Protein Alignment ACXC and adcy6a

DIOPT Version :10

• Sequence 1: NP_609593.1
• Gene: ACXC / 34689
• FlyBaseID: FBgn0040508
• Length: 1130
• Species: Drosophila melanogaster
• Sequence 2: XP_017209219.1
• Gene: adcy6a / 570652
• ZFINID: ZDB-GENE-060221-1
• Length: 1203
• Species: Danio rerio
• Alignment Length: 1165
• Identity: 315/1165 - (27%)
• Similarity: 511/1165 - (43%)
• Gaps: 241/1165 - (20%)

  Fly    38 EKCKELNLEEEYRYYQVRLMVSNLTIFYVLFIILAMSFLTIELLYVQHYNAVFFNFVIRVVSTIL 102
            :|.:...||..|:.|..||..|:||:...:.:|:....||...::... :.|:.:.:...::..|
Zfish   156 KKFQSRKLERLYQRYFFRLNQSSLTMLMGVLVIVCGVMLTFHCIHGPP-DVVYASVLSVAMALFL 219

  Fly   103 VLTVLSINFCEK--FVSRHRWVMIASSVLSVYLVV-LTDIVMISYHFYKNDWPLNTS----FDVF 160
            .|.|:    |.:  |...:.| |::..|:.|.::| :..::|::        |.:.|    :.||
Zfish   220 ALMVV----CNRNGFHQDYMW-MVSYLVIGVLIIVQVFGVLMVA--------PRSASEGIWWSVF 271

  Fly   161 TLCMIYMFLPIPSIKGAALLASSVSLIYVAFFMHSLTFNAVYTDRDSFGYDVISTDILHNLGFNM 225
            .:.:||..||: .::.|.|....:|.|      |.||...:..| |.|.:..:|.::|..|..|:
Zfish   272 FIYIIYTLLPV-RMRAAVLSGGVLSAI------HLLTTWRINQD-DEFLWKQLSANVLIFLCTNI 328

  Fly   226 MGIFFRIMNDTMVRASFLDRHQFIMEETWLRHALLQESILLDSILPPQIAKPVQEKIKSKITQSE 290
            :||......:...|.:|.:...:|.....|:....|:..||.|:||..:|..::..|.:|
Zfish   329 IGICTHYPAEVSQRQAFQETRGYIQARLHLQRENQQQERLLLSVLPRHVAMEMKADINAK----- 388

  Fly   291 NSPDRFQMGPRTTESFM----AIQIHPDVSILYADVVNYTHLTTTLTVGNLVKVLHDLYGRFDIA 351
                        .|..|    .||.|.:||||:||:..:|.|.:..|...||..|::|:.|||..
Zfish   389 ------------KEDMMFHKIYIQKHDNVSILFADIEGFTSLASQCTAQELVMTLNELFARFDKL 441

  Fly   352 ASNFKVQRIKFLGDCYYCVAGLTTPDPDHAKCCVSLGISMISNIQEVRAERGLDIDMRIGVHSGS 416
            ||.....|||.||||||||:||..|..|||.|||.:|:.||..|..||...|::::||:|:|||.
Zfish   442 ASENHCLRIKILGDCYYCVSGLPEPRADHAHCCVEMGVDMIEAISLVREVTGVNVNMRVGIHSGR 506

  Fly   417 LLAGIIGEAKLQFDIWGTDVEIANHLESTGEPGYVHVSGRTLSMLNPADYTI---LSGTQKAQSD 478
            :..|::|..|.|||:|..||.:|||:|:.|:.|.:|::..||..|| .||.:   ..|.:.|...
Zfish   507 VHCGVLGLRKWQFDVWSNDVTLANHMEAGGKAGRIHITKATLQYLN-GDYEVEPGFGGERNAYLK 570

  Fly   479 PVLQYIHTYLLTG---------------QVAR----ESFI------TSIGGVRSSSVLEVKSIDR 518
            .  ..|.|:|:.|               |..|    |:.:      .|....:.|.|.....||.
Zfish   571 E--NSIETFLVLGCSQKRKDEKAMMAKMQRTRTNSNEALVPRWVPDRSFSRTKDSKVFRQMGIDE 633

  Fly   519 IRS--SRPSQSSMTDEFR-EEFRNMPVGGINLNSPCCRRTRLDTHKKTQREIGIFCAAFKDSSLE 580
            ..|  :|.:|.::..|.. :||....:...:::     :.|.|..||       |...|:.||||
Zfish   634 TSSKDNRGAQEALNPEDEVDEFLGRAIDARSID-----QLRKDHVKK-------FLLTFQTSSLE 686

  Fly   581 WNYLHQPDFIFKSSMLLAWGIGCCLIYIQIVTNNFSCTACIVVDLVTFFFLTSLLCLAWYKNVCW 645
            ..|..:.|..|...:.....:.|.:.:||||.  |..|..::...::.|.:.:        |:.:
Zfish   687 KKYAKKVDDRFGGYVACTLLVFCFISFIQIVV--FPHTLVMLGIYISIFIILA--------NILF 741

  Fly   646 WKSGRYEFRIYGKYSCMAFHIFEKIQHSVSLRI------TVYLGILFSYYAVISLI--MLNCDRD 702
                     |...|||:  .:|.....:||.:|      :..:|:.......||..  |.:||..
Zfish   742 ---------ICAIYSCV--KLFPAAMQTVSKKIVQSRTNSTLVGVFTIILVFISAFVNMFSCDTQ 795

  Fly   703 M----------YELSYIESKIYHYEMDRD-------------TCFHPWVFTNMISLILGISYTFA 744
            .          :....:...|.| .|.|.             :|..|..|:..:.|.|.....|.
Zfish   796 KLVDCVAKQLNWSSEMVTPCIIH-NMSRSVADGLSICPNNTPSCPFPEYFSYSVLLTLLACSVFL 859

  Fly   745 RIPFGLKIVISCCETLAYLLIVFFQFAFIFQHS--------------------ATTTP------- 782
            :|....|:.:.....|.:||:|.:....:|.::                    .|||.
Zfish   860 QISSIGKLALMLLIQLTFLLLVEWPEVALFDNADLFVTANALVFNETLQWSNFNTTTEQCTFRVT 924

  Fly   783 --FMKAELAHCLRVCMMLLTMYAKERQSEFNTKMNYKLNVDLQNKQKAADLT--NQSIIILLNNI 843
              .:|......|.|.::.|.::|::.:|.......:||.. .:.|::..:|.  |:.   ||:||
Zfish   925 KVSLKVMTPVILTVFVLALYLHAQQVESTARLDFLWKLQA-TEEKEEMEELQAYNRR---LLHNI 985

  Fly   844 LPSHVVDLYL-NSLAKHELYYENYRMVSVMFAMLINFP----------MNLPSLRVLNDIITQFD 897
            ||..|...:| ......||||::...|:||||.:.||.          ..:..||:||:||..||
Zfish   986 LPKDVAAHFLARERRNDELYYQSCECVAVMFASISNFSEFYVELEANNEGVECLRLLNEIIADFD 1050

  Fly   898 RLLTAYREYYVVEKIKVVGCTYMAACGLDFNLASNIRQTDHFRNSSLHVEVEHARNHRMTDENYD 962
            .:::. .:|..:||||.:|.|||||.||:                               |..||
Zfish  1051 EIISE-EKYRQLEKIKTIGSTYMAASGLN-------------------------------DSTYD 1083

  Fly   963 SDMNNDEVVFIMTTFALDLMRTLAACNRAYSSSFFERSLSQGKICIGISSGEIMAGVVGASQPHY 1027
            .:..:.  :..:..:|:.|...:...|        |.|.:..::.||::.|.::|||:||.:|.|
Zfish  1084 KEGRSH--ITALADYAMHLREQMKYIN--------EHSFNNFQMKIGLNIGPVVAGVIGARKPQY 1138

  Fly  1028 DIWGNPVNMASRMESTGLPGHIQVTEESAKILQE--FDIKCIYRGMTFVKGRGDIPTYFV 1085
            |||||.||:||||:|||:|..||||.:..::|..  :.::|  ||:..|||:|::.|||:
Zfish  1139 DIWGNTVNVASRMDSTGVPDRIQVTTDLHQVLHSKGYQLEC--RGVIKVKGKGEMTTYFL 1196

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ACXC	NP_609593.1	Nucleotidyl_cyc_III	307..466	CDD:448371	75/162 (46%)
		Nucleotidyl_cyc_III	861..1085	CDD:448371	78/235 (33%)
adcy6a	XP_017209219.1	AC_N	<97..395	CDD:318454	64/277 (23%)
		Guanylate_cyc	397..559	CDD:425528	76/162 (47%)
		Adcy_cons_dom	609..697	CDD:461877	23/99 (23%)
		Guanylate_cyc	1004..1197	CDD:425528	79/237 (33%)