DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ACXC and Adcy2

DIOPT Version :9

Sequence 1:	NP_609593.1	Gene:	ACXC / 34689	FlyBaseID:	FBgn0040508	Length:	1130	Species:	Drosophila melanogaster
Sequence 2:	NP_705762.2	Gene:	Adcy2 / 210044	MGIID:	99676	Length:	1095	Species:	Mus musculus

Alignment Length:	1194	Identity:	327/1194 - (27%)
Similarity:	541/1194 - (45%)	Gaps:	222/1194 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly    30 LWEHS-----YLREKCKE-----------LNLEEEYRYYQVRLMVSNLTIFYVLFIILAMSFLTI 78
            :|:.:     |||::.:.           |....::.|.....|.....:  ::|::|.:....:
Mouse     1 MWQEAMRRRRYLRDRAEAAAAAAAGGGEGLQRSRDWLYESYYCMSQQHPL--IVFLLLIVMGACL 63

  Fly    79 ELLYVQHYNAVFF----------NFVIRVVSTILVLTVLSINFCEKFVSRHRWVMIASSVLSVY- 132
            .||      ||||          .|:|.|.:.:.:...:.|..|.:.|.:        .:|.|:
Mouse    64 ALL------AVFFALGLEVEDHVAFLITVPTALAIFFAIFILVCIESVFK--------KLLRVFS 114

  Fly   133 LVVLTDIVMISYHFY-----KNDWPLNTSFDVFTLCMIYMFLPI---PSIKGAALLASSVSLIYV 189
            ||:...:|.:.|.|.     .:.|. ..||.:|.:.::|..||.   .:|..:.|.:||.:::.
Mouse   115 LVIWICLVAMGYLFMCFGGTVSAWD-QVSFFLFIIFVVYTMLPFNMRDAIIASVLTSSSHTIVL- 177

  Fly   190 AFFMHSLTFNAVYTDRDSFGYDVISTDILHNLGFNMMGIFFRIMNDTMVRASFLDRHQFIMEETW 254
                 |:..:|....::...:.:::..|:...| |:.|.:.:.:.:..::.::.|....|.....
Mouse   178 -----SVYLSATPGAKEHLFWQILANVIIFICG-NLAGAYHKHLMELALQQTYRDTCNCIKSRIK 236

  Fly   255 LRHALLQESILLDSILPPQIAKPVQEKIKSKITQSENSPDRFQMGPRTTESF--MAIQIHPDVSI 317
            |.....|:..||.|:||..||.    ::|::|.|....|...||  ..|.:|  :.::.|.:|||
Mouse   237 LEFEKRQQERLLLSLLPAHIAM----EMKAEIIQRLQGPKAGQM--ENTNNFHNLYVKRHTNVSI 295

  Fly   318 LYADVVNYTHLTTTLTVGNLVKVLHDLYGRFDIAASNFKVQRIKFLGDCYYCVAGLTTPDPDHAK 382
            ||||:|.:|.|.:..:.|.||.:|::|:|:||..|...:..|||.||||||||:||....|:|||
Mouse   296 LYADIVGFTRLASDCSPGELVHMLNELFGKFDQIAKENECMRIKILGDCYYCVSGLPISLPNHAK 360

  Fly   383 CCVSLGISMISNIQEVRAERGLDIDMRIGVHSGSLLAGIIGEAKLQFDIWGTDVEIANHLESTGE 447
            .||.:|:.|...|::||...|:||:||:|||||::|.|:||..|.|:|:|..||.:|||:|:.|.
Mouse   361 NCVKMGLDMCEAIKKVRDATGVDINMRVGVHSGNVLCGVIGLQKWQYDVWSHDVTLANHMEAGGV 425

  Fly   448 PGYVHVSGRTLSMLNPADYTILSGTQKAQSDPVLQ--YIHTYLL---TGQVARESFI-----TSI 502
            ||.||:|..||..||.| |.:..|..:.: ||.|:  .:.||.:   .|:......:     |..
Mouse   426 PGRVHISSVTLEHLNGA-YKVEEGDGEIR-DPYLKQHLVKTYFVINPKGERRSPQHLFRPRHTLD 488

  Fly   503 GGVRSSSVLEVKSIDRIRSSRP-----SQSSMTDE-FREEFRNMPVGGINLNSPCCRRTRLDTHK 561
            |....:||...:.::...:::|     .:.|||.| .:....::|:|..|..:   |..|..:.|
Mouse   489 GAKMRASVRMTRYLESWGAAKPFAHLHHRDSMTTENGKISTTDVPMGQHNFQN---RTLRTKSQK 550

  Fly   562 KTQRE---------------------------IGIFCAAFKDSSLEWNYLHQPDFIFKSSMLLAW 599
            |...|                           |.:|   |.:.::|..|.......||..:..|.
Mouse   551 KRFEEELNERMIQAIDGINAQKQWLKSEDIQRISLF---FYNKNIEKEYRATALPAFKYYVTCAC 612

  Fly   600 GIGCCLIYIQIVTNNFSCTACIVVDLVTFFFLTSLLCLAWYKNVCW----------------W-- 646
            .|..|:..:||:       ......::.|.|..:.|.|.:...||:                |
Mouse   613 LIFLCIFIVQIL-------VLPKTSILGFSFGAAFLSLIFILFVCFAGQLLQCSKKASASLLWLL 670

  Fly   647 -KSGRYEFRIYGKYSCMAFHIFEKIQHSVSLRITVYLGILFSYYAVISLIMLNCDRDMYELSYIE 710
             .||....|.:.:.|...      :..::.|.:.|:.....|.....:|...|.......:...:
Mouse   671 KSSGIIANRPWPRISLTI------VTTAIILTMAVFNMFFLSNSEETTLPTANASNANVSVPDNQ 729

  Fly   711 SKIYHYEMDRDTCFHPWVFTNMISLILGI--SYTFARIPFGLKIVISCCETLAYLLIVFFQFAFI 773
            :.|.|   .|:..|.|:.   :.|.|||:  ...|.|:.:.||::|.....:.|.:|:....|.:
Mouse   730 TAILH---ARNLFFLPYF---IYSCILGLISCSVFLRVNYELKMLIMMVALVGYNIILLHTHAHV 788

  Fly   774 FQHSATTTPFMKAELAHCLR------VCMMLLTMYAKERQSEFNTKMNYKLNVDLQNKQKAADLT 832
            .. :.:...|.:..:...|:      :.:..:|:....||||:..::::......:.:::..:..
Mouse   789 LD-AYSQVLFQRPGIWKDLKTMGSVSLSIFFITLLVLGRQSEYYCRLDFLWKNKFKKEREEIETM 852

  Fly   833 NQSIIILLNNILPSHVVDLYL-NSLAKHELYYENYRMVSVMFAMLINF----------PMNLPSL 886
            .....:||.|:||:||.:.:| .||...|||:::|..|.||||.:.:|          ...|..|
Mouse   853 ENLNRVLLENVLPAHVAEHFLARSLKNEELYHQSYDCVCVMFASIPDFKEFYTESDVNKEGLECL 917

  Fly   887 RVLNDIITQFDRLLTAYREYYVVEKIKVVGCTYMAACGLDFNLASNIRQTDHFRNSSLHVEVEHA 951
            |:||:||..||.||:. .::..|||||.:|.|||||.||     |.:...:|.:      |.|..
Mouse   918 RLLNEIIADFDDLLSK-PKFSGVEKIKTIGSTYMAATGL-----SAVPSQEHAQ------EPERQ 970

  Fly   952 RNHRMTDENYDSDMNNDEVVFIMTTFALDLMRTLAACNRAYSSSFFERSLSQGKICIGISSGEIM 1016
            ..|                :..|..||..|:..|.|.|:        .|.:..|:.:||:.|.::
Mouse   971 YMH----------------IGTMVEFAYALVGKLDAINK--------HSFNDFKLRVGINHGPVI 1011

  Fly  1017 AGVVGASQPHYDIWGNPVNMASRMESTGLPGHIQVTEESAKILQEFDIKCIYRGMTFVKGRGDIP 1081
            |||:||.:|.||||||.||:||||:|||:...||||||::.|||.....|..||:..|||:||:.
Mouse  1012 AGVIGAQKPQYDIWGNTVNVASRMDSTGVLDKIQVTEETSLILQTLGYTCTCRGIINVKGKGDLK 1076

  Fly  1082 TYFVGIDENLKFMSAKLVNRSLSR 1105
            ||||..:          ::||||:
Mouse  1077 TYFVNTE----------MSRSLSQ 1090

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ACXC	NP_609593.1	AC_N	<33..285	CDD:292831	56/286 (20%)
		CYCc	293..468	CDD:214485	85/176 (48%)
		Nucleotidyl_cyc_III	307..466	CDD:299850	79/158 (50%)
		CYCc	833..1060	CDD:214485	89/237 (38%)
		Nucleotidyl_cyc_III	861..1085	CDD:299850	90/233 (39%)
Adcy2	NP_705762.2	AC_N	<37..264	CDD:292831	52/254 (20%)
		CYCc	240..443	CDD:214485	95/209 (45%)
		Guanylate_cyc	285..469	CDD:278633	86/185 (46%)
		DUF1053	499..603	CDD:283888	18/109 (17%)
		CYCc	852..1060	CDD:214485	91/243 (37%)
		Guanylate_cyc	882..1081	CDD:278633	91/234 (39%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D181177at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR45627
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	5	4.880