  1081 NTE----------MSRSLSQ 1090

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ACXC	NP_609593.1	AC_N	<33..285	CDD:292831	58/285 (20%)
		CYCc	293..468	CDD:214485	85/176 (48%)
		Nucleotidyl_cyc_III	307..466	CDD:299850	79/158 (50%)
		CYCc	833..1060	CDD:214485	90/237 (38%)
		Nucleotidyl_cyc_III	861..1085	CDD:299850	91/233 (39%)
Adcy2	NP_112269.2	AC_N	<37..264	CDD:318454	54/253 (21%)
		Guanylate_cyc	285..469	CDD:306677	86/185 (46%)
		DUF1053	499..603	CDD:399378	16/106 (15%)
		Guanylate_cyc	882..1081	CDD:306677	92/234 (39%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D181177at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR45627
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	5	4.880