Protein Alignment ACXC and adcy3a

DIOPT Version :9

• Sequence 1: NP_609593.1
• Gene: ACXC / 34689
• FlyBaseID: FBgn0040508
• Length: 1130
• Species: Drosophila melanogaster
• Sequence 2: XP_009290286.1
• Gene: adcy3a / 571825
• ZFINID: ZDB-GENE-111027-6
• Length: 1119
• Species: Danio rerio
• Alignment Length: 1181
• Identity: 310/1181 - (26%)
• Similarity: 492/1181 - (41%)
• Gaps: 257/1181 - (21%)

  Fly    44 NLEEEYRYYQVR-----LMVSNLTIFYVLFIILAMSFLTIELLYVQHYNAVFFNFVIRVVSTILV 103
            :||..|:.|..|     |:|  |.:|..||....:...|:  ||.....|     .:.|.|..|.
Zfish    61 SLENLYQTYFRRQRHETLLV--LVVFAALFDCYIIVMCTV--LYTADKLA-----SVAVASVGLA 116

  Fly   104 LTVLSINFC----------EKFVSRHRWVMIASSVLSVYLVVLTDIVMISYHFYKNDWPLNT--- 155
            ..||....|          .:.|....||:||:.:. .||         ..:|.:...|.:|
Zfish   117 ADVLLYLLCRYGLLPDRVTRRLVPYALWVLIAAQIF-CYL---------GLNFARFHQPSDTVGW 171

  Fly   156 -SFDVFTLCMIYMFLPIPSIKGAALLASSVSLIYVAFFMHSLTFNAVYTDRD-------SFGYDV 212
             :|..|:     .||.:|......:|.:|||.     .:|:|........:.       :.|..:
Zfish   172 QAFFSFS-----FFLTLPLRLTPIVLITSVSC-----GVHTLVLGVTIAQQQQEDIQGAALGRQL 226

  Fly   213 ISTDILHNLGFNMMGIFFRIMNDTMVRASFLDRHQFIMEETWLRHALLQESILLDSILPPQIAKP 277
            ::..:::..... :|:....|.|...|.:||:..|.:..:..|.....|:..||.||||..||..
Zfish   227 LANMVIYVCAIT-VGVMSYYMADRKHRKAFLEARQSLEVKLNLEEQSQQQERLLLSILPKHIADE 290

  Fly   278 VQEKIKSKITQSENSPDRFQMGPRTTESF--MAIQIHPDVSILYADVVNYTHLTTTLTVGNLVKV 340
            :.:.:|.:.:|.|            .:.|  |.:..|.:||||:||:|.:|.|:::.:...|||:
Zfish   291 MLQDMKKEASQKE------------MQQFNTMYMYRHENVSILFADIVGFTQLSSSCSAQELVKL 343

  Fly   341 LHDLYGRFDIAASNFKVQRIKFLGDCYYCVAGLTTPDPDHAKCCVSLGISMISNIQEVRAERGLD 405
            |::|:.|||..|:.:...|||.|||||||:.||.....|||.|.:.:|::|:..|..||.:...|
Zfish   344 LNELFARFDKLAAKYHQLRIKILGDCYYCICGLPDYREDHAACSIMMGLAMVEAISYVREKTQTD 408

  Fly   406 IDMRIGVHSGSLLAGIIGEAKLQFDIWGTDVEIANHLESTGEPGYVHVSGRTLSML--------- 461
            :|||:|||||::|.|::|:.:.|:|:|.|||.:||.:|:.|.||.||:|..||..|
Zfish   409 VDMRVGVHSGTVLGGVLGQKRWQYDVWSTDVTVANKMEAGGIPGRVHISQNTLECLHGEFDVEPG 473

  Fly   462 NPAD------------YTI----------------LSGTQKAQSDPVL-------QYIHTYLLTG 491
            |..|            |.:                ||.|....:.|:|       ..:||...|.
Zfish   474 NGGDRCEYLKERGIETYLVVLPKGPVGKNGINGVKLSVTSSNGNSPLLINTTECNGSVHTACTTP 538

  Fly   492 Q--------VARESFITSIGGVRSSSVLEVKSIDRIRSSRPSQSSMTDEFREEFRNMPVGGINLN 548
            :        |...||......:|...:.| :.||...:.:.....:.:...|......:.|...|
Zfish   539 EDPEELDTRVVNPSFPNPRRRLRLRDLAE-RVIDAQENEQELNKLLNEALLERETVQALKGKYTN 602

  Fly   549 SPCCR------RTRLDTHKKTQREIGIFCA-----------AFKDSSLEWNYLHQPDFIFKSSML 596
            ....|      .||....|:.|......|:           |..|..|..||
Zfish   603 RLSLRFTDPELETRFSVEKEKQSGAAFSCSCVVLLFTAVMEALIDPWLVANY------------- 654

  Fly   597 LAWGIGCCLIYIQIVTNNFSCTACIVVDLVTFFFLTSLLCLA-WYKNVCW----WKSGRYEF--- 653
            :...:|..|:.|        .|.|.:..:....|...|:..: |..:..|    |.......
Zfish   655 VTLAVGEVLLLI--------LTICSLAAIFPRVFPKRLVSFSTWIDHTRWARNTWAMAAIFIVTL 711

  Fly   654 -RIYGKYSCMAFHIFEKIQHSVSLRITVYLGILFS--YYAVISLIMLNCDRDMYELSYIESKIYH 715
             .|....||.|.........:|...:|...|...:  ||:.|:::.|.....:.::|:
Zfish   712 ADIVDMLSCRAPQTSTVESTAVPPVVTAIRGCAENPKYYSFIAVLALIATTMLVQVSH------- 769

  Fly   716 YEMDRDTCFHPWVFTNMISLILGISYTFARIPFGLKIVISCCETL-AYLLIVFFQFAFIFQHSAT 779
                            |:.|.|.:..|.|.   |...:.|..:|. .|.|..|.::......|..
Zfish   770 ----------------MVKLTLMLLITVAT---GAVNIYSWSQTFDLYDLTRFKEYRVNLVPSKY 815

  Fly   780 TTPFMKAELAHCLRVCMMLLTMYAKERQSE--FNTKMNYKLNVDLQNKQKAADLT--NQSIIILL 840
            |...|         :.:|:::.|...|..|  ..|...:|:.|. :.|:|..::.  |::   |:
Zfish   816 TMSVM---------IFIMMVSFYYFSRHVEKLARTLFLWKIEVH-EQKEKVYEMRRWNEA---LV 867

  Fly   841 NNILPSHVVDLYLNSLAK-HELYYENYRMVSVMFAMLINF-------PMN---LPSLRVLNDIIT 894
            .|:||.||...:|.|..: .|||.::|..:.||||.:.||       .:|   :..||.||:||:
Zfish   868 TNMLPEHVARHFLGSKKRDEELYSQSYDEIGVMFASIPNFSDFYTEESINNGGIECLRFLNEIIS 932

  Fly   895 QFDRLLTAYREYYVVEKIKVVGCTYMAACGLDFNLASNIRQTDHFRNSSLHVEVEHARNHRMTDE 959
            .||.||.. .::..:.|||.:|.|||||.|:         .:|:..|....::.|..
Zfish   933 DFDSLLDE-PQFRCITKIKTIGSTYMAASGV---------TSDNNTNGYACMKKEEI-------- 979

  Fly   960 NYDSDMNNDEVVFIMTTFALDLMRTLAACNRAYSSSFFERSLSQGKICIGISSGEIMAGVVGASQ 1024
               ||....:.:..:..|||.:..||...|....::|..|        ||::.|.::|||:||.:
Zfish   980 ---SDRERWQHLADLADFALAMKVTLMNINYQSFNNFMLR--------IGLNKGAVLAGVIGARK 1033

  Fly  1025 PHYDIWGNPVNMASRMESTGLPGHIQVTEESAKILQEFDIKCIYRGMTFVKGRGDIPTYFV-GID 1088
            ||:|||||.||:||||||||:.|:|||.|:...||:::..:.:.||..||||:|::.|||: |.:
Zfish  1034 PHFDIWGNTVNVASRMESTGVMGNIQVVEDCYCILKDYGFRFVRRGPIFVKGKGELLTYFLKGRE 1098

  Fly  1089 ENLKFMSAKLV 1099
            :...|::...|
Zfish  1099 KQGSFINGSFV 1109

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ACXC	NP_609593.1	AC_N	<33..285	CDD:292831	61/266 (23%)
		CYCc	293..468	CDD:214485	75/197 (38%)
		Nucleotidyl_cyc_III	307..466	CDD:299850	73/179 (41%)
		CYCc	833..1060	CDD:214485	84/237 (35%)
		Nucleotidyl_cyc_III	861..1085	CDD:299850	84/233 (36%)
adcy3a	XP_009290286.1	AC_N	<37..304	CDD:292831	63/284 (22%)
		CYCc	273..468	CDD:214485	84/206 (41%)
		Guanylate_cyc	310..492	CDD:278633	74/181 (41%)
		CYCc	858..1075	CDD:214485	85/248 (34%)
		Guanylate_cyc	889..1096	CDD:278633	85/235 (36%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.810