DRSC/TRiP Functional Genomics Resources

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Protein Alignment ACXC and Adcy5

DIOPT Version :9

Sequence 1:NP_609593.1 Gene:ACXC / 34689 FlyBaseID:FBgn0040508 Length:1130 Species:Drosophila melanogaster
Sequence 2:NP_072122.2 Gene:Adcy5 / 64532 RGDID:71014 Length:1262 Species:Rattus norvegicus


Alignment Length:1159 Identity:295/1159 - (25%)
Similarity:503/1159 - (43%) Gaps:248/1159 - (21%)


- Green bases have known domain annotations that are detailed below.


  Fly    45 LEEEYRYYQVRLMVSNLTIFYVLFIILAMSFLTIELLYVQH-----YNAVFFNFVIRVVSTILVL 104
            ||..|:.|..||..|:||:...:.:::.:..|..      |     ...|:...:...|..||::
  Rat   227 LERLYQRYFFRLNQSSLTMLMAVLVLVCLVMLAF------HAARPPLQVVYLAVLAAAVGVILIM 285

  Fly   105 TVLSINFCEK--FVSRHRWVMIASSVLSVYLVVLTDIVMISYHFYKNDWPLNTS----FDVFTLC 163
            .||    |.:  |...|..:...:.:..|..|.:..:::        ..|.:.|    :.||.:.
  Rat   286 AVL----CNRAAFHQDHMGLACYALIAVVLAVQVVGLLL--------PQPRSASEGIWWTVFFIY 338

  Fly   164 MIYMFLPIPSIKGAALLASSVSLIYVAFFMHSLTFNAVYTDRDSFGYDVISTDILHNLGFNMMGI 228
            .||..||: .::.|.|....:|.:::|..:|:   ||    :|.|....:.:::|.....|::|:
  Rat   339 TIYTLLPV-RMRAAVLSGVLLSALHLAISLHT---NA----QDQFLLKQLVSNVLIFSCTNIVGV 395

  Fly   229 FFRIMNDTMVRASFLDRHQFIMEETWLRHALLQESILLDSILPPQIAKPVQEKIKSKITQSENSP 293
            ......:...|.:|.:..:.|......:....|:..||.|:||..:|..::..|.:|        
  Rat   396 CTHYPAEVSQRQAFQETRECIQARLHSQRENQQQERLLLSVLPRHVAMEMKADINAK-------- 452

  Fly   294 DRFQMGPRTTESFM----AIQIHPDVSILYADVVNYTHLTTTLTVGNLVKVLHDLYGRFDIAASN 354
                     .|..|    .||.|.:||||:||:..:|.|.:..|...||..|::|:.|||..|:.
  Rat   453 ---------QEDMMFHKIYIQKHDNVSILFADIEGFTSLASQCTAQELVMTLNELFARFDKLAAE 508

  Fly   355 FKVQRIKFLGDCYYCVAGLTTPDPDHAKCCVSLGISMISNIQEVRAERGLDIDMRIGVHSGSLLA 419
            ....|||.||||||||:||.....|||.|||.:|:.||..|..||...|::::||:|:|||.:..
  Rat   509 NHCLRIKILGDCYYCVSGLPEARADHAHCCVEMGMDMIEAISLVREVTGVNVNMRVGIHSGRVHC 573

  Fly   420 GIIGEAKLQFDIWGTDVEIANHLESTGEPGYVHVSGRTLSMLNPADYTILSGTQKAQSDPVLQY- 483
            |::|..|.|||:|..||.:|||:|:.|:.|.:|::..||:.|| .||.:..|....::..:.:: 
  Rat   574 GVLGLRKWQFDVWSNDVTLANHMEAGGKAGRIHITKATLNYLN-GDYEVEPGCGGERNAYLKEHS 637

  Fly   484 IHTYLL---------------------TGQV--------ARESFITSIGGVRSSSVLEVKSIDRI 519
            |.|:|:                     |..:        |...|...:||.:.|..::....:..
  Rat   638 IETFLILRCTQKRKEEKAMIAKMNRQRTNSIGHNPPHWGAERPFYNHLGGNQVSKEMKRMGFEDP 702

  Fly   520 RSSRPSQSSMTDEFREEFRNMPVGGINLNSPCCRRTRLDTHKKTQREIGIFCAAFKDSSLEWNYL 584
            :.....:|:..::..:||....:...:::     |.|.:..:|       |...|::..||..|.
  Rat   703 KDKNAQESANPEDEVDEFLGRAIDARSID-----RLRSEHVRK-------FLLTFREPDLEKKYS 755

  Fly   585 HQPD-----FIFKSSMLLAWGIGCCLIYIQIVTNNFSCTACIVVDLVTFFFLTS--LLCLAWYKN 642
            .|.|     ::..:|::..:   .|.:.|.||.::.         .:..|:|:.  ||.|..:.:
  Rat   756 KQVDDRFGAYVACASLVFLF---ICFVQITIVPHSL---------FMLSFYLSCFLLLALVVFIS 808

  Fly   643 VCWWKSGRYEFRIYGKYSCMAFH------IFEKIQHSV--SLRITVYLGILFSYYAVISLIMLN- 698
            |.              |:|:...      :..||..|.  |..:.|:...|....|.:::.|.| 
  Rat   809 VI--------------YACVKLFPTPLQTLSRKIVRSKKNSTLVGVFTITLVFLSAFVNMFMCNS 859

  Fly   699 -----CDRDMYELS-------YIESKIYHYEM---------DRDTCFHPWVFTNMISLILGISYT 742
                 |..:.:.::       ::....::|.:         .:..|..|..||..:.|.|.....
  Rat   860 KNLVGCLAEEHNITVNQVNACHVMESAFNYSLGDEQGFCGSPQSNCNFPEYFTYSVLLSLLACSV 924

  Fly   743 FARIPFGLKIVISCCETLAYLLIVFFQFAFIFQH-----SATTTPFMKAELAHC----------- 791
            |.:|....|:|:.....|.|:|||......:|.:     :|....|.....:.|           
  Rat   925 FLQISCIGKLVLMLAIELIYVLIVEVPGVTLFDNADLLVTANAIDFSNNGTSQCPEHATKVALKV 989

  Fly   792 ---LRVCMMLLTMYAKERQSEFNTKMNY--KLNVDLQNKQKAADLT--NQSIIILLNNILPSHVV 849
               :.:.:.:|.:|...:|.|...::::  ||.. .:.|::..:|.  |:.   ||:||||..|.
  Rat   990 VTPIIISVFVLALYLHAQQVESTARLDFLWKLQA-TEEKEEMEELQAYNRR---LLHNILPKDVA 1050

  Fly   850 DLYL-NSLAKHELYYENYRMVSVMFAMLINFP----------MNLPSLRVLNDIITQFDRLLTAY 903
            ..:| ......||||::...|:||||.:.||.          ..:..||:||:||..||.:::..
  Rat  1051 AHFLARERRNDELYYQSCECVAVMFASIANFSEFYVELEANNEGVECLRLLNEIIADFDEIISED 1115

  Fly   904 REYYVVEKIKVVGCTYMAACGLDFNLASNIRQTDHFRNSSLHVEVEHARNHRMTDENYDSDMNND 968
            | :..:||||.:|.|||||.||:                               |..||......
  Rat  1116 R-FRQLEKIKTIGSTYMAASGLN-------------------------------DSTYDKAGKTH 1148

  Fly   969 EVVFIMTTFALDLMRTLAACNRAYSSSFFERSLSQGKICIGISSGEIMAGVVGASQPHYDIWGNP 1033
              :..:..||:.||..:...|        |.|.:..::.||::.|.::|||:||.:|.||||||.
  Rat  1149 --IKALADFAMKLMDQMKYIN--------EHSFNNFQMKIGLNIGPVVAGVIGARKPQYDIWGNT 1203

  Fly  1034 VNMASRMESTGLPGHIQVTEESAKIL--QEFDIKCIYRGMTFVKGRGDIPTYFV 1085
            ||:||||:|||:|..||||.:..::|  ..:.::|  ||:..|||:|::.|||:
  Rat  1204 VNVASRMDSTGVPDRIQVTTDMYQVLAANTYQLEC--RGVVKVKGKGEMMTYFL 1255

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
ACXCNP_609593.1 AC_N <33..285 CDD:292831 53/250 (21%)
CYCc 293..468 CDD:214485 76/178 (43%)
Nucleotidyl_cyc_III 307..466 CDD:299850 73/162 (45%)
CYCc 833..1060 CDD:214485 81/239 (34%)
Nucleotidyl_cyc_III 861..1085 CDD:299850 80/235 (34%)
Adcy5NP_072122.2 AC_N 1..459 CDD:318454 56/274 (20%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..196
Guanylate_cyc 461..634 CDD:306677 75/173 (43%)
DUF1053 669..761 CDD:399378 18/103 (17%)
Guanylate_cyc 1063..1257 CDD:306677 81/237 (34%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG2114
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 1 1.100 - - O PTHR45627
Phylome 1 0.910 - -
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
43.910

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