DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ACXC and ACXA

DIOPT Version :9

Sequence 1:	NP_609593.1	Gene:	ACXC / 34689	FlyBaseID:	FBgn0040508	Length:	1130	Species:	Drosophila melanogaster
Sequence 2:	NP_620475.2	Gene:	ACXA / 53432	FlyBaseID:	FBgn0040510	Length:	1112	Species:	Drosophila melanogaster

Alignment Length:	1104	Identity:	703/1104 - (63%)
Similarity:	862/1104 - (78%)	Gaps:	23/1104 - (2%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 RTNSRKSPLKRKRLRPCHLDYANERLWEHSYLREKCKELNLEEEYRYYQVRLMVSNLTIFYVLFI 69
            :.|:.|:|. |:|.|.|:|:|.||||||.|||:.:||||:|||||..|::|||:|:||:|..:.|
  Fly     3 KKNTYKTPY-RERFRRCNLEYTNERLWEQSYLKARCKELHLEEEYMKYKIRLMISSLTVFVPMLI 66

  Fly    70 ILAMSFLTIELLYVQHYNAVFFNFVIRVVSTILVLTVLSINFCEKFVSRHRWVMIASSVLSVYLV 134
            :|.::...|...:.::...::.|.:..:.|.|||..:|||||.|.||.||||||..:|.||.|:|
  Fly    67 LLIVALQVIIWSFTEYTKYIYINAIFDLGSLILVTGLLSINFFEDFVIRHRWVMTFTSTLSAYVV 131

  Fly   135 VLTDIVMISYHFYKNDWPLNTSFDVFTLCMIYMFLPIPSIKGAALLASSVSLIYVAFFMHSLTFN 199
            ||.||...:|::||::|||||.:|||.||||||||||||.|.|||||.||||.||.:|:|.:.||
  Fly   132 VLGDIAFNTYYYYKSNWPLNTLYDVFVLCMIYMFLPIPSSKAAALLAISVSLTYVIYFIHFMAFN 196

  Fly   200 AVYTDRDSFGYDVISTDILHNLGFNMMGIFFRIMNDTMVRASFLDRHQFIMEETWLRHALLQESI 264
            .....:...|.|::|.|..|.|||||||||||||||||||:|||||:|||.||.|||.|..|||:
  Fly   197 EHNVAKYVHGLDIVSIDFFHYLGFNMMGIFFRIMNDTMVRSSFLDRYQFITEEIWLRQARRQESL 261

  Fly   265 LLDSILPPQIAKPVQEKIKSKITQSENSPDRFQMG-PRTTESFMAIQIHPDVSILYADVVNYTHL 328
            |||||||||||||:|:.||.||.|.:|  |.:.:| .||.|:||:||||.||||||||:||||.|
  Fly   262 LLDSILPPQIAKPIQKSIKEKIIQPDN--DFYHLGTSRTAENFMSIQIHNDVSILYADLVNYTQL 324

  Fly   329 TTTLTVGNLVKVLHDLYGRFDIAASNFKVQRIKFLGDCYYCVAGLTTPDPDHAKCCVSLGISMIS 393
            ||||||..|||||||||.|||:||.:|||||||||||||||||||...|||||...||||||||:
  Fly   325 TTTLTVEKLVKVLHDLYARFDLAALSFKVQRIKFLGDCYYCVAGLGESDPDHATMAVSLGISMIA 389

  Fly   394 NIQEVRAERGLDIDMRIGVHSGSLLAGIIGEAKLQFDIWGTDVEIANHLESTGEPGYVHVSGRTL 458
            ||:||...|.|:|.||||||||:|.||:||:||||:||||.||.||:.||:||.|||||||||||
  Fly   390 NIKEVSVNRSLNIGMRIGVHSGTLFAGVIGKAKLQYDIWGADVNIASRLEATGSPGYVHVSGRTL 454

  Fly   459 SMLNPADYTILSGTQKAQSDPVLQY--IHTYLLTGQVARESFITSIGGVRSSSVLE-VKSID--R 518
            |.||..:|.|..||:.||.|||||.  :.|||||.       |.|:...::.|::| |.::|  .
  Fly   455 SSLNAEEYNIYPGTESAQKDPVLQKHPMSTYLLTA-------IPSLDSDKTISIVEGVPNLDLQT 512

  Fly   519 IRSSRPSQ----SSMTDEFREEFRNMPVGGINLNSPCCRRTRLDTHKKTQREIGIFCAAFKDSSL 579
            :.|:|.||    :.::.|.|||||.|||||.....|..||.|...::|.:|::||||.||||.|:
  Fly   513 VGSNRKSQILKPNLLSHEMREEFRKMPVGGFKFQFPWSRRERNLKNEKVERDLGIFCVAFKDKSV 577

  Fly   580 EWNYLHQPDFIFKSSMLLAWGIGCCLIYIQIVTNNFSCTACIVVDLVTFFFLTSLLCLAWYKNVC 644
            |||||||||:|||.|:.|.|||||||||||.|.|:......:|::::.||.||.||.:.|||.||
  Fly   578 EWNYLHQPDYIFKYSVALGWGIGCCLIYIQSVNNSDIFYTGVVINIIAFFVLTFLLFICWYKKVC 642

  Fly   645 WWKSGRYEFRIYGKYSCMAFHIFEKIQHSVSLRITVYLGILFSYYAVISLIMLNCDRDMYELSYI 709
            ||.||:.|.|.|||.||..||:|||||||..||:|||:.|:..||.|||||:::|::|.|||..|
  Fly   643 WWHSGQNEHRSYGKLSCAIFHLFEKIQHSFVLRLTVYMMIILCYYMVISLILMSCEKDQYELDII 707

  Fly   710 ESKIYHYEMDRDTCFHPWVFTNMISLILGISYTFARIPFGLKIVISCCETLAYLLIVFFQFAFIF 774
            |||:|:|:||..||||||.:|||::||||:|||||||||.||..|.|.|.:.::|:|.||:||||
  Fly   708 ESKLYNYDMDPFTCFHPWAYTNMMALILGMSYTFARIPFALKTFIGCAEAVVFVLVVCFQYAFIF 772

  Fly   775 QHSATTTPFMKAELAHCLRVCMMLLTMYAKERQSEFNTKMNYKLNVDLQNKQKAADLTNQSIIIL 839
            :||.||:|::|||:||..||||||:||||||||||||||||||||:|||||||:||:||||||||
  Fly   773 EHSVTTSPYLKAEIAHSCRVCMMLITMYAKERQSEFNTKMNYKLNLDLQNKQKSADVTNQSIIIL 837

  Fly   840 LNNILPSHVVDLYLNSLAKHELYYENYRMVSVMFAMLINFPMNLPSLRVLNDIITQFDRLLTAYR 904
            ||||||||||::||:|:||||||||||||||||||||.||.|:||||||||||||.|||||:||:
  Fly   838 LNNILPSHVVEVYLSSIAKHELYYENYRMVSVMFAMLTNFQMDLPSLRVLNDIITAFDRLLSAYK 902

  Fly   905 EYYVVEKIKVVGCTYMAACGLDFNLASNIRQTDHFRNSSLHVEVEHARNHRMTDENYDSDMNNDE 969
            :||||||||||||||||||||||:|..|:....:|.::||..|:|..|:..   |:...:.|:||
  Fly   903 QYYVVEKIKVVGCTYMAACGLDFSLIENLDSNSNFGSTSLSSELEQVRSRL---ESSIKEKNHDE 964

  Fly   970 VVFIMTTFALDLMRTLAACNRAYSSSFFERSLSQGKICIGISSGEIMAGVVGASQPHYDIWGNPV 1034
            |.|||.||||||||.|:.||:||:...|:|:||.|:|.||||:|:||||||||||||||||||||
  Fly   965 VAFIMATFALDLMRVLSVCNKAYAGEPFDRALSTGEIRIGISTGQIMAGVVGASQPHYDIWGNPV 1029

  Fly  1035 NMASRMESTGLPGHIQVTEESAKILQEFDIKCIYRGMTFVKGRGDIPTYFVGIDENLKFMSAKL 1098
            |||||||||||.||||||:|:|:.|:|||:.|.|||:|||||||:|||||||||::|||||.|:
  Fly  1030 NMASRMESTGLSGHIQVTKETAQTLEEFDVMCYYRGLTFVKGRGEIPTYFVGIDKDLKFMSKKI 1093

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ACXC	NP_609593.1	AC_N	<33..285	CDD:292831	147/251 (59%)
		CYCc	293..468	CDD:214485	127/175 (73%)
		Nucleotidyl_cyc_III	307..466	CDD:299850	120/158 (76%)
		CYCc	833..1060	CDD:214485	163/226 (72%)
		Nucleotidyl_cyc_III	861..1085	CDD:299850	158/223 (71%)
ACXA	NP_620475.2	AC_N	<42..291	CDD:292831	145/250 (58%)
		CYCc	262..464	CDD:214485	147/203 (72%)
		Nucleotidyl_cyc_III	306..489	CDD:299850	133/182 (73%)
		CYCc	831..1055	CDD:214485	163/226 (72%)
		Nucleotidyl_cyc_III	859..1080	CDD:299850	158/223 (71%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45449934
Domainoid	1	1.000	187	1.000	Domainoid score	I6943
eggNOG	1	0.900	-	-		E1_COG2114
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG27505
OrthoDB	1	1.010	-	-		D181177at33208
OrthoFinder	1	1.000	-	-		FOG0007605
OrthoInspector	1	1.000	-	-		otm48748
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR45627
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	9	8.860