DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment ACXC and gucy1b2

DIOPT Version :9

Sequence 1:	NP_609593.1	Gene:	ACXC / 34689	FlyBaseID:	FBgn0040508	Length:	1130	Species:	Drosophila melanogaster
Sequence 2:	XP_685297.5	Gene:	gucy1b2 / 557191	ZFINID:	ZDB-GENE-130530-664	Length:	757	Species:	Danio rerio

Alignment Length:	198	Identity:	56/198 - (28%)
Similarity:	98/198 - (49%)	Gaps:	24/198 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly   265 LLDSILPPQIAKPVQEKIKSKITQSENSPDRFQMGPRTTESFMAIQIHPDVSILYADVVNYTHLT 329
            ||.::||..:|..::|                  |.|.......:     .:||::|||.:|::.
Zfish   440 LLYAMLPTHVANQLKE------------------GKRVEAGEFKV-----CTILFSDVVTFTNIC 481

  Fly   330 TTLTVGNLVKVLHDLYGRFDIAASNFKVQRIKFLGDCYYCVAGLTTPDPDHAKCCVSLGISMISN 394
            .......:|.:|:.:|.|||...|...|.:::.:||.|..|.|:..|...||:...:..:.|...
Zfish   482 AACEPIQIVNMLNAMYSRFDRLTSIHNVYKVETIGDAYMVVGGVPVPTNTHAERVANFALGMRIA 546

  Fly   395 IQEV-RAERGLDIDMRIGVHSGSLLAGIIGEAKLQFDIWGTDVEIANHLESTGEPGYVHVSGRTL 458
            .:|| ....|..|.:|:|:|:|.:|||::||...::.::|..|..|:.:||.|.|.::|||..|.
Zfish   547 AREVTNPITGQPIQIRVGLHTGPVLAGVVGEKMPRYCLFGDTVNTASRMESHGVPDHIHVSPFTF 611

  Fly   459 SML 461
            |::
Zfish   612 SVI 614

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ACXC	NP_609593.1	AC_N	<33..285	CDD:292831	6/19 (32%)
		CYCc	293..468	CDD:214485	50/170 (29%)
		Nucleotidyl_cyc_III	307..466	CDD:299850	48/156 (31%)
		CYCc	833..1060	CDD:214485
		Nucleotidyl_cyc_III	861..1085	CDD:299850
gucy1b2	XP_685297.5	HNOB	2..163	CDD:285002
		CAF-1_p150	<166..277	CDD:288454
		HNOBA	269..453	CDD:285003	5/12 (42%)
		CYCc	432..618	CDD:214485	56/198 (28%)
		Guanylate_cyc	459..642	CDD:278633	48/161 (30%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.810