DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ACXC and GUCY2D

DIOPT Version :9

Sequence 1:	NP_609593.1	Gene:	ACXC / 34689	FlyBaseID:	FBgn0040508	Length:	1130	Species:	Drosophila melanogaster
Sequence 2:	NP_000171.1	Gene:	GUCY2D / 3000	HGNCID:	4689	Length:	1103	Species:	Homo sapiens

Alignment Length:	921	Identity:	185/921 - (20%)
Similarity:	305/921 - (33%)	Gaps:	337/921 - (36%)

- Green bases have known domain annotations that are detailed below.

  Fly   384 CVSLGISMISNIQEVRAERGLDIDMRIGVHS---GS------LLAGIIGEAKLQF-DIWGTDVEI 438
            |.|.| |::.:::..:..|.|..|:.:...|   |:      |||..:.||:... ..|.:...:
Human   315 CPSEG-SVLDSLRRAQERRELPSDLNLQQVSPLFGTIYDAVFLLARGVAEARAAAGGRWVSGAAV 378

  Fly   439 ANHLESTGEPGYVHVSGRTLSMLNPADYTILSGTQKAQSDPVLQYIHTYLLTGQVARESFI---T 500
            |.|:.....||:....|.     :.....:|..|..|..    :...||:|  ..||.||:   |
Human   379 ARHIRDAQVPGFCGDLGG-----DEEPPFVLLDTDAAGD----RLFATYML--DPARGSFLSAGT 432

  Fly   501 SIGGVRSSSVLEVKSIDRIRSSRPSQSSMTDEFREEFRNMPVGGINLNSPCCRRTRLDTHKKTQR 565
            .:...|..|           :..|..|...|.     .|:..||:
Human   433 RMHFPRGGS-----------APGPDPSCWFDP-----NNICGGGL-------------------- 461

  Fly   566 EIGIFCAAFKDSSLEWNYLHQPDFIFKSSMLLAWGIGCC-----------LIYIQIVT--NNFSC 617
                                :|..:| ...||..|:|..           |:::|:|:  |....
Human   462 --------------------EPGLVF-LGFLLVVGMGLAGAFLAHYVRHRLLHMQMVSGPNKIIL 505

  Fly   618 TACIVVDLVTFFFL---TSLLCLAWYKNVCWWKS-----------------GRYE-FRIYGKYSC 661
            |    ||.:||...   ||.......::....:|                 |.|| .|::.|...
Human   506 T----VDDITFLHPHGGTSRKVAQGSRSSLGARSMSDIRSGPSQHLDSPNIGVYEGDRVWLKKFP 566

  Fly   662 MAFHI---------FEKIQHSVSLRITVYLGILFS---------YYAVISLIMLNCDRDMYE--L 706
            ...||         |.|:|......:.:|||:..:         :...::::..:|.|...:  |
Human   567 GDQHIAIRPATKTAFSKLQELRHENVALYLGLFLARGAEGPAALWEGNLAVVSEHCTRGSLQDLL 631

  Fly   707 SYIESKIYHYEMDRDTCFHPWVFTN--MISLILGISYTFAR-IPFGLKIVISCCETLAYLLIV-- 766
            :..|.|:            .|:|.:  ::.||.||.|...| :..|.....:|.....::|.:
Human   632 AQREIKL------------DWMFKSSLLLDLIKGIRYLHHRGVAHGRLKSRNCIVDGRFVLKITD 684

  Fly   767 --------------------------------------------FFQFAFIFQH-SATTTPFMKA 786
                                                        .|..|.|.|. ...:.|:...
Human   685 HGHGRLLEAQKVLPEPPRAEDQLWTAPELLRDPALERRGTLAGDVFSLAIIMQEVVCRSAPYAML 749

  Fly   787 ELAH-------------CLRV---------CMMLLTMYAKERQSEFNTKMN-------------- 815
            ||..             |..:         |::|:.....| |.|....|:
Human   750 ELTPEEVVQRVRSPPPLCRPLVSMDQAPVECILLMKQCWAE-QPELRPSMDHTFDLFKNINKGRK 813

  Fly   816 -------------YKLNVD--LQNKQKAADLTNQSIIILLNNILPSHVVDLYLNSLAKHELYYEN 865
                         |..|::  ::.:.:..:|..|....||..:||..|.:...........|:|
Human   814 TNIIDSMLRMLEQYSSNLEDLIRERTEELELEKQKTDRLLTQMLPPSVAEALKTGTPVEPEYFE- 877

  Fly   866 YRMVSVMFAMLINF--------PMNLPSLRVLNDIITQFDRLLTAYREYYVVEKIKVVGCTYMAA 922
              .|::.|:.::.|        |:.:..|  |||:.|.||.::.::..|    |::.:|..||.|
Human   878 --QVTLYFSDIVGFTTISAMSEPIEVVDL--LNDLYTLFDAIIGSHDVY----KVETIGDAYMVA 934

  Fly   923 CGLDFNLASNIRQTDHFRNSSLHVEVEHARNHRMTDENYDSDMNNDEVVFIMTTFALDLMRTLAA 987
            .||.            .||...|.                :::.|         .:||::..:
Human   935 SGLP------------QRNGQRHA----------------AEIAN---------MSLDILSAV-- 960

  Fly   988 CNRAYSSSFFERSLSQ--GKICIGISSGEIMAGVVGASQPHYDIWGNPVNMASRMESTGLPGHIQ 1050
                  .:|..|.:.:  .:|.||:.||..:|||||.:.|.|.::|:.||.||||||||||..|.
Human   961 ------GTFRMRHMPEVPVRIRIGLHSGPCVAGVVGLTMPRYCLFGDTVNTASRMESTGLPYRIH 1019

  Fly  1051 VTEESAKILQEFD--IKCIYRGMTFVKGRGDIPTYFVGIDENLKFMSAKLVNRSLSRRFSVMSSL 1113
            |...:..||:..|  .:...||.|.:||:|...|::             ||.|   |.|:.....
Human  1020 VNLSTVGILRALDSGYQVELRGRTELKGKGAEDTFW-------------LVGR---RGFNKPIPK 1068

  Fly  1114 DPDSLRKSSSS 1124
            .|| |:..||:
Human  1069 PPD-LQPGSSN 1078

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ACXC	NP_609593.1	AC_N	<33..285	CDD:292831
		CYCc	293..468	CDD:214485	20/93 (22%)
		Nucleotidyl_cyc_III	307..466	CDD:299850	20/91 (22%)
		CYCc	833..1060	CDD:214485	63/236 (27%)
		Nucleotidyl_cyc_III	861..1085	CDD:299850	66/235 (28%)
GUCY2D	NP_000171.1	PBP1_sensory_GC_DEF-like	55..431	CDD:380594	30/127 (24%)
		PK_GC-2D	536..811	CDD:270945	43/287 (15%)
		HNOBA	<820..865	CDD:369471	9/44 (20%)
		CYCc	846..1036	CDD:214485	65/243 (27%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1065..1103		5/15 (33%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.900