DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment ACXC and GUCY1B1

DIOPT Version :9

Sequence 1:	NP_609593.1	Gene:	ACXC / 34689	FlyBaseID:	FBgn0040508	Length:	1130	Species:	Drosophila melanogaster
Sequence 2:	XP_011530203.1	Gene:	GUCY1B1 / 2983	HGNCID:	4687	Length:	662	Species:	Homo sapiens

Alignment Length:	228	Identity:	59/228 - (25%)
Similarity:	104/228 - (45%)	Gaps:	41/228 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly   265 LLDSILPPQIAKPVQEKIKSKITQSENSPDRFQMGPRTTESFMAIQIHPDVSILYADVVNYTHLT 329
            ||.|:|||.:|..::.|......:.:|                       |:||::.:|.:....
Human   436 LLYSVLPPSVANELRHKRPVPAKRYDN-----------------------VTILFSGIVGFNAFC 477

  Fly   330 TTLTVG----NLVKVLHDLYGRFDIAASNFK---VQRIKFLGDCYYCVAGLTTPDPDHAKCCVSL 387
            :....|    .:|.:|:|||.|||....:.|   |.:::.:||.|..|:||..|...||:....|
Human   478 SKHASGEGAMKIVNLLNDLYTRFDTLTDSRKNPFVYKVETVGDKYMTVSGLPEPCIHHARSICHL 542

  Fly   388 GISMISNIQEVRAERGLDIDMRIGVHSGSLLAGIIGEAKLQFDIWGTDVEIANHLESTGEPGYVH 452
            .:.|:....:|:.: |..:.:.||:|:|.::.|:||:...::.::|..|.:.:..|:|||.|.::
Human   543 ALDMMEIAGQVQVD-GESVQITIGIHTGEVVTGVIGQRMPRYCLFGNTVNLTSRTETTGEKGKIN 606

  Fly   453 VSGRTLSMLNPADYTILSGTQKAQSDPVLQYIH 485
            ||          :||.........|||.....|
Human   607 VS----------EYTYRCLMSPENSDPQFHLEH 629

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ACXC	NP_609593.1	AC_N	<33..285	CDD:292831	8/19 (42%)
		CYCc	293..468	CDD:214485	45/181 (25%)
		Nucleotidyl_cyc_III	307..466	CDD:299850	44/165 (27%)
		CYCc	833..1060	CDD:214485
		Nucleotidyl_cyc_III	861..1085	CDD:299850
GUCY1B1	XP_011530203.1	HNOB	2..166	CDD:311572
		HNOBA	207..449	CDD:311573	7/12 (58%)
		Guanylate_cyc	455..648	CDD:306677	51/209 (24%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810