DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ACXC and Adcy5

DIOPT Version :9

Sequence 1:	NP_609593.1	Gene:	ACXC / 34689	FlyBaseID:	FBgn0040508	Length:	1130	Species:	Drosophila melanogaster
Sequence 2:	NP_001012783.3	Gene:	Adcy5 / 224129	MGIID:	99673	Length:	1262	Species:	Mus musculus

Alignment Length:	1161	Identity:	295/1161 - (25%)
Similarity:	501/1161 - (43%)	Gaps:	252/1161 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly    45 LEEEYRYYQVRLMVSNLTIFYVLFIILAMSFLT-------IELLYVQHYNAVFFNFVIRVVSTIL 102
            ||..|:.|..||..|:||:...:.:::.:..|.       :::.|:    ||    :...|..||
Mouse   227 LERLYQRYFFRLNQSSLTMLMAVLVLVCLVMLAFHAARPPLQIAYL----AV----LAAAVGVIL 283

  Fly   103 VLTVLSINFCEK--FVSRHRWVMIASSVLSVYLVVLTDIVMISYHFYKNDWPLNTS----FDVFT 161
            ::.||    |.:  |...|..:...:.:..|..|.:..:::        ..|.:.|    :.||.
Mouse   284 IMAVL----CNRAAFHQDHMGLACYALIAVVLAVQVVGLLL--------PQPRSASEGIWWTVFF 336

  Fly   162 LCMIYMFLPIPSIKGAALLASSVSLIYVAFFMHSLTFNAVYTDRDSFGYDVISTDILHNLGFNMM 226
            :..||..||: .::.|.|....:|.:::|..:|:       ..:|.|....:.:::|.....|::
Mouse   337 IYTIYTLLPV-RMRAAVLSGVLLSALHLAISLHT-------NSQDQFLLKQLVSNVLIFSCTNIV 393

  Fly   227 GIFFRIMNDTMVRASFLDRHQFIMEETWLRHALLQESILLDSILPPQIAKPVQEKIKSKITQSEN 291
            |:......:...|.:|.:..:.|......:....|:..||.|:||..:|..::..|.:|
Mouse   394 GVCTHYPAEVSQRQAFQETRECIQARLHSQRENQQQERLLLSVLPRHVAMEMKADINAK------ 452

  Fly   292 SPDRFQMGPRTTESFM----AIQIHPDVSILYADVVNYTHLTTTLTVGNLVKVLHDLYGRFDIAA 352
                       .|..|    .||.|.:||||:||:..:|.|.:..|...||..|::|:.|||..|
Mouse   453 -----------QEDMMFHKIYIQKHDNVSILFADIEGFTSLASQCTAQELVMTLNELFARFDKLA 506

  Fly   353 SNFKVQRIKFLGDCYYCVAGLTTPDPDHAKCCVSLGISMISNIQEVRAERGLDIDMRIGVHSGSL 417
            :.....|||.||||||||:||.....|||.|||.:|:.||..|..||...|::::||:|:|||.:
Mouse   507 AENHCLRIKILGDCYYCVSGLPEARADHAHCCVEMGMDMIEAISLVREVTGVNVNMRVGIHSGRV 571

  Fly   418 LAGIIGEAKLQFDIWGTDVEIANHLESTGEPGYVHVSGRTLSMLNPADY---------------- 466
            ..|::|..|.|||:|..||.:|||:|:.|:.|.:|::..||:.|| .||
Mouse   572 HCGVLGLRKWQFDVWSNDVTLANHMEAGGKAGRIHITKATLNYLN-GDYEVEPGCGGDRNAYLKE 635

  Fly   467 ------TILSGTQKAQSDPVLQYIHTYLLTGQV--------ARESFITSIGGVRSSSVLEVKSID 517
                  .|||.|||.:.:..:........|..:        |...|...:||.:.|..::....:
Mouse   636 HSIETFLILSCTQKRKEEKAMIAKMNRQRTNSIGHNPPHWGAERPFYNHLGGNQVSKEMKRMGFE 700

  Fly   518 RIRSSRPSQSSMTDEFREEFRNMPVGGINLNSPCCRRTRLDTHKKTQREIGIFCAAFKDSSLEWN 582
            ..:.....:|:..::..:||....:...:::     |.|.:..:|       |...|::..||..
Mouse   701 DPKDKNAQESANPEDEVDEFLGRAIDARSID-----RLRSEHVRK-------FLLTFREPDLEKK 753

  Fly   583 YLHQPD-----FIFKSSMLLAWGIGCCLIYIQIVTNNFSCTACIVVDLVTFFFLTS--LLCLAWY 640
            |..|.|     ::..:|::..:   .|.:.|.||.::.         .:..|:|:.  ||.|..:
Mouse   754 YSKQVDDRFGAYVACASLVFLF---ICFVQITIVPHSL---------FMLSFYLSCFLLLALVVF 806

  Fly   641 KNVCWWKSGRYEFRIYGKYSCMAFH------IFEKIQHSV--SLRITVYLGILFSYYAVISLIML 697
            .:|.              |:|:...      :..||..|.  |..:.|:...|....|.:::.|.
Mouse   807 VSVI--------------YACVKLFPTPLQTLSRKIVRSKKNSTLVGVFTITLVFLSAFVNMFMC 857

  Fly   698 N------CDRDMYELS-------YIESKIYHYEM---------DRDTCFHPWVFTNMISLILGIS 740
            |      |..:.:.::       ::....::|.:         .:..|..|..||..:.|.|...
Mouse   858 NSKNLVGCLAEEHNITVNQVNACHVMESAFNYSLGDEQGFCGSPQPNCNFPEYFTYSVLLSLLAC 922

  Fly   741 YTFARIPFGLKIVISCCETLAYLLIVFFQFAFIFQH-----SATTTPFMKAELAHC--------- 791
            ..|.:|....|:|:.......|:|||......:|.:     :|....|.....:.|
Mouse   923 SVFLQISCIGKLVLMLAIEFIYVLIVEVPGVTLFDNADLLVTANAIDFSNNGTSQCPEHATKVAL 987

  Fly   792 -----LRVCMMLLTMYAKERQSEFNTKMNY--KLNVDLQNKQKAADLT--NQSIIILLNNILPSH 847
                 :.:.:.:|.:|...:|.|...::::  ||.. .:.|::..:|.  |:.   ||:||||..
Mouse   988 KVVTPIIISVFVLALYLHAQQVESTARLDFLWKLQA-TEEKEEMEELQAYNRR---LLHNILPKD 1048

  Fly   848 VVDLYL-NSLAKHELYYENYRMVSVMFAMLINFP----------MNLPSLRVLNDIITQFDRLLT 901
            |...:| ......||||::...|:||||.:.||.          ..:..||:||:||..||.:::
Mouse  1049 VAAHFLARERRNDELYYQSCECVAVMFASIANFSEFYVELEANNEGVECLRLLNEIIADFDEIIS 1113

  Fly   902 AYREYYVVEKIKVVGCTYMAACGLDFNLASNIRQTDHFRNSSLHVEVEHARNHRMTDENYDSDMN 966
            ..| :..:||||.:|.|||||.||:                               |..||....
Mouse  1114 EDR-FRQLEKIKTIGSTYMAASGLN-------------------------------DSTYDKAGK 1146

  Fly   967 NDEVVFIMTTFALDLMRTLAACNRAYSSSFFERSLSQGKICIGISSGEIMAGVVGASQPHYDIWG 1031
            ..  :..:..||:.||..:...|        |.|.:..::.||::.|.::|||:||.:|.|||||
Mouse  1147 TH--IKAIADFAMKLMDQMKYIN--------EHSFNNFQMKIGLNIGPVVAGVIGARKPQYDIWG 1201

  Fly  1032 NPVNMASRMESTGLPGHIQVTEESAKIL--QEFDIKCIYRGMTFVKGRGDIPTYFV 1085
            |.||:||||:|||:|..||||.:..::|  ..:.::|  ||:..|||:|::.|||:
Mouse  1202 NTVNVASRMDSTGVPDRIQVTTDMYQVLAANTYQLEC--RGVVKVKGKGEMMTYFL 1255

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ACXC	NP_609593.1	AC_N	<33..285	CDD:292831	52/252 (21%)
		CYCc	293..468	CDD:214485	76/200 (38%)
		Nucleotidyl_cyc_III	307..466	CDD:299850	73/162 (45%)
		CYCc	833..1060	CDD:214485	81/239 (34%)
		Nucleotidyl_cyc_III	861..1085	CDD:299850	80/235 (34%)
Adcy5	NP_001012783.3	AC_N	1..459	CDD:292831	55/276 (20%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..194
		CYCc	425..620	CDD:214485	84/212 (40%)
		Guanylate_cyc	461..622	CDD:278633	74/161 (46%)
		DUF1053	669..761	CDD:283888	18/103 (17%)
		CYCc	1037..1238	CDD:214485	81/245 (33%)
		Guanylate_cyc	1063..1257	CDD:278633	81/237 (34%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR45627
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.910