Protein Alignment ACXC and gucy2ca

DIOPT Version :10

• Sequence 1: NP_609593.1
• Gene: ACXC / 34689
• FlyBaseID: FBgn0040508
• Length: 1130
• Species: Drosophila melanogaster
• Sequence 2: XP_073799927.1
• Gene: gucy2ca / 572052
• ZFINID: ZDB-GENE-091118-67
• Length: 1071
• Species: Danio rerio
• Alignment Length: 1158
• Identity: 247/1158 - (21%)
• Similarity: 380/1158 - (32%)
• Gaps: 432/1158 - (37%)

  Fly   176 GAALLASSVSLIYVAFFM----HSLTFNAVYTDRDSFGYDVISTDILHNL------GFNMMGIFF 230
            |..:|..|.:  |..|.:    ..||.........|||   :|.|....|      ...:...||
Zfish   111 GCVMLGPSCT--YATFQLVDQEVGLTLTIPIISAGSFG---LSCDYKQKLTRLLPPARKIAEFFF 170

  Fly   231 RIMNDTMVR--------ASFLDRHQFIMEETWLRHALLQESILLDSILPPQIAKPVQE---KIKS 284
            ...: |.|:        |....:..:..|..|..:||...|.|..|.:..::.:...|   .:|.
Zfish   171 HFWH-TSVKNLKPAWKTAYVYKKDNYTEECFWYINALEAPSALFSSNISREMLRSESELSTALKR 234

  Fly   285 K------------------ITQSENSP--------DRFQMGPRTTESFMAIQIHPDVSILYADVV 323
            |                  |.::...|        |.:..|.||.||..|
Zfish   235 KDRHSNIIVMCGTPDDIYTIKKNNTVPSQVVFILIDLYNEGYRTNESSPA--------------- 284

  Fly   324 NYTHLTTTLTVGNLVKVLHDL--YGRFDIAASNFKVQRIKFLGDCYYCVAGLTTPDPDHAKCCVS 386
               |:...     ||..:|..  |....:..:|...     |.|  |.|.        :....|.
Zfish   285 ---HMRNV-----LVLTMHSFRNYSSNSVWRNNTTA-----LND--YVVG--------YHDAVVL 326

  Fly   387 LGISMISNIQEVRAERGLDIDMRIGVHSGSLLAGIIGEAKLQFDIWGTDVEIANHLESTGEP--- 448
            .|.:|.:|:|.::.::||..::.....:.|.. ||.|..|               |:|:|:.
Zfish   327 FGNAMRNNLQRIKQQQGLSDNIDPPFRNMSFY-GIGGYYK---------------LDSSGDRDLN 375

  Fly   449 -GYVHVSG----RTLSMLNPADYTILSGTQKAQSDPVLQYIHTYL----LTGQVARESFITSIG- 503
             ..|:.:|    |||...:    |..:.|:...|.|.|.:..:.|    .||...:|..:..:|
Zfish   376 LSVVYTTGSYKYRTLFSFD----TSQNRTKVKDSSPDLPWDRSQLPRDKHTGMEIQEIMMIVLGL 436

  Fly   504 GVRSSSVLE---VKSIDRIRSSRPS----QSSMTDEFREEFRNMPVGGINL---------NSPCC 552
            .|..::|:.   .:...|:|..:..    .||:.....::.||.    |:|         ||...
Zfish   437 SVVLATVIAFILYRQNRRVRFDQKKWSHISSSLITPLDDKERNY----ISLTIDEDKKGDNSSLI 497

  Fly   553 RRTRLDTHKKTQREI----GIFCAAFKDSSLEWNYLHQPDFIFKSSMLLAWGIGCCLIYIQIVTN 613
            |:.|.|......:|:    |.|.   .|..:|.|.|.:.|
Zfish   498 RKGRYDKKPVILKELRNTDGNFT---DDQRIELNALLRID------------------------- 534

  Fly   614 NFSCTACIVVDLVTFFFLTSLLCLAWYKNVCWWKSGRYEFRIYG--KYSCMAFHIFEKIQHSVSL 676
                          ::.||                     :.||  ::.|..|.:||..:.. ||
Zfish   535 --------------YYNLT---------------------KFYGTVRFDCGVFGVFEFCERG-SL 563

  Fly   677 RITVYLGILFSYYAVISL-----IMLNCDRDMYELSYIESKI--YHYEMDRDTCFHPWVFTNMIS 734
            |..:...|.:...:.:.|     :|.:..:.|   ||:.|..  .|..:....|.   |...|:.
Zfish   564 RYVLDDKISYPDASFMDLEFRISVMYDIAKGM---SYLHSSNVGVHGRLKSTNCV---VDNRMVV 622

  Fly   735 LIL------------------------GIS-----YTFARI---------PFGLKIVISCCETLA 761
            .|.                        |||     |:||.|         ||.    .|||..:|
Zfish   623 KITDFGCNTILSPGKDLWTAPEHMRVEGISQKGDVYSFAIISQEIILRKSPFH----TSCCSDMA 683

  Fly   762 YLLIVFFQFAFIFQHSATTTPF-----------MKAELAHCLRVC-------------------- 795
            ..|       ::.|:......|           .:|||...::.|
Zfish   684 EKL-------YLVQYPRGPNVFRPDLSFEGVGETEAELFVLIKSCWEEDPEKRPDFKRIEGALGK 741

  Fly   796 -----------------MMLLTMYAK--ERQSEFNTKMNYKLNVDLQNKQKAADLTNQSIIILLN 841
                             :..|.||::  |...|..|.: ||...|      .||..|..
Zfish   742 IFSNLHNQANASYMDNLIRRLQMYSRNLEHLVEERTAL-YKAERD------RADQLNFM------ 793

  Fly   842 NILPSHVV-DLYLNSLAKHELYYENYRMVSVMFAMLINF--------PMNLPSLRVLNDIITQFD 897
             :||..|| .|......:.|||.|    |::.|:.::.|        ||.:  :.:||||...||
Zfish   794 -LLPGPVVRSLKETGRVEPELYDE----VTIYFSDIVGFTTICHHSTPMEV--VDMLNDIYKNFD 851

  Fly   898 RLLTAYREYYVVEKIKVVGCTYMAACGLDFNLASNIRQTDHFRNSSLHVEVEHARNHRMTDENYD 962
            .:|    :::.|.|::.:|..||.|.||.                            |.....:.
Zfish   852 SIL----DHHDVYKVETIGDAYMVASGLP----------------------------RCNGNRHA 884

  Fly   963 SDMNNDEVVFIMTTFALDLMRTLAACNRAYSSSFFERSLSQGK--ICIGISSGEIMAGVVGASQP 1025
            .|         :...|||::.        :..:|..|.|....  |.|||.||...|||||...|
Zfish   885 VD---------ICLMALDILE--------FMGTFQLRHLPGIPLWIRIGIHSGPCAAGVVGNKMP 932

  Fly  1026 HYDIWGNPVNMASRMESTGLPGHIQVTEESAKILQEFD--IKCIYRGMTFVKGRGDIPTYFV-GI 1087
            .|.::|:.||.||||||||||..|.|:|.:.||||..|  .:|..||.||:||:|...||:: |:
Zfish   933 RYCLFGDTVNTASRMESTGLPLRIHVSESTIKILQRTDCEFECERRGETFLKGKGKEMTYWLTGV 997

  Fly  1088 D------------ENLKFMSAKLVNRSLSRRFSVMSSLDP--DSLRKSSSSDQ 1126
            .            ||.:.:...|..|       ::|:|:.  :..||:.|:.|
Zfish   998 TGQKYSLPTPPTVENFQRLQQDLAER-------IVSTLNKRGNERRKTLSTRQ 1043

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ACXC	NP_609593.1	Nucleotidyl_cyc_III	307..466	CDD:448371	31/168 (18%)
		Nucleotidyl_cyc_III	861..1085	CDD:448371	75/235 (32%)
gucy2ca	XP_073799927.1	None