DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment ACXC and npr1a

DIOPT Version :9

Sequence 1:	NP_609593.1	Gene:	ACXC / 34689	FlyBaseID:	FBgn0040508	Length:	1130	Species:	Drosophila melanogaster
Sequence 2:	NP_001038402.1	Gene:	npr1a / 560653	ZFINID:	ZDB-GENE-060503-539	Length:	1067	Species:	Danio rerio

Alignment Length:	300	Identity:	72/300 - (24%)
Similarity:	139/300 - (46%)	Gaps:	47/300 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly   214 STDILHNLGFNMMGIFFRIMNDTMVRASFLDR------------HQFIMEETWLRHALLQES-IL 265
            |.|:.....|:.:.:..| .|:....::.||.            .:.:.|.|...|...::: .|
Zfish   792 SEDVNERPDFSQIKVLLR-KNNCGYGSNILDNLLSRMEQYANNLEELVEERTQAYHEEKRKAEAL 855

  Fly   266 LDSILPPQIAKPVQEKIKSKITQSENSPDRFQMGPRTTESFMAIQIHPDVSILYADVVNYTHLTT 330
            |..|||..:|:.::   :.::.|:|                    ....|:|.::|:|.:|.|:.
Zfish   856 LYQILPHSVAEQLK---RGEMVQAE--------------------AFDSVTIYFSDIVGFTALSA 897

  Fly   331 TLTVGNLVKVLHDLYGRFDIAASNFKVQRIKFLGDCYYCVAGLTTPDPD-HAKCCVSLGISMISN 394
            ..|...:|.:|:|||..||....||.|.:::.:||.|..|:||...:.. ||:....:.::::..
Zfish   898 ESTPMEVVTLLNDLYTCFDAIIDNFDVYKVETIGDAYMVVSGLPVRNGKLHAREIARMSLALLEA 962

  Fly   395 IQ--EVRAERGLDIDMRIGVHSGSLLAGIIGEAKLQFDIWGTDVEIANHLESTGEPGYVHVSGRT 457
            :.  .:|....|.:.:|||:|||.:.||::|....::.::|..|..|:.:||.||...:|||..|
Zfish   963 VHSFRIRHRPNLQLRLRIGIHSGPVCAGVVGLKMPRYCLFGDTVNTASRMESNGEALKIHVSEAT 1027

  Fly   458 LSMLNPADYTILSGTQKAQSDPVLQ---YIHTYLLTGQVA 494
            .::|...:...|    :.:.|..::   .:.||.|.|:::
Zfish  1028 RAVLQEFNCFQL----ELRGDVEMKGKGRMRTYWLLGEIS 1063

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ACXC	NP_609593.1	AC_N	<33..285	CDD:292831	16/83 (19%)
		CYCc	293..468	CDD:214485	48/177 (27%)
		Nucleotidyl_cyc_III	307..466	CDD:299850	48/161 (30%)
		CYCc	833..1060	CDD:214485
		Nucleotidyl_cyc_III	861..1085	CDD:299850
npr1a	NP_001038402.1	PBP1_NPR_A	48..449	CDD:107380
		ANF_receptor	66..421	CDD:279440
		PK_GC-A_B	540..814	CDD:270944	5/22 (23%)
		TyrKc	554..808	CDD:197581	3/15 (20%)
		HNOBA	<823..868	CDD:285003	9/44 (20%)
		CYCc	847..1032	CDD:214485	55/207 (27%)
		Guanylate_cyc	874..1060	CDD:278633	55/209 (26%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.900