DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ACXC and Adcy8

DIOPT Version :9

Sequence 1:	NP_609593.1	Gene:	ACXC / 34689	FlyBaseID:	FBgn0040508	Length:	1130	Species:	Drosophila melanogaster
Sequence 2:	NP_058838.1	Gene:	Adcy8 / 29241	RGDID:	2036	Length:	1248	Species:	Rattus norvegicus

Alignment Length:	1157	Identity:	332/1157 - (28%)
Similarity:	518/1157 - (44%)	Gaps:	210/1157 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly    22 HLDYA--NERLW---EHSY-------LREKCKELNLEEEYRYYQVRLMVSNLTIFYVLFIILAMS 74
            |||.|  |...:   .:||       ||...|..:||..|:.|.:.....:..:..||.::..::
  Rat   128 HLDCAPSNSDFFLNGGYSYRGVIFPTLRNSFKSRDLERLYQRYFLGQRRKSEVVMNVLDVLTKLT 192

  Fly    75 FLTIELLY----VQHYNAVFFNFVIRVVSTILVLTVLSINFCEKFVSRHRWVMIASSVLSVYLVV 135
            .|.:.|..    :.....:...|...:...|..|.|:     .|..:.|.::..:..|  .::.:
  Rat   193 LLVLHLSLASAPMDPLKGILLGFFTGIEVVICALVVV-----RKDTTSHTYLQYSGVV--TWVAM 250

  Fly   136 LTDIVM--ISYHFYKNDWPLNTSFDVFTLCMIYMFLPIPSIKGAALLASSVSLIYVAFFMHSLTF 198
            .|.|:.  :.|....:    ...:.:|||...|..||:| :..|.|.....||:.|       |.
  Rat   251 TTQILAAGLGYGLLGD----GIGYVLFTLFATYSMLPLP-LTWAILAGLGTSLLQV-------TL 303

  Fly   199 NAVYTDRDSFGYDVISTDILHNLGFNMMGIFFRIMNDTMVRASFLDRHQFIMEETWLRHALLQES 263
            ..:......|..:.:...::..:..|..|||...::|...|.:||:..:.:.....|.....::.
  Rat   304 QVLIPRLAVFSINQVLAQVVLFMCMNTAGIFISYLSDRAQRQAFLETRRCVEARLRLETENQRQE 368

  Fly   264 ILLDSILPPQIAKPVQEKIKSKITQSENSPDRFQMGPRTTESFMAIQIH--PDVSILYADVVNYT 326
            .|:.|:||..:   |.|.| :.:|..|:...:.|        |..|.||  .:||||:|||..:|
  Rat   369 RLVLSVLPRFV---VLEMI-NDMTNVEDEHLQHQ--------FHRIYIHRYENVSILFADVKGFT 421

  Fly   327 HLTTTLTVGNLVKVLHDLYGRFDIAASNFKVQRIKFLGDCYYCVAGLTTPDPDHAKCCVSLGISM 391
            :|:|||:...||::|::|:.|||..|......|||.||||||||:||..|..|||.|||.:|:||
  Rat   422 NLSTTLSAQELVRMLNELFARFDRLAHEHHCLRIKILGDCYYCVSGLPEPRQDHAHCCVEMGLSM 486

  Fly   392 ISNIQEVRAERGLDIDMRIGVHSGSLLAGIIGEAKLQFDIWGTDVEIANHLESTGEPGYVHVSGR 456
            |..|:.||:....|:|||||:||||:|.|::|..|.|||:|..||:|||.|||.|.||.:|:|..
  Rat   487 IKTIRFVRSRTKHDVDMRIGIHSGSVLCGVLGLRKWQFDVWSWDVDIANKLESGGIPGRIHISKA 551

  Fly   457 TLSMLNPADYTILSGTQKAQSDPVLQY-IHTYL----------LTGQVARESFITSIGGVRSSSV 510
            ||..|: .||.:..|..|.:::.:.:: |.|||          |...:.:||  .|....|:|..
  Rat   552 TLDCLS-GDYNVEEGHGKERNEFLRKHNIETYLIKQPEESLLSLPEDIVKES--VSCSDRRNSGA 613

  Fly   511 LEVKS-------IDRIRSSRPSQSSMTDEFREEFRNMP----------VGGINLNSPCCRRTRLD 558
            ...:.       .|.|...:.:.:::|   |.....:|          .|...:|........|.
  Rat   614 TFTEGSWSPELPFDNIVGKQNTLAALT---RNSINLLPNHLAQALHVQSGPEEINKRIEHTIDLR 675

  Fly   559 THKKTQRE-IGIFCAAFKDSSLEWNYLHQPDFIFKSSMLLAWGIGCCLIYIQIV----------- 611
            :..|.:|| |..|...|||||||..|....|.:|||:::.|:.:   |::|..:
  Rat   676 SGDKLRREHIKPFSLMFKDSSLEHKYSQMRDEVFKSNLVCAFIV---LLFITAIQSLLPSSRLMP 737

  Fly   612 -TNNFSCTACIVVDLVTFFFLTSLLCLAW-YKNVCWWKSGRYEFRIYGKYSCMAFHIFEKIQHSV 674
             |..||....:...||.........||.. .:..|.|.:..|                      :
  Rat   738 MTIQFSILIMLHSALVLITTAEDYKCLPLILRKTCCWINETY----------------------L 780

  Fly   675 SLRITVYLGILFSYY-AVISLIMLNCDRD----MYELSYIESKIYHYEMDRDTCFHP--WVFTNM 732
            :..:.::..||.::. |||:::.  ||.|    :..|::..|.::     .|.|.:|  :|||.:
  Rat   781 ARNVIIFASILINFLGAVINILW--CDFDKSIPLKNLTFNSSAVF-----TDICSYPEYFVFTGV 838

  Fly   733 ISLILGISYTFARIPFGLKIVISCCETLAYLLIVFFQFAFIF------QHSATTTPFMKAELAHC 791
            ::::  ....|.|:...||:.:.......|.|:....:|.:|      .||.  ..|:..:.|..
  Rat   839 LAMV--TCAVFLRLNSVLKLAVLLIMIAIYALLTETIYAGLFLSYDNLNHSG--EDFLGTKEASL 899

  Fly   792 LRVCMMLLTMYAKERQSEFNTKMNYKLNVDLQ---NKQKAADLTNQSIIILLNNILPSHVVDLYL 853
            |.:.|.||.::...:|.|:..::::...|..:   |:.|.....|::   :|.||||.||...:|
  Rat   900 LLMAMFLLAVFYHGQQLEYTARLDFLWRVQAKEEINEMKDLREHNEN---MLRNILPGHVARHFL 961

  Fly   854 -NSLAKHELYYENYRMVSVMFAMLINF-------PMN---LPSLRVLNDIITQFDRLLTAYREYY 907
             ......|||.::|..|.||||.:..|       .||   :..||:||:||..||.||...| :.
  Rat   962 EKDRDNEELYSQSYDAVGVMFASIPGFADFYSQTEMNNQGVECLRLLNEIIADFDELLGEDR-FQ 1025

  Fly   908 VVEKIKVVGCTYMAACGLDFNLASNIRQTDHFRNSSLHVEVEHARNHRMTDENYDSDMNNDEVVF 972
            .:||||.:|.||||..||                |....:.|....|                :.
  Rat  1026 DIEKIKTIGSTYMAVSGL----------------SPEKQQCEDKWGH----------------LC 1058

  Fly   973 IMTTFALDLMRTLAACNRAYSSSFFERSLSQGKICIGISSGEIMAGVVGASQPHYDIWGNPVNMA 1037
            .:..|:|.|..::...|: :|.:.||       :.||||.|.::|||:||.:|.|||||..||:|
  Rat  1059 ALADFSLALTESIQEINK-HSFNNFE-------LRIGISHGSVVAGVIGAKKPQYDIWGKTVNLA 1115

  Fly  1038 SRMESTGLPGHIQVTEESAKILQEFDIKCIYRGMTFVKG----RGDIPTYFV 1085
            |||:|||:.|.|||.||:..||::......|||..:|||    .|.|.|||:
  Rat  1116 SRMDSTGVSGRIQVPEETYLILKDQGFAFDYRGEIYVKGISEQEGKIKTYFL 1167

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ACXC	NP_609593.1	AC_N	<33..285	CDD:292831	53/264 (20%)
		CYCc	293..468	CDD:214485	88/176 (50%)
		Nucleotidyl_cyc_III	307..466	CDD:299850	84/160 (53%)
		CYCc	833..1060	CDD:214485	85/237 (36%)
		Nucleotidyl_cyc_III	861..1085	CDD:299850	86/237 (36%)
Adcy8	NP_058838.1	Involved in ORAI1, STIM1, PPP2CA and PPP2R1A interaction. /evidence=ECO:0000269\|PubMed:16258073, ECO:0000269\|PubMed:22494970, ECO:0000269\|PubMed:22976297	1..179		14/50 (28%)
		Involved in AKAP5 and PRKAR2A interaction. /evidence=ECO:0000269\|PubMed:22976297	1..106
		Essential for CALM1 interaction. /evidence=ECO:0000269\|PubMed:16258073	38..40
		Essential for CALM1 interaction. /evidence=ECO:0000269\|PubMed:16258073	49..51
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	51..117
		AC_N	<158..397	CDD:292831	51/261 (20%)
		CYCc	363..561	CDD:214485	96/210 (46%)
		Guanylate_cyc	402..586	CDD:278633	92/184 (50%)
		DUF1053	614..708	CDD:283888	22/96 (23%)
		CYCc	941..1145	CDD:214485	86/247 (35%)
		Guanylate_cyc	970..1169	CDD:278633	87/239 (36%)
		Involved in CALM1 interaction. /evidence=ECO:0000269\|PubMed:16258073	1106..1248		32/62 (52%)
		Required for both calcium stimulation and maintenance of autoinhibition. /evidence=ECO:0000269\|PubMed:19305019	1197..1212
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1220..1248
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810