Protein Alignment ACXC and gcy-15

DIOPT Version :10

• Sequence 1: NP_609593.1
• Gene: ACXC / 34689
• FlyBaseID: FBgn0040508
• Length: 1130
• Species: Drosophila melanogaster
• Sequence 2: NP_001364713.1
• Gene: gcy-15 / 191648
• WormBaseID: WBGene00001541
• Length: 1104
• Species: Caenorhabditis elegans
• Alignment Length: 1178
• Identity: 221/1178 - (18%)
• Similarity: 373/1178 - (31%)
• Gaps: 448/1178 - (38%)

  Fly   211 DVISTDILHNLGFNMMGIFFRIMNDTMVRA--SFLDRHQFIMEETWLRHALLQES---------- 263
            ||...|:....||:...:......:::.::  .|||::|      |.:.||:..|
 Worm    72 DVCEMDLSSVKGFDQTSVLMNSQTNSLAKSVMYFLDKYQ------WKKVALVSPSAVLTAFAARV 130

  Fly   264 --------------ILLDSILPPQIAKPVQEKIKSKITQ---------SENS------------P 293
                          ||:||.|.|.  ..:.||:|....:         |.|:            .
 Worm   131 RSDLLDALTANKIDILVDSRLDPM--SDITEKVKEDAEKARIFIICDWSSNANLLRNYIFKLGEM 193

  Fly   294 DRFQMGPRTTESFMAIQIHPDVSILYADVVN----YTHL-TTTLTVGNLVK-VLHDLYGRFDIAA 352
            ::.|.|    |.|:...|..|.:..:.:..:    ..|| .:.:...||.: .||::|....|.:
 Worm   194 NKMQSG----EYFVLGYISYDTNYQWLEASSGDQRLVHLGASDINDYNLTENDLHEVYKNVVILS 254

  Fly   353 ------------SNFKVQ---------------------------RIKFLGDCYYCVAGLTTPDP 378
                        .:.|.|                           |||.|.|....:|..|. |.
 Worm   255 DGPPPAEPNSTWEDIKTQVLKKKPAKMCPPYCNTTISEKITPRWDRIKLLFDSIQYLADATN-DA 318

  Fly   379 --------------DHAKCCVSLGISMISNIQEVRAERGLDI-DMRIGVH-------SGSLL-AG 420
                          :|   .:|..:..::.:.|.....|..: .|:|..|       |.||. ..
 Worm   319 LNIGANIYQSDIFYEH---LISRKVDSVTGVTEYIDGYGAIVGSMQIYYHFSSSSHNSYSLFPCA 380

  Fly   421 IIGEAKLQFDIW-------GTDVEIAN------------HLESTGEPGYVHVSGRTLSMLNPADY 466
            .:.::.|...:|       |..::..|            :.|:.|.|     :..|..::.....
 Worm   381 RLAQSSLLNTVWSLTDYSEGLSIDFVNKSAPKDTPVCGFYGENCGPP-----ANNTFIIVISVGV 440

  Fly   467 TILSGTQKAQS---------------------DPVLQYIHTYLLTGQVARESFITSIGGVRSSSV 510
            .:|.|...|.:                     :.::...||.|::.|..|.  :.||.|    ||
 Worm   441 AVLIGLAIAAAFLYKRYRYERRLHSLFFMIDRNQIILKKHTNLMSQQSLRS--MASIHG----SV 499

  Fly   511 LEVKSIDRIRSSRPSQSSMTDEFREEFRNMPVGGINLNSPCCRRTRLDTHKKTQRE--------I 567
              |.:...:|.|.        .|.|::.|  ...||.:|       :.....|.|.        .
 Worm   500 --VAASQTLRDSH--------FFIEDYNN--ASSINASS-------IFNTGSTARAGPFGPIPGF 545

  Fly   568 GIFCAAFKDSSLEWNYLHQ-PDFIFKSSMLLAWGIGCCLIYIQIVTNNFSCTACIVVDLVTFFFL 631
            |....|.:|.  :|   || |||          |:|                        .:...
 Worm   546 GGVTGASEDE--KW---HQIPDF----------GVG------------------------LYEGR 571

  Fly   632 TSLLCLAWYKNVCWWKSGRYEFRIYGKYSCMAFHIFEKIQHSVSLRITVYLGILF---SYYAVIS 693
            |..|...:..:|.:.:|.|.|              ..|:|.||:..:..::|::.   ..:.|..
 Worm   572 TVALKRIYRSDVEFTRSNRLE--------------IAKLQESVNSNVIEFVGMVVQSPDVFVVYE 622

  Fly   694 LIMLNCDRDMYE---------------------LSYIESKIY--HYEMDRDTCF----------- 724
            |......:|:.:                     |.|:.|...  |..:....|.
 Worm   623 LAQRGSLKDILDNDDMPLDDVFRSQMTKDIIAGLEYLHSSPVGCHGRLKSTNCLIDARWMVRLSS 687

  Fly   725 -----------------------HPWVFTNMISLILGIS------------YTFARI-------- 746
                                   ..|....::....|:|            |:.|.:
 Worm   688 FGLRELRGEETWQQEDDVQEGKDQLWTSPELLRWSTGLSQCGVLLVQKSDVYSLAIVLYELFGRL 752

  Fly   747 ------PFGLKIVISCCETLAYL--------LIVFFQFAFIFQHSA----TTTPFMKAELAHCLR 793
                  |...:.::|..:..|..        :.|..:...|.|.:.    |..|..:..| |.::
 Worm   753 GPWGDEPMEPREIVSLVKREALAGKKPFRPDMAVLKESPRIVQETVVAAWTEDPLNRPSL-HQIK 816

  Fly   794 VCMMLLTMYAK----ERQSEFNTKMNYKLNVDLQNKQKAADLTNQSIIILLNNILPSHVVD-LYL 853
            ..:..||:..|    :.......|...||..|:..:.:..:........||..:||..|.| |.|
 Worm   817 RKLKPLTIGLKRTIMDNMVSMIEKYTDKLEKDIAERNEELEAEKAKSEALLKMMLPEVVADSLKL 881

  Fly   854 NSLAKHELYYENYRMVSVMFAMLINF--------PMNLPSLRVLNDIITQFDRLLTAYREYYVVE 910
            .|    .:..|::...:|.|:....|        |:::  ::.|||:.|.|||::..:..|
 Worm   882 GS----NVSAESFENCTVFFSDCPGFVEMSATSKPIDI--VQFLNDLYTVFDRIIDQFDVY---- 936

  Fly   911 KIKVVGCTYMAACGLDFNLASNIRQTDHFRNSSLHVEVEHARNHRMTDENYDSDMNNDEVVFIMT 975
            |::.:...||.|.||.      :...:|           ||..                    :.
 Worm   937 KVETIADAYMVASGLP------VPNGNH-----------HAGE--------------------IA 964

  Fly   976 TFALDLMRTLAACNRAYSSSFFERSLSQGKI--CIGISSGEIMAGVVGASQPHYDIWGNPVNMAS 1038
            :..|.|::.:        .||..|.|...|:  .||::||..:|||||...|.|.::|:.||.||
 Worm   965 SLGLALLKAV--------ESFKIRHLPNEKVRLRIGMNSGPCVAGVVGLKMPRYCLFGDTVNTAS 1021

  Fly  1039 RMESTGLPGHIQVTEESAKILQE---FDIKCIYRGMTFVKGRGDIPTYFVG-----------IDE 1089
            ||||.|:|..|..:..:.:||.:   ::|:  .||:..:||:|...||||.           |.|
 Worm  1022 RMESNGIPLRINCSGTAKEILDQLGGYEIE--ERGIVEMKGKGKQMTYFVRGENSDMRRERIIRE 1084

  Fly  1090 NLKFMSAK 1097
            .:||.|.|
 Worm  1085 RVKFASLK 1092

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ACXC	NP_609593.1	Nucleotidyl_cyc_III	307..466	CDD:448371	38/245 (16%)
		Nucleotidyl_cyc_III	861..1085	CDD:448371	62/236 (26%)
gcy-15	NP_001364713.1	Periplasmic_Binding_Protein_type1	2..363	CDD:471960	53/306 (17%)
		PK_GC	553..822	CDD:270894	43/322 (13%)
		HNOBA	<831..879	CDD:462234	10/47 (21%)
		Guanylate_cyc	885..1071	CDD:425528	64/238 (27%)