Protein Alignment ACXC and adcy5

DIOPT Version :10

• Sequence 1: NP_609593.1
• Gene: ACXC / 34689
• FlyBaseID: FBgn0040508
• Length: 1130
• Species: Drosophila melanogaster
• Sequence 2: XP_068079526.2
• Gene: adcy5 / 562619
• ZFINID: ZDB-GENE-081104-470
• Length: 1191
• Species: Danio rerio
• Alignment Length: 1203
• Identity: 313/1203 - (26%)
• Similarity: 527/1203 - (43%)
• Gaps: 231/1203 - (19%)

  Fly     5 RTNSRKSPLKRK-RLRPCHLDYA-----------NERLWEHSYLREKC-------------KELN 44
            |.|:|.||..|. .:||..::..           .|.:.|.::....|             :...
Zfish    91 RNNNRSSPRYRDGEVRPKSVELGLEDRRTKSKPEEELMPEVNFSMSACCNSVMQIFRSKKFQSEK 155

  Fly    45 LEEEYRYYQVRLMVSNLTIFYVLFIILAMSFL-------TIELLYVQHYNAVFFNFVIRVVSTIL 102
            ||..|:.|..||..|:||:...:.:::....|       ..:|.||..:.|          :.:|
Zfish   156 LERLYQRYFFRLNQSSLTMLMAVLVLVCAVMLGFHCAGGMCQLTYVLVFTA----------AIVL 210

  Fly   103 VLTVLSINFCEK--FVSRHRWVMIASSVLSVYLVVLTDIVMISYHFYKNDWPLNTS----FDVFT 161
            :||::.:  |.:  |...|.|::....:|.|..|.:..::.:.        |.:.|    :.||.
Zfish   211 ILTLMVV--CNRNGFHQDHMWIVCYLLILLVLAVQVVGVLFVK--------PRSASEGIWWTVFF 265

  Fly   162 LCMIYMFLPIPSIKGAALLASSVSLIYVAFFMHSLTFNAVYTDRDSFGYDVISTDILHNLGFNMM 226
            :.:||..||: .::.|.:....:|.|:|   :.|...|    |.|.|.:..:.:::|.....|::
Zfish   266 IHVIYTLLPV-RMRAAVITGIILSAIHV---LISWRLN----DMDVFLWKQLVSNVLIFSCSNIV 322

  Fly   227 GIFFRIMNDTMVRASFLDRHQFIMEETWLRHALLQESILLDSILPPQIAKPVQEKIKSKITQSEN 291
            |:......:...|.:|.:..:.|......:....|:..||.|:||..:|..::..|.:|
Zfish   323 GVCTHYPAEGSQRQAFQETRECIQARLHSQRENQQQERLLLSVLPRHVALEMKADINAK------ 381

  Fly   292 SPDRFQMGPRTTESFM----AIQIHPDVSILYADVVNYTHLTTTLTVGNLVKVLHDLYGRFDIAA 352
                       .|..|    .||.|.:||||:||:..:|.|.:..|...||..|::|:.|||..|
Zfish   382 -----------QEDMMFHKIYIQKHDNVSILFADIEGFTSLASQCTAQELVMTLNELFARFDKLA 435

  Fly   353 SNFKVQRIKFLGDCYYCVAGLTTPDPDHAKCCVSLGISMISNIQEVRAERGLDIDMRIGVHSGSL 417
            :.....|||.||||||||:||.....|||.|||.:|:.||..|..||...|::::||:|:|||.:
Zfish   436 AENHCLRIKILGDCYYCVSGLPEARADHAHCCVEMGVDMIEAISLVREVTGVNVNMRVGIHSGRV 500

  Fly   418 LAGIIGEAKLQFDIWGTDVEIANHLESTGEPGYVHVSGRTLSMLNPADYTILSGTQKAQSDPVLQ 482
            ..|::|..|.|||:|..||.:|||:|:.|:.|.:|::..||:.|| .||.:..|:...::..:.:
Zfish   501 HCGVLGLRKWQFDVWSNDVTLANHMEAGGKAGRIHITKATLNYLN-GDYDVEPGSGGERNVYLKK 564

  Fly   483 Y-IHTYLLTG--QVARE--SFITSIGGVRSSSVLEVKS--IDRIRSSRPSQSSMTDEFREE---- 536
            : |.|||:.|  |..:|  :.|..:...|::||....:  .||...:..:.:|::.|.:..
Zfish   565 HNIETYLIVGCSQKRKEEKAMIAKMNRQRTNSVTHNSTHWTDRPFYNHLNANSVSKEMKRMGFED 629

  Fly   537 -------FRNMPVG-----------GINLNSPCCRRTRLDTHKKTQREIGIFCAAFKDSSLEWNY 583
                   |||....           |..:::....|.|.:..||       |...|::..||..|
Zfish   630 PKDKHFIFRNTQENLNPEDEVDEFLGRAIDARSIDRLRSEHVKK-------FLLTFREPDLEKKY 687

  Fly   584 LHQPDFIFKSSMLLAWGIGCCLIYIQIVTNNFS------CTACIVVDLVTFFFLTSLLCLAWYKN 642
            ..|.|..|.:.::.|..:...:.:|||:....|      ...|:||.:|..|......|..::..
Zfish   688 SKQVDSSFGAYVVCASLVFLFICFIQIIIVPHSGLMVGFYVLCLVVLMVVMFISAIYSCFGFFPI 752

  Fly   643 VCWWKSGRYEFRIYGKYSCMAFHIFEKIQHSVSLRITVY----------LGILFSYYAVISLIML 697
            .....|.|.   :..:.:.....:|..:...:|..|.::          ||..|:    ||...:
Zfish   753 PLQTLSKRI---VQSRLNSTLVGVFTIVLVFISAFINIFTCSTDDLKTCLGQEFN----ISPSNV 810

  Fly   698 N-CDRDMYELSY-IESKIYHYEMDRDTCFHPWVFTNMISLILGISYTFARIPFGLKIVISCCETL 760
            | |......|:| :.|:.........||..|..|::.:.|.|.....|.::....|:.:.....:
Zfish   811 NACHAHFSSLNYTLWSQNRLCNSSSPTCNFPEYFSSCVLLSLLACSVFLQVSSIGKLFLMLFIEI 875

  Fly   761 AYLLIVFFQFAFIFQH------------------SATTTPFMKAELAHCLRVCMMLLTMYAKERQ 807
            .|:||:......:|.:                  ..|..|.   ::...:.:.:.:|.:|...:|
Zfish   876 LYVLIMEVPEVSLFDNVDLLVMANALAPNNGTCIVDTRVPL---KIVTPVVITVFVLALYLHAQQ 937

  Fly   808 SEFNTKMNY--KLNVDLQNKQKAADLT--NQSIIILLNNILPSHVVDLYL-NSLAKHELYYENYR 867
            .|...::::  ||.. .:.|::..:|.  |:.   ||:||||..|...:| ......||||::..
Zfish   938 VESTARLDFLWKLQA-TEEKEEMEELQAYNRR---LLHNILPKDVAAHFLARERRNDELYYQSCE 998

  Fly   868 MVSVMFAMLINFP----------MNLPSLRVLNDIITQFDRLLTAYREYYVVEKIKVVGCTYMAA 922
            .|:||||.:.||.          ..:..||:||:||..||.:::. .::..:||||.:|.|||||
Zfish   999 CVAVMFASISNFSEFYVELEANNEGVECLRLLNEIIADFDEIISE-DQFRQLEKIKTIGSTYMAA 1062

  Fly   923 CGLDFNLASNIRQTDHFRNSSLHVEVEHARNHRMTDENYDSDMNNDEVVFIMTTFALDLMRTLAA 987
            .||:                               |..||....:.  :..:..:|:.||..:..
Zfish  1063 SGLN-------------------------------DSTYDKAGRSH--IRALADYAMRLMDQMKY 1094

  Fly   988 CNRAYSSSFFERSLSQGKICIGISSGEIMAGVVGASQPHYDIWGNPVNMASRMESTGLPGHIQVT 1052
            .|        |.|.:..|:.||::.|.::|||:||.:|.||||||.||:||||:|||:|..||||
Zfish  1095 IN--------EHSFNNFKMKIGLNMGPVVAGVIGARKPQYDIWGNTVNVASRMDSTGVPERIQVT 1151

  Fly  1053 EESAKILQEFDIKCIYRGMTFVKGRGDIPTYFV 1085
            .:..::|..::....|||:..|||:|::.|||:
Zfish  1152 TDLYQVLSSYNYTLEYRGVVKVKGKGEMMTYFL 1184

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ACXC	NP_609593.1	Nucleotidyl_cyc_III	307..466	CDD:448371	73/162 (45%)
		Nucleotidyl_cyc_III	861..1085	CDD:448371	79/233 (34%)
adcy5	XP_068079526.2	None