Protein Alignment ACXC and Adcy1

DIOPT Version :10

• Sequence 1: NP_609593.1
• Gene: ACXC / 34689
• FlyBaseID: FBgn0040508
• Length: 1130
• Species: Drosophila melanogaster
• Sequence 2: NP_001100709.1
• Gene: Adcy1 / 305509
• RGDID: 1309318
• Length: 967
• Species: Rattus norvegicus
• Alignment Length: 1023
• Identity: 273/1023 - (26%)
• Similarity: 450/1023 - (43%)
• Gaps: 227/1023 - (22%)

  Fly   159 VFTLCMI----YMFLPIPSIKGAALLASSVSLIYVAFFMHSLTFNAVYTDRDSFGYDVISTDILH 219
            |:.|.::    |..||:.|     |||....|:..|  .|.|...|:...:....:..:..:.|.
  Rat    10 VWQLLLVTFVSYALLPVRS-----LLAIGFGLVVAA--SHLLVTAALVPAKRPRLWRTLGANALL 67

  Fly   220 NLGFNMMGIFFRIMNDTMVRASFLDRHQFIMEETWLRHALLQESILLDSILPPQIAKPVQEKIKS 284
            ..|.||.|:|.||:.:...|.:||.....|.:...|.....::..||.|:||..:|..::|.
  Rat    68 FFGVNMYGVFVRILTERSQRKAFLQARNCIEDRLRLEDENEKQERLLMSLLPRNVAMEMKED--- 129

  Fly   285 KITQSENSPDRFQMGPRTTESFMAIQIHPDVSILYADVVNYTHLTTTLTVGNLVKVLHDLYGRFD 349
                       |...|......:.||.|.:||||:||:|.:|.|.:..|...|||:|::|:|:||
  Rat   130 -----------FLKPPERIFHKIYIQRHDNVSILFADIVGFTGLASQCTAQELVKLLNELFGKFD 183

  Fly   350 IAASNFKVQRIKFLGDCYYCVAGLTTPDPDHAKCCVSLGISMISNIQEVRAERGLDIDMRIGVHS 414
            ..|:....:|||.||||||||:|||.|..|||.|||.:|:.||..|..|.....:|::||:|:|:
  Rat   184 ELATENHCRRIKILGDCYYCVSGLTQPKTDHAHCCVEMGLDMIDTITSVAEATEVDLNMRVGLHT 248

  Fly   415 GSLLAGIIGEAKLQFDIWGTDVEIANHLESTGEPGYVHVSGRTLSMLNPADYTILSGTQKAQSDP 479
            |.:|.|::|..|.|:|:|..||.:||.:|:.|.||.||::..||:.|| .||.:..|....::..
  Rat   249 GRVLCGVLGLRKWQYDVWSNDVTLANVMEAAGLPGKVHITKTTLACLN-GDYEVEPGHGHERNTF 312

  Fly   480 VLQY-IHTYLLTGQVARESFITSI-GGVRSSSVLEVKSI-----------DRIRSSRPSQSSMT- 530
            :..: |.|:.:.....|:.|...| ..::.:..::.|::           ...::..|..:.||
  Rat   313 LRTHNIETFFIVPSHRRKIFPGLILSDIKPAKRMKFKTVCYLLVQLMHCRKMFKAEIPFSNVMTC 377

  Fly   531 --DEFR-------EEFRNMPVGGINL--NSPCCR----RTRLDTHKKTQRE---IGIFCAAFKDS 577
              |:.|       |:.||......|:  .:|..|    .:||...::|:.|   :..|...:|..
  Rat   378 EDDDKRRALRTASEKLRNRSSFSTNVVYTTPGTRVNRYISRLLEARQTELEMADLNFFTLKYKHV 442

  Fly   578 SLEWNYLHQPDFIFKSSMLLAWGIGCC--LIYIQIVTNNFSC------TACIVVDLVTFFFLTSL 634
            ..|..|....|..|.|:::||..:...  |||:.::..:.:.      :.|.:|....:..:|.:
  Rat   443 EREQKYHQLQDEYFTSAVVLALILATLFGLIYLLVIPQSVAVLLLLVFSICFLVACTLYLHITRV 507

  Fly   635 LCLAWYKNVCWWKSGRYEFRIYGKYSCMAFHIFEKIQHSVSLRITVYLGILFSYYAVISLIMLNC 699
            .|..                     .|:          ::.:|..:.:.|:...|:|....:::|
  Rat   508 QCFP---------------------GCL----------TIQIRTALCVFIVVLIYSVAQGCVVSC 541

  Fly   700 DRDMYELSYIESKIYHYEMDRDTCFHPWVF-----TNMISLILGISYTFARIPFGLKIVIS---- 755
                                     .||.:     ::::.|..|          |.:.|:.
  Rat   542 -------------------------LPWAWSSHSNSSLVVLAAG----------GRRTVLPALPC 571

  Fly   756 --------CCETLAYLLIVFFQFA----FIFQHSATTTPFMKAELAHCLRV------------CM 796
                    ||......|.:|.:.:    .|.....||:..:..||:...:|            .|
  Rat   572 ESAHHGLLCCLVGTLPLAIFLRVSSLPKMILLSGLTTSYILVLELSGYTKVGGGALSGRSYEPIM 636

  Fly   797 MLL----TMYAKERQSEFNTKMNYKLNVDLQNKQ---KAADLTNQSIIILLNNILPSHVVDLYLN 854
            .:|    |:....||.:...:::|......:.::   :...|.|:.|:.   |:||:||...:|.
  Rat   637 AILLFSCTLALHARQVDVRLRLDYLWAAQAEEERDDMERVKLDNKRILF---NLLPAHVAQHFLM 698

  Fly   855 SLAKH-ELYYENYRMVSVMFAMLINF----------PMNLPSLRVLNDIITQFDRLLTAYREYYV 908
            |..:: :|||::|..|.||||.:.||          .|.:..||:||:||..||.|:.  :::|.
  Rat   699 SNPRNMDLYYQSYSQVGVMFASIPNFNDFYIELDGNNMGVECLRLLNEIIADFDELMD--KDFYK 761

  Fly   909 -VEKIKVVGCTYMAACGLDFNLASNIRQTDHFRNSSLHVEVEHARNHRMTDENYDSDMNNDEVVF 972
             :||||.:|.|||||.||.....:..:     ::.|.|:..
  Rat   762 DLEKIKTIGSTYMAAVGLAPTAGTRAK-----KSISSHLST------------------------ 797

  Fly   973 IMTTFALDLMRTLAACNRAYSSSFFERSLSQGKICIGISSGEIMAGVVGASQPHYDIWGNPVNMA 1037
             :..||:|:...|...|....:.|..|        :||:.|.::|||:||.:|.||||||.||:|
  Rat   798 -LADFAIDMFDVLDEINYQSYNDFVLR--------VGINVGPVVAGVIGARRPQYDIWGNTVNVA 853

  Fly  1038 SRMESTGLPGHIQVTEESAKILQEFDIKCIYRGMTFVKGRGDIPTYFV 1085
            |||:|||:.|.||||||..::|.....:.:.||...|||:|::.|||:
  Rat   854 SRMDSTGVQGRIQVTEEVHRLLNRCSYQFVCRGKVSVKGKGEMLTYFL 901

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ACXC	NP_609593.1	Nucleotidyl_cyc_III	307..466	CDD:448371	75/158 (47%)
		Nucleotidyl_cyc_III	861..1085	CDD:448371	83/234 (35%)
Adcy1	NP_001100709.1	AC_N	<6..139	CDD:318454	36/149 (24%)
		Guanylate_cyc	141..323	CDD:425528	80/182 (44%)
		Guanylate_cyc	706..903	CDD:425528	84/236 (36%)