DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ACXC and adcy1b

DIOPT Version :9

Sequence 1:	NP_609593.1	Gene:	ACXC / 34689	FlyBaseID:	FBgn0040508	Length:	1130	Species:	Drosophila melanogaster
Sequence 2:	NP_001161822.1	Gene:	adcy1b / 569499	ZFINID:	ZDB-GENE-100805-1	Length:	1114	Species:	Danio rerio

Alignment Length:	1209	Identity:	313/1209 - (25%)
Similarity:	512/1209 - (42%)	Gaps:	281/1209 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly    40 CKELNLEEEYRYYQVRL-MVSNLTIFYVLFIILAMSFLTIELLYV---------QH--YNAVFFN 92
            |.|  ||..:|.|:::| ..:.|....|| |:|:.|...:|||..         .|  ::.:|.:
Zfish    31 CAE--LEALFRRYRLKLEQTATLKALSVL-ILLSCSLSLLELLLSGTGLSVAQGSHPVHSVLFIS 92

  Fly    93 -FVIRVVSTILV-----LTVLSINFCEKF---------VSRHRWVMIASSVLSVYLVVLTDIVMI 142
             |::..|..:||     :..||:.|...|         |||     .|.....|
Zfish    93 LFIVTNVQYLLVTQLQQIAHLSLLFGFTFAVPCCPLPQVSR-----AAGPEQGV----------- 141

  Fly   143 SYHFYKNDWPLNTSFDVFTLCMIYMFLPIPSIKGAALLASSVSLIYVAFFMHSLTFNAVYTDRDS 207
                    |||     :....|.|..||:.:  |.|||..  .|:.:|   |:|...:...|...
Zfish   142 --------WPL-----LLLTFMAYCLLPVRT--GLALLFG--LLLPLA---HTLITASTLPDNTQ 186

  Fly   208 FGYDVISTDILHNLGFNMMGIFFRIMNDTMVRASFLDRHQFIMEETWLRHALLQESILLDSILPP 272
            ..:..:..:.|...|.|:.|:|.||:.:...|.:||.....|.|...:.....::..||.|:||.
Zfish   187 RLWRSLVANTLLFTGVNVSGLFVRILTERAQRKAFLQARNCIEERLRMEDENEKQERLLMSLLPR 251

  Fly   273 QIAKPVQEKIKSKITQSENSPDRFQMGPRTTESFMAIQIHPDVSILYADVVNYTHLTTTLTVGNL 337
            .:|..::|.              |...|......:.||.|.:||||:||:|..|.|.:..|...|
Zfish   252 NVAMEMKED--------------FLKPPERIFHKIYIQRHDNVSILFADIVGSTSLASQCTAQEL 302

  Fly   338 VKVLHDLYGRFDIAASNFKVQRIKFLGDCYYCVAGLTTPDPDHAKCCVSLGISMISNIQEVRAER 402
            ||:|::|:|:||..|:....:|||.||||||||:|||.|..|||.|||.:|:.||..|..|....
Zfish   303 VKLLNELFGKFDELATENHCRRIKILGDCYYCVSGLTQPKTDHAHCCVEMGLDMIDTITSVAEAT 367

  Fly   403 GLDIDMRIGVHSGSLLAGIIGEAKLQFDIWGTDVEIANHLESTGEPGYVHVSGRTLSMLNPADYT 467
            .:|::||:|:|:|.:|.|::|..|.|:|:|..||.:||.:|:.|.||.||::..||..|| .||.
Zfish   368 EVDLNMRVGLHTGRVLCGVLGLRKWQYDVWSNDVTLANMMEAGGLPGKVHITRSTLECLN-GDYE 431

  Fly   468 ILSGTQKAQSDPVLQY-IHTYLLTGQVARESFITSI-GGVRSSSVLEVKSI-----------DRI 519
            :..|..:.:...:|:: |.|:.:.....|:.|...| ..::.:..::.|::           ...
Zfish   432 VEPGNGRERHAFLLKHDIETFFIVPPHRRKIFPGLILSDIKPAKKMKFKTVCYLLVQLMHCRKMF 496

  Fly   520 RSSRPSQSSMT----DEFR------EEFRN-MPVG--------GINLNSPC-----CRRTRLDTH 560
            |:..|..:.|.    |:.|      |:.|| .|..        |..:|...     .|:|..||
Zfish   497 RAEIPFSNVMNCEDGDKRRVLRSAPEKLRNRTPTAASAPQSSPGTRVNRYINRLIEARQTESDT- 560

  Fly   561 KKTQREIGIFCAAFKDSSLEWNYLHQPDFIFKS----SMLLAWGIGCCLIYIQIVTNNFSCTACI 621
                .::......::||..|..|....|..|..    |:||...:|  .:|:.|:..     ..:
Zfish   561 ----ADLNYLTLMYRDSERERRYHQLNDEYFTGAVVLSLLLVVLLG--FLYLLIIPQ-----GTV 614

  Fly   622 VVDLVTFFFLTSLLCLAWYKNVCWWKSGRYEFRIYGKYSCMAFHIFEKIQ-----HSVSLRITVY 681
            |:.|:.|.....::|:                        |..|| .::|     .::.:|..:.
Zfish   615 VLVLLVFCICFLVVCI------------------------MYLHI-TRVQCFPGCLTIQIRTALC 654

  Fly   682 LGILFSYYAVISLIMLNCDRDMYELSYIESKIYHYEMDRDTCFHPWVFTN-------MISLILGI 739
            :.|:...|||....::.|                         .||::.:       :|....|:
Zfish   655 VFIVLLIYAVAQACVVGC-------------------------MPWLWPSNSTRSIVIIDAAAGL 694

  Fly   740 SYTFARIP-FGLKIVISCC-----------------ETLAYLLIVFFQFAFI----FQHSATTTP 782
            :.|.|.:| .|.:....||                 :|:..||::......:    |:.::....
Zfish   695 NRTMAELPCAGAQYAFLCCMLGTLSMALFLRVSWIPKTILLLLLLVLYITILELSGFRRASGWAL 759

  Fly   783 FMKAELAHCLRVCMMLLTMYAKERQSEFNTKMNYKLNVDLQNKQKAAD---LTNQSIIILLNNIL 844
            .....|...|.:.:....:....||.:...::::......:.::...:   |.|:.|:.   |:|
Zfish   760 LSVRGLEPLLSLLLFSTAVALHSRQLDLKLRLDFLWATQAEEERDGMEKVKLDNKRILF---NLL 821

  Fly   845 PSHVVDLYLNSLAKH-ELYYENYRMVSVMFAMLINF----------PMNLPSLRVLNDIITQFDR 898
            |.||...:|.|..:: :|||::|..|.|:||.:.||          .|.:..||:||:||..||.
Zfish   822 PVHVAQHFLLSNPRNMDLYYQSYAQVGVLFASIPNFNDFYIELDGNNMGVECLRLLNEIIADFDE 886

  Fly   899 LL--TAYREYYVVEKIKVVGCTYMAACGLDFNLASNIRQTDHFRNSSLHVEVEHARNHRMTDENY 961
            |:  ..|::   :||||.:|.|||:|.||...:.:..:     ::::.|:..
Zfish   887 LMDKECYKD---IEKIKTIGSTYMSAVGLVPTIGTKAK-----KSTATHLST------------- 930

  Fly   962 DSDMNNDEVVFIMTTFALDLMRTLAACNRAYSSSFFERSLSQGKICIGISSGEIMAGVVGASQPH 1026
                        :..||:::...|...|....:.|..|        :||:.|.::|||:||.:|.
Zfish   931 ------------IADFAIEMFDVLDEINYQSYNDFVLR--------VGINVGPVVAGVIGARRPQ 975

  Fly  1027 YDIWGNPVNMASRMESTGLPGHIQVTEESAKILQ-EFDIKCIYRGMTFVKGRGDIPTYFVGIDEN 1090
            ||||||.||:||||:|||:||.|||||:..::|| .:|:.|  ||...|||:|.:.|||:.....
Zfish   976 YDIWGNTVNVASRMDSTGVPGKIQVTEDVYRLLQNNYDLMC--RGNVSVKGKGQMLTYFLEGKAQ 1038

  Fly  1091 LKFMSAKLVNRSLSRRFSVMSSLDPDSLRKSSSSDQESG 1129
            ...:.|......|.||...::.......:..|.|...||
Zfish  1039 DPGIRAPHHTGGLERRVHAIARTSSTQTKAGSVSSATSG 1077

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ACXC	NP_609593.1	AC_N	<33..285	CDD:292831	66/271 (24%)
		CYCc	293..468	CDD:214485	79/174 (45%)
		Nucleotidyl_cyc_III	307..466	CDD:299850	75/158 (47%)
		CYCc	833..1060	CDD:214485	79/239 (33%)
		Nucleotidyl_cyc_III	861..1085	CDD:299850	82/236 (35%)
adcy1b	NP_001161822.1	AC_N	<128..270	CDD:292831	42/191 (22%)
		CYCc	236..431	CDD:214485	85/209 (41%)
		Guanylate_cyc	272..454	CDD:278633	81/182 (45%)
		DUF1053	498..585	CDD:283888	18/91 (20%)
		CYCc	806..1012	CDD:214485	82/249 (33%)
		Guanylate_cyc	839..1035	CDD:278633	83/238 (35%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.810