Protein Alignment ACXC and Adcy6

DIOPT Version :10

• Sequence 1: NP_609593.1
• Gene: ACXC / 34689
• FlyBaseID: FBgn0040508
• Length: 1130
• Species: Drosophila melanogaster
• Sequence 2: NP_001257714.1
• Gene: Adcy6 / 25289
• RGDID: 2035
• Length: 1180
• Species: Rattus norvegicus
• Alignment Length: 1185
• Identity: 308/1185 - (25%)
• Similarity: 518/1185 - (43%)
• Gaps: 233/1185 - (19%)

  Fly     4 PRTNSRKSPLKRKRLRPCHLDYANERLWEHSYLREKCKELNLEEEYRYYQVRLMVSNLTIFYVLF 68
            |.|:.|..|....||             ...:..::.:...||..|:.|..::..|:||:...:.
  Rat   120 PDTSPRSGPSCWHRL-------------AQVFQSKQFRSAKLERLYQRYFFQMNQSSLTLLMAVL 171

  Fly    69 IILAMSFLTIELLYVQHYNAVFFNFVIRVVSTILVLTVLSINFCEKFV--SRHRWVMIASSVLSV 131
            ::|....||..........|.           :.:||..|:.|....|  :||.:...:..|:|.
  Rat   172 VLLMAVLLTFHAAPALPQPAY-----------VALLTCASVLFVVLMVVCNRHSFRQDSMWVVSY 225

  Fly   132 YLVVLTDIVMISYHFYKNDWPLNTS----FDVFTLCMIYMFLPIPSIKGAALLASSVSLIYVAFF 192
            .::.:...|.:......|  |.:.|    ..||.:.:.|..||| .::.|.|....:|.:::...
  Rat   226 VVLGILAAVQVGGALAAN--PRSPSAGLWCPVFFVYITYTLLPI-RMRAAVLSGLGLSTLHLILA 287

  Fly   193 MHSLTFNAVYTDRDSFGYDVISTDILHNLGFNMMGIFFRIMNDTMVRASFLDRHQFIMEETWLRH 257
            .|       ..:.|.|.:..:..:::..|..|.:|:......:...|.:|.:...:|.....|:|
  Rat   288 WH-------LNNGDPFLWKQLGANVVLFLCTNAIGVCTHYPAEVSQRQAFQETRGYIQARLHLQH 345

  Fly   258 ALLQESILLDSILPPQIAKPVQEKIKSKITQSENSPDRFQMGPRTTESFM----AIQIHPDVSIL 318
            ...|:..||.|:||..:|..::|.|.:|                 .|..|    .||.|.:||||
  Rat   346 ENRQQERLLLSVLPQHVAMEMKEDINTK-----------------KEDMMFHKIYIQKHDNVSIL 393

  Fly   319 YADVVNYTHLTTTLTVGNLVKVLHDLYGRFDIAASNFKVQRIKFLGDCYYCVAGLTTPDPDHAKC 383
            :||:..:|.|.:..|...||..|::|:.|||..|:.....|||.||||||||:||.....|||.|
  Rat   394 FADIEGFTSLASQCTAQELVMTLNELFARFDKLAAENHCLRIKILGDCYYCVSGLPEARADHAHC 458

  Fly   384 CVSLGISMISNIQEVRAERGLDIDMRIGVHSGSLLAGIIGEAKLQFDIWGTDVEIANHLESTGEP 448
            ||.:|:.||..|..||...|::::||:|:|||.:..|::|..|.|||:|..||.:|||:|:.|..
  Rat   459 CVEMGVDMIEAISLVREVTGVNVNMRVGIHSGRVHCGVLGLRKWQFDVWSNDVTLANHMEAGGRA 523

  Fly   449 GYVHVSGRTLSMLNPADYTILSGTQKAQSDPVL--QYIHTYLLTG--QVARE--SFITSIGGVRS 507
            |.:|::..||..|| .||.:..| :..:.:..|  |.|.|:|:.|  |..:|  :.:..:...|:
  Rat   524 GRIHITRATLQYLN-GDYEVEPG-RGGERNAYLKEQCIETFLILGASQKRKEEKAMLVKLQRTRA 586

  Fly   508 SSV-------LEVKSIDRIRSSRPSQSSMTDEFREEFRNMPVG-----------GINLNSPCCRR 554
            :|:       :..::..|.:.|:..:....|:..:|.|.....           |..:::....:
  Rat   587 NSMEGLMPRWVPDRAFSRTKDSKAFRQMGIDDSSKENRGAQDALNPEDEVDEFLGRAIDARSIDQ 651

  Fly   555 TRLDTHKKTQREIGIFCAAFKDSSLEWNYLHQPDFIFKSSMLLAWGIGCCLIYIQIVTNNFSCTA 619
            .|.|..::       |...|:...||..|..:.|..|.:.:..|..:.|.:.:||.:.  |..:|
  Rat   652 LRKDHVRR-------FLLTFQREDLEKKYSRKVDPRFGAYVACALLVFCFICFIQFLV--FPHSA 707

  Fly   620 CIVVDLVTFFFL---TSLLCLAWYKNVCWWKSGRYEFRIYGKYSCMAF--HIFEKIQHSV----- 674
            .|:......|.|   |.|:|.     ||               ||.:|  :..:::..|:
  Rat   708 LILGIYAGIFLLLLVTVLICA-----VC---------------SCGSFFPNALQRLSRSIVRSRV 752

  Fly   675 -SLRITVYLGILFSYYAVISLI-------------MLN--------CDRDMYELSY---IESKIY 714
             |..:.|:..:|....|:.::.             |||        |  .:.:|:|   :|:.:
  Rat   753 HSTAVGVFSVLLVFISAIANMFTCSHTPLRTCAARMLNLTPSDVTAC--HLRQLNYSLGLEAPL- 814

  Fly   715 HYEMDRDTCFHPWVFTNMISLILGISYTFARIPFGLKIVISCCETLAYLLIVFF-QFAFIFQH-- 776
             .|....||..|..|...:.|.|..|..|..|....|:|::......|||::.. ..|.||.:
  Rat   815 -CEGTAPTCSFPEYFVGSVLLSLLASSVFLHISSIGKLVMTFVLGFIYLLLLLLGPPATIFDNYD 878

  Fly   777 ---------SATTT------PFM-KAELAHCLRVCMML--LTMYAKERQSEFNTKMNYKLNVDLQ 823
                     |:..|      |.: :..|.:...|.:::  |.:|...:|.|...::::...:...
  Rat   879 LLLSVHGLASSNETFDGLDCPAVGRVALKYMTPVILLVFALALYLHAQQVESTARLDFLWKLQAT 943

  Fly   824 NKQKAADLTNQSIIILLNNILPSHVVDLYL-NSLAKHELYYENYRMVSVMFAMLINFP------- 880
            .:::..:........||:||||..|...:| ......||||::...|:||||.:.||.
  Rat   944 GEKEEMEELQAYNRRLLHNILPKDVAAHFLARERRNDELYYQSCECVAVMFASIANFSEFYVELE 1008

  Fly   881 ---MNLPSLRVLNDIITQFDRLLTAYREYYVVEKIKVVGCTYMAACGLDFNLASNIRQTDHFRNS 942
               ..:..||:||:||..||.:::..| :..:||||.:|.|||||.||               |:
  Rat  1009 ANNEGVECLRLLNEIIADFDEIISEER-FRQLEKIKTIGSTYMAASGL---------------NA 1057

  Fly   943 SLHVEVEHARNHRMTDENYDSDMNNDEVVFIMTTFALDLMRTLAACNRAYSSSFFERSLSQGKIC 1007
            |.:.:|  .|:|                :..:..:|:.||..:...|        |.|.:..::.
  Rat  1058 STYDQV--GRSH----------------ITALADYAMRLMEQMKHIN--------EHSFNNFQMK 1096

  Fly  1008 IGISSGEIMAGVVGASQPHYDIWGNPVNMASRMESTGLPGHIQVTEESAKIL--QEFDIKCIYRG 1070
            ||::.|.::|||:||.:|.||||||.||::|||:|||:|..||||.:..::|  :.:.::|  ||
  Rat  1097 IGLNMGPVVAGVIGARKPQYDIWGNTVNVSSRMDSTGVPDRIQVTTDLYQVLAAKGYQLEC--RG 1159

  Fly  1071 MTFVKGRGDIPTYFV 1085
            :..|||:|::.|||:
  Rat  1160 VVKVKGKGEMTTYFL 1174

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ACXC	NP_609593.1	Nucleotidyl_cyc_III	307..466	CDD:448371	73/162 (45%)
		Nucleotidyl_cyc_III	861..1085	CDD:448371	80/235 (34%)
Adcy6	NP_001257714.1	AC_N	28..380	CDD:318454	62/310 (20%)
		Guanylate_cyc	382..566	CDD:425528	80/185 (43%)
		Adcy_cons_dom	594..681	CDD:461877	14/93 (15%)
		Guanylate_cyc	982..1176	CDD:425528	81/237 (34%)