DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ACXC and gcy-14

DIOPT Version :9

Sequence 1:	NP_609593.1	Gene:	ACXC / 34689	FlyBaseID:	FBgn0040508	Length:	1130	Species:	Drosophila melanogaster
Sequence 2:	NP_506660.2	Gene:	gcy-14 / 191647	WormBaseID:	WBGene00001540	Length:	1111	Species:	Caenorhabditis elegans

Alignment Length:	356	Identity:	88/356 - (24%)
Similarity:	164/356 - (46%)	Gaps:	78/356 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly   239 RASFLDRHQFIMEETWLRHALLQESILLDSILPPQIAKPVQEKIKSKITQSENSP----DRFQMG 299
            |.|.|..|.|.|.||:.  :.|:|.:      ..:..:.|:||.||.:......|    |:.::|
Worm   807 RKSNLMDHVFNMLETYA--STLEEEV------SDRTKELVEEKKKSDVLLYRMLPKMVADKLKLG 863

  Fly   300 ----PRTTESFMAIQIHPDVSILYADVVNYTHLTTTLTVGNLVKVLHDLYGRFDIAASNFKVQRI 360
                |.|.|         .|:|.::|||.:|.|....|...:|.:|:|||..||.......|.::
Worm   864 QTVEPETFE---------QVTIFFSDVVQFTTLAGKCTPLQVVTLLNDLYTIFDGIIEQNDVYKV 919

  Fly   361 KFLGDCYYCVAGLTTPD-PDHAKCCVSLGISMISN-----IQEVRAERGLDIDMRIGVHSGSLLA 419
            :.:||.|.||:||...: .:|.:....:.:..:|:     :|.:.:||   |::|||::.||::|
Worm   920 ETIGDGYLCVSGLPHRNGNEHIRHIARMSLGFLSSLEFFRVQHLPSER---INLRIGINCGSVVA 981

  Fly   420 GIIGEAKLQFDIWGTDVEIANHLESTGEPGYVHVSGRTLSMLNPADYTILSGTQ-KAQSDPVLQ- 482
            |::|....::.::|..|..|:.:||.|:||.:||:.....||.    .::.|.: :::.:.:::
Worm   982 GVVGLTMPRYCLFGDAVNTASRMESNGKPGKIHVTAEANQMLT----QVVGGFRTESRGEVIIKG 1042

  Fly   483 --YIHTYLLTGQVARESFITSIGGVRSSSVLEVKSIDRIRSSRPSQSSMTDEFREEFRNMPVGGI 545
              .:.||.|.|:.:|.|                     :.:..|.:.:.....|:..|::
Worm  1043 KGVMETYWLLGEQSRIS---------------------VSAQAPREKTPEPPRRQSVRSI----- 1081

  Fly   546 NLNSPCCRRTRLDTHKKTQREIGIFCAAFKD 576
               ||...:...:|.|      |:: :|:||
Worm  1082 ---SPIIEKMSEETQK------GLY-SAYKD 1102

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ACXC	NP_609593.1	AC_N	<33..285	CDD:292831	14/45 (31%)
		CYCc	293..468	CDD:214485	55/188 (29%)
		Nucleotidyl_cyc_III	307..466	CDD:299850	49/164 (30%)
		CYCc	833..1060	CDD:214485
		Nucleotidyl_cyc_III	861..1085	CDD:299850
gcy-14	NP_506660.2	PBP1_NPR_GC_like	21..423	CDD:107347
		ANF_receptor	43..418	CDD:279440
		PKc_like	535..800	CDD:304357
		HNOBA	<817..860	CDD:285003	12/50 (24%)
		CYCc	839..1031	CDD:214485	60/207 (29%)
		Guanylate_cyc	866..1053	CDD:278633	56/202 (28%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900