DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment ACXC and Gycalpha99B

DIOPT Version :9

Sequence 1:	NP_609593.1	Gene:	ACXC / 34689	FlyBaseID:	FBgn0040508	Length:	1130	Species:	Drosophila melanogaster
Sequence 2:	NP_477088.2	Gene:	Gycalpha99B / 43493	FlyBaseID:	FBgn0013972	Length:	676	Species:	Drosophila melanogaster

Alignment Length:	453	Identity:	101/453 - (22%)
Similarity:	169/453 - (37%)	Gaps:	108/453 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly   104 LTVLSINFCEKFVSRHRWVMIASSVLSVYLVVLTDIVMISYHFYKNDWPLNTSFDVFTLCMIYMF 168
            |.:.|.:||:.|    .|..|.:..|        ::|.:...|.|...|....|.    |....:
  Fly   259 LQMNSSSFCKMF----PWHFIMNEQL--------ELVQLGRGFSKLYKPYMADFG----CQATTY 307

  Fly   169 LPIPSIKGAAL-LASSVSLIYVAFFMHSLTFNAVYTDRDSFGYDV---------------ISTDI 217
            ......||..: ....|...|..|.: .|.......|..:.|.::               |.:..
  Fly   308 FDFKRPKGLTMKFRDIVRRTYTPFLI-GLNNPPGAVDFPAIGLEIKGQMVHCPESNSLLFIGSPF 371

  Fly   218 LHNL-GFNMMGIFFR-----------IMNDTMVRAS-----FLDRHQFIMEETWLRHALLQES-- 263
            |..| |....|:|..           |:.....||.     .:|:.:..:||.  ..|:.:|.
  Fly   372 LDGLDGLTCNGLFISDIPLHDATREVILVGEQARAQDGLRRRMDKIKNSIEEA--NSAVTKERKK 434

  Fly   264 --ILLDSILPPQIAKPVQEKIKSKITQSENSPDRFQMGPRTTESFMAIQIHPDVSILYADVVNYT 326
              .||..|.|.:||                  ::..:|     |.:..:.:|||:||::|:|.:|
  Fly   435 NVSLLHLIFPAEIA------------------EKLWLG-----SSIDAKTYPDVTILFSDIVGFT 476

  Fly   327 HLTTTLTVGNLVKVLHDLYGRFDIAASNFKVQRIKFLGDCYYCVAGLTTPDPDHAKCCVSLGISM 391
            .:.:..|...::.:|..||..||.....|.|.:::.:||.|...:||.......|.....:.:.|
  Fly   477 SICSRATPFMVISMLEGLYKDFDEFCDFFDVYKVETIGDAYCVASGLHRASIYDAHKVAWMALKM 541

  Fly   392 ISNIQEVRAERGLDIDMRIGVHSGSLLAGIIGEAKLQFDIWGTDVEIANHLESTGEPGYVHVSGR 456
            |....:.....|..|.||||:|:|::|||::|....::.::|..|.|||..||..|...::||..
  Fly   542 IDACSKHITHDGEQIKMRIGLHTGTVLAGVVGRKMPRYCLFGHSVTIANKFESGSEALKINVSPT 606

  Fly   457 TLSM----------LNPADYTIL-------SGTQKA-----------QSD-PVLQYIHTYLLT 490
            |...          |.|.|.:.|       .||:..           .|: |::::|:..:.|
  Fly   607 TKDWLTKHEGFEFELQPRDPSFLPKEFPNPGGTETCYFLESFRNPALDSELPLVEHINVSMKT 669

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ACXC	NP_609593.1	AC_N	<33..285	CDD:292831	42/217 (19%)
		CYCc	293..468	CDD:214485	52/184 (28%)
		Nucleotidyl_cyc_III	307..466	CDD:299850	49/168 (29%)
		CYCc	833..1060	CDD:214485
		Nucleotidyl_cyc_III	861..1085	CDD:299850
Gycalpha99B	NP_477088.2	HNOB	76..208	CDD:285002
		HNOBA	259..451	CDD:285003	42/228 (18%)
		CYCc	430..619	CDD:214485	56/211 (27%)
		Guanylate_cyc	457..647	CDD:278633	53/189 (28%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45453982
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	3	2.740