DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ACXC and ADCY10

DIOPT Version :9

Sequence 1:	NP_609593.1	Gene:	ACXC / 34689	FlyBaseID:	FBgn0040508	Length:	1130	Species:	Drosophila melanogaster
Sequence 2:	NP_060887.2	Gene:	ADCY10 / 55811	HGNCID:	21285	Length:	1610	Species:	Homo sapiens

Alignment Length:	987	Identity:	182/987 - (18%)
Similarity:	333/987 - (33%)	Gaps:	339/987 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly   272 PQIAKPVQEKIKSKITQSENSPDRFQMGPRTTESFMAIQIHPDVSILYADVV------------- 323
            |::...:|:.:...|.:        |:..:..:.::: ::.| |:|::.:::
Human   259 PELEMSLQKYVMESILK--------QIDNKQLQGYLS-ELRP-VTIVFVNLMFEDQDKAEEIGPA 313

  Fly   324 ---NYTHLTTTLTV--GNLVKVLHDLYGRFDIAASNFKVQRIKFLGDCYYCVAGLTTPDP-DHAK 382
               .|.|:|:.|.:  |.:.||.     .||...|        ||  |.:...|...||. .||.
Human   314 IQDAYMHITSVLKIFQGQINKVF-----MFDKGCS--------FL--CVFGFPGEKVPDELTHAL 363

  Fly   383 CCVSLGISMISNIQEVRAERGLDIDMRIGVHSGSLLAGIIGE-AKLQFDIWGTDVEIANHLESTG 446
            .|........|.:.:::.       :.|||.||.:..||:|. .:.::.:.|..|.:|..: ...
Human   364 ECAMDIFDFCSQVHKIQT-------VSIGVASGIVFCGIVGHTVRHEYTVIGQKVNLAARM-MMY 420

  Fly   447 EPGYVHVSGRTLSMLN-PADY------TILSGTQKAQSDPVLQY------------------IHT 486
            .||.|.....|.:..| ||.:      .::.|.  |.|.|:.||                  ...
Human   421 YPGIVTCDSVTYNGSNLPAYFFKELPKKVMKGV--ADSGPLYQYWGRTEKVMFGMACLICNRKED 483

  Fly   487 YLLTGQ--------VARESFITSIGGVRSSSVLEVKSIDRIRSSRPSQSSMTDEFREEFRNMPVG 543
            |.|.|:        ...:.|:.|    .||.||..:.:.   ....||..|..|:..:.:|..:.
Human   484 YPLLGRNKEINYFMYTMKKFLIS----NSSQVLMYEGLP---GYGKSQILMKIEYLAQGKNHRII 541

  Fly   544 GINLNS---------------------------------------------------------PC 551
            .|:||.                                                         |.
Human   542 AISLNKISFHQTFYTIQMFMANVLGLDTCKHYKERQTNLRNKVMTLLDEKFYCLLNDIFHVQFPI 606

  Fly   552 CRR-TRLDTHKKTQREIGIFC-------------------AAFKDSSLEWNYLHQ-----PDFIF 591
            .|. :|:.|.|| |:::.|..                   |.|.||: .|.::.:     |.||.
Human   607 SREISRMSTLKK-QKQLEILFMKILKLIVKEERIIFIIDEAQFVDST-SWRFMEKLIRTLPIFII 669

  Fly   592 KSSMLLAWGIGCCLIYIQIVTNNFSCTACIVVDLVTFFFLTSLLCLAWYKNV-CWWKSGRYEFRI 655
            .|..... .|.|......|...|   |..||:..|....:::.:||.  .|| |..|    |...
Human   670 MSLCPFV-NIPCAAARAVIKNRN---TTYIVIGAVQPNDISNKICLD--LNVSCISK----ELDS 724

  Fly   656 Y-GKYSC-MAFHIFEKIQHSVSLRITVY------------LGILFSY----YAVISLIMLNCDRD 702
            | |:.|| :.|:..|.:::.....:.|:            ...||.|    ...::::.|:.|::
Human   725 YLGEGSCGIPFYCEELLKNLEHHEVLVFQQTESEEKTNRTWNNLFKYSIKLTEKLNMVTLHSDKE 789

  Fly   703 MYELSYIESKIYHYEMDRDTCFHPWVFTNMISL------------ILGISYT----FARIP-FGL 750
            ..|:.::.|.:....:...|.........:.|:            |:|:::|    |..:| :.:
Human   790 SEEVCHLTSGVRLKNLSPPTSLKEISLIQLDSMRLSHQMLVRCAAIIGLTFTTELLFEILPCWNM 854

  Fly   751 KIVISCCETLAYLL--IVFFQF---------------AF-IFQHSATTTPF-------------M 784
            |::|   :|||.|:  .:|:.|               :| :...|.:..|.             :
Human   855 KMMI---KTLATLVESNIFYCFRNGKELQKALKQNDPSFEVHYRSLSLKPSEGMDHGEEEQLREL 916

  Fly   785 KAELAHC--LRVC--MMLLTMY---AKERQSEFNTKMNYKLNVDLQNKQKAADLTNQSIIILLNN 842
            :.|:..|  :|.|  ||..|.|   .|:::...:.|....|..|.........          .:
Human   917 ENEVIECHRIRFCNPMMQKTAYELWLKDQRKAMHLKCARFLEEDAHRCDHCRG----------RD 971

  Fly   843 ILPSH--VVDLYLNSL---------------AKHELYYENYRMVSVMFAMLINFPMNLPSLRVLN 890
            .:|.|  .|::.||:|               .:.:|...|..:....    ..||.|.....:..
Human   972 FIPYHHFTVNIRLNALDMDAIKKMAMSHGFKTEEKLILSNSEIPETS----AFFPENRSPEEIRE 1032

  Fly   891 DIITQFDRLLTAYR---------EYYVVEKIKVVGCTYMAACGLDFNLASNIRQTDHF-----RN 941
            .|:..||.:||..:         |....|:|..:....:|               .||     .:
Human  1033 KILNFFDHVLTKMKTSDEDIIPLESCQCEEILEIVILPLA---------------HHFLALGEND 1082

  Fly   942 SSLHVEVEHARNHRMTDENYDSDMNNDEVVFIMTTFALDLMRTLAACNRAYSSSFFERSL--SQG 1004
            .:|:..:|.|..:.:..:||.:.|..:|        ...|::||.. ::::|.:|...:.  .:|
Human  1083 KALYYFLEIASAYLIFCDNYMAYMYLNE--------GQKLLKTLKK-DKSWSQTFESATFYSLKG 1138

  Fly  1005 KICIGISSGEIM 1016
            ::|..:  |:|:
Human  1139 EVCFNM--GQIV 1148

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ACXC	NP_609593.1	AC_N	<33..285	CDD:292831	2/12 (17%)
		CYCc	293..468	CDD:214485	42/201 (21%)
		Nucleotidyl_cyc_III	307..466	CDD:299850	41/179 (23%)
		CYCc	833..1060	CDD:214485	38/217 (18%)
		Nucleotidyl_cyc_III	861..1085	CDD:299850	32/172 (19%)
ADCY10	NP_060887.2	CHD	40..214	CDD:143636
		AcyC	<42..197	CDD:225025
		CHD	292..461	CDD:143636	44/193 (23%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900