Protein Alignment ACXC and Gucy1b2

DIOPT Version :9

• Sequence 1: NP_609593.1
• Gene: ACXC / 34689
• FlyBaseID: FBgn0040508
• Length: 1130
• Species: Drosophila melanogaster
• Sequence 2: NP_001257640.1
• Gene: Gucy1b2 / 25206
• RGDID: 2770
• Length: 742
• Species: Rattus norvegicus
• Alignment Length: 908
• Identity: 169/908 - (18%)
• Similarity: 301/908 - (33%)
• Gaps: 350/908 - (38%)

  Fly   282 IKSKITQSENSPDRFQMGPRTTESFMAIQIHPDVSILYADVVNYTHLTTTLTVGNLVKVLHDLYG 346
            ::|.:|:        :.|..|.|...|.....||.:.|   ..|..:.|...:....|||
  Rat     9 LQSLVTE--------KFGEETWEKLKASAEVQDVFMTY---TVYDDIITIKLIQEACKVL----- 57

  Fly   347 RFDIAASNFKVQRIKFLGDCYYCVAGLTTPDPDHAKCCVSLG---ISMISNI-----------QE 397
              |::....    :|..|:.::....::..|    :...:||   ...|.|:           ||
  Rat    58 --DVSMEAI----LKLFGEYFFKFCKMSGYD----RMLRTLGGNLTEFIENLDALHSYLALSYQE 112

  Fly   398 V-----RAERGLDIDMRIGVHSG-----SLLAGIIGEAKLQFDIWGTDV-----EIANHLESTGE 447
            :     |.|.|.|..|.:..:|.     .::.||| ||..: |.:.|||     ::...:|.||:
  Rat   113 MNAPSFRVEEGADGAMLLHYYSDRHGLCHIVPGII-EAVAK-DFFDTDVAMSILDMNEEVERTGK 175

  Fly   448 PGYVHVSGRTLSMLNPADYTILSGTQKAQSDPVLQYIHTYLLTGQVARESFITSIGGVRSSSVLE 512
                            .::.:....|||.
  Rat   176 ----------------KEHVVFLVVQKAH------------------------------------ 188

  Fly   513 VKSIDRIRSSRP--SQSSMTDE---------FREEFRNMPV-GGINLNSPCCRRTRL-------D 558
             :.|...::|||  |:.|..|:         .:|.:.|:|| .|...:|...|.:.|       |
  Rat   189 -RQIRGAKASRPQGSEDSQADQEALQGTLLRMKERYLNIPVCPGEKSHSTAVRASVLFGKGPLRD 252

  Fly   559 THKKT--QR---EIGIFCAAFKDSSLEWNYLHQPDFIFKSSMLLAW-GIGCCLIYIQIVTNNFSC 617
            |.:..  :|   |..:||.||.        .|   .:|..::.:.. |:........|:|..|:.
  Rat   253 TFQPVYPERLWVEEEVFCDAFP--------FH---IVFDEALRVKQAGVNIQKYVPGILTQKFAL 306

  Fly   618 TA--CIVVDLVTF------FFLTSLLCLAWYK-----------------NVCWWKSGRYEFRIYG 657
            ..  .|:...|||      .|:.|...|...|                 .:.|.:|.|
  Rat   307 DEYFSIIHPQVTFNISSICKFINSQFVLKTRKEMMPKARKSQPMLKLRGQMIWMESLR------- 364

  Fly   658 KYSCMAFHIFEKIQHSVSLRITVYLGILFSYYAVISLIMLNCDRDMYELSYIESKIYHYEMDRDT 722
               ||.|....|:                              |.:.||.  |||::
  Rat   365 ---CMIFMCSPKL------------------------------RSLQELE--ESKMH-------- 386

  Fly   723 CFHPWVFTNMISLILGISYTFARIPFGLKIVISCCETLAYLLIVFFQFAFIFQHSATTTPFMKAE 787
                                                           .:.|..|..|....
  Rat   387 -----------------------------------------------LSDIAPHDTTRDLI---- 400

  Fly   788 LAHCLRVCMMLLTMYAKERQSEFNTKMNYKLNVDLQNKQKAADLTNQSIIILLNNILPSHVVDLY 852
            |.:..|:..|.|:...::::.|.....|:     |..::|..:       .||..:||.||.
  Rat   401 LLNQQRLAEMELSCQLEKKKEELRVLSNH-----LAIEKKKTE-------TLLYAMLPEHVA--- 450

  Fly   853 LNSLAK-HELYYENYRMVSVMFAMLINF--------PMNLPSLRVLNDIITQFDRLLTAYREYYV 908
             |.|.: .::....:...:::|:.::.|        |:.:  :.:||.:.::||||.:.:..|
  Rat   451 -NQLKEGRKVAAGEFETCTILFSDVVTFTNICAACEPIQI--VNMLNSMYSKFDRLTSVHDVY-- 510

  Fly   909 VEKIKVVGCTYMAACGLDFNLASNIRQTDHFRNSSLHVEVEHARNHRMTDENYDSDMNNDEVVFI 973
              |::.:|..||...|:...:.|:.::..:|           |...|::.:...:.:..:.:
  Rat   511 --KVETIGDAYMVVGGVPVPVESHAQRVANF-----------ALGMRISAKEVMNPVTGEPI--- 559

  Fly   974 MTTFALDLMRTLAACNRAYSSSFFERSLSQGKICIGISSGEIMAGVVGASQPHYDIWGNPVNMAS 1038
                                           :|.:||.:|.::|||||...|.|.::|:.||.||
  Rat   560 -------------------------------QIRVGIHTGPVLAGVVGDKMPRYCLFGDTVNTAS 593

  Fly  1039 RMESTGLPGHIQVTEESAKILQEFDIKCIYRGMTFVKGRGDIPTYFVGIDENLKFMSAKLVNR 1101
            ||||.|||..:.::..:.:.|:....:.:.||...|||:|.:.|||  :.:||.....:::.|
  Rat   594 RMESHGLPSKVHLSPTAHRALKNKGFEIVRRGEIEVKGKGKMTTYF--LIQNLNATEDEIMGR 654

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ACXC	NP_609593.1	AC_N	<33..285	CDD:292831	0/2 (0%)
		CYCc	293..468	CDD:214485	40/203 (20%)
		Nucleotidyl_cyc_III	307..466	CDD:299850	37/187 (20%)
		CYCc	833..1060	CDD:214485	50/235 (21%)
		Nucleotidyl_cyc_III	861..1085	CDD:299850	51/231 (22%)
Gucy1b2	NP_001257640.1	HNOB	2..163	CDD:285002	39/181 (22%)
		HNOBA	267..453	CDD:285003	49/313 (16%)
		CYCc	432..622	CDD:214485	52/251 (21%)
		Guanylate_cyc	459..642	CDD:278633	52/235 (22%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810