Protein Alignment ACXC and Gucy1b2

DIOPT Version :9

• Sequence 1: NP_609593.1
• Gene: ACXC / 34689
• FlyBaseID: FBgn0040508
• Length: 1130
• Species: Drosophila melanogaster
• Sequence 2: XP_011243363.2
• Gene: Gucy1b2 / 239134
• MGIID: 2660873
• Length: 829
• Species: Mus musculus
• Alignment Length: 905
• Identity: 171/905 - (18%)
• Similarity: 317/905 - (35%)
• Gaps: 303/905 - (33%)

  Fly   282 IKSKITQSENSPDRFQMGPRTTESFMAIQIHPDVSILYADVVNYTHLTTTLTVGNLVKVLHDLYG 346
            ::|.:|:        :.|..|.|...|.....||      .:.||....|:|    ||::.:...
Mouse   122 LQSLVTE--------KFGEETWEKLKASAEVQDV------FMTYTVYDDTIT----VKLIQEACK 168

  Fly   347 RFDIAASNFKVQRIKFLGDCYYCVAGLTTPDPDHAKCCVSLG---ISMISNI-----------QE 397
            ..|::....    :|..|:.::....::..|    :...:||   ...|.|:           ||
Mouse   169 ALDVSMEAI----LKLFGEYFFKFCKMSGYD----RMLRTLGGNLTEFIENLDALHSYLALSYQE 225

  Fly   398 V-----RAERGLDIDMRIGVHSG-----SLLAGIIGEAKLQFDIWGTDVEIANHLESTGEPGYVH 452
            :     |.|.|.|..||:..:|.     .::.||| ||..: |.:.|||
Mouse   226 MNAPSFRVEGGADGAMRLHYYSDRRGLCHIVPGII-EAVAK-DFFDTDV---------------- 272

  Fly   453 VSGRTLSMLNPADYTILSGTQKAQSDPVLQYIHTYLLTGQVARESFITSIGGVRSSSVLEVKSID 517
                .:|:|:..:....:|.::          |...|..|.||..       :|.:.|...:..:
Mouse   273 ----AMSILDMNEEVERTGKKE----------HVVFLVVQKARRQ-------IRGAKVNRPRDSE 316

  Fly   518 RIRSSRPSQSSMTDEFREEFRNMPV-GGINLNSPCCRRTRL-------DTHKKT--QR---EIGI 569
            .|::.:.|........:|.:.::|| .|...:|...|.:.|       ||.:..  :|   |..:
Mouse   317 NIQAKQESLQGTLLRKKERYLSIPVCPGEKSHSAVVRASVLLGKGPLGDTFQPVFPERLWIEEEV 381

  Fly   570 FCAAFKDSSLEWNYLHQPDFIFKSSMLLAW-GIGCCLIYIQIVTNNFSCTA--CIVVDLVTF--- 628
            ||.||.        .|   .:|..::.:.. |:........|:|..|....  .||...|||
Mouse   382 FCNAFP--------FH---VVFDEALRVKQAGVNIQKYVPGILTQKFGLDEYFSIVHPQVTFNIS 435

  Fly   629 ---FFLTSLLCLAWYKNVC--WWKSGRYEFRIYGKYSCMAFHIFEKIQHSVSLRITVYLGILFSY 688
               .|:.|...|...:.:.  .||| :...::.|:...|.           ||:..|::
Mouse   436 SICKFINSQFILKTRREMMPEAWKS-QPTLKLRGQMIWME-----------SLKCMVFM------ 482

  Fly   689 YAVISLIMLNCDRDMYELSYIESKIYHYEMDRDTCFHPWVFTNMISLILGISYTFARIPFGLKIV 753
                      |...:..|..:|....|..   |...|
Mouse   483 ----------CSPKLRSLQELEESKMHLS---DIAPH---------------------------- 506

  Fly   754 ISCCETLAYLLIVFFQFAFIFQHSATTTPFMKAELAHCLRVCMMLLTMYAKERQSEFNTKMNYKL 818
                :|...|:::..|                       |:..|.|:...::::.|.....|:
Mouse   507 ----DTTRDLILLNQQ-----------------------RLAEMELSCQLEKKKEELRVLSNH-- 542

  Fly   819 NVDLQNKQKAADLTNQSIIILLNNILPSHVVDLYLNSLAK-HELYYENYRMVSVMFAMLINF--- 879
               |..::|..:       .||..:||.||.    |.|.: .::....:...:::|:.::.|
Mouse   543 ---LAIEKKKTE-------TLLYAMLPEHVA----NQLKEGKKVAAGEFETCTILFSDVVTFTNI 593

  Fly   880 -----PMNLPSLRVLNDIITQFDRLLTAYREYYVVEKIKVVGCTYMAACGLDFNLASNIRQTDHF 939
                 |:.:  :.:||.:.::||||...:..|    |::.:|..||...|:...:.|:.::..:|
Mouse   594 CAACEPIQI--VNMLNSMYSKFDRLTNIHDVY----KVETIGDAYMVVGGVPVPVESHAQRVANF 652

  Fly   940 RNSSLHVEVEHARNHRMTDENYDSDMNNDEVVFIMTTFALDLMRTLAACNRAYSSSFFERSLSQG 1004
                       |...|::.:...:.:..:.:
Mouse   653 -----------ALGMRISAKEVMNPVTGEPI---------------------------------- 672

  Fly  1005 KICIGISSGEIMAGVVGASQPHYDIWGNPVNMASRMESTGLPGHIQVTEESAKILQEFDIKCIYR 1069
            :|.:||.:|.::|||||...|.|.::|:.||.||||||.|||..:.::..:.:.|:....:.:.|
Mouse   673 QIRVGIHTGPVLAGVVGDKMPRYCLFGDTVNTASRMESHGLPNKVHLSPTAHRALENKGFEIVTR 737

  Fly  1070 GMTFVKGRGDIPTYFVGIDENLKFMSAKLVNR---------------SLSRRFSVMSSLD 1114
            |...|||:|.:.|||  :..||.....:::.|               .:.:..:|:|::|
Mouse   738 GEIEVKGKGKMTTYF--LIRNLNATEVEIMGRPSALADGKEASTPRNQVKKPRAVLSNMD 795

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ACXC	NP_609593.1	AC_N	<33..285	CDD:292831	0/2 (0%)
		CYCc	293..468	CDD:214485	40/198 (20%)
		Nucleotidyl_cyc_III	307..466	CDD:299850	37/182 (20%)
		CYCc	833..1060	CDD:214485	50/235 (21%)
		Nucleotidyl_cyc_III	861..1085	CDD:299850	51/231 (22%)
Gucy1b2	XP_011243363.2	HNOB	115..276	CDD:400167	40/201 (20%)
		HNOBA	380..566	CDD:400168	49/298 (16%)
		Guanylate_cyc	572..754	CDD:306677	52/234 (22%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810