DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ACXC and adcy5

DIOPT Version :9

Sequence 1:	NP_609593.1	Gene:	ACXC / 34689	FlyBaseID:	FBgn0040508	Length:	1130	Species:	Drosophila melanogaster
Sequence 2:	NP_001165056.1	Gene:	adcy5 / 562619	ZFINID:	ZDB-GENE-081104-470	Length:	1186	Species:	Danio rerio

Alignment Length:	1196	Identity:	308/1196 - (25%)
Similarity:	518/1196 - (43%)	Gaps:	222/1196 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 RTNSRKSPLKRK-RLRPCHLDYA-----------NERLWEHSYLREKC-------------KELN 44
            |.|:|.||..|. .:||..::..           .|.:.|.::....|             :...
Zfish    91 RNNNRSSPRYRDGEVRPKSVELGLEDRRTKSKPEEELMPEVNFSMSACCNSVMQIFRSKKFQSEK 155

  Fly    45 LEEEYRYYQVRLMVSNLTIFYVLFIILAMSFL-------TIELLYVQHYNAVFFNFVIRVVSTIL 102
            ||..|:.|..||..|:||:...:.:::....|       ..:|.:|..:.|          :.:|
Zfish   156 LERLYQRYFFRLNQSSLTMLMAVLVLVCAVMLGFHCAGGMCQLTFVLVFTA----------AIVL 210

  Fly   103 VLTVLSINFCEKFVSRHRWVMIASSVLSVYLVVLTDIVMISYHFYKNDWPLNTS----FDVFTLC 163
            :||::.:.....|...|.|::....:|.|..|.:..::.:.        |.:.|    :.||.:.
Zfish   211 ILTLMVVCNRNSFHQDHMWIVCYLLILLVLAVQVVGVLFVK--------PRSASEGIWWTVFFIH 267

  Fly   164 MIYMFLPIPSIKGAALLASSVSLIYVAFFMHSLTFNAVYTDRDSFGYDVISTDILHNLGFNMMGI 228
            :||..||: .::.|.:....:|.|:|   :.|...|    |.|.|.:..:.:::|.....|::|:
Zfish   268 VIYTLLPV-RMRAAVITGIILSAIHV---LISWRLN----DMDVFLWKQLVSNVLIFSCSNIVGV 324

  Fly   229 FFRIMNDTMVRASFLDRHQFIMEETWLRHALLQESILLDSILPPQIAKPVQEKIKSKITQSENSP 293
            ......:...|.:|.:..:.|......:....|:..||.|:||..:|..::..|.:|
Zfish   325 CTHYPAEGSQRQAFQETRECIQARLHSQRENQQQERLLLSVLPRHVALEMKADINAK-------- 381

  Fly   294 DRFQMGPRTTESFM----AIQIHPDVSILYADVVNYTHLTTTLTVGNLVKVLHDLYGRFDIAASN 354
                     .|..|    .||.|.:||||:||:..:|.|.:..|...||..|::|:.|||..|:.
Zfish   382 ---------QEDMMFHKIYIQKHDNVSILFADIEGFTSLASQCTAQELVMTLNELFARFDKLAAE 437

  Fly   355 FKVQRIKFLGDCYYCVAGLTTPDPDHAKCCVSLGISMISNIQEVRAERGLDIDMRIGVHSGSLLA 419
            ....|||.||||||||:||.....|||.|||.:|:.||..|..||...|::::||:|:|||.:..
Zfish   438 NHCLRIKILGDCYYCVSGLPEARADHAHCCVEMGVDMIEAISLVREVTGVNVNMRVGIHSGRVHC 502

  Fly   420 GIIGEAKLQFDIWGTDVEIANHLESTGEPGYVHVSGRTLSMLNPADYTILSGTQKAQSDPVLQY- 483
            |::|..|.|||:|..||.:|||:|:.|:.|.:|::..||:.|| .||.:..|:...::..:.::
Zfish   503 GVLGLRKWQFDVWSNDVTLANHMEAGGKAGRIHITKATLNYLN-GDYDVEPGSGGERNVYLKKHN 566

  Fly   484 IHTYLLTG--QVARE--SFITSIGGVRSSSVLE-------------------VKSIDRIRSSRPS 525
            |.|||:.|  |..:|  :.|..:...|::||..                   .|.:.|:....|.
Zfish   567 IETYLIVGCSQKRKEEKAMIAKMNRQRTNSVTHNSTHWTDRPFYNHLNANSVSKEMKRMGFEDPK 631

  Fly   526 QSSMTDEFREEFRNMPVGGINLNSPCCRRTRLDTHKKTQREIGIFCAAFKDSSLEWNYLHQPDFI 590
            ..:..:....|.......|..:::....|.|.:..||       |...|::..||..|..|.|..
Zfish   632 DKNTQENLNPEDEVDEFLGRAIDARSIDRLRSEHVKK-------FLLTFREPDLEKKYSKQVDSS 689

  Fly   591 FKSSMLLAWGIGCCLIYIQIVTNNFS------CTACIVVDLVTFFFLTSLLCLAWYKNVCWWKSG 649
            |.:.:..|..:...:.:|||:....|      ...|:||.:|..|......|..::.......|.
Zfish   690 FGAYVACASLVFLFICFIQIIIVPHSGLMVGFYVLCLVVLMVVMFISAIYSCFGFFPIPLQTLSK 754

  Fly   650 RYEFRIYGKYSCMAFHIFEKIQHSVSLRITVY----------LGILFSYYAVISLIMLN-CDRDM 703
            |.   :..:.:.....:|..:...:|..|.::          ||..|:    ||...:| |....
Zfish   755 RI---VQSRLNSTLVGVFTIVLVFISAFINIFTCSTDDLKTCLGQEFN----ISPSNVNACHAHF 812

  Fly   704 YELSY-IESKIYHYEMDRDTCFHPWVFTNMISLILGISYTFARIPFGLKIVISCCETLAYLLIVF 767
            ..|:| :.|:.........||..|..|::.:.|.|.....|.::....|:.:.....:.|:||:.
Zfish   813 SSLNYTLWSQNRLCNSSSPTCNFPEYFSSCVLLSLLACSVFLQVSSIGKLFLMLFIEILYVLIME 877

  Fly   768 FQFAFIFQH------------------SATTTPFMKAELAHCLRVCMMLLTMYAKERQSEFNTKM 814
            .....:|.:                  ..|..|.   ::...:.:.:.:|.:|...:|.|...::
Zfish   878 VPEVSLFDNVDLLVMANALAPNNGTCIVDTRVPL---KIVTPVVITVFVLALYLHAQQVESTARL 939

  Fly   815 NY--KLNVDLQNKQKAADLT--NQSIIILLNNILPSHVVDLYL-NSLAKHELYYENYRMVSVMFA 874
            ::  ||.. .:.|::..:|.  |:.   ||:||||..|...:| ......||||::...|:||||
Zfish   940 DFLWKLQA-TEEKEEMEELQAYNRR---LLHNILPKDVAAHFLARERRNDELYYQSCECVAVMFA 1000

  Fly   875 MLINFP----------MNLPSLRVLNDIITQFDRLLTAYREYYVVEKIKVVGCTYMAACGLDFNL 929
            .:.||.          ..:..||:||:||..||.:::. .::..:||||.:|.|||||.||:
Zfish  1001 SISNFSEFYVELEANNEGVECLRLLNEIIADFDEIISE-DQFRQLEKIKTIGSTYMAASGLN--- 1061

  Fly   930 ASNIRQTDHFRNSSLHVEVEHARNHRMTDENYDSDMNNDEVVFIMTTFALDLMRTLAACNRAYSS 994
                                        |..||....:.  :..:..:|:.||..:...|
Zfish  1062 ----------------------------DSTYDKAGRSH--IRALADYAMRLMDQMKYIN----- 1091

  Fly   995 SFFERSLSQGKICIGISSGEIMAGVVGASQPHYDIWGNPVNMASRMESTGLPGHIQVTEESAKIL 1059
               |.|.:..|:.||::.|.::|||:||.:|.||||||.||:||||:|||:|..||||.:..::|
Zfish  1092 ---EHSFNNFKMKIGLNMGPVVAGVIGARKPQYDIWGNTVNVASRMDSTGVPERIQVTTDLYQVL 1153

  Fly  1060 QEFDIKCIYRGMTFVKGRGDIPTYFV 1085
            ..::....|||:..|||:|::.|||:
Zfish  1154 SSYNYTLEYRGVVKVKGKGEMMTYFL 1179

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ACXC	NP_609593.1	AC_N	<33..285	CDD:292831	54/275 (20%)
		CYCc	293..468	CDD:214485	76/178 (43%)
		Nucleotidyl_cyc_III	307..466	CDD:299850	73/162 (45%)
		CYCc	833..1060	CDD:214485	79/237 (33%)
		Nucleotidyl_cyc_III	861..1085	CDD:299850	79/233 (34%)
adcy5	NP_001165056.1	AC_N	1..388	CDD:292831	67/339 (20%)
		CYCc	354..548	CDD:214485	83/211 (39%)
		Guanylate_cyc	390..574	CDD:278633	79/184 (43%)
		DUF1053	598..687	CDD:283888	15/95 (16%)
		CYCc	961..1155	CDD:214485	80/238 (34%)
		Guanylate_cyc	987..1181	CDD:278633	80/235 (34%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR45627
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.910