Protein Alignment ACXC and gucy2ca

DIOPT Version :9

• Sequence 1: NP_609593.1
• Gene: ACXC / 34689
• FlyBaseID: FBgn0040508
• Length: 1130
• Species: Drosophila melanogaster
• Sequence 2: XP_009297342.1
• Gene: gucy2ca / 572052
• ZFINID: ZDB-GENE-091118-67
• Length: 1025
• Species: Danio rerio
• Alignment Length: 1118
• Identity: 240/1118 - (21%)
• Similarity: 386/1118 - (34%)
• Gaps: 398/1118 - (35%)

  Fly   176 GAALLASSVSLIYVAFFM----HSLTFNAVYTDRDSFGYDVISTDILHNL------GFNMMGIFF 230
            |..:|..|.:  |..|.:    ..||.........|||   :|.|....|      ...:...||
Zfish   111 GCVMLGPSCT--YATFQLVDQEVGLTLTIPIISAGSFG---LSCDYKQKLTRLLPPARKIAEFFF 170

  Fly   231 RIMNDTMVR--------ASFLDRHQFIMEETWLRHALLQESILLDSILPPQIAKPVQE---KIKS 284
            ...: |.|:        |....:..:..|..|..:||...|.|..|.:..::.:...|   .:|.
Zfish   171 HFWH-TSVKNLKPAWKTAYVYKKDNYTEECFWYINALEAPSALFSSNISREMLRSESELSTALKR 234

  Fly   285 K------------------ITQSENSP--------DRFQMGPRTTESFMAIQIHPDVSILYADVV 323
            |                  |.::...|        |.:..|.||.||..|...:..|..::: ..
Zfish   235 KDRHSNIIVMCGTPDDIYTIKKNNTVPSQVVFILIDLYNEGYRTNESSPAHMRNVLVLTMHS-FR 298

  Fly   324 NYT-----HLTTTLTVGNLVKV---------LHDLYG----------RFDIAASNFKVQRIKFLG 364
            ||:     ...||:::|...|:         |..:|.          .||.:.:..||:.
Zfish   299 NYSSNSVWRNNTTVSIGGYYKLDSSGDRDLNLSVVYTTGSYKYRTLFSFDTSQNRTKVKD----- 358

  Fly   365 DCYYCVAGLTTPD-P-DHAKCCVSLGISMISNIQEVRAERGLDIDMRIGVHSGSLLAGII--GEA 425
                     ::|| | |.::........|  .|||:     :.|.:.:.|...:::|.|:  ...
Zfish   359 ---------SSPDLPWDRSQLPRDKHTGM--EIQEI-----MMIVLGLSVVLATVIAFILYRQNR 407

  Fly   426 KLQFDIWGTDVEIANHLESTGEPGYVHVSGRTLSMLNPAD-----YTILSGTQKAQSDPVLQYIH 485
            :::||                :..:.|:|.   |::.|.|     |..|:..:..:.|
Zfish   408 RVRFD----------------QKKWSHISS---SLITPLDDKERNYISLTIDEDKKGD------- 446

  Fly   486 TYLLTGQVARESFITSIGGVRSSSVLEVKSIDR----IRSSRPSQSSMTDEFREEFRNMPVGGIN 546
                                 :||::.....|:    ::..|.:..:.||:.|          |.
Zfish   447 ---------------------NSSLIRKGRYDKKPVILKELRNTDGNFTDDQR----------IE 480

  Fly   547 LNSPCCRRTRLDTHKKT------QREIGI-----FC-----------------AAFKDSSLEWNY 583
            ||:    ..|:|.:..|      :.:.|:     ||                 |:|.|  ||:..
Zfish   481 LNA----LLRIDYYNLTKFYGTVRFDCGVFGVFEFCERGSLRYVLDDKISYPDASFMD--LEFRI 539

  Fly   584 LHQPDFIFKSSMLLAWGIGCCLIYIQIVTNNFSCTACIV----VDLVTFFFLTSLLCLAWYKNVC 644
            ....|.....|.|.:..:|        |......|.|:|    |..:|.|...::|...  |::
Zfish   540 SVMYDIAKGMSYLHSSNVG--------VHGRLKSTNCVVDNRMVVKITDFGCNTILSPG--KDL- 593

  Fly   645 WWKSGRYEFRIYGKYSCMAFHIFEKIQHSVSLRITVYLGILFSYYAVISLIML-------NCDRD 702
             |.:..: .|:.|        |.:|             |.::|:..:...|:|       :|..|
Zfish   594 -WTAPEH-MRVEG--------ISQK-------------GDVYSFAIISQEIILRKSPFHTSCCSD 635

  Fly   703 MYELSYIESKIYHYEMDRDTCFHPWVFTNMISLILGISYTFARIPFGLKIVISCCE--------- 758
            |.|      |:|..:..|.    |.||...:| ..|:..|.|.:   ..::.||.|
Zfish   636 MAE------KLYLVQYPRG----PNVFRPDLS-FEGVGETEAEL---FVLIKSCWEEDPEKRPDF 686

  Fly   759 -----TLAYLLIVFFQFAFIFQHSATTTPFMKAELAHCLRVCMMLLTMYAK--ERQSEFNTKMNY 816
                 .|..:        |...|:.....:|...:..        |.||::  |...|..|.: |
Zfish   687 KRIEGALGKI--------FSNLHNQANASYMDNLIRR--------LQMYSRNLEHLVEERTAL-Y 734

  Fly   817 KLNVDLQNKQKAADLTNQSIIILLNNILPSHVV-DLYLNSLAKHELYYENYRMVSVMFAMLINF- 879
            |...|      .||..|..       :||..|| .|......:.|||.|    |::.|:.::.|
Zfish   735 KAERD------RADQLNFM-------LLPGPVVRSLKETGRVEPELYDE----VTIYFSDIVGFT 782

  Fly   880 -------PMNLPSLRVLNDIITQFDRLLTAYREYYVVEKIKVVGCTYMAACGLDFNLASNIRQTD 937
                   ||.:  :.:||||...||.:|    :::.|.|::.:|..||.|.||.
Zfish   783 TICHHSTPMEV--VDMLNDIYKNFDSIL----DHHDVYKVETIGDAYMVASGLP----------- 830

  Fly   938 HFRNSSLHVEVEHARNHRMTDENYDSDMNNDEVVFIMTTFALDLMRTLAACNRAYSSSFFERSLS 1002
                             |.....:..|         :...|||::.        :..:|..|.|.
Zfish   831 -----------------RCNGNRHAVD---------ICLMALDILE--------FMGTFQLRHLP 861

  Fly  1003 QGK--ICIGISSGEIMAGVVGASQPHYDIWGNPVNMASRMESTGLPGHIQVTEESAKILQEFD-- 1063
            ...  |.|||.||...|||||...|.|.::|:.||.||||||||||..|.|:|.:.||||..|
Zfish   862 GIPLWIRIGIHSGPCAAGVVGNKMPRYCLFGDTVNTASRMESTGLPLRIHVSESTIKILQRTDCE 926

  Fly  1064 IKCIYRGMTFVKGRGDIPTYFV-GID------------ENLKFMSAKLVNRSLSRRFSVMSSLDP 1115
            .:|..||.||:||:|...||:: |:.            ||.:.:...|..|       ::|:|:.
Zfish   927 FECERRGETFLKGKGKEMTYWLTGVTGQKYSLPTPPTVENFQRLQQDLAER-------IVSTLNK 984

  Fly  1116 --DSLRKSSSSDQ 1126
              :..||:.|:.|
Zfish   985 RGNERRKTLSTRQ 997

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ACXC	NP_609593.1	AC_N	<33..285	CDD:292831	27/129 (21%)
		CYCc	293..468	CDD:214485	41/215 (19%)
		Nucleotidyl_cyc_III	307..466	CDD:299850	33/191 (17%)
		CYCc	833..1060	CDD:214485	69/237 (29%)
		Nucleotidyl_cyc_III	861..1085	CDD:299850	75/235 (32%)
gucy2ca	XP_009297342.1	Periplasmic_Binding_Protein_Type_1	31..365	CDD:299141	52/274 (19%)
		PKc_like	428..698	CDD:304357	65/369 (18%)
		Pkinase_Tyr	451..689	CDD:285015	58/301 (19%)
		CYCc	736..929	CDD:214485	75/260 (29%)
		Guanylate_cyc	763..950	CDD:278633	76/241 (32%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	1.000