DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment ACXC and Adcy3

DIOPT Version :9

Sequence 1:NP_609593.1 Gene:ACXC / 34689 FlyBaseID:FBgn0040508 Length:1130 Species:Drosophila melanogaster
Sequence 2:NP_570135.2 Gene:Adcy3 / 64508 RGDID:71009 Length:1144 Species:Rattus norvegicus


Alignment Length:1216 Identity:322/1216 - (26%)
Similarity:532/1216 - (43%) Gaps:302/1216 - (24%)


- Green bases have known domain annotations that are detailed below.


  Fly    44 NLEEEYRYYQVR-----LMVSNLTIFYVLF-----IILAMSFLTIELLYVQHYNAVFFNFVIRVV 98
            :||..|:.|..|     |:|  |.:|..||     ::.|:.|.:.:|.            .:.|.
  Rat    61 SLENLYQTYFKRQRHETLLV--LVVFAALFDCYVVVMCAVVFSSDKLA------------PLMVA 111

  Fly    99 STILVLTVLSINFCEKFVSRHR----------WVMIASSVLSVYLVV-------LTDIVMISYHF 146
            ...|||.::....|:|.:...|          |::|.:.:.| ||.:       .:|.|      
  Rat   112 GVGLVLDIILFVLCKKGLLPDRVSRKVVPYLLWLLITAQIFS-YLGLNFSRAHAASDTV------ 169

  Fly   147 YKNDWPLNTSFDVFTLCMIYMFLPIPSIKGAALLASSVSLIYVAFFMHSLTFNAVYT--DRDSFG 209
               .|   .:|.||:     .|:.:|......::.|.||.:     :|:|.......  .:|...
  Rat   170 ---GW---QAFFVFS-----FFITLPLSLSPIVIISVVSCV-----VHTLVLGVTVAQQQQDELE 218

  Fly   210 YDVISTDILHNLGFNMMGIFFRIMN----DTMVRASFLDRHQFIMEETWLRHALLQESILLDSIL 270
            ...:..:||.|:...:..|...||:    |...|.:||:..|.:..:..|.....|:..|:.|||
  Rat   219 GMQLLREILANVFLYLCAIIVGIMSYYMADRKHRKAFLEARQSLEVKMNLEEQSQQQENLMLSIL 283

  Fly   271 PPQIAKPVQEKIKSKITQSENSPDRFQMGPRTTESFMAIQIHPDVSILYADVVNYTHLTTTLTVG 335
            |..:|..:.:.:|    :.|:..|:.|.      :.|.:..|.:||||:||:|.:|.|::..:..
  Rat   284 PKHVADEMLKDMK----KDESQKD
QQQF------NTMYMYRHENVSILFADIVGFTQLSSACSAQ 338

  Fly   336 NLVKVLHDLYGRFDIAASNFKVQRIKFLGDCYYCVAGLTTPDPDHAKCCVSLGISMISNIQEVRA 400
            .|||:|::|:.|||..|:.:...|||.|||||||:.||.....|||.|.:.:|::|:..|..||.
  Rat   339 ELVKLLNELFARFDKLAAKYHQLRIKILGDCYYCICGLPDYREDHAVCSILMGLAMVEAISYVRE 403

  Fly   401 ERGLDIDMRIGVHSGSLLAGIIGEAKLQFDIWGTDVEIANHLESTGEPGYVHVSGRTLSMLNPAD 465
            :....:|||:|||:|::|.|::|:.:.|:|:|.|||.:||.:|:.|.||.||:|..|:..|. .:
  Rat   404 KTKTGVDMRVGVHTGTVLGGVLGQKRWQYDVWSTDVTVANKMEAGGIPGRVHISQSTMDCLK-GE 467

  Fly   466 YTILSGTQKAQSDPVLQY-IHTYLLTGQVARESFI--TSIGGVRSSSV------LEVKSIDRIRS 521
            :.:..|...::.|.:.:. |.|||:   :|.:..:  |:..|:..|::      .:..|...|.:
  Rat   468 FDVEPGDGGSRCDYLDEKGIETYLI---IASKPEVKKTAQNGLNGSALPNGAPASKPSSPALIET 529

  Fly   522 SRPS----QSSMTDEFREEFRNMPVGGINLNSPCCRRTRL------------DTHKKTQ------ 564
            ..|:    .|..|.|..|| :.......:..:| .||.||            |.|:..|      
  Rat   530 KEPNGSAHASGSTSEEAEE-QEAQADNPSFPNP-RRRLRLQDLADRVVDASEDEHELNQLLNEAL 592

  Fly   565 -----------REIGIFCAAFKDSSLEWNYLHQPDFIFKSSMLLAWGIGCCLIYIQIVTNNFSCT 618
                       |...:....|.|..:|..|..:.:   |.|. .|:...|.:::         ||
  Rat   593 LERESAQVVKKRNTFLLTMRFMDPEMETRYSVEKE---KQSG-AAFSCSCVVLF---------CT 644

  Fly   619 ACI--------VVDLVTFFFLTSLLCL----------------------AWYKNVCWWKSGRYEF 653
            |.:        :.:.|||.....||.:                      :|.....|.::.....
  Rat   645 AMVEILIDPWLMTNYVTFVVGEVLLLILTICSMAAIFPRAFPKKLVAFSSWIDRTRWARNTWAML 709

  Fly   654 RIY--------GKYSCMAFHIFEKIQHSVSLRITVYLGIL-----FSYYAVISL---IMLNCDRD 702
            .|:        ...||:.:::.   .::|:..|.:..|.:     ::|.||:||   |||.....
  Rat   710 AIFILVMANVVDMLSCLQYYMG---PYNVTTGIELDGGCMENPKYYNYVAVLSLIATIMLVQVSH 771

  Fly   703 MYELS--------------YIESKIY-HYE----MDRDTCFHPWVFTNMISLIL--GISYTFARI 746
            |.:|:              |....:: .|:    .::|:   |.|....:.::.  |::.|.:|:
  Rat   772 MVKLTLMLLVTGAVTAINLYAWCPVFDEYDHKRFQEKDS---PMVALEKMQVLSTPGLNGTDSRL 833

  Fly   747 PFGLKIVISCCETLAYLLIVFFQFAFIFQHSATTTPFMKAELAHCLRVCMMLLTMYAKERQSE-- 809
            |    :|.|                   ::|.|...|            :|:|:.|...|..|  
  Rat   834 P----LVPS-------------------KYSMTVMMF------------VMMLSFYYFSRHVEKL 863

  Fly   810 FNTKMNYKLNVDLQNKQKAADLT--NQSIIILLNNILPSHVVDLYLNSLAK-HELYYENYRMVSV 871
            ..|...:|:.|..| |::..::.  |::   |:.|:||.||...:|.|..: .|||.::|..:.|
  Rat   864 ARTLFLWKIEVHDQ-KERVYEMRRWNEA---LVTNMLPEHVARHFLGSKKRDEELYSQSYDEIGV 924

  Fly   872 MFAMLINF-------PMN---LPSLRVLNDIITQFDRLLTAYREYYVVEKIKVVGCTYMAACGL- 925
            |||.|.||       .:|   :..||.||:||:.||.||. ..::.|:.|||.:|.|||||.|: 
  Rat   925 MFASLPNFADFYTEESINNGGIECLRFLNEIISDFDSLLD-NPKFRVITKIKTIGSTYMAASGVT 988

  Fly   926 -DFNLASNIRQTDHFRNSSLHVEVEHARNHRMTDENYDSDMNNDEVVFIMTTFALDLMRTLAACN 989
             |.|       |:.|.:||...:.:..|...:.|               :..|||.:..||...|
  Rat   989 PDVN-------TNGFTSSSKEEKSDKERWQHLAD---------------LADFALAMKDTLTNIN 1031

  Fly   990 RAYSSSFFERSLSQGKICIGISSGEIMAGVVGASQPHYDIWGNPVNMASRMESTGLPGHIQVTEE 1054
            ....::|..|        ||::.|.::|||:||.:||||||||.||:||||||||:.|:|||.||
  Rat  1032 NQSFNNFMLR--------IGMNKGGVLAGVIGARKPHYDIWGNTVNVASRMESTGVMGNIQVVEE 1088

  Fly  1055 SAKILQEFDIKCIYRGMTFVKGRGDIPTYFV-GIDENLKFMSAKLV 1099
            :..||:|:..:.:.||..||||:|::.|:|: |.|....|.:...|
  Rat  1089 TQVILREYGFRFVRRGPIFVKGKGELLTFFLKGRDRPAAFPNGSSV 1134

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
ACXCNP_609593.1 AC_N <33..285 CDD:292831 60/273 (22%)
CYCc 293..468 CDD:214485 70/174 (40%)
Nucleotidyl_cyc_III 307..466 CDD:299850 68/158 (43%)
CYCc 833..1060 CDD:214485 91/239 (38%)
Nucleotidyl_cyc_III 861..1085 CDD:299850 91/235 (39%)
Adcy3NP_570135.2 AC_N <44..303 CDD:318454 61/282 (22%)
Guanylate_cyc 310..494 CDD:306677 74/187 (40%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 504..563 11/60 (18%)
Guanylate_cyc 914..1121 CDD:306677 92/237 (39%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG2114
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
21.810

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