DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment ACXC and gcy-21

DIOPT Version :9

Sequence 1:	NP_609593.1	Gene:	ACXC / 34689	FlyBaseID:	FBgn0040508	Length:	1130	Species:	Drosophila melanogaster
Sequence 2:	NP_001364740.1	Gene:	gcy-21 / 191651	WormBaseID:	WBGene00001546	Length:	1163	Species:	Caenorhabditis elegans

Alignment Length:	310	Identity:	83/310 - (26%)
Similarity:	131/310 - (42%)	Gaps:	82/310 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly   813 KMNYKLNVDLQNKQKAADLTNQSIIILLNNILPSHVVD-LYLNSLAKHELYYENYRMVSVMFAML 876
            |...||..|:..:.:..:........||..:||..|.| |.|.|    .:..|::...:|.|:..
Worm   899 KYTDKLEKDIAERNEELEGEKAKSEALLKMMLPEVVADSLKLGS----NVSAESFENCTVFFSDC 959

  Fly   877 INF--------PMNLPSLRVLNDIITQFDRLLTAYREYYVVEKIKVVGCTYMAACGLDFNLASNI 933
            ..|        |:::  ::.|||:.|.|||::..:..|    |::.:...||.|.||.      :
Worm   960 PGFVEMSATSKPIDI--VQFLNDLYTVFDRIIDQFDVY----KVETIADAYMVASGLP------V 1012

  Fly   934 RQTDHFRNSSLHVEVEHARNHRMTDENYDSDMNNDEVVFIMTTFALDLMRTLAACNRAYSSSFFE 998
            ...:|           ||..                    :.:..|.|::.:        .||..
Worm  1013 PNGNH-----------HAGE--------------------IASLGLALLKAV--------ESFKI 1038

  Fly   999 RSLSQGKI--CIGISSGEIMAGVVGASQPHYDIWGNPVNMASRMESTGLPGHIQVTEESAKILQE 1061
            |.|...|:  .||::||..:|||||...|.|.::|:.||.||||||.|:|..|..:..:.:||.:
Worm  1039 RHLPNEKVRLRIGMNSGPCVAGVVGLKMPRYCLFGDTVNTASRMESNGIPLRINCSGTAKEILDQ 1103

  Fly  1062 ---FDIKCIYRGMTFVKGRGDIPTYFVG-----------IDENLKFMSAK 1097
               ::|:  .||:..:||:|...||||.           |.|.:||.|.|
Worm  1104 LGGYEIE--ERGIVEMKGKGKQMTYFVRGENSDMRRERIIRERVKFASLK 1151

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ACXC	NP_609593.1	AC_N	<33..285	CDD:292831
		CYCc	293..468	CDD:214485
		Nucleotidyl_cyc_III	307..466	CDD:299850
		CYCc	833..1060	CDD:214485	62/237 (26%)
		Nucleotidyl_cyc_III	861..1085	CDD:299850	62/236 (26%)
gcy-21	NP_001364740.1	Periplasmic_Binding_Protein_type1	58..422	CDD:415822
		PK_GC	612..881	CDD:270894
		HNOBA	<890..938	CDD:400168	10/38 (26%)
		Guanylate_cyc	944..1130	CDD:306677	64/238 (27%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810