DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ACXC and Gucy2f

DIOPT Version :9

Sequence 1:	NP_609593.1	Gene:	ACXC / 34689	FlyBaseID:	FBgn0040508	Length:	1130	Species:	Drosophila melanogaster
Sequence 2:	NP_001007577.1	Gene:	Gucy2f / 245650	MGIID:	105119	Length:	1108	Species:	Mus musculus

Alignment Length:	839	Identity:	174/839 - (20%)
Similarity:	306/839 - (36%)	Gaps:	291/839 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly   343 DLYGRFDIAASNFKVQRIKFLG---------------DCYY-----CVAGLTTPDPDHA-KCCVS 386
            :|.|.:.:   :.:.:.::|.|               .|::     |..|:   ||..| ..|.:
Mouse   417 ELRGTYTV---DMETELLRFRGTPIHFPGGRPTSADAKCWFAERKICQGGI---DPALAMMVCFA 475

  Fly   387 LGISMIS----------NIQEVRAERG-------LDIDMRIGVHSGSLLAGIIGEAKLQFDIWGT 434
            |.|:::|          .|.:::..:|       |:....|..|.||...   ..|.:.|
Mouse   476 LLIALLSINGFAYFIRRRINKIQLIKGPNRILLTLEDVTFINPHFGSKRG---SRASVSF----- 532

  Fly   435 DVEIANHLESTGEPGYVHVSGRTLSMLNPADYTILSGTQKAQSDPVLQYIHTYLLTGQVARESFI 499
              :|.:.::|...|.....||    .|.||.|         ::..:..|...::...:.....|
Mouse   533 --QIISEVQSGRSPRLSFSSG----SLTPATY---------ENSNIAIYEGDWVWLKKFPPGDF- 581

  Fly   500 TSIGGVRSSSVLEVKSIDRIRSSRPSQSSMTDEFREEFRNMPVGGINLNSP--------CCRRTR 556
               |.::|           |:||......|..:.|.|..| |:.|...:|.        |.||:.
Mouse   582 ---GDIKS-----------IKSSASDVFEMMKDLRHENVN-PLLGFFYDSGMFAIVSEFCSRRSL 631

  Fly   557 LDTHKKTQREIGIFCAAFKDSSLEWNYLHQPDFIFKSSMLLAWGIGC-CLIYIQIVTNNFSCTAC 620
            .|            .....|..|:|        :||||:||....|. .|.:.:.:........|
Mouse   632 ED------------ILTNDDVKLDW--------MFKSSLLLDLIKGMKYLHHREFIHGRLKSRNC 676

  Fly   621 IVVDLVTFFFLTSLLCLAWYKNVCWWKSGRYEFRI--YGKYSCMAFH-IFEKIQHSV-------- 674
            :|                         .||:..::  ||      |: |.|.::.|.
Mouse   677 VV-------------------------DGRFVLKVTDYG------FNDILEMLRLSEEEPSEEEL 710

  Fly   675 ------------SLRITVYLGILFSYYAVISLIMLN----CDRDMYELSYIESKIYHYEMDRDTC 723
                        .:|:..:.|.::|:..::..:|:.    |..|:.....|:    ..:|.
Mouse   711 LWTAPELLRAPGGIRLGSFAGDVYSFAIIMQEVMVRGAPFCMMDLPAKEIID----RLKMP---- 767

  Fly   724 FHPWVFTNMISLILGISYTFARIPFGLKIVISCCETLAYLLIVFFQFAFIFQHSATTTPFMKAEL 788
              |.|:..::|    ..|..|..   |:::..|....:.....|.:   ||....|   |.|.:.
Mouse   768 --PPVYRPVVS----PEYAPAEC---LQLMKQCWAEASEQRPTFDE---IFNQFKT---FNKGKK 817

  Fly   789 AHCLRVCMMLLTMYA-------KERQSEFNTKMNYKLNVDLQNKQKAADLTNQSIIILLNNILPS 846
            .:.:...:.:|..|:       :||..|        |.::.|..:|           ||..:||.
Mouse   818 TNIIDSMLRMLEQYSSNLEDLIRERTEE--------LEIEKQKTEK-----------LLTQMLPL 863

  Fly   847 HVVDLYLNSLAKH-ELYYENYRMVSVMFAMLINF--------PMNLPSLRVLNDIITQFDRLLTA 902
            .|.:    ||.|. .:..|.:.:|::.|:.::.|        |:.:..|  |||:.|.||.::.:
Mouse   864 SVAE----SLKKGCTVEPEGFDLVTLYFSDIVGFTTISAMSEPIEVVDL--LNDLYTLFDAIIGS 922

  Fly   903 YREYYVVEKIKVVGCTYMAACGLDFNLASNIRQTDHFRNSSLHVEVEHARNHRMTDENYDSDMNN 967
            :..|    |::.:|..||.|.||.            .||.|.|.                :::.|
Mouse   923 HDVY----KVETIGDAYMVASGLP------------KRNGSRHA----------------AEIAN 955

  Fly   968 DEVVFIMTTFALDLMRTLAACNRAYSSSFFERSLSQ--GKICIGISSGEIMAGVVGASQPHYDIW 1030
                     .:||::.::        .:|..|.:.:  .:|.||:.||.::|||||.:.|.|.::
Mouse   956 ---------MSLDILSSV--------GTFKMRHMPEVPVRIRIGLHSGPVVAGVVGLTMPRYCLF 1003

  Fly  1031 GNPVNMASRMESTGLPGHIQVTEESAKILQE----FDIKCIYRGMTFVKGRGDIPTYFV 1085
            |:.||.||||||||||..|.|:..:..|||.    ::::  .||.|.:||:|...|:::
Mouse  1004 GDTVNTASRMESTGLPYRIHVSLSTVTILQTLSEGYEVE--LRGRTELKGKGTEETFWL 1060

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ACXC	NP_609593.1	AC_N	<33..285	CDD:292831
		CYCc	293..468	CDD:214485	32/162 (20%)
		Nucleotidyl_cyc_III	307..466	CDD:299850	31/160 (19%)
		CYCc	833..1060	CDD:214485	65/237 (27%)
		Nucleotidyl_cyc_III	861..1085	CDD:299850	66/237 (28%)
Gucy2f	NP_001007577.1	PBP1_sensory_GC_DEF-like	54..435	CDD:380594	3/20 (15%)
		PKc_like	545..815	CDD:419665	65/372 (17%)
		HNOBA	<824..869	CDD:400168	13/67 (19%)
		CYCc	848..1040	CDD:214485	69/257 (27%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810