DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ACXC and GUCY1A1

DIOPT Version :9

Sequence 1:	NP_609593.1	Gene:	ACXC / 34689	FlyBaseID:	FBgn0040508	Length:	1130	Species:	Drosophila melanogaster
Sequence 2:	NP_000847.2	Gene:	GUCY1A1 / 2982	HGNCID:	4685	Length:	690	Species:	Homo sapiens

Alignment Length:	480	Identity:	97/480 - (20%)
Similarity:	197/480 - (41%)	Gaps:	109/480 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly    75 FLTIELLYVQHYNAVFFNFVIRVVSTILVLTVLSI--------NFCEKFVSRHRWV--------- 122
            ||.:...:.:...::....:|:..:.:|..|.:.:        |.|.:||::...:
Human   199 FLHVYYFFPKRTTSLILPGIIKAAAHVLYETEVEVSLMPPCFHNDCSEFVNQPYLLYSVHMKSTK 263

  Fly   123 -MIASSVLSVYLVVLTDIVMISYHFY---------------------KNDWPLNTSFDVF----- 160
             .::.|.....||:.|.:...::.|:                     :.|:....:|:.:
Human   264 PSLSPSKPQSSLVIPTSLFCKTFPFHFMFDKDMTILQFGNGIRRLMNRRDFQGKPNFEEYFEILT 328

  Fly   161 -----TLCMIYMFLPIPSI-----------KGAALLASSVSLIYVAFFMHSLTFNAVYTDR--DS 207
                 |...|...|.:..:           |.:.::.....:||:......|...:...||  |.
Human   329 PKINQTFSGIMTMLNMQFVVRVRRWDNSVKKSSRVMDLKGQMIYIVESSAILFLGSPCVDRLEDF 393

  Fly   208 FGYDVISTDI-LHNLGFNMM----------GIFFRIMNDTMVRASFLDRHQFIMEETWLRHALLQ 261
            .|..:..:|| :||...:::          |:..|:   ..::|:....||.:.||.       :
Human   394 TGRGLYLSDIPIHNALRDVVLIGEQARAQDGLKKRL---GKLKATLEQAHQALEEEK-------K 448

  Fly   262 ESI-LLDSILPPQIAKPVQEKIKSKITQSENSPDRFQMGPRTTESFMAIQIHPDVSILYADVVNY 325
            ::: ||.||.|.::|   |:..:.::.|::    :|.                :|::|::|:|.:
Human   449 KTVDLLCSIFPCEVA---QQLWQGQVVQAK----KFS----------------NVTMLFSDIVGF 490

  Fly   326 THLTTTLTVGNLVKVLHDLYGRFDIAASNFKVQRIKFLGDCYYCVAGLTTPDPD-HAKCCVSLGI 389
            |.:.:..:...::.:|:.||.|||.......|.:::.:||. |||||....:.| ||.....:.:
Human   491 TAICSQCSPLQVITMLNALYTRFDQQCGELDVYKVETIGDA-YCVAGGLHKESDTHAVQIALMAL 554

  Fly   390 SMISNIQEVRAERGLDIDMRIGVHSGSLLAGIIGEAKLQFDIWGTDVEIANHLESTGEPGYVHVS 454
            .|:....||.:..|..|.||||:||||:.||::|....::.::|.:|.:||..||...|..::||
Human   555 KMMELSDEVMSPHGEPIKMRIGLHSGSVFAGVVGVKMPRYCLFGNNVTLANKFESCSVPRKINVS 619

  Fly   455 GRTLSMLNPADYTILSGTQKAQSDP 479
            ..|..:|......:.:...:.:..|
Human   620 PTTYRLLKDCPGFVFTPRSREELPP 644

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ACXC	NP_609593.1	AC_N	<33..285	CDD:292831	45/283 (16%)
		CYCc	293..468	CDD:214485	50/175 (29%)
		Nucleotidyl_cyc_III	307..466	CDD:299850	49/159 (31%)
		CYCc	833..1060	CDD:214485
		Nucleotidyl_cyc_III	861..1085	CDD:299850
GUCY1A1	NP_000847.2	HNOBA	277..466	CDD:400168	33/201 (16%)
GUCY1A1	NP_000847.2	Guanylate_cyc	472..643	CDD:306677	51/191 (27%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810