DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ACXC and Adcy4

DIOPT Version :9

Sequence 1:	NP_609593.1	Gene:	ACXC / 34689	FlyBaseID:	FBgn0040508	Length:	1130	Species:	Drosophila melanogaster
Sequence 2:	NP_062158.2	Gene:	Adcy4 / 54223	RGDID:	2034	Length:	1072	Species:	Rattus norvegicus

Alignment Length:	1187	Identity:	312/1187 - (26%)
Similarity:	507/1187 - (42%)	Gaps:	293/1187 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly    51 YY----QVRLMVSNLTIFYVLFIILAM---------------SFLTIELLYVQHYNAVFFNFVIR 96
            ||    |..|::  |.:..||..|:|:               ||||..|..:..::
  Rat    20 YYSLSQQYPLLI--LLLVIVLCAIVALPAVAWASGRELTSDPSFLTTVLCALGGFS--------- 73

  Fly    97 VVSTILVLTVLSINFCEKFVSRHRWVMIASSVLSVYLVVLTDIVMISYHF-----YKNDWPLNTS 156
                      |.:....:.....||....|.::...|:.|      .|.|     ..:.|. ..|
  Rat    74 ----------LLLGLASREQQLQRWTRPLSGLIWAALLAL------GYGFLFTGGVVSAWD-QVS 121

  Fly   157 FDVFTLCMIYMFLPIPSIKGAAL-LASSVSLIYVAFFMHSLTFNAVYTDRDSFGYDVI----STD 216
            |.:|.:..:|..||:.....||. :.||:|        |.|........|.....|::    :..
  Rat   122 FFLFIIFTVYAMLPLGMRDAAAAGVISSLS--------HLLVLGLYLGWRPESQRDLLPQLAANA 178

  Fly   217 ILHNLGFNMMGIFFRIMNDTMVRASFLDR----HQFIMEETWLRHALLQESILLDSILPPQIAKP 277
            :|...| |::|.:.:.:.:..:||:|.:.    |.....:|..:|   ||.:|| ||||..:|:.
  Rat   179 VLFLCG-NVVGAYHKALMERALRATFREALSSLHSRRRLDTEKKH---QEHLLL-SILPAYLARE 238

  Fly   278 VQEKIKSKITQSENSPDRFQMGPRTTESFMAIQI--HPDVSILYADVVNYTHLTTTLTVGNLVKV 340
            ::.:|.:::...::|      .|..|.:|.::.:  |..||:||||:|.:|.|.:..:...||.:
  Rat   239 MKAEIMARLQAGQSS------RPENTNNFHSLYVKRHQGVSVLYADIVGFTRLASECSPKELVLM 297

  Fly   341 LHDLYGRFDIAASNFKVQRIKFLGDCYYCVAGLTTPDPDHAKCCVSLGISMISNIQEVRAERGLD 405
            |::|:|:||..|...:..|||.||||||||:||....||||..||.:|:.|...|:::|...|:|
  Rat   298 LNELFGKFDQIAKEHECMRIKILGDCYYCVSGLPLSLPDHAINCVRMGLDMCRAIRKLRVATGVD 362

  Fly   406 IDMRIGVHSGSLLAGIIGEAKLQFDIWGTDVEIANHLESTGEPGYVHVSGRTLSMLNPADYTILS 470
            |:||:||||||:|.|:||..|.|:|:|..||.:|||:|:.|.||.||::|.||::|..| |.: .
  Rat   363 INMRVGVHSGSVLCGVIGLQKWQYDVWSHDVTLANHMEAGGVPGRVHITGATLALLAGA-YAV-E 425

  Fly   471 GTQKAQSDPVLQYI--HTYL---------------------LTGQVARES-----FITSIGGVR- 506
            .......||.|:.:  .|||                     |.|...|.|     ::.|.|..:
  Rat   426 RADMEHRDPYLRELGEPTYLVIDPWAEEEDEKGTERGLLSSLEGHTMRPSLLMTRYLESWGAAKP 490

  Fly   507 ------------SSSVLEVK------SIDRIRSSRPSQSSMTDEFREEFRNMPVGGINLNSPCCR 553
                        :|:.|..|      |:||.|:.|.....:.....:.|:.:.    .|||
  Rat   491 FAHLSHVDSPASTSTPLPEKAFSPQWSLDRSRTPRGLHDELDTGDAKFFQVIE----QLNS---- 547

  Fly   554 RTRLDTHKKTQREIGIFCAAFKDSSLEWNYLHQPDFIFKSSMLLAWGIGCCLIYIQIVTNNFSCT 618
                ....|..::..:....|::..:|..|        :.|.|.|:.......:: :..:||:..
  Rat   548 ----QKQWKQSKDFNLLTLYFREKEMEKQY--------RLSALPAFKYYAACTFL-VFLSNFTIQ 599

  Fly   619 ACIVV---DLVTFFFLTSLL-------CLAWYKNVCWWKSGRYEFRIYGKYSCMAFHIFEKIQHS 673
            ..:..   .|.|.:.:|.||       |.:.:...|..|..:            ..|....:...
  Rat   600 MLVTTRPPALATTYSITFLLFLLLLFVCFSEHLTKCVQKGPK------------MLHWLPALSVL 652

  Fly   674 VSLR--ITVYLG----ILFSYYAVISLIMLNCDRDMYELSYIESKIYHYEMDRDTCFHPWVFTNM 732
            |:.|  :.|.||    :|....||:||:.|....|                    |  |::..|:
  Rat   653 VATRPGLRVALGTATILLVFTMAVVSLLFLPVSSD--------------------C--PFLAPNV 695

  Fly   733 ISLILGISYTFARIPFGLKIV-----ISCCETLAYL---LIVFFQF------------------- 770
            .|:....|:   .:|..|.::     :.|| .|.:|   |.:...|
  Rat   696 SSVAFNTSW---ELPASLPLISIPYSMHCC-VLGFLSCSLFLHMSFELKLLLLLLWLVASCSLFL 756

  Fly   771 -----------AFIFQHSATTTP--FMKAELAHCLRVCMMLLTMYAKERQSEFNTKMNYKLNVDL 822
                       |.::|.|..:.|  ..:.:|...:...:...|:....||:|:..::::.....|
  Rat   757 HSHAWLSDCLIARLYQGSLGSRPGVLKEPKLMGAIYFFIFFFTLLVLARQNEYYCRLDFLWKKKL 821

  Fly   823 QNKQKAADLTNQSIIILLNNILPSHVVDLYLNSLAKHE-LYYENYRMVSVMFAMLINFP------ 880
            :.:::..:.......:||.|:||:||...::....::| ||:::|..|.|:||.:.:|.
  Rat   822 RQEREETETMENLTRLLLENVLPAHVAPQFIGQNRRNEDLYHQSYECVCVLFASIPDFKEFYSES 886

  Fly   881 ----MNLPSLRVLNDIITQFDRLLTAYREYYVVEKIKVVGCTYMAACGLDFNLASNIRQTDHFRN 941
                ..|..||:||:||..||.||:. .::..|||||.:|.|||||.||:.....:.:|
  Rat   887 NINHEGLECLRLLNEIIADFDELLSK-PKFSGVEKIKTIGSTYMAATGLNATPGQDTQQ------ 944

  Fly   942 SSLHVEVEHARNHRMTDENYDSDMNNDEVVFIMTTFALDLMRTLAACNRAYSSSFFERSLSQGKI 1006
                 :.|.:.:|..|                |..||:.|...|...|:        .|.:..::
  Rat   945 -----DAERSCSHLGT----------------MVEFAVALGSKLGVINK--------HSFNNFRL 980

  Fly  1007 CIGISSGEIMAGVVGASQPHYDIWGNPVNMASRMESTGLPGHIQVTEESAKILQEFDIKCIYRGM 1071
            .:|::.|.::|||:||.:|.||||||.||:||||||||:.|.||||||:|:.||.....|..||:
  Rat   981 RVGLNHGPVVAGVIGAQKPQYDIWGNTVNVASRMESTGVLGKIQVTEETARALQSLGYTCYSRGV 1045

  Fly  1072 TFVKGRGDIPTYFVGID 1088
            ..|||:|.:.|||:..|
  Rat  1046 IKVKGKGQLCTYFLNTD 1062

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ACXC	NP_609593.1	AC_N	<33..285	CDD:292831	58/266 (22%)
		CYCc	293..468	CDD:214485	80/176 (45%)
		Nucleotidyl_cyc_III	307..466	CDD:299850	76/160 (48%)
		CYCc	833..1060	CDD:214485	83/237 (35%)
		Nucleotidyl_cyc_III	861..1085	CDD:299850	86/233 (37%)
Adcy4	NP_062158.2	AC_N	<115..246	CDD:292831	36/144 (25%)
		CYCc	219..422	CDD:214485	91/213 (43%)
		Guanylate_cyc	264..430	CDD:278633	77/167 (46%)
		DUF1053	479..580	CDD:283888	20/120 (17%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	498..523		6/24 (25%)
		CYCc	824..1039	CDD:214485	85/250 (34%)
		Guanylate_cyc	861..1060	CDD:278633	87/234 (37%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D181177at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR45627
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	5	4.920