DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment ACXC and gcy-13

DIOPT Version :9

Sequence 1:	NP_609593.1	Gene:	ACXC / 34689	FlyBaseID:	FBgn0040508	Length:	1130	Species:	Drosophila melanogaster
Sequence 2:	NP_506097.3	Gene:	gcy-13 / 191646	WormBaseID:	WBGene00001539	Length:	1028	Species:	Caenorhabditis elegans

Alignment Length:	282	Identity:	78/282 - (27%)
Similarity:	134/282 - (47%)	Gaps:	52/282 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly   224 NMMGIFFRIMNDTMVRASFL-DRHQFIMEETWLRHALLQE----SILLDSILPPQIAKPVQEKIK 283
            |:|...|.::..   .||.| |..|..|:|      |::|    .|||..:||.|:|:      :
Worm   779 NLMDHVFSVLEK---HASSLEDEVQERMKE------LVEEKKKSDILLYRMLPQQVAE------R 828

  Fly   284 SKITQSENSPDRFQMGPRTTESFMAIQIHPDVSILYADVVNYTHLTTTLTVGNLVKVLHDLYGRF 348
            .|:.||. .|:.|:                .|:|.::|||.:|.|....|...:|.:|:|||..|
Worm   829 LKLGQSV-EPEAFE----------------SVTIFFSDVVGFTVLANKSTPLQVVNLLNDLYTTF 876

  Fly   349 DIAASNFKVQRIKFLGDCYYCVAGLTTPD-PDHAKCCVSLGISMISNIQEVR-----AERGLDID 407
            |.........:::.:||.|..|:||...: .:|.....::.:.::.::|..:     .|:   :.
Worm   877 DAIIEKNDSYKVETIGDAYLVVSGLPRRNGTEHVANIANMSLELMDSLQAFKIPHLPQEK---VQ 938

  Fly   408 MRIGVHSGSLLAGIIGEAKLQFDIWGTDVEIANHLESTGEPGYVHVSGRTLSMLNP--ADYTILS 470
            :|||:||||.:||::|....::.::|..|..|:.:||.|:||::|:|.....:|..  .:|...|
Worm   939 IRIGMHSGSCVAGVVGLTMPRYCLFGDTVNTASRMESNGKPGFIHLSSDCYDLLTSLYKEYNTES 1003

  Fly   471 -GTQKAQSDPVLQYIHTYLLTG 491
             |....:...|:|   ||.|.|
Worm  1004 RGEVIIKGKGVMQ---TYWLLG 1022

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ACXC	NP_609593.1	AC_N	<33..285	CDD:292831	19/65 (29%)
		CYCc	293..468	CDD:214485	48/182 (26%)
		Nucleotidyl_cyc_III	307..466	CDD:299850	45/166 (27%)
		CYCc	833..1060	CDD:214485
		Nucleotidyl_cyc_III	861..1085	CDD:299850
gcy-13	NP_506097.3	PBP1_NPR_GC_like	3..397	CDD:107347
		ANF_receptor	13..368	CDD:279440
		PKc_like	548..770	CDD:304357
		HNOBA	<797..829	CDD:285003	13/43 (30%)
		CYCc	808..1000	CDD:214485	58/217 (27%)
		Guanylate_cyc	835..1022	CDD:278633	55/209 (26%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810