DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ACXC and Gucy2g

DIOPT Version :9

Sequence 1:	NP_609593.1	Gene:	ACXC / 34689	FlyBaseID:	FBgn0040508	Length:	1130	Species:	Drosophila melanogaster
Sequence 2:	NP_620611.2	Gene:	Gucy2g / 245708	RGDID:	621853	Length:	1103	Species:	Rattus norvegicus

Alignment Length:	1051	Identity:	202/1051 - (19%)
Similarity:	346/1051 - (32%)	Gaps:	405/1051 - (38%)

- Green bases have known domain annotations that are detailed below.

  Fly   214 STDILH------NLGFNMMGIFFRIMNDTMVRASFLDRHQFIMEETWLRHALLQESILLDSILP- 271
            |.|..|      :||.|.....|.::.  .:..||.  .:.:.|:...|...:.||:.|  |.|
  Rat   255 SEDAKHILQAAEDLGLNSREFVFLLLQ--QLEDSFW--KEVLAEDKVTRFPKVYESVFL--IAPS 313

  Fly   272 --------PQIAKPVQEKIKSKITQSENSPDRFQMGPRTTESFMAIQIHPDVSILYADVV----- 323
                    ....|.|.::::....||..|.:. |:.|      .:..:| |..:|||..|
  Rat   314 TYGGSAGDDDFRKQVYQRLRRPPFQSSISSED-QVSP------YSAYLH-DALLLYAQTVEEMMK 370

  Fly   324 ------NYTHLTTTLTVGNLV------KVLHDLYGRFDIAASNFKVQR----IKFLGDCYY---- 368
                  :...|.:||....:.      .||.|..|:..:..|.:.:|:    .:||...:|
  Rat   371 AEKDFRDGRQLISTLRADQVTLQGITGPVLLDAQGKRHMDYSVYALQKSGNGSRFLPFLHYDSFQ 435

  Fly   369 ----------CVAGLTTPDPDHAKCC----------VSLGISMISNIQEVRAERGLDIDMRIGVH 413
                      ..:|.....|::...|          ...|..|.:::..|     :.....:.|.
  Rat   436 KVIRPWRDDLNASGPHGSHPEYKPDCGFHEDLCRTKPPTGAGMTASVTAV-----IPTVTLLVVA 495

  Fly   414 SGSLLAGIIGEAKLQFDIWGTDVEIANHLESTGEPG----YVHVS-------------GRTLSML 461
            |.:.:.|::        :|....::.||      ||    .:|..             |..:|..
  Rat   496 SAAAITGLM--------LWRLRGKVQNH------PGDTWWQIHYDSITLLPQHKPSHRGTPMSRC 546

  Fly   462 NPADYTILSGTQKAQSDPVLQYIHTYLLTGQVAR-----ESFITSIGGVRSSSVL------EVKS 515
            |.::    :.|.|..:|           .|..|:     |.|...:|..:.:.|.      |.::
  Rat   547 NVSN----ASTVKISAD-----------CGSFAKTHQDEELFYAPVGLYQGNHVALCYIGEEAEA 596

  Fly   516 IDRIRSSRPS---QSSMTDEFREEFRNMPVGGINLNSP-------CCRRTRLDTHKKTQREIGIF 570
                |..:|:   :..:..|.:.| ..:|..|:....|       ||::..|   |...|
  Rat   597 ----RIKKPTVLREVWLMCELKHE-NIVPFFGVCTEPPNICIVTQCCKKGSL---KDVLR----- 648

  Fly   571 CAAFKDSSLEWNYLHQPDFIFKSSMLLAWGIGCCLIYIQIVTN--NFSCTACIVVDLVTFFFLTS 633
                       |..|:.|:|||.|.:.....|...::...:.:  |...:.|:|...:.
  Rat   649 -----------NSDHEMDWIFKLSFVYDIVNGMLFLHGSPLRSHGNLKPSNCLVDSHMQ------ 696

  Fly   634 LLCLAWYKNVCWWKSGRYEF------RIYGKYSCMAFHIFEKIQHSVSLRITVYLGILFSYYAVI 692
             |.||.:        |.:||      |||.:         |...||.            .|:...
  Rat   697 -LKLAGF--------GLWEFKHGSTCRIYNQ---------EATDHSE------------LYWTAP 731

  Fly   693 SLIMLNCDRDMYELSYIESKIYHYEMDRDTCFHPWVFTNMISLILGISYTFARI----------- 746
            .|:.|.      ||                   ||..|..     |..|:||.:
  Rat   732 ELLRLR------EL-------------------PWSGTPQ-----GDVYSFAILLRDLIHQQAHG 766

  Fly   747 PF-----GLKIVISCCETLAYLLIVFFQFAFIFQHSATTTPFMKA--------ELAHCLRVC--- 795
            ||     ..:.:|||                 .:.|....|...:        .:...:|.|
  Rat   767 PFEDLEAAPEEIISC-----------------IKDSRAPVPLRPSLLEDKGDERIVALVRACWAE 814

  Fly   796 ------------------------------MMLLTMYAKERQSEFNTKMNYKLNVDLQNKQKAAD 830
                                          |..|.|||...:..          |:.:..|..|:
  Rat   815 SPEQRPAFPSIKKTLREASPRGRVSILDSMMGKLEMYASHLEEV----------VEERTCQLVAE 869

  Fly   831 LTNQSIIILLNNILPSHVVDLYLNSLAKHELYYENYRMVSVMFAMLINF--------PMNLPSLR 887
              .:.:..||:.:|||.|.:   ..:|...:..|::..|::.|:.::.|        |:.:  ::
  Rat   870 --KRKVEKLLSTMLPSFVGE---QLIAGKSVEPEHFESVTIFFSDIVGFTKLCSLSSPLQV--VK 927

  Fly   888 VLNDIITQFDRLLTAYREYYVVEKIKVVGCTYMAACGLDFNLASNIRQTDHFRNSSLHVEVEHAR 952
            :|||:.:.||..:..:..|    |::.:|..||.|.||.  :.:..:..|.....|||
  Rat   928 LLNDLYSLFDHTIQTHDVY----KVETIGDAYMVASGLP--IRNGAQHADEIATMSLH------- 979

  Fly   953 NHRMTDENYDSDMNNDEVVFIMTTFALDLMRTLAACNRAYSSSFFERSLSQGKICIGISSGEIMA 1017
                             ::.:.|.|.:..|.              |..|   |:.||:.:|.::|
  Rat   980 -----------------LLSVTTNFQIGHMP--------------EERL---KLRIGLHTGPVVA 1010

  Fly  1018 GVVGASQPHYDIWGNPVNMASRMESTGLPGHIQVTEESAKI--------LQEFDIKCIYRGMTFV 1074
            ||||.:.|.|.::|:.|||||||||:.||..|.|::.:|:.        ||:       ||...|
  Rat  1011 GVVGITMPRYCLFGDTVNMASRMESSSLPLRIHVSQSTARALLVAGGYHLQK-------RGTISV 1068

  Fly  1075 KGRGDIPTYFV 1085
            ||:|:..|:::
  Rat  1069 KGKGEQTTFWL 1079

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ACXC	NP_609593.1	AC_N	<33..285	CDD:292831	18/85 (21%)
		CYCc	293..468	CDD:214485	38/236 (16%)
		Nucleotidyl_cyc_III	307..466	CDD:299850	36/220 (16%)
		CYCc	833..1060	CDD:214485	60/242 (25%)
		Nucleotidyl_cyc_III	861..1085	CDD:299850	62/239 (26%)
Gucy2g	NP_620611.2	PBP1_GC_G_like	50..439	CDD:107367	41/197 (21%)
		ANF_receptor	66..417	CDD:279440	37/175 (21%)
		PK_GC	558..832	CDD:270894	64/391 (16%)
		CYCc	868..1058	CDD:214485	61/243 (25%)
		Guanylate_cyc	895..1081	CDD:278633	62/241 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.900