DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment ACXC and npr3

DIOPT Version :9

Sequence 1:	NP_609593.1	Gene:	ACXC / 34689	FlyBaseID:	FBgn0040508	Length:	1130	Species:	Drosophila melanogaster
Sequence 2:	XP_005165413.1	Gene:	npr3 / 569395	ZFINID:	ZDB-GENE-060531-91	Length:	503	Species:	Danio rerio

Alignment Length:	305	Identity:	48/305 - (15%)
Similarity:	107/305 - (35%)	Gaps:	71/305 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly   288 QSENSPDRFQMGP---RTTESFMAIQIHPDVSILYADVV---------NYTHLTTTL-TVGNLVK 339
            |.:..|| ..:||   ....|...:..|.::.::.|..:         .|:|||... |...:.:
Zfish    90 QKDERPD-LVLGPVCEYAASSVTRVASHWNIPVISAGALATGFNSKTPEYSHLTRIAPTYLKMAE 153

  Fly   340 VLHDLYGRFDIAASNFKVQRIKFLGDCYYCVAGLTTPDPDHAKCCVSLGISMISNIQEVRAERGL 404
            ....::|.|....:.......|...:||:.:.|:.|...::.   :|...:::::.:|     .:
Zfish   154 TFQAIFGHFGWRTAYLIYDDDKDERNCYFTMEGVFTVLSEYH---ISTDFAVLNSNEE-----RV 210

  Fly   405 DIDMRIGVHSGSLLAGIIGEAKLQFDIWGTDVEIANHLESTGEPGYVHVSGRTLSMLNPADYTIL 469
            |.|..|....||.:..:..:|.:.     .|:.:|.|........::..:   :.:.|.:.|...
Zfish   211 DPDGIITSVYGSEVVIMCSKADIV-----RDLMLAAHRRKLTSDSHIFFN---IELFNSSSYGDG 267

  Fly   470 SGTQKAQSDPVLQYIHTYLLTGQVARESFITSIGGVRSSSVLEVKSIDRIRSSRPSQSSMTDEFR 534
            |..::.:.|...:..:::|.|                         :..:||::|.....:.|.:
Zfish   268 SWRRRDKYDDEARAAYSFLNT-------------------------VTLLRSTKPEFEDFSIEMK 307

  Fly   535 EEFRNMPVGGINLNSPCCRRTRLDTHKKTQREIGIFCAAFKDSSL 579
            :..:..       |.|.|         :....:.:|...|.|:.|
Zfish   308 KSLQQS-------NIPIC---------EDCSAVNMFMEGFHDALL 336

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ACXC	NP_609593.1	AC_N	<33..285	CDD:292831
		CYCc	293..468	CDD:214485	32/187 (17%)
		Nucleotidyl_cyc_III	307..466	CDD:299850	26/168 (15%)
		CYCc	833..1060	CDD:214485
		Nucleotidyl_cyc_III	861..1085	CDD:299850
npr3	XP_005165413.1	Periplasmic_Binding_Protein_Type_1	29..416	CDD:299141	48/305 (16%)
		ANF_receptor	46..389	CDD:279440	48/305 (16%)
		TM_EphA1	436..468	CDD:214014
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.900